Bizarre Patents
A method to tenderize meat with an explosive shockwave.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7300663 | Adhesion and sealing of tissue with compositions containing polyfunctional crosslinking agents and protein polymers Proteinaceous polymers having repetitive units from naturally occurring structural proteins are employed as backbones for functionalities for crosslinking to provide strongly adherent tissue adhesives and sealants. Particularly, block copolymers of elastin and fibro... | 11/27/2007 |
| 7267938 | Patterning of surfaces utilizing microfluidic stamps including three-dimensionally arrayed channel networks The present invention describes improved microfluidic systems and procedures for fabricating improved microfluidic systems, which contain one or more levels of microfluidic channels. The methods for fabrication the systems disclosed can provide a convenient route to... | 09/11/2007 |
| 7267959 | Drug target within the sulfonylurea receptor It has been found that syntaxin binds and regulates the nucleotide binding folds (NBFs) of sulfonylurea receptors (SURs) in a ATP- and ADP-dependent manner. The present invention therefore provides methods for identifying compounds that effect the binding between a ... | 09/11/2007 |
| 7262281 | Method of depositing S-layer proteins on a carrier to immobilize functional molecules On a carrier surface, a layer of S-layer proteins is produced as a carrier of functional molecules. A solution containing S-layer proteins in the form of monomers or oligomers is brought into contact with the carrier surface. Electrochemical conditions are produced ... | 08/28/2007 |
| 7256259 | Methods for ligation of molecules to surfaces The present invention is a method for a covalent ligation of one or more molecules to one or more surfaces, that is site-specific and both rapid and high yielding. The covalent ligation to the surface is based on the reaction of an azide and a phosphinothioester to ... | 08/14/2007 |
| 7226603 | HBV core antigen particles with multiple immunogenic components attached via peptide ligands This invention relates to hepatitis B virus (“HBV”) core antigen particles that are characterized by multiple immunogen specificities. More particularly, the invention relates to HBV core antigen particles comprising immunogens, epitopes, or other related struct... | 06/05/2007 |
| 7214388 | Degradable heterobifunctional poly(ethylene glycol) acrylates A heterobifunctional poly(ethylene glycol) is provided having a hydrolytically degradable linkage, a first terminus comprising an acrylate group, and a second terminus comprising a target such as a protein or pharmaceutical agent or a reactive moiety capable of coup... | 05/08/2007 |
| 7195924 | Method for immobilizing a biomolecule on a solid substrate at a high density by using the substrate having an activated carboxyl group on a surface thereof and microarray produced using the method Provided is a method for immobilizing a biomolecule on a solid substrate. The method includes coating the solid substrate with silane anhydride to introduce an anhydride functional group onto a surface of the solid substrate; obtaining a carboxyl group from the anhy... | 03/27/2007 |
| 7195913 | Randomly ordered arrays and methods of making and using Arrays including microparticles having probe and marker moieties are used for the detection of a target in a sample. Microparticles are randomly immobilized on at least a portion of a substrate. A detection scheme is performed to detect the marker associated with th... | 03/27/2007 |
| 7193066 | Preparation of highly pure toxin fragments Toxin derivatives are prepared by proteolytic treatment of holotoxin, and their toxicity is reduced by contacting the preparation with a ligand, which can be a metal or an antibody or another ligand. This ligand selectively binds to the toxin but not to the toxin de... | 03/20/2007 |
| 7166697 | V-like domain binding molecules The present invention relates to binding moieties comprising at least one monomeric V-like domain (VLD) derived from a non-antibody ligand, the at least one monomeric V-like domain being characterized in that at least one CDR loop structure or part thereof is modifi... | 01/23/2007 |
| 7166304 | Degradable heterobifunctional poly(ethylene glycol) acrylates A heterobifunctional poly(ethylene glycol) is provided having a hydrolytically degradable linkage, a first terminus comprising an acrylate group, and a second terminus comprising a target such as a protein or pharmaceutical agent or a reactive moiety capable of coup... | 01/23/2007 |
| 7166708 | Process for preparing conjugate vaccines and the conjugate vaccines This invention relates to a process for preparing a hapten-protein-polysaccharide conjugate and a hapten-protein conjugate by reacting a protein with a hapten to produce a hapten-protein conjugate, followed by reacting the hapten-protein conjugate with a polysacchar... | 01/23/2007 |
| 7122356 | Method for attachment of biomolecules to medical device surfaces A method for making a medical device having at least one biomolecule immobilized on a substrate surface is provided. One method of the present invention includes immobilizing a biomolecule comprising an unsubstituted amide moiety on a biomaterial surface. Another me... | 10/17/2006 |
| 7101966 | Selection of peptide ligands specific for baculovirus DNA-binding protein from the FliTrx™ random peptide display library Autographa californica nucleopolyhedrovirus (AcNPV) is a baculovirus widely employed as a vector for the expression of foreign genes and pest control. Although baculoviruses efficiently replicate in the nuclei of arthropod cells, the dynamics and mechanism of DNA re... | 09/05/2006 |
| 7067639 | Method to provide bacterial ghosts provided with antigens Methods for improving binding of a proteinaceous substance to cell-wall material of a Gram-positive bacterium are disclosed. The proteinaceous substance includes an AcmA cell-wall binding domain, homolog or functional derivative thereof. The method includes treating... | 06/27/2006 |
| 7033597 | Intracellular delivery of biological effectors The invention relates to sequences of amino acids with the capacity to facilitate transport of an effector across a biological membrane. More specifically, the present invention relates to novel peptide transporters that specifically target certain cell types for th... | 04/25/2006 |
| 7022309 | Targeting molecule linked to an imaging agent Targeting molecules are provided for use in delivering imaging agents to epithelial tissue. The targeting molecule comprises a polypeptide that forms a closed covalent loop, contains at least three peptide domains having β-sheet character, each of the domains being... | 04/04/2006 |
| 7018637 | Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines Multivalent immunogenic molecules comprise a carrier molecule containing at least one functional T-cell epitope and multiple different carbohydrate fragments each linker to the carrier molecule and each containing at least one functional B-cell epitope. The carrier ... | 03/28/2006 |
| 6984486 | Synthetic peptide of regulatory virus protein R (VPR) of human immunodeficiency virus type 1 (HIV-1) and the utilization thereof The invention pertains to synthetic (s) peptides derived from the viral regulatory protein R (Vpr) of the human immunodeficiency virus type 1 (HIV-1), particularly the chemical synthesis of the 96 amino acid full length Vpr protein (sVpr1-96), of a 47 ami... | 01/10/2006 |
| 6974707 | Dextran-coated surface In a dextran coated surface disposed on a carrier, the connections between the dextran and the carrier surface are formed by a photolinker, the dextran coating being attached to the carrier surface by co-immobilization of a mixture of dextran and the photolinker. | 12/13/2005 |
| 6960457 | Reversible immobilization of arginine-tagged moieties on a silicate surface This invention provides materials and methods for the site specific attachment of virtually any moiety to a layered silicate surface. The methods involve covalently attaching the moiety to an arginine tag; and contacting the arginine tag with the layered silicate (e... | 11/01/2005 |
| 6906169 | Immunogenic peptide composition comprising measles virus Fprotein Thelper cell epitope (MUFThl-16) and N-terminus of β-amyloid peptide The present invention relates to a composition comprsing a peptide immunogen useful for the prevention and treatment of Alzheimer's Disease. More particularly, the peptide immunogen comprises a main functional/regulatory site, an N-terminal fragment of Amyloid β (A... | 06/14/2005 |
| 6900047 | Apparatus for coating a substrate quickly and uniformly with a small volume of fluid A method is provided for applying a fluid onto a surface of a solid substrate. The method employs a distribution member having an upper surface and a lower surface, and including a permeable portion having channels therethough. The distribution member is positioned ... | 05/31/2005 |
| 6875845 | Mouse cytokine receptor Cytokines and their receptors have proven usefulness in both basic research, animal models, and as therapeutics. The present invention provides a new cytokine receptor designated as “mouse Zcytor16,” which can bind and antagonize the IL-TIF cytokine. ... | 04/05/2005 |
| 6872576 | Antigens embedded in thermoplastic The invention relates to an immunoassays, binding assays, solid phase substrates (12) and other devices with an antigen or antibody or ligand or receptor (11) embedded into a solid phase substrate (12). The antigen or antibody is mixed with a mo... | 03/29/2005 |
| 6822071 | Polypeptides from Chlamydia pneumoniae and their use in the diagnosis, prevention and treatment of disease Chlamydia pneumoniae polypeptides are provided. The C. pneumoniae polypeptides can be used to prepare pharmaceutical compositions for the treatment or prevention of disease. In addition, the proteins can be used in methods for the diagnosis of C. pn... | 11/23/2004 |
| 6803196 | Methods and compositions for detecting signals in binding assays using microparticles Methods and compounds are provided for detecting target molecules in a sample using specific binding assays. In particular, methods are provided for detecting a nucleic acid target in a sample. In one embodiment, the presently claimed invention provides a method of ... | 10/12/2004 |
| 6800728 | Hydrazine-based and carbonyl-based bifunctional crosslinking reagents Reagents and methods are provided for crosslinking and immobilizing biomolecules, drugs and synthetic polymers. The reagents possess (i) a thiol or amino reactive group; and (ii) a hydrazino or oxyamino moiety. Conjugates and immobilized biomolecules are also provid... | 10/05/2004 |
| 6783838 | Coated film laminate having an ionic surface A coated laminate having an ionic surface including a shrinkable polymeric film, an ionic coating and, optionally, a hydrogel is disclosed. A method for transferring sample molecules from a matrix to a coated laminate having an ionic surface also is disclosed. ... | 08/31/2004 |
| 6756041 | Process for preparing conjugate vaccines including free protein and the conjugate vaccines, immunogens, and immunogenic reagents produced by this process A process for preparing a protein-polysaccharide conjugate includes reacting a protein with a polysaccharide to produce a mixture including a protein-polysaccharide conjugate and free protein. At least one unreacted reagent or low molecular weight component is remov... | 06/29/2004 |
| 6720304 | Conjugate comprising a folic acid antagonist and a carrier The invention relates to conjugates comprising a D-enantiomer of a folic acid antagonist and a carrier. Furthermore, the invention relates to the production of such conjugates as well as their use. ... | 04/13/2004 |
| 6649395 | Tyrosine-containing cyclophilin and related methods The present invention relates to the use of these cyclophilins, hereinafter referred to as `tyrosine-containing` cyclophilins, in a method for identifying compounds capable of binding to and/or inhibiting the enzymatic activity of these proteins. Such com... | 11/18/2003 |
| 6649354 | Catalytically generated mass labels The present invention involves a method for assaying a substance. The method of the present invention comprises contacting the substance with an assay agent comprising a catalytic agent to associate the substance with the catalytic agent, contacting the r... | 11/18/2003 |
| 6635744 | Fibroblast growth factor homologous factor-4 The invention provides fibroblast growth factor homologous factor (FHF) polypeptides and nucleic acid molecules that encode them. Also included in the invention are diagnostic and therapeutic methods using FHF polypeptides and nucleic acids.... | 10/21/2003 |
| 6630577 | 1,2-Phenylenediboronic acid reagents and complexes A reagent having the general formula of General Formula I: ##STR1## wherein group Z comprises a spacer selected from an aliphatic chain up to about 6 carbon equivalents in length, an unbranched aliphatic chain of from about 6 to 18 carbon equivalents in l... | 10/07/2003 |
| 6627404 | Methods for improving the recovery of troponin I and T in membranes, filters and vessels A method to facilitate recovery troponin I and/or troponin T from a sample comprising addition of troponin C to the sample or to a surface from which the troponin I and/or troponin T are recovered.... | 09/30/2003 |
| 6617142 | Method for attachment of biomolecules to medical device surfaces Methods are provided for forming a coating of an immobilized biomolecule on a surface of a medical device to impart improved biocompatibility for contacting tissue and bodily fluids. A biomolecule such as a glycoprotein having an unsubstituted amide moiet... | 09/09/2003 |
| 6600014 | Adsorbent for eliminating hepatitis C virus, adsorber, and adsorption method An adsorbent for removing hepatitis C virus which has the ability to adsorb HCV particles, particularly immune-complex HCV particles, from a patient's body blood safely and with high efficiency and high selectivity for enhancing the efficacy of interferon... | 07/29/2003 |
| 6569426 | Tresyl-monomethoxypolyethylene glycol-modified viruses having viral infectivity Viruses are modified by coupling a polymer such as polyethylene glycol to obtain polymer-modified viruses that can exhibit reduced antigenicity while retaining infectivity, and which may exhibit increased circulation time in vivo. The polymer may be direc... | 05/27/2003 |
