Did You Know...
...that the x-ray was discovered purely by accident? When German physicist Wilhelm Konrad von Roentgen was experimenting with cathode rays in 1895, he put an activated Crookes tube in a book and went out to lunch. When he returned, he discovered that a key that had also been placed in the book showed up as an image on the developed film!
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7423010 | Nonporous microparticle-prodrug conjugates for treatment of infection This invention provides novel methods and reagents for specifically delivering biologically active compounds to phagocytic mammalian cells. The invention also relates to specific uptake of such biologically active compounds by phagocytic cells and delivery of such c... | 09/09/2008 |
| 7419807 | protein, gene sequence and uses thereof A high molecular weight (“HMW”) protein of Chlamydia, the amino acid sequence thereof, and antibodies that specifically bind the HMW protein are disclosed as well as the nucleic acid sequence encoding the same. Also disclosed are prophylactic and therapeu... | 09/02/2008 |
| 7335370 | antigens and corresponding DNA fragments and uses thereof The present invention provides a method of immunizing a host against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae. The method involves nucleic acid immunization, including DNA immunization, and employs a vector conta... | 02/26/2008 |
| 7326545 | antigens and corresponding DNA fragments and uses thereof The present invention provides a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae, employing a vector containing a nucleotide seque... | 02/05/2008 |
| 7223836 | Peptides for chlamydophila pneumoniae vaccine and diagnosis Peptides are disclosed that include SEQ ID NO:1, SEQ ID NO: 2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, and SEQ ID NO:6, or a conservative variant or mimic thereof, wherein the conservative variant or mimic specifically binds an antibody that specifically binds SEQ ID... | 05/29/2007 |
| 7052915 | Selective labeling and isolation of phosphopeptides and applications to proteome analysis A method for selective labeling of phosphate groups in natural and synthetic oligomers and polymers in the presence of chemically related groups such as carboxylic acid groups. The method is specifically applicable to biological oligomers and polymers, including pho... | 05/30/2006 |
| 6858582 | Composition containing porous microparticle impregnated with biologically-active compound for treatment of infection Methods and reagents are provided for specifically targeting biologically active compounds such as antiviral and antimicrobial drugs, or prodrugs containing the biologically active compound to specific sites such as specific organelles in phagocytic mammalian cells.... | 02/22/2005 |
| 6822071 | Polypeptides from Chlamydia pneumoniae and their use in the diagnosis, prevention and treatment of disease Chlamydia pneumoniae polypeptides are provided. The C. pneumoniae polypeptides can be used to prepare pharmaceutical compositions for the treatment or prevention of disease. In addition, the proteins can be used in methods for the diagnosis of C. pn... | 11/23/2004 |
| 6809186 | Simple method for labeled conjugate production The present invention relates to methods for coupling labels to particular target moieties. The coupling reactions of the present invention use temporal spacing of the reactants through phase change (i.e. by rapid freezing) to control the initiation and termination ... | 10/26/2004 |
| 6723539 | Absorbent medium containing particles of chopped cellulose or agarose sponge material having functional groups An adsorbent medium is prepared comprising particles of a sponge material made of cellulose or agarose carrying functional groups such as diethylaminoethane groups. The particles may be obtained by chopping a larger block of the sponge material. The medium preferabl... | 04/20/2004 |
| 6680184 | Encapsulating liquid with hydrocolloid membrane stable from about -20 to 90 degrees C without bursting A temperature-stable droplet is provided containing a temperature-stable hydrocolloid membrane. The hydrocolloid membrane encapsulates a liquid that contains at least one enzyme, a cell, a biological agent, a pharmaceutical agent, an immunological agent, ... | 01/20/2004 |
| 6635744 | Fibroblast growth factor homologous factor-4 The invention provides fibroblast growth factor homologous factor (FHF) polypeptides and nucleic acid molecules that encode them. Also included in the invention are diagnostic and therapeutic methods using FHF polypeptides and nucleic acids.... | 10/21/2003 |
| 6599620 | Cellulosic particles, spherical object comprising cross-linked polymer particles, and adsorbent for body fluid purification The present invention relates to a cellulosic particle body comprising interconnected cellulosic small particles with small interparticle spaces and to a method of producing said cellulosic particle body which comprises dispersing cellulosic small particl... | 07/29/2003 |
| 6444261 | Storage-stable particle, in particular carrier for carrier-bound reactions, and methods of producing said particle A particle resistant to storage of at least one first and at least one second component, wherein said second component of at least one crosslinkable polymer as a shell at least partially envelops and/or encloses said first component as a core and said fir... | 09/03/2002 |
| 6399750 | IGG separation medium A separation medium having a base matrix and matrix-bound groups which exhibit recombinant Protein A containing a cysteine. The groups are of formula: --B--X--rProtein A-cys where B is a bridge which binds to the base matrix and X includes a heteroatom N ... | 06/04/2002 |
| 6384188 | Lipopolysaccharide-binding and neutralizing peptides Substance which bind with high affinity to endotoxin (lipopolysaccharide [LPS]), and which are useful for the prevention or treatment of, for example, Gram-negative and Gram-positive bacterial sepsis, and for the treatment of bacterial and fungal infectio... | 05/07/2002 |
| 6339060 | Conjugate of biologically active compound and polar lipid conjugated to a microparticle for biological targeting Methods and reagents are provided for specifically targeting biologically active compounds such as antiviral and antimicrobial drugs, or prodrugs containing the biologically active compound to specific sites such as specific organelles in phagocytic mamma... | 01/15/2002 |
| 6270983 | Surfaces coated with streptavidin/avidin The invention relates to surfaces coated with streptavidin and avidin for use in immunoassays, wherein the surfaces comprise a layer of streptavidin and avidin which are bonded on a surface of a solid supporting material through a biotinylated adhering ag... | 08/07/2001 |
| 6252054 | Immobilization of SH group-containing compounds in the presence of a sulfite-containing antioxidant Immobilization of SH group-containing compounds on a solvent-insoluble support is carried out in the presence of an antioxidant to prevent oxidation of SH groups to S--S bonds. This improves immobilization efficiency and suppresses deterioration of inhere... | 06/26/2001 |
| 6190916 | Troponin I composition The present invention relates to stable compositions useful as primary standards and calibrators and controls comprising a cardiac troponin I (cTnI) such as native, recombinant, addition and deletion forms thereof, whether or not complexed with other trop... | 02/20/2001 |
| 6174700 | Purification of a polypeptide compound having a polysaccharide binding domain by affinity phase separation A compound having a polysaccharide binding domain such as contained by a cellulose and essentially lacking in polysaccharidase activity is purified from other ingredients in a mixture using an affinity partition system. A mixture containing the compound i... | 01/16/2001 |
| 6127339 | Peptide for binding thereto a low density lipoprotein Disclosed is a peptide for binding thereto a low density lipoprotein, which has an amino acid sequence represented by the formula (I) or (II) and which has an electric charge (E) satisfying the following requirement: +1ࣘEࣘ+4 wherein E is defined by th... | 10/03/2000 |
| 6114180 | Synthetic calibrators for use in immunoassays, comprising the analytes or partial sequences thereof which are conjugated to inert carrier molecules The invention relates to synthetic calibrators for immunological tests, analyte-specific epitopes being coupled to other proteins or to synthetic carriers.... | 09/05/2000 |
| 6093558 | Binding protein of biologically active compositions to an adhesive formulation on a substrate Compositions and methods are provided for adhering and binding biologically active proteins and protein-containing composites to substrates. Adhesive formulations comprising a nonproteinaceous polymer of monomeric units comprising an aromatic moiety subst... | 07/25/2000 |
| 6063759 | Conjugate of biologically active compound and polar lipid conjugated to a microparticle for biological targeting Methods and reagents are provided for specifically targeting biologically active compounds such as antiviral and antimicrobial drugs, or prodrugs containing the biologically active compound to specific sites such as specific organelles in phagocytic mamma... | 05/16/2000 |
| 6048715 | Two-phase partition affinity separation system and affinity separated cell-containing composition A two-phase partition system is provided for affinity separation of a composition containing a polysaccharide binding peptide from a mixture such as a fermentation broth. The peptide may be from an enzyme and lacking in polysaccharidase activity such as t... | 04/11/2000 |
| 5969040 | Factor IX -- polymeric conjugates Conjugates containing a substance with coagulant activity, such as recombinant Factor IX, non-antigenic polymers, such as poly(ethylene glycol), are disclosed. Also disclosed are methods of forming the novel conjugates of this invention.... | 10/19/1999 |
| 5968794 | Biodegradable particulate vector for transporting molecules having biological activity A biodegradable particulate vector for transporting biologically active molecules is prepared containing a nucleus formed of a cross-linked polysaccharide or oligosaccharide matrix having grafted ionic ligands, a layer of fatty acid compounds covalently b... | 10/19/1999 |
| 5962289 | Polysaccharide binding fusion proteins and conjugates Fusion proteins or conjugates are provided containing an amino acid sequence having a substrate binding region of a polysaccharidase such as cellulase that binds to a ଲ-1,4-glycan matrix such as cellulose. The substrate binding region is essentially... | 10/05/1999 |
| 5952473 | Reagent and kit for determining isoprenylating activity and inhibition thereof The invention provides an immobilised oligopeptide for detecting protein prenylation consisting of an oligopeptide containing the amino acid sequence Xad-Xac-Xab-Xaa-OH at its carboxyl-terminus, at least one of Xaa, Xab, Xac and Xad representing cysteine ... | 09/14/1999 |
| 5948889 | Compositions and methods for screening antimicrobials A method for screening compounds for antimicrobial activity is described that utilizes bacterial protein-protein binding in vitro. The method may be performed using immobilized elements and the immobilization may be carried out using a variety of immobili... | 09/07/1999 |
| 5928917 | Conjugate of non-protein chemical moiety and polypeptide having cellulose binding region Fusion proteins or conjugates are provided containing an amino acid sequence having a substrate binding region of a polysaccharidase such as cellulase that binds to a ଲ-1,4-glycan matrix such as cellulose. The substrate binding region is essentially... | 07/27/1999 |
| 5866387 | Method for immobilizing ligand or compound having ligand bonded thereto There is provided a method for immobilizing a ligand by reacting a solvent-insoluble carrier having aldehyde group with a compound shown by the general formula: ##STR1## wherein X is --S-- or --O--, R1, R2 and R6 are ... | 02/02/1999 |
| 5858392 | Supported polyionic hydrogels A supported polyionic hydrogel is prepared by impregnating a support matel with a solution of anionic polysaccharide and a solution of cationic polysaccharide where the anionic polysaccharide and cationic polysaccharide react with each other to form a po... | 01/12/1999 |
| 5851554 | Purified cardiac troponin I A method is provided for isolating substantially intact cardiac troponin I from cardiac tissue comprising extracting the, troponin I and purifying it in the presence of an effective amount of a mixture of protease inhibitors. The human cardiac troponin I ... | 12/22/1998 |
| 5817527 | Conjugation of ligand to immobilized protein in organic solvent A new method for immobilization of small molecules on solid supports via a macromolecular spacer has been developed. A protein or another macromolecule is first immobilized in an aqueous medium, and the solid support is than washed with an organic solvent... | 10/06/1998 |
| 5766908 | High-flux semipermeable membrane containing immobilized affinity ligands An affinity support is provided containing a high flux semipermeable hydrogel membrane surface-modified with an affinity ligand, such as a protein which may be an antibody or enzyme, or a cell receptor complement, useful for affinity separation of biologi... | 06/16/1998 |
| 5736371 | Biodegradable particulate vector for transporting molecules having biological activity A biodegradable particulate vector for transporting biologically active molecules is prepared containing a nucleus for containing a biologically active molecule, a first layer of fatty acid compounds covalently bonded to the nucleus and a second layer of ... | 04/07/1998 |
| 5719031 | Dye labeled polymers as reagents for measuring polymer degradation This invention relates to polymers labeled with fluorescent dye to the point that significant fluorescence quenching occurs, such that degradation of the polymer results in fluorescence enhancement. The resulting fluorescence enhancement is useful for mea... | 02/17/1998 |
| 5648252 | Supported polyionic hydrogels containing biologically active material A supported polyionic hydrogel containing biologically active material is epared by impregnating into a porous support material a solution of anionic polysaccharide, a solution of cationic polysaccharide and a biologically active material. The anionic pol... | 07/15/1997 |
