Quotables
"We are probably nearing the limit of all we can know about astronomy."
Simon Newcomb, astronomer ; 1888
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7423117 | Surface-functionalized carrier material and solid phase synthesis method The invention concerns a novel surface-functionalized carrier material with a polymeric surface and at least one linker compound according to the general formula (I), which is covalently bound to the surface. In the formula, P indicates the polymeric surface; R... | 09/09/2008 |
| 7419600 | Method for purifying a branched water-soluble polymer Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure wherein Z is a moiety that can be activated for attachment to biologically active molecules such as proteins and wherein P a... | 09/02/2008 |
| 7417021 | Biologically active conjugate of a biopolymer and therapeutic agent A biologically active conjugate is disclosed comprising a biopolymer and a therapeutic agent joined by a disulfide bond. The conjugate, when formulated in a pharmaceutical composition with a suitable carrier, has improved in vivo stability and activity, and can be t... | 08/26/2008 |
| 7238360 | Alteration of cell membrane with B7 Methods and compositions are provided for the persistent modification of cell membranes with exogenous proteins so as to alter the function of the cell to achieve effects similar to those of gene therapy, without the introduction of exogenous DNA. DNA sequences, the... | 07/03/2007 |
| 7214388 | Degradable heterobifunctional poly(ethylene glycol) acrylates A heterobifunctional poly(ethylene glycol) is provided having a hydrolytically degradable linkage, a first terminus comprising an acrylate group, and a second terminus comprising a target such as a protein or pharmaceutical agent or a reactive moiety capable of coup... | 05/08/2007 |
| 7208299 | Composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces The present invention is directed to a composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces and hydrophobic coated surfaces. The composition is a biomolecule conjugated end-group activated polymer (EGAP). The biomolecu... | 04/24/2007 |
| 7195913 | Randomly ordered arrays and methods of making and using Arrays including microparticles having probe and marker moieties are used for the detection of a target in a sample. Microparticles are randomly immobilized on at least a portion of a substrate. A detection scheme is performed to detect the marker associated with th... | 03/27/2007 |
| 7166304 | Degradable heterobifunctional poly(ethylene glycol) acrylates A heterobifunctional poly(ethylene glycol) is provided having a hydrolytically degradable linkage, a first terminus comprising an acrylate group, and a second terminus comprising a target such as a protein or pharmaceutical agent or a reactive moiety capable of coup... | 01/23/2007 |
| 7122356 | Method for attachment of biomolecules to medical device surfaces A method for making a medical device having at least one biomolecule immobilized on a substrate surface is provided. One method of the present invention includes immobilizing a biomolecule comprising an unsubstituted amide moiety on a biomaterial surface. Another me... | 10/17/2006 |
| 7087728 | Carbohydrate crosslinked glycoprotein crystals The present invention relates to the field of carbohydrate crosslinked glycoprotein crystals. Advantageously, such crosslinked glycoprotein crystals display stability to harsh environmental conditions, while maintaining the structural and functional integrity of the... | 08/08/2006 |
| 7083936 | Aminodextran compositions and conjugates and method of making and using them A composition containing polydisperse aminodextran polymer molecules is soluble in an aqueous solution at a concentration of 10 mg/ml. The molecules therein have a narrow size distribution characterized by an average molecule mean hydrodynamic diameter of greater th... | 08/01/2006 |
| 7067619 | Integrin-binding peptides This invention is directed to novel integrin binding peptides. These peptides bind to αv- of α5-containing integrins and can exhibit high binding affinity. They contain one of the following sequence motifs: RX1ETX2WX | 06/27/2006 |
| 7018624 | Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels A degradable PEG hydrogel is described that, upon hydrolysis, releases conjugates of substantially non-peptidic polymers and biologically active molecules. For example, PEG and protein conjugates can be released in vivo from the hydrogels for therapeutic application... | 03/28/2006 |
| 7008634 | Cell growth substrates with tethered cell growth effector molecules Described are compositions with tethered growth effector molecules, and methods of using these compositions for growing cells and tissues. Growth effector molecules, including growth factors and extracellular matrix molecules, are flexibly tethered to a solid substr... | 03/07/2006 |
| 6960457 | Reversible immobilization of arginine-tagged moieties on a silicate surface This invention provides materials and methods for the site specific attachment of virtually any moiety to a layered silicate surface. The methods involve covalently attaching the moiety to an arginine tag; and contacting the arginine tag with the layered silicate (e... | 11/01/2005 |
| 6911535 | Biomolecule/polymer conjugates The present invention is directed to methods for immobilizing natural or synthetic biomolecules to surfaces. The methods comprise covalently linking the natural or synthetic biomolecule to a mono- or bi-functional polymer and covalently and/or electrostatically immo... | 06/28/2005 |
| 6894025 | Biologically active molecules having thiol moiety conjugated to polymers containing ethyl sulfone moiety A poly(ethylene glycol) derivative is disclosed that is activated with a sulfone moiety for selective attachment to thiol moieties on molecules and surfaces. The activated PEG is water soluble, hydrolytically stable for extended periods, and forms hydrolytically sta... | 05/17/2005 |
| 6809186 | Simple method for labeled conjugate production The present invention relates to methods for coupling labels to particular target moieties. The coupling reactions of the present invention use temporal spacing of the reactants through phase change (i.e. by rapid freezing) to control the initiation and termination ... | 10/26/2004 |
| 6808908 | Functionalized porous substrate for binding chemical and biological moieties The invention relates to porous polymeric materials, methods of making them, and applications in medical devices. A specific embodiment of the invention encompasses a material comprising a porous polyolefin substrate containing inclusions of a material to which chem... | 10/26/2004 |
| 6783838 | Coated film laminate having an ionic surface A coated laminate having an ionic surface including a shrinkable polymeric film, an ionic coating and, optionally, a hydrogel is disclosed. A method for transferring sample molecules from a matrix to a coated laminate having an ionic surface also is disclosed. ... | 08/31/2004 |
| 6770220 | Production and use of luminescent microparticles and nanoparticles Luminescent microparticles and nanoparticles are provided for use either as internal standards for referencing fluorescent signals, or as markers for detecting biomolecules. Luminescence dyes are incorporated in inert form into solid materials such that they are pro... | 08/03/2004 |
| 6749865 | Modification of biopolymers for improved drug delivery A biologically active conjugate is disclosed comprising a biopolymer and a therapeutic agent joined by a disulfide bond. The conjugate, when formulated in a pharmaceutical composition with a suitable carrier, has improved in vivo stability and activity, and can be t... | 06/15/2004 |
| 6720304 | Conjugate comprising a folic acid antagonist and a carrier The invention relates to conjugates comprising a D-enantiomer of a folic acid antagonist and a carrier. Furthermore, the invention relates to the production of such conjugates as well as their use. ... | 04/13/2004 |
| 6703207 | Method of screening substances with a glycidyl methacrylate covered styrene-glycidyl methacrylate polymer A compound possessing physiological activity is coupled to a styrene-glycidyl methacrylate polymer through a spacer. Compounds that may be used include receptors such as proteins, and 3-[(5-(2,3-dimethoxy-6-methyl-benzoquinonyl)]-2-nonyl-2-propionic a ... | 03/09/2004 |
| 6677438 | Method for attaching polyethylene glycol to macromolecules A process for attaching a polyethylene glycol compound to a macromolecule to prepare a conjugate or adduct between the polyethylene glycol compound and the macromolecule is described. The process comprises the steps of (1) preparing an activated PEG or an... | 01/13/2004 |
| 6670199 | Composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces The present invention is directed to a composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces and hydrophobic coated surfaces. The composition is a biomolecule conjugated end-group activated polymer (EGAP). Th... | 12/30/2003 |
| 6670159 | Preparing monomeric metal ion chelator containing diacetyl glycine group linked to proteinaceous molecule A precursor for the construction of chelated metal conjugates which demonstrate improved assay performance and utility in minimizing non-specific binding while maintaining specificity for target molecules is disclosed. The precursor has tridentate functio... | 12/30/2003 |
| 6664331 | Poly(ethylene glycol) derivatives with proximal reactive groups An activated, substantially water soluble poly(ethylene glycol) is provided having of a linear or branched poly(ethylene glycol) backbone and at least one terminus linked to the backbone through a hydrolytically stable linkage, wherein the terminus is bra... | 12/16/2003 |
| 6638725 | Method for assaying receptor binding property and reagent for the assay The present invention provides a method capable of simultaneous processing of plural test samples for the receptor binding property of a chemical substance, which does not require immobilization of the receptor or a special device, and a reagent to be use... | 10/28/2003 |
| 6630577 | 1,2-Phenylenediboronic acid reagents and complexes A reagent having the general formula of General Formula I: ##STR1## wherein group Z comprises a spacer selected from an aliphatic chain up to about 6 carbon equivalents in length, an unbranched aliphatic chain of from about 6 to 18 carbon equivalents in l... | 10/07/2003 |
| 6617142 | Method for attachment of biomolecules to medical device surfaces Methods are provided for forming a coating of an immobilized biomolecule on a surface of a medical device to impart improved biocompatibility for contacting tissue and bodily fluids. A biomolecule such as a glycoprotein having an unsubstituted amide moiet... | 09/09/2003 |
| 6566409 | Lock and key micelles A lock unimolecular micelle includes at least one engineered acceptor specifically binding a ligand (or specifically a "key" unimolecular micelle) thereto. A key unimolecular micelle comprises a core molecule and a plurality of branches extending therefro... | 05/20/2003 |
| 6551598 | Vaccination against canine herpesvirosis and vaccines therefor Use of a CHV antigen for the preparation of a vaccine against canine herpesvirosis, which is intended to be administered to gestating bitches as close as possible to whelping, preferably during the final third of gestation, and which produces a high level... | 04/22/2003 |
| 6545132 | Microsphere containing glycidyl methacrylate covered polymer and spacer coupled compound for isolating substances A microsphere is prepared containing a compound possessing physiological activity coupled to a styrene-glycidyl methacrylate polymer through a spacer. Compounds that may be used include receptors such as proteins, and 3-[(5-(2,3-dimethoxy-6-methyl-benzoqu... | 04/08/2003 |
| 6528291 | Activated inorganic slide having aldehyde groups deposited by plasma deposition A method is provided for preparing an active slide, including introducing a monomer containing an aldehyde group, or a mixture of a monomer containing an aldehyde group and an acidic functional group provider into a plasma chamber; and depositing the alde... | 03/04/2003 |
| 6514734 | Polybifunctional reagent having a polymeric backbone and latent reactive moieties and bioactive groups A polybifunctional reagent is provided having a polymeric backbone, one or more pendent latent reactive (preferably photoreactive) moieties, and two or more pendent bioactive groups. The reagent can be activated to form a bulk material or can be brought i... | 02/04/2003 |
| 6514688 | Separating, detecting or quantifying biological materials using magnetic cross-linked polyvinyl alcohol particles Biological materials in a mixture of substances are separated, detected or quantified using magnetic spherically shaped cross-linked polyvinyl alcohol (PVAL) polymer particles ranging in size from 1 to 10 μm. The particles containing a coupled ligand are... | 02/04/2003 |
| 6500933 | Methods of preparing carbohydrate crosslinked glycoprotein crystals The present invention relates to the field of carbohydrate crosslinked glycoprotein crystals. Advantageously, such crosslinked glycoprotein crystals display stability to harsh environmental conditions, while maintaining the structural and functional integ... | 12/31/2002 |
| 6462179 | Phenyldiboronic acid reagents and complexes Reagents suitable for the modification of a bioactive species for the purpose of incorporating one or more phenyldiboronic acid (PDBA) moieties for subsequent conjugation to a different (or the same) bioactive species having one or more pendant boronic co... | 10/08/2002 |
| 6458923 | Modified position (7) bradykinin antagonist peptides The substitution of the L-Pro at the 7-position of the peptide hormone bradykinin or other substituted analogs of bradykinin with an isoquinoline derivative which converts bradykinin agonists into bradykinin antagonists. The invention further includes the... | 10/01/2002 |
