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| Number | Title | Issue Date |
| 7422739 | Anti-CD20 antibodies Disclosed are chimeric, immunologically active, isolated, and radiolabeled antibodies directed against the CD20 antigen. The antibodies are useful for treating and diagnosing B cell disorders. ... | 09/09/2008 |
| 7220559 | Development of human monoclonal antibodies and uses thereof This invention provides: a heteromyeloma, other than B6B11, capable of producing a trioma when fused with a human lymphoid cell, wherein the trioma is capable of producing a monoclonal antibody-secreting tetroma when fused with a second, antibody-secreting human lym... | 05/22/2007 |
| 7186686 | Formulated composition A composition is disclosed that comprises a mixture of polypeptides of opposite charge and an excipient selected from the group consisting of arginine, lysine, glutamic acid, sodium dodecyl sulfate, beta-hydroxy cyclodextrin, and beta-cyclodextrin sulfobutyl ether. | 03/06/2007 |
| 7166697 | V-like domain binding molecules The present invention relates to binding moieties comprising at least one monomeric V-like domain (VLD) derived from a non-antibody ligand, the at least one monomeric V-like domain being characterized in that at least one CDR loop structure or part thereof is modifi... | 01/23/2007 |
| 6844423 | Compositions and methods for regulating bacterial pathogenesis The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. Autoinducer-2 stimul... | 01/18/2005 |
| 6596536 | Nucleotide sequences coding for variable regions of the alpha chains of human T lymphocyte receptors, corresponding peptide segments and the diagnostic and therapeutic uses An isolated antibody that specifically binds a peptide coded by a nucleotide sequence coding for a variable region of chain of an human T lymphocyte receptor, said nucleotide sequence having a nucleotide sequence chosen from any of: V segme... | 07/22/2003 |
| 6432402 | Anti-idiotypic antibody which induces an immune response against a glycosphingolipid and use thereof The present invention provides an anti-idiotypic monoclonal antibody which specifically induces an immune response against a glycosphingolipid. Additionally, this invention provides a method of producing the anti-idiotypic monoclonal antibody. Finally, th... | 08/13/2002 |
| 6407217 | Imidazolinone haptens and antigens and enzyme conjugates prepared therefrom The present invention provides an imidazolinone hapten having the structural formula ##STR1## Further provided are an antigen and an enzyme conjugate which are prepared from the imidazolinone hapten. The haptens, antigens and enzyme conjugates provid... | 06/18/2002 |
| 6407218 | Method and compositions for enhancing immune response and for the production of in vitro mabs The methods and compositions of the present invention are directed to enhancing an immune response and increasing vaccine efficacy through the simultaneous or sequential targeting of specific immune system components. More particularly, specific immune co... | 06/18/2002 |
| 6395282 | Immunogenic conjugates of Gram-negative bacterial autoinducer molecules The present invention relates to an immunogenic conjugate comprising a carrier molecule coupled to an autoinducer of a Gram negative bacteria. The immunogenic conjugate, when combined with a pharmaceutically acceptable carrier, forms a suitable vaccine fo... | 05/28/2002 |
| 6372215 | Monoclonal antibodies to human CD6 The invention provides antibodies and other binding agents that bind specifically to SRCR domains of human CD6 (hCD6) and have advantageous properties, including the capacity to substantially inhibit binding of activated leukocyte adhesion molecule (ALCAM... | 04/16/2002 |
| 6326159 | Receptors for immune complexes Receptors are disclosed that are antibodies that exhibit a binding affinity for an immune complex of a monoepitopic antigen and an antibody for such antigen that is substantially greater than the binding affinity for the monoepitopic antigen or the antibo... | 12/04/2001 |
| 6300104 | Secretory immunoglobulin produced by single cells and methods for making and using same Disclosed is a method of producing secretory Ig molecules. The method comprises transfecting a cell producing an Ig with a polynucleotide encoding an SC to fonn SC transfected Ig producing cells. Secretory Ig molecules, such as secretory IgA, can be used ... | 10/09/2001 |
| 6277964 | Anti-PAH monoclonal antibodies and cell lines producing the same The present invention provides monoclonal antibodies suitable for monitoring polycyclic aromatic hydrocarbons (PAHs) by an immunoasay, hybridoma cell lines producing said antibodies, and an immunoassay for analyzing PAHs in a sample using said monoclonal ... | 08/21/2001 |
| 6239259 | Multivalent and multispecific antigen-binding protein A multivalent antigen-binding protein comprises a first polypeptide comprising, in series, three or more variable domains of an antibody heavy chain and a second polypeptide comprising, in series, three of more variable domains of an antibody light chain,... | 05/29/2001 |
| 6222014 | NrdE of staphylococcus aureus The invention provides nrdE polypeptides and polynucleotides encoding nrdE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing nrdE polypeptides to screen for antibacterial compounds.... | 04/24/2001 |
| 6172188 | Fluorescent proteins The present invention relates to novel variants of the fluorescent protein GFP having improved fluorescence properties.... | 01/09/2001 |
| 6165472 | folC from Streptococcus pneumoniae The invention provides folC polypeptides and DNA (RNA) encoding folC polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing folC polypeptides to screen for antibacterial compounds.... | 12/26/2000 |
| 6159751 | Development of DNA probes and immunological reagents of human tumor associated antigens This invention provides a method for preparing a hybridoma cell line which produces a monoclonal antibody which specifically recognizes and binds to a tumor associated antigen which comprises: (a) cotransfecting a CREF-Trans 6 cell line with DNA isolated ... | 12/12/2000 |
| 6072029 | Derivatives of human 1 -antitrypsin and process for their preparation The invention relates to an analog of human 댑 -antitrypsin characterized in that it is all or part of the protein corresponding to human 댑 -antitrypsin in which, in 358 position, the amino-acid is selected from among ar... | 06/06/2000 |
| 6048527 | Antibodies that define unique Meningococcal B epitopes and vaccine compositions Novel bactericidal antibodies against Neisseria meningitidis serogroup B ("MenB") are disclosed. The antibodies either do not cross-react or minimally cross-react with host tissue polysialic acid and hence pose minimal risk of autoimmune activity. The ant... | 04/11/2000 |
| 6022951 | Streptavidin mutants The present invention relates to streptavidin proteins and peptides having a altered physical properties such as an increased stability or increased or decreased affinity for binding biotin. The invention also relates to methods for the detection, identif... | 02/08/2000 |
| 6013478 | Method for identifying active domains and amino acid residues in polypeptides and hormone variants The invention provides methods for the systematic analysis of the structure and function of polypeptides by identifying active domains which influence the activity of the polypeptide with a target substance. Such active domains are determined by substitut... | 01/11/2000 |
| 5990297 | Human monoclonal antibody specifically binding to surface antigen of cancer cell membrane A human monoclonal antibody specifically binding to a surface antigen of cancer cell membrane, an isolated DNA encoding the antibody, and a hybridoma producing the antibody. An anti-cancer formulation comprising the monoclonal antibody bonded to the surfa... | 11/23/1999 |
| 5972628 | Pyruvatekinase-iosenzyme typ-M2 (Tumor-M2-PK)-specific antibody/process for the preparation and use thereof A qualitative, quantitative, as well as local determination of pyruvatkinase (ATP:pyruvate-2-O-phosphotransferase, EC 2.7.1.40)-isoenzyme typ M2 (Tumor-M2-PK) is possible in blood, plasma, tissue culture, tissue sections as well as in the animal and human... | 10/26/1999 |
| 5962289 | Polysaccharide binding fusion proteins and conjugates Fusion proteins or conjugates are provided containing an amino acid sequence having a substrate binding region of a polysaccharidase such as cellulase that binds to a ଲ-1,4-glycan matrix such as cellulose. The substrate binding region is essentially... | 10/05/1999 |
| 5928917 | Conjugate of non-protein chemical moiety and polypeptide having cellulose binding region Fusion proteins or conjugates are provided containing an amino acid sequence having a substrate binding region of a polysaccharidase such as cellulase that binds to a ଲ-1,4-glycan matrix such as cellulose. The substrate binding region is essentially... | 07/27/1999 |
| 5919454 | Nucleotide and peptide sequences of a hepatitis C virus isolate, diagnostic and therapeutic applications This invention relates to human or murine monoclonal antibodies specific for a peptide sequence of HCV E1, fragments of said monoclonal antibodies, hybridomas producing said monoclonal antibodies, in vitro diagnostic methods for detecting HCV E1-specific ... | 07/06/1999 |
| 5874228 | Methods and kits for determining the levels of IGE-BF The invention relates to novel purified human immunoglobulin E binding factors (IgE-BFs), its individual optionally glycosylated proteins, and fragments thereof, processes for the purification of IgE-BFs, novel monoclonal antibodies to lymphocyte cellular... | 02/23/1999 |
| 5859203 | Monoclonal antibodies for N-peptide The present invention relates to a sandwich immunoassay for rapidly and readily measuring N-peptide using two kinds of monoclonal antibodies recognizing different portions of the N-peptide. The method for measuring N-peptide or a precursor thereof include... | 01/12/1999 |
| 5858682 | E2A/pbx1 fusion protein specific monoclonal antibodies A monoclonal antibody which specifically binds with an E2A/pbx1 fusion epitope.... | 01/12/1999 |
| 5795736 | Genes coding for a protein having human MACIF activity, expression vectors containing said genes, transformant cells and proteins having human macif activity Genes coding for a protein having human MACIF activity, expression vectors containing the genes, transformed cells with the vectors and proteins having human MACIF activity.... | 08/18/1998 |
| 5719050 | Animal cell culturing media containing N-acetyl-L-glutamic acid The present invention relates to a medium composition for culturing animal cells which is obtained by combining at least one component selected from the group of substances mentioned below with a medium composition comprising inorganic salts, saccharides,... | 02/17/1998 |
| 5709859 | Mixed specificity fusion proteins Mixed specificity fusion proteins capable of binding to cellular adhesion molecules have been produced. The fusion proteins contain a polypeptide region, such as an IgG constant region, operatively attached to at least two binding regions each of which co... | 01/20/1998 |
| 5674712 | Recombinant vector and use thereof for exocellular preparation of antibodies in single molecule form from Bacillus subtilis A recombinant vector for the expression and secretion of antibodies in single molecule form (scFv) from B. subtilis, where said vector comprises the promoter of the gene for neutral protease, a new secretion sequence (I) and a DNA sequence coding a scFv a... | 10/07/1997 |
| 5643550 | Method of treating colorectal carcinoma lesion and composition for use therein This invention provides a method of imaging a colorectal carcinoma lesion in a human patient which comprises administering to the patient a monoclonal antibody capable of binding to a cell surface antigen associated with the colorectal carcinoma lesion an... | 07/01/1997 |
| 5629197 | Monoclonal anti-human breast cancer antibodies Murine monoclonal antibodies are prepared and characterized which bind selectively to high molecular weight mucins by immunoprecipitation test and are IgGs or IgMs. Immunotoxins comprising the monoclonal antibody and cytotoxic moiety were produced.... | 05/13/1997 |
| 5589384 | Fusion proteins A fusion protein suitable for use as a vaccine comprises an amino acid sequence having biological activity which is fused via an intervening hinge comprising from two to eight glycine-proline repeats to the C-terminus of sufficient of the amino acid seque... | 12/31/1996 |
| 5580723 | Method for identifying active domains and amino acid residues in polypeptides and hormone variants The invention provides methods for the systematic analysis of the structure and function of polypeptides by identifying active domains which influence the activity of the polypeptide with a target substance. Such active domains are determined by substitut... | 12/03/1996 |
| 5532137 | Anti-FR-900506 substance antibodies and highly-sensitive enzyme immunoassay method Monoclonal or polyclonal antibodies capable of recognizing at least one antigenic determinant located on the FR-900506 compound, are disclosed. FR-900506 is a compound having pharmacological activities such as immunosuppressive activity and antimicrobial ... | 07/02/1996 |
