Did You Know...
...that several people are credited with the invention of the flush toilet? Most people have heard of Thomas Crapper (1837-1910), the sanitary engineer who invented the valve-and-siphon arrangement that made the modern toilet possible. Another claimant to "the throne" was British inventor Alexander Cumming who patented a toilet in 1775. Then there's a nameless Minoan (a native of ancient Crete) who lived 4,000 years ago who supposedly was ahead of his time and created the first flush toilet!
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7250298 | Monomeric red fluorescent proteins Disclosed are sequences encoding monomeric variants of DsRed fluorescent proteins and methods of use. ... | 07/31/2007 |
| 7230117 | Stable cyanine dye phosphoramidites This invention provides dye phosphoramidites, particularly phosphoramidites of substituted cyclic bridged cyanine and related dyes, of the general formula: In this formula, each dotted line represents carbon atoms ... | 06/12/2007 |
| 6455303 | Detection of biologically active molecules by use of pre-activated cell-based biosensors in liquid-based separation systems The invention provides a method for detection of receptor- or ion channel-modulators (e.g., antagonists, blockers, etc.). The method comprises fractionating a sample by using a liquid-based separation means (e.g., such as a capillary electrophoresis devic... | 09/24/2002 |
| 6140062 | Method of determining the heparin content In a method of determining heparin content, a known amount of thrombin (FIIa) or activated coagulation factor X (FXa) is added to a mixture which comprises a known concentration of chromogenic substrate (S), a known concentration of antithrombin (AT) and ... | 10/31/2000 |
| 5965713 | Dye labeled protein conjugate its preparing method and sensor using the same It is intended to present a sensor capable of labeling with more dyes, applying the labeled protein in immunochromatography making use of antigen-antibody reaction, and having an excellent sensitivity. In a buffer, a protein and a first covalent bonding c... | 10/12/1999 |
| 5877310 | Glycoconjugated fluorescent labeling reagents Water soluble glycoconjugated fluorescent labeling reagents comprised of a fluorescent dye, one or more sugar or carbohydrate residues that impart water solubility, and a reactive group that allows covalent attachment of the reagent to a substrate are dis... | 03/02/1999 |
| 5866348 | Bioluminescence measurement system The present invention provides a method of increasing the duration of detectable photon emission of a luciferase-luciferin reaction. The method provides a luciferase-luciferin reaction in which photon emission can be detected for up to and including eight... | 02/02/1999 |
| 5866335 | Preparation of derivatized 10,10'-substituted-9,9'-biacridine luminescent molecules and signal solutions The synthesis of 10,10'-substituted-9,9'-biacridine molecules and their derivatives is disclosed. These molecules are shown to catalyze the production of light by chemiluminescence in the presence of a signal solution having at a pH from about 10.0 to abo... | 02/02/1999 |
| 5589384 | Fusion proteins A fusion protein suitable for use as a vaccine comprises an amino acid sequence having biological activity which is fused via an intervening hinge comprising from two to eight glycine-proline repeats to the C-terminus of sufficient of the amino acid seque... | 12/31/1996 |
| 5518858 | Photochromic compositions and materials containing bacteriorhodopsin Photochromic compositions comprise a bacteriorhodopsin suspension, at least one organic nitrogen-containing compound and a binder. The composition may further include a detergent. Photochromic materials comprise a support and a photochromic film formed on... | 05/21/1996 |
| 5463027 | Fluorescence polarazation immunoassay for tetrahydrocannabinoids This disclosure related to a method and reagents for determining tetrahydrocannabinoids (THC) and THC metabolites in a biological fluid such as urine. In particular, this disclosure relates to a fluorescence polarization immunoassay procedure for determin... | 10/31/1995 |
| 5453505 | N-heteroaromatic ion and iminium ion substituted cyanine dyes for use as fluorescence labels The present invention relates to iminium ion substituted cyanine dyes having a fluoresence absorbance of between about 500 and 900 nm, a reduced tendency to aggregate and enhanced photostability. The cyanine dyes of the present invention are represented b... | 09/26/1995 |
| 5384241 | Specific binding assay compound with inhibitive self-quenching characteristics Disclosed is an assay system including a compound comprising an analyte-specific moiety having substituted thereon a polymer comprising plurality of self-quenching emitter moieties and a plurality of isocharged functionality separating the emitter moietie... | 01/24/1995 |
| 5362628 | Fluorescent haloalkyl derivatives of reporter molecules well retained in cells The subject invention provides a method for analyzing the metabolic activity in cells by improving the retention of a detectable reporter molecule only in intact cells where a particular enzyme is present. In particular, improved retention results from a ... | 11/08/1994 |
| 5270213 | Protein sequencing A method for the generation of phenylthiocarbamyl (PTC) amino acids from phenylthiohydantoin (PTH) or anilinothiozolinone (ATZ) amino acids. The method involves a base-catalyzed ring opening of the PTH or ATZ in the presence of a reducing agent. The metho... | 12/14/1993 |
| 5223404 | Composition for testing periodontal diseases A composition for testing periodontal diseases which diagnoses or prognosticates contraction or progress of the diseases or diagnoses the therapeutic value by promptly determining peptidase-like enzymatic activity in a specimen. The composition is a combi... | 06/29/1993 |
| 5137811 | Method for diagnosing periodontal diseases with a substrate specific for aminopeptidase activity of periodontopathic bacteria A method for diagnosing contraction or progress of periodontal diseases is carried and by determining periodontopathic bacteria specific aminopeptidase activity in a specimen by using as a substrate for the enzyme. The substrate is either or both compound... | 08/11/1992 |
| 5120644 | Peptide derivatives and activity measuring method of physiologically active substances using the same as substrates Activities of physiologically active substances such as endopeptidases, proteases, transferases, phosphatases, protein kinase and the like enzymes can be measured specifically with high sensitivity by using as a substrate a peptide derivative having 2 to ... | 06/09/1992 |
| 5079149 | Process for the preparation of purple membrane containing bacteriorhodopsin The invention relates to a process for the preparation of purple membrane containing bacteriorhodopsin, which process comprises obtaining, in a manner know per se, the cell membrane from halobacteria cells, and subjecting the material to gel filtration ch... | 01/07/1992 |
| 5077200 | Azo dye chromogenic substrates Chromogenic substrates for the detection of hydrolyzing enzymes, processes for the preparation of these chromogenic substrates and the use of the chromogenic substrates. The quantification of hydrolyzing enzymes for diagnostic purposes has to date been ca... | 12/31/1991 |
| 5063152 | Synthetic peptidic substrate for determination of trypsin and 1 A synthetic peptide of the formula: H-D -A1 -Leu-Lys-NH ##STR1## wherein A1 is Pro or Ala, is excellent in solubility in water and substrate specificity and is suitable as a substrate for determining trypsin and ... | 11/05/1991 |
| 5059525 | Dry reagent for blood coagulation tests The present invention provides a dry reagent for blood coagulation tests in which an at least partial course of the coagulation cascade takes place, comprising a carrier material which contains a chromophoric substrate of a protease of the blood coagulati... | 10/22/1991 |
| 4996296 | Cromolyn binding protein in highly purifed form, and methods for the isolation thereof Substantially pure cromolyn binding protein is prepared by means of affinity chromatography of cromolyn derivatives bound to insoluble matrices. Aminocromolyn is prepared by a six-step synthesis and amine derivatives thereof are prepared by conventional m... | 02/26/1991 |
| 4954630 | Resorufin derivatives The present invention provides resorufin derivatives of the general formulae: ##STR1## wherein R1, R2, R3, R4 and R5, which can be the same or different, are hydrogen, halogen, carboxyl, carboxam... | 09/04/1990 |
| 4952493 | Peptide substrates for detecting virus-specified protease activity A method for preparing selected peptide substrates for detecting the activity of virus-specified proteases is provided. Specific tetrapeptide substrates are disclosed which are conjugates of protease-cleavable indicator groups and peptide sequences resemb... | 08/28/1990 |
| 4946958 | Chemiluminescent acridinium labelling compounds A compound for use as a chemiluminescent label in immunoassay comprises an aryl acridinium ester linked to an N-succinimidyl moiety. The compound is conveniently linked to a monoclonal antibody or other protein and is used in a two-site immunoassay for th... | 08/07/1990 |
| 4900658 | Chromophoric peptides for detecting peptidylglycine--amidizing monooxygenase A chromophoric peptide is prepared of the formula DIS--D--Ala-Pro-R and salts thereof in which R represents Gly-OH, NH2 or Gly-R2 wherein R2 denotes a carboxyl protective group, and DIS denotes 5-dimethylaminonaphthalene-1-sulf... | 02/13/1990 |
| 4894348 | Fluorescein-conjugated proteins with enhanced fluorescence A method for conducting assays for an analyte, usually in a biological sample, utilizes reagents which contain biological ligands linked to fluorescein or a derivative of fluorescein through a linkage to the fluorescein nucleus selected from acetamido and... | 01/16/1990 |
| 4891319 | Protection of proteins and the like Sensitive proteins and other macromolecules, such as enzymes, antibodies, antigens, serum complement, fluorescent proteins, vaccine components, polysaccharides such as agarose etc, can be preserved by drying at ambient temperature and at atmospheric press... | 01/02/1990 |
| 4876190 | Peridinin-chlorophyll complex as fluorescent label Peridinin-chlorophyll-protein complexes are provided for use as fluorescent labels and are particularly useful in diagnostic assays employing as a reagent a fluorescent compound conjugated to a member of a specific binding pair, wherein the pair consists ... | 10/24/1989 |
| 4873318 | Oxazine-ureas and thiazine urea chromophors Novel adducts of oxazine urea chromophors or thiazine urea chromophors with organic substrates are provided which are useful in analytical techniques for the detection and measurement of biological and clinical compounds of interest.... | 10/10/1989 |
| 4857475 | Labelled and labellable reagents for fluorometric assays Labellable reagents for fluormetric assays comprise a cyclic condensation product of a ଲ-diketone, an aldehyde and an NH2 -bearing macromolecule, for example an antigen or antibody or a substance having an active group to which an antibod... | 08/15/1989 |
| 4816562 | Novel substrate for plasma kallikrein and a method for measuring biological components using the same Novel compounds represented by the following general formula (1) and salts thereof: ##STR1## wherein n represents an integer of 3 to 4, R1 represents ##STR2## or --SO2 R2, and R2 represents optionally ... | 03/28/1989 |
| 4797472 | New peptide derivatives Tripeptide derivatives, characterized by the general formula: wherein R1 is hydrogen, - or ଲ-naphtyl residue, lower alkyl residue which may be substituted with a carboxyl group, unsubstituted or substituted phenyl- or phenylalkyl residu... | 01/10/1989 |
| 4748116 | Peptide substrates for determination of protease activity Peptide sequences consisting of 2-4 amino acids with high affinity and comparatively high specificity to a number of various, physiologically important proteases are known to have been synthetized before. Such sequences with an added C-terminal marker hav... | 05/31/1988 |
| 4745181 | Polysubstituted aryl acridinium esters The present invention relates to novel acridinium esters which are useful as luminescent labels in specific binding assays such as immunoassays or nucleic acid hybridization assays. More particularly, polysubstituted aryl acridinium esters are highly stab... | 05/17/1988 |
| 4694070 | Water soluble xanthylium derivatives substrates Water soluble xanthylium derivative substrates of rhodamine 110 and rhodol permit spectrophotometric and fluorescent measurements of trypsin-like enzymes without the addition of organic solvent additives and/or special water solubilizing agents. These nov... | 09/15/1987 |
| 4665022 | Bioluminescent assay reagent and method Reagent for immunoassay, ligand binding assay and ligand receptor assay in which luciferin is covalently bonded to a molecule having biological activity for bonding to a particular biologically active group of a material and method in which the luciferin ... | 05/12/1987 |
| 4650753 | Novel substrates for use in measuring the concentration of kallikrein in urine A novel chromogenic and fluorescent substrate for measuring the concentration of kallikrein in urine. The novel substrate according to the present invention has very excellent substrate specificity to kallikreins and good solubility in water or biological... | 03/17/1987 |
| 4629695 | Peptide derivatives and use thereof as substrates for quantitatively assaying enzymes Peptide derivatives of formula ##STR1## wherein R1 represents a substituted amino group which is capable of being split off enzymatically with formation of a colored or fluorescent compound R1 -H. The said peptide derivatives ar... | 12/16/1986 |
