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| Number | Title | Issue Date |
| 7396904 | Tumor-associated peptides binding to MHC-molecules The invention relates to a tumor-associated peptide containing an amino sequence, which is selected from the group consisting of SEQ ID NO:1 to SEQ ID NO:79 of the enclosed listing. The peptide has the ability to bind to a molecule of the human major histocompatibil... | 07/08/2008 |
| 7393921 | Prostate-specific polypeptide pamp and encoding nucleic acid molecules The present invention relates to novel prostate specific nucleic acid molecules and polypeptides and related methods for diagnosing or predicting susceptibility to a prostate neoplastic condition. ... | 07/01/2008 |
| 7351793 | PRO1286 polypeptide The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 04/01/2008 |
| 7342099 | cDNA encoding a gene BOG (B5T over-expressed gene) and its protein product Nucleic acids that encode novel polypeptides, designated in the present application as “BOG” (B5T Over-expressed Gene) are provided. BOG binds to pRb and is over-expressed in a number transformed rat liver epithelial (RLE) cell lines resistant to the growth inhi... | 03/11/2008 |
| 7329410 | Compositions and method for WT1 specific immunotherapy A method for enhancing or inducing an immune response to WT1 is disclosed. In particular, the method comprises administering to a patient an immunogenic composition comprising an isolated polypeptide consisting of amino acids 1-249 of WT1 and a non-specific immune r... | 02/12/2008 |
| 7317086 | Basal cell carcinoma tumor suppressor protein This invention provides for a tumor suppressor gene inactivation of which is a causal factor in nevoid basal cell carcinoma syndrome and various sporadic basal cell carcinomas. The NBCCS gene is a homologue of the Drosophila patched (ptc) gene. ... | 01/08/2008 |
| 7202334 | Compositions and methods for the therapy and diagnosis of ovarian cancer Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune... | 04/10/2007 |
| 7199218 | ICBP90 polypeptide and its fragments and polynucleotides coding for said polypeptides and applications for diagnosing and treating cancer The invention concerns a novel ICBP90 (Inverted CCAAT box binding protein 90) and its fragments, polynucleotides coding for said polypeptides and specific antibodies directed against said polypeptides. The invention also concerns methods and kits for diagnosing cell... | 04/03/2007 |
| 7157091 | MAGE-A1 peptides presented by HLA class II molecules The invention provides isolated HLA DRB1*15-binding peptides consisting of the amino acid sequence set forth as SEQ ID NO:7 with 0–10 amino acids added to either or both ends of the amino acid sequence set forth as SEQ ID NO:7, and an endosomal targeting signal co... | 01/02/2007 |
| 7115710 | Diagnosis and treatment of PTP related disorders The present invention relates to PTP05 polypeptides and PTP10 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating ... | 10/03/2006 |
| 7087393 | Methods for detecting CS198 antigen A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS198 and transcribed from GI tract tissue, is described. These sequences are useful for detecting, diagnosing, staging, monitoring, prognosticating, prevent... | 08/08/2006 |
| 6919435 | Human lung adenocarcinoma-related monoclonal antibody and antigen and immunoassay method which uses the same The monoclonal antibody produced by a hybridoma cell strain TRD-L1, -L2 or -L3 which is obtained by the fusion between mouse myeloma cells and spleen cells of a mouse immunized with a human lung adenocarcinoma cell secretion component reacts in a specific fashion wi... | 07/19/2005 |
| 6858709 | Component of von Hippel-Lindau tumor suppressor complex and SCF ubiquitin ligase Rbx1, an evolutionarily conserved Cullin-interacting RING-H2 finger protein, has been discovered. Mammalian Rbx1 has been identified as a component of the CUL2-containing VHL complex. An Rbx1 homolog from S. cerevisiae has also been identified as a subunit an... | 02/22/2005 |
| 6809179 | Tumor-associated antigen (R11) Tumor-associated antigens, immunogenic peptides derived therefrom and DNA molecules coding therefor, and the use thereof in the immunotherapy of cancers. ... | 10/26/2004 |
| 6773707 | Heat shock protein-based vaccines and immunotherapies The present invention relates to methods and compositions for inducing an immune response in a subject, wherein the subject is administered an effective amount of a heat shock protein complexed to a hybrid antigen comprising an antigenic domain and a heat shock prot... | 08/10/2004 |
| 6767711 | Treatment and diagnosis of prostate cancer The present invention is directed to the use of antibodies or binding portions thereof or probes which recognize an antigen of normal, benign, hyperplastic, and cancerous prostate epithelial cells or portions thereof. These antibodies or binding portions thereof or ... | 07/27/2004 |
| 6761892 | Heat shock protein-based vaccines and immunotherapies The present invention relates to methods and compositions for inducing an immune response in a subject, wherein the subject is administered an effective amount of a heat shock protein complexed to a hybrid antigen comprising an antigenic domain and a heat shock prot... | 07/13/2004 |
| 6756477 | Compositions and methods for the therapy and diagnosis of breast cancer Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeu... | 06/29/2004 |
| 6719974 | Heat shock protein-based vaccines and immunotherapies The present invention relates to methods and compositions for inducing an immune response in a subject, wherein the subject is administered an effective amount of a heat shock protein complexed to a hybrid antigen comprising an antigenic domain and a heat shock prot... | 04/13/2004 |
| 6676934 | Pharmaceutical composition with tumor necrosis factor A and 2-methoxyestrone-3-0-sulphamate for inhibition of estrone sulphatase A composition is described. The composition comprises i) a compound comprising a sulphamate group ("a sulphamate compound"); and ii) a biological response modifier.... | 01/13/2004 |
| 6669946 | METHOD FOR IDENTIFYING INDIVIDUALS SUFFERING FROM A CELLULAR ABNORMALITY SOME OF WHOSE ABNORMAL CELLS PRESENT COMPLEXES OF HUMAN LEUKOCYTE ANTIGEN TYROSINASE DERIVED PEPTIDES, AND METHODS FOR TREATING SAID INDIVIDUALS The invention relates to complexes of human leukocyte antigen molecules and tyrosinase derived peptides SEQ ID NO: 2, on the surfaces of abnormal cells. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.... | 12/30/2003 |
| 6663868 | Heat shock protein-based vaccines and immunotherapies The present invention relates to methods and compositions for inducing an immune response in a subject, wherein the subject is administered an effective amount of a heat shock protein complexed to a hybrid antigen comprising an antigenic domain and a heat... | 12/16/2003 |
| 6660834 | Reagents useful for detecting diseases of the gastrointestinal tract A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS198 and transcribed from GI tract tissue, is described. These sequences are useful for detecting, diagnosing, staging, monitoring, prognosticati... | 12/09/2003 |
| 6656480 | Compositions and methods for the treatment and diagnosis of breast cancer Compositions and methods for the detection and therapy of breast cancer are disclosed. The compounds provided include nucleotide sequences that are preferentially expressed in breast tumor tissue, as well as polypeptides encoded by such nucleotide sequenc... | 12/02/2003 |
| 6488931 | Compositions and methods for therapy and diagnosis of ovarian cancer Compositions and methods for the therapy of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune sy... | 12/03/2002 |
| 6433149 | Compounds and methods for inhibiting cancer metastasis Agents for inhibiting cancer metastasis are provided. The methods comprise administering to a patient an antimetastatic agent that comprises one or more of: (a) a peptide sequence that is at least 50% identical to an OB-cadherin CAR sequence; (b) a non-pe... | 08/13/2002 |
| 6410026 | Methods for preparation of vaccines against cancer The present invention relates to methods for preparing immunogenic, prophylactically and therapeutically effective complexes of heat shock proteins noncovalently associated with antigenic peptides of cancer cells. The claimed methods comprise the construc... | 06/25/2002 |
| 6410027 | Methods for preparation of vaccines against cancer The present invention relates to methods for preparing immunogenic, prophylactically and therapeutically effective complexes of heat shock proteins noncovalently associated with antigenic peptides of cancer cells. The claimed methods comprise the construc... | 06/25/2002 |
| 6406700 | Methods for preparation of vaccines against cancer The present invention relates to methods for preparing immunogenic, prophylactically and therapeutically effective complexes of heat shock proteins noncovalently associated with antigenic peptides of cancer cells. The claimed methods comprise the construc... | 06/18/2002 |
| 6372473 | Tissue plasminogen activator-like protease The present invention relates to a novel t-PALP protein which is a member of the serine protease family. In particular, isolated nucleic acid molecules are provided encoding the human t-PALP protein. t-PALP polypeptides are also provided as are vectors, h... | 04/16/2002 |
| 6326464 | P53 protein variants and therapeutic uses thereof Proteins derived from the product of tumor suppressor gene p53 and having enhanced functions for therapeutical use are disclosed. The proteins advantageously have enhanced tumour suppressor and programmed cell death inducer functions, particularly in prol... | 12/04/2001 |
| 6284873 | Complex of human kallikrein 2 (hK2) and protease inhibitor-6 (PI-6) in prostate tumor tissue and methods of using the complex The present invention provides a novel complex of hK2 and PI-6 and methods of using the novel complex. The novel complexes of hK2 and PI-6 of the present invention exist at an elevated level in prostate cancer tissues. Therefore, the hK2-PI6 complexes of ... | 09/04/2001 |
| 6258779 | Method of using fetuin to induce apoptosis in cancer cells The present invention provides the methods to isolate the proteins specifically induced apoptosis (programmed cell death) in prostate cancer cells (LNCAP), leukemia cells (HL-60), and breast cancer cells (MCF-70), but without effect in normal human lung f... | 07/10/2001 |
| 6238876 | Methods and materials for the diagnosis and treatment of sporadic basal cell carcinoma Methods for detection of the onset or presence of sporadic basal cell carcinoma in an animal by measuring for elevated levels of ectopic expression of Gli1 in the animal's epidermal tissue sample suspected of harboring sporadic basal cell carcinoma.... | 05/29/2001 |
| 6174858 | Conjugates useful in the treatment of prostate cancer Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA) and known cytotoxic agents are disclosed. The conjugates of the invention are characterized ... | 01/16/2001 |
| 6172191 | Protein for inhibition and activation of protooncogene Ras and method for isolation thereof The method to isolate a protein, designated as p10, which strongly inhibits the activity of H-Ras bound to GTP in vitro while in the presence of cAMP, which inactivates the biological function of Ras is provided. Protein p10 also inhibits intrinsic GTPase... | 01/09/2001 |
| 6168793 | Heat shock protein 70 preparations in vaccination against cancer and infectious disease The present invention relates to compositions comprising a population of non-covalent heat shock protein 70-peptide complexes purified from mammalian tumor tissues or mammalian cells infected with an infectious agent. When administered to a mammal, the co... | 01/02/2001 |
| 6166178 | Telomerase catalytic subunit The invention provides compositions and methods related to telomerase reverse transcriptase, the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of huma... | 12/26/2000 |
| 6149921 | Vaccine compositions for eliciting an immune response against N-acetylated gangliosides and their use for cancer treatment The invention provides novel uses for n-glycolylated gangliosides and N-acetylated gangliosides, or derivatives and/or oligosaccharides thereof The invention further provides methods of obtaining such gangliosides, as well as vaccine compositions comprisi... | 11/21/2000 |
| 6143507 | High throughput compatible assay for receptor-TRAF interactions Disclosed is a high throughput compatible assay that is useful for the identification of specific antagonists of TRAF-receptor interactions. The modular flexibility of the assay makes it possible to introduce simple modifications in order to measure the i... | 11/07/2000 |
