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| Number | Title | Issue Date |
| 7423010 | Nonporous microparticle-prodrug conjugates for treatment of infection This invention provides novel methods and reagents for specifically delivering biologically active compounds to phagocytic mammalian cells. The invention also relates to specific uptake of such biologically active compounds by phagocytic cells and delivery of such c... | 09/09/2008 |
| 7351798 | Stabilized protein crystals, formulations comprising them and methods of making them This invention relates to methods for the stabilization, storage and delivery of biologically active macromolecules, such as proteins, peptides and nucleic acids. In particular, this invention relates to protein or nucleic acid crystals, formulations and composition... | 04/01/2008 |
| 7300779 | Preparation of a granule containing protein, corn starch and sugar layered on an inert particle Granules that include a protein core are described. The protein core includes a protein matrix which includes a protein mixed together with a starch. The protein matrix can be layered over a seed particle or the protein core can be homogeneous. The protein can be an... | 11/27/2007 |
| 7183067 | Versatile linker compound, ligand, and producing method thereof A versatile linker compound has a structure represented by following general formula (1), wherein Y has a structure represented by O or NH, and X has a structure serving as a multi-branched moiety including four hydrocarbon derivative chains each of which has an aro... | 02/27/2007 |
| 7153519 | Implantable substrate coated with a macromer having free radical polymerizable substituents Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions to encapsulate tissues, cells, or biologically active materials. The... | 12/26/2006 |
| 7101846 | Methods and compositions for optimization of oxygen transport by cell-free systems Compositions, and methods of use thereof, for use as blood substitute products comprise aqueous mixtures of oxygen-carrying and non-oxygen carrying plasma expanders and methods for the use thereof. The oxygen-carrying component may consist of any hemoglobin-based ox... | 09/05/2006 |
| 7087728 | Carbohydrate crosslinked glycoprotein crystals The present invention relates to the field of carbohydrate crosslinked glycoprotein crystals. Advantageously, such crosslinked glycoprotein crystals display stability to harsh environmental conditions, while maintaining the structural and functional integrity of the... | 08/08/2006 |
| 7083936 | Aminodextran compositions and conjugates and method of making and using them A composition containing polydisperse aminodextran polymer molecules is soluble in an aqueous solution at a concentration of 10 mg/ml. The molecules therein have a narrow size distribution characterized by an average molecule mean hydrodynamic diameter of greater th... | 08/01/2006 |
| 6987022 | Leukemic cell-adsorbing material containing lectin protein from beans or soybeans An efficient method for therapeutic treatment of a leukemic patient is disclosed in which the patient's body fluid under external circulation is brought into direct contact with an adsorbent material capable of adsorbing the leukemic cells in the body fluid specific... | 01/17/2006 |
| 6858582 | Composition containing porous microparticle impregnated with biologically-active compound for treatment of infection Methods and reagents are provided for specifically targeting biologically active compounds such as antiviral and antimicrobial drugs, or prodrugs containing the biologically active compound to specific sites such as specific organelles in phagocytic mammalian cells.... | 02/22/2005 |
| 6822071 | Polypeptides from Chlamydia pneumoniae and their use in the diagnosis, prevention and treatment of disease Chlamydia pneumoniae polypeptides are provided. The C. pneumoniae polypeptides can be used to prepare pharmaceutical compositions for the treatment or prevention of disease. In addition, the proteins can be used in methods for the diagnosis of C. pn... | 11/23/2004 |
| 6783962 | Particulate material for purification of bio-macromolecules The present invention relates to particulate material having a density of at least 2.5 g/ml, where the particles of the particulate material have an average diameter of 5-75 μm, and the particles of the particulate material are essentially constructed of a polymeri... | 08/31/2004 |
| 6723539 | Absorbent medium containing particles of chopped cellulose or agarose sponge material having functional groups An adsorbent medium is prepared comprising particles of a sponge material made of cellulose or agarose carrying functional groups such as diethylaminoethane groups. The particles may be obtained by chopping a larger block of the sponge material. The medium preferabl... | 04/20/2004 |
| 6680184 | Encapsulating liquid with hydrocolloid membrane stable from about -20 to 90 degrees C without bursting A temperature-stable droplet is provided containing a temperature-stable hydrocolloid membrane. The hydrocolloid membrane encapsulates a liquid that contains at least one enzyme, a cell, a biological agent, a pharmaceutical agent, an immunological agent, ... | 01/20/2004 |
| 6635744 | Fibroblast growth factor homologous factor-4 The invention provides fibroblast growth factor homologous factor (FHF) polypeptides and nucleic acid molecules that encode them. Also included in the invention are diagnostic and therapeutic methods using FHF polypeptides and nucleic acids.... | 10/21/2003 |
| 6632446 | Coating substrates by polymerizing macromers having free radical-polymerizable substituents Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions to encapsulate tissues, cells, or biologically active mat... | 10/14/2003 |
| 6616946 | Triblock copolymer hollow particles for agent delivery by permeability change Polymeric hollow particles for delivery of an agent are provided that change permeability in response to a change in an external stimulus such as pH, temperature, light, ionic strength, electric field, magnetic field and/or solvent composition. The partic... | 09/09/2003 |
| 6541606 | Stabilized protein crystals formulations containing them and methods of making them This invention relates to methods for the stabilization, storage and delivery of biologically active macromolecules, such as proteins, peptides and nucleic acids. In particular, this invention relates to protein or nucleic acid crystals, formulations and ... | 04/01/2003 |
| 6540999 | Immunomodulatory methods using Lewisx oligosacchardies Methods for modulating immune responses are provided. The methods involve contacting an immune cell with an agent that modulates interaction of a compound comprising a Lewis antigen with the immune cell such that production by the immune cell of at least ... | 04/01/2003 |
| 6521431 | Biodegradable cross-linkers having a polyacid connected to reactive groups for cross-linking polymer filaments Biodegradable cross-linkers are provided having a polyacid core with at least two acidic groups covalently connected to reactive groups usable to cross-link polymer filaments. Between at least one reactive group and an acidic group of the polyacid is a bi... | 02/18/2003 |
| 6500933 | Methods of preparing carbohydrate crosslinked glycoprotein crystals The present invention relates to the field of carbohydrate crosslinked glycoprotein crystals. Advantageously, such crosslinked glycoprotein crystals display stability to harsh environmental conditions, while maintaining the structural and functional integ... | 12/31/2002 |
| 6465001 | Treating medical conditions by polymerizing macromers to form polymeric materials Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions to encapsulate tissues, cells, or biologically active mat... | 10/15/2002 |
| 6444261 | Storage-stable particle, in particular carrier for carrier-bound reactions, and methods of producing said particle A particle resistant to storage of at least one first and at least one second component, wherein said second component of at least one crosslinkable polymer as a shell at least partially envelops and/or encloses said first component as a core and said fir... | 09/03/2002 |
| 6432918 | Methods and compositions for optimization of oxygen transport by cell-free systems Compositions, and methods of use thereof, for use as blood substitute products comprise aqueous mixtures of oxygen-carrying and non-oxygen carrying plasma expanders and methods for the use thereof. The oxygen-carrying component may consist of any hemoglob... | 08/13/2002 |
| 6423517 | Granule containing protein and salt layered on an inert particle Granules are prepared containing an admixture of protein and salt layered over an inert particle. A preferred amount of salt is about between 63.7 and 84.3% of the total weight of the admixture. Proteins include pharmaceutically important proteins such as... | 07/23/2002 |
| 6420171 | Leukemic cell-adsorbing material containing lectin protein from Agrocybe cylindracea or jequirity plant seed An efficient method for therapeutic treatment of leukemia is provided in which a patient's body fluid during external circulation is brought into direct contact with an adsorbent material capable of specifically and selectively adsorbing leukemic cells in... | 07/16/2002 |
| 6399750 | IGG separation medium A separation medium having a base matrix and matrix-bound groups which exhibit recombinant Protein A containing a cysteine. The groups are of formula: --B--X--rProtein A-cys where B is a bridge which binds to the base matrix and X includes a heteroatom N ... | 06/04/2002 |
| 6359118 | Carbohydrate crosslinked glycoprotein crystals The present invention relates to the field of carbohydrate crosslinked glycoprotein crystals. Advantageously, such crosslinked glycoprotein crystals display stability to harsh environmental conditions, while maintaining the structural and functional integ... | 03/19/2002 |
| 6339060 | Conjugate of biologically active compound and polar lipid conjugated to a microparticle for biological targeting Methods and reagents are provided for specifically targeting biologically active compounds such as antiviral and antimicrobial drugs, or prodrugs containing the biologically active compound to specific sites such as specific organelles in phagocytic mamma... | 01/15/2002 |
| 6312942 | Apparatus for encapsulating substances in small spherical particles formed from an encapsulating fluid Substances such as chemical substances and biological substances including animal, vegetable and microbial cells are encapsulated using a process and an apparatus wherein a coil through which alternating current flows causes a magnet to vibrate creating v... | 11/06/2001 |
| 6287558 | Devices containing cells or tissue and an agent that inhibits damage by a host cell molecule A device that includes a living cell or tissue and an agent that inhibits the ability of a host molecule to damage the cell or tissue. The device can be constructed in various forms including an implantable device, a composite microreactor and a double co... | 09/11/2001 |
| 6270983 | Surfaces coated with streptavidin/avidin The invention relates to surfaces coated with streptavidin and avidin for use in immunoassays, wherein the surfaces comprise a layer of streptavidin and avidin which are bonded on a surface of a solid supporting material through a biotinylated adhering ag... | 08/07/2001 |
| 6252054 | Immobilization of SH group-containing compounds in the presence of a sulfite-containing antioxidant Immobilization of SH group-containing compounds on a solvent-insoluble support is carried out in the presence of an antioxidant to prevent oxidation of SH groups to S--S bonds. This improves immobilization efficiency and suppresses deterioration of inhere... | 06/26/2001 |
| 6204256 | Acylated cyclodextrin derivatives A cyclodextrin derivative, wherein at least 60 percent of the free hydroxy groups of said cyclodextrin are acylated with acyl groups where at least one of said acyl groups comprise a free carboxylic group.... | 03/20/2001 |
| 6174700 | Purification of a polypeptide compound having a polysaccharide binding domain by affinity phase separation A compound having a polysaccharide binding domain such as contained by a cellulose and essentially lacking in polysaccharidase activity is purified from other ingredients in a mixture using an affinity partition system. A mixture containing the compound i... | 01/16/2001 |
| 6156572 | Bioartificial extracellular matrix containing hydrogel matrix derivatized with cell adhesive peptide fragment A bioartificial extracellular matrix for use in tissue regeneration or replacement is provided by derivatizing a three-dimensional hydrogel matrix with a cell adhesive extracellular matrix protein or cell adhesive peptide fragment of the protein. Preferab... | 12/05/2000 |
| 6150151 | Affinity chromatographic matrix containing non-covalently bound ligand for purification of biological material An affinity chromatographic matrix for purification of a biological material is provided having an ionically charged polymeric ligand such as glycoaminoglycan non-covalently bound directly by an ionic bond to an oppositely ionically charged group on a chr... | 11/21/2000 |
| 6063759 | Conjugate of biologically active compound and polar lipid conjugated to a microparticle for biological targeting Methods and reagents are provided for specifically targeting biologically active compounds such as antiviral and antimicrobial drugs, or prodrugs containing the biologically active compound to specific sites such as specific organelles in phagocytic mamma... | 05/16/2000 |
| 6054427 | Methods and compositions for optimization of oxygen transport by cell-free systems Compositions, and methods of use thereof, for use as blood substitute products comprise aqueous mixtures of oxygen-carrying and non-oxygen carrying plasma expanders and methods for the use thereof. The oxygen-carrying component may consist of any hemoglob... | 04/25/2000 |
| 6048720 | Conjugates of a polypeptide and a biocompatible polymer Processes for improving the in vivo function of factor VIII by shielding exposed targets of the factor VIII comprise a) immobilizing the factor VIII by interaction with a group-specific adsorbent carrying ligands manufactured by organic-chemical synthesis... | 04/11/2000 |
