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| Number | Title | Issue Date |
| 5837483 | Enzymatic method for producing N-formyl--L-aspartyl-L-phenylalanine methyl ester An enzymatic method for producing N-formyl--L-aspartyl-L-phenylalanine methyl ester by a condensation reaction between N-formyl-L-aspartic acid and L-phenylalanine methyl ester or D,L-phenylalanine methyl ester, which comprises: supplying an organi... | 11/17/1998 |
| 5763392 | Treatment of diabetes by administration of myo-inositol Method for lowering the plasma glucose levels of diabetics by administering myo-inositol. Also the invention concerns a nutritional composition containing myo-inositol.... | 06/09/1998 |
| 5741537 | Brazzein sweetener Disclosed herein is a protein sweetener that has been isolated from Pentadiplandra brazzeana Baillon. The sweetener is thermostable, lysine rich, and has a relative long lasting taste. Also disclosed is a recombinant host capable of producing the sweetene... | 04/21/1998 |
| 5723165 | Aspartyldipeptide derivatives and sweetener compositions containing the same Aspartyldipeptide compounds of the formula (I) L-Asp-X-NH-C*R1 R2 (I) where R1 is alkyl or alkoxymethyl, R2 is phenyl, benzyl, cyclohexyl or cyclohexylmethyl, C* has an (S) configuration when... | 03/03/1998 |
| 5501712 | Method for crystallization of -L-aspartyl-L-phenylalanine methyl ester The problems in crystallization of -L-aspartyl-L-phenylalanine methyl ester, namely, problems in crystal slurry properties in solid-liquid separation, scaling at heat transfer surfaces, and the like, are solved by a method for crystallization of ... | 03/26/1996 |
| 5432262 | Method of purifying -L-aspartyl-L-phenylalanine methyl ester Mixture containing -L-aspartyl-L-phenylalanine methyl ester and 3-benzyl-6-carboxymethyl-2,5-dioxopiperazine are brought into contact with hydrochloric acid in an aqueous solvent to precipitate -L-aspartyl-L-phenylalanine methyl ester hydroc... | 07/11/1995 |
| 5425787 | Method for crystallization of -L-aspartyl-L-phenylalanine methyl ester The problems in crystallization of -L-aspartyl-L-phenylalanine methyl ester, namely, problems in crystal slurry properties in solid-liquid separation, scaling at heat transfer surfaces, and the like, are solved by a method for crystallization of ... | 06/20/1995 |
| 5350681 | Enzymatic membrane method for the synthesis and separation of peptides The present invention discloses a method for the enzymatic synthesis of a peptide. A protected peptide having a C-terminal carboxylate group or a protected, N-acyl amino acid having an alpha carboxylate group is reacted with a protected peptide having an ... | 09/27/1994 |
| 5017690 | Deblocking N-formyl aspartame compounds N-formyl amino acid or peptide is deformylated by reaction with aniline or methylene dianiline over noble metal catalyst, e.g., Pt-on-carbon. N-formanilide is formed as by-product. The process is particularly useful in deformylating N-formyl aspartame.... | 05/21/1991 |
| 4851563 | Method for the removal of the formyl group from an ester of an N-formyl peptide or N-formyl aminoacid A method for the removal of the formyl group from an ester of an N-formyl peptide or N-formyl aminoacid, in which the ester is reacted with urea in the presence of a polar solvent and a strong acid.... | 07/25/1989 |
| 4835258 | Conjugation of aromatic amines or nitro-containing compounds with proteins or polypeptides by photoirradiation of the azide derivatives with ultraviolet light in order to produce antibodies against the haptens A method of linking primary aromatic amine- or nitro-compounds to carrier proteins by photochemical reactions in order to produce antibodies against the haptens.... | 05/30/1989 |
| 4803300 | Process for separation of N-protected--L-aspartyl-L-phenylalanines Disclosed herein is a process for separating N-protected--L-aspartyl-L-phenylalanine, more particularly a process for selectively separating N-protected--L-aspartyl-L-phenylalanine from a solution of N-protected--L-aspartyl-L-phe... | 02/07/1989 |
| 4789758 | Process for the production of an N-protected-L--aspartyl-L-phenylalanine A process is described for the synthesis of N-protected-L--aspartyl-L-phenylalanine by both (a) the rection of an N-protected-L-aspartic anhydride and a R1 -L-phenylalanine, and (b) the reaction of an N-protected-L-aspartic anhydride and... | 12/06/1988 |
| 4780528 | Tripeptides and sweetening agents containing the same Tripeptide sweeteners represented by formula (I) wherein X is glycine or a D or DL-isomer of alanine, -aminobutyric acid, serine, threonine, norvaline, asparagine, B-methyl aspartate, proline or pipecolic acid, and Y is a D, L or DL-isomer of alanine, p... | 10/25/1988 |
| 4780561 | Preparation process of -L-aspartyl-L-phenylalanine methyl ester or hydrochloride thereof Disclosed herein is a process for preparing -L-aspartyl-L-phenylalanine methyl ester or its hydrochloride from 5-benzyl-3,6-dioxo-2-piperazine acetic acid or its methyl ester, prepared without using L-penylalanine methyl ester which involves proble... | 10/25/1988 |
| 4778916 | Preparation process of -L-aspartyl-L-phenylalanine methyl ester or hydrochloride thereof The present invention relates to a process for preparing -L-aspartyl-L-phenylalanine methyl ester or its hydrochloride. -L-aspartyl-L-phenylalanine methyl ester or its hydrochloride is prepared by a process comprising: condensating N-formyl-... | 10/18/1988 |
| 4740616 | Process for the production of an N-protected-L--aspartyl-L-phenylalanine A process is described for the synthesis of N-protected-L--aspartyl-L-phenylalanine by both (a) the reaction of an N-protected-L-aspartic anhydride and a R1 -L-phenylalanine, and (b) the reaction of an N-protected-L-aspartic anhydride an... | 04/26/1988 |
| 4677220 | Process for the preparation of -L-aspartyl-L-phenylalanine methyl ester A regioselective process for the preparation of -L-aspartyl-L-phenylalanine methyl ester is disclosed. A controlled aqueous coupling reaction between ଲ-methyl-L-aspartate-N-carboxyanhydride and L-phenylalanine produces the aspartyl methy... | 06/30/1987 |
| 4642367 | Process for the preparation of alfa-L-aspartyl-L-phenyl-alanine alkyl esters A new process for preparing alfa-L-aspartyl-L-phenylalanine alkyl esters of formula I ##STR1## wherein R represents an alkyl group having from 1 to 5 carbon atoms, starting from the corresponding alfa-haloacyl-alfa-L-aspartyl-L-phenylalanine alk... | 02/10/1987 |
| 4638081 | Process for preparing -aspartyl-L-phenylalanine methyl ester A process for preparing -L-aspartyl-L-phenylalanine methyl ester consisting of: bringing N-formyl-L-aspartic anhydride and L-phenylalanine methyl ester, in a molar ratio equal or approximately equal to 1:1, into contact with a solid cation exchange... | 01/20/1987 |
| 4634792 | L-aminodicarboxylic acid aminoalkenoic acid ester amides This invention relates to novel sweeteners of the formula: ##STR1## wherein A is CO2 R wherein R is alkyl containing 1-3 carbon atoms; A' is hydrogen or alkyl containing 1-3 carbon atoms; Y is alkyl containing 4-11 carbon atoms, and M=0 or 1; and fo... | 01/06/1987 |
| 4622418 | L-aminodicarboxylic acid amides Amides of -aminodicarboxylic acids and ଲ-aminoethers are low calorie sweetners.... | 11/11/1986 |
| 4622417 | L-aminodicarboxylic-(O-cycloalkyl)-L-aminocarboxylate alkyl ester sweeteners Dipeptides of certain -amino dicarboxylic acids and etherified hydroxy -amino-mono-carboxylic acid esters possess a high order of sweetness. These dipeptides have the following formula: ##STR1## wherein R is alkyl containing 1-3 carbon ... | 11/11/1986 |
| 4572799 | L-Aminodicarboxylic acid amides Sweeteners of the formula: ##STR1## and food-acceptable salts thereof, where the substituents are disclosed herein.... | 02/25/1986 |
| 4571308 | L-Aminodicarboxylic acid aminoalkenoic acid ester amides This invention relates to new compounds of the formula: ##STR1## wherein A is CO2 R in which R is alkyl containing 1-3 carbon atoms; A' is hydrogen or alkyl containing 1-3 carbon atoms; Y is --(CHR2)n --R1 or --CHR | 02/18/1986 |
| 4564528 | Aminomalonyl alanine compounds and use as dietary sweeteners Compounds having relatively long shelf lives in acidic aqueous media and which are useful as sweeteners have the formula ##STR1## or are pharmaceutically acceptable salts thereof, wherein X is --OR or --NHR, or --NH2, with R being alkyl ha... | 01/14/1986 |
| 4539147 | Process for preparing alpha-L-aspartyl-L-phenylalanine alkyl esters A process for preparing alpha-L-aspartyl-L-phenylalanine alkyl esters from L-aspartic acid, of which the amino group is protected by bonding it to a 3,5-dimethoxy-,-dimethyl-benzyloxycarbonyl group, then transforming this intermediate into t... | 09/03/1985 |
| 4507231 | Process for the preparation of -aspartyl phenylalanine methyl ester The present invention relates to a process for the preparation of -aspartyl phenylalanine methyl ester by reacting phenylalanine methyl ester with the anhydride of N-formyl L-aspartic acid, process wherein the product from said reaction is treated ... | 03/26/1985 |
| 4487717 | Process for recovering a dipeptide derivative A process for recovering a dipeptide derivative comprises admixing an aqueous mixture of a solid dipeptide ester derivative of the formula ##STR1## wherein R1 is a lower alkyl group, R2 is a side chain group of an amino acid, n ... | 12/11/1984 |
| 4465626 | Process for preparation, isolation and purification of dipeptide sweeteners Aromatic sulfonic acid salts of certain dipeptide sweeteners which are L-aspartyl-D-alaninamides or L-aspartyl-D-serinamides, each substituted on amide nitrogen with an organic radical having a highly branched carbon skeleton; the process for preparing sa... | 08/14/1984 |
| 4462943 | Carboxyalkyl amino acid derivatives of various substituted prolines Carboxyalkyl dipeptides of the formula ##STR1## wherein R4 is a 3-, 4-, 5-, or 4,4-substituted proline are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity.... | 07/31/1984 |
| 4448716 | Dipeptide sweetener-metal complexes The invention relates to metal complexes of dipeptide sweeteners, such as L-aspartyl-L-phenylalanine methyl ester, with improved dissolution rate, solubility and stability.... | 05/15/1984 |
| 4440677 | Method and intermediates for producing -L-aspartyl-L-phenylalanine This invention encompasses a method and intermediates for preparing a commercial sweetening agent, -L-aspartyl-L-phenylalanine methyl ester. The process involves reacting L-aspartic acid with diketene to form N-acetoacetyl-L-aspartic acid which is ... | 04/03/1984 |
| 4439460 | Dipeptide sweetener sulfate and sulfonate salts Aspartyl dipeptide sweetener sulfate and alkyl sulfonate salts are described which have high thermal stability and a fast rate of dissolution in aqueous media. These salts can be almost universally substituted in place of sugar and are effective in baking... | 03/27/1984 |
| 4411925 | Branched amides of L-aspartyl-d-amino acid dipeptides Amides of L-aspartyl-D-amino acid dipeptides of the formula ##STR1## and physiologically acceptable cationic and acid addition salts thereof wherein Ra is methyl, ethyl, n-propyl or isopropyl; R is a branched member selected from the group... | 10/25/1983 |
| 4399163 | Branched amides of L-aspartyl-D-amino acid dipeptides Amides of L-aspartyl-D-amino acid dipeptides of the formula ##STR1## and physiologically acceptable cationic and acid addition salts thereof wherein Ra is CH2 OH or CH2 OCH3 ; R is a branched member selecte... | 08/16/1983 |
| 4375430 | Processes for preparation, isolation and purification of dipeptide sweeteners Aromatic sulfonic acid salts of certain dipeptide sweeteners which are L-aspartyl-D-alaninamides or L-aspartyl-D-serinamides, each substituted on amide nitrogen with an organic radical having a highly branched carbon skeleton; the process for preparing sa... | 03/01/1983 |
| 4371464 | Dipeptide sweetener Novel sweetener compounds having the formula: ##STR1## wherein M represents hydrogen, ammonium, alkali or alkaline earth, R represents ##STR2## R1 represents methyl, ethyl, or propyl, R2 represents --OH, or --OCH3 | 02/01/1983 |
| 4348317 | Recovery of L-phenylalanine and L-aspartic acid during preparation of -L-aspartyl-L-phenylalanine methyl ester There is described an improved process for the separation and recovery of L-phenylalanine and L-aspartic acid from sidestreams resulting from the preparation of -L-aspartyl-L-phenylalanine methyl ester. It has been found that superior separation is... | 09/07/1982 |
| 4333872 | Method of producing -L-aspartyl-L-phenylalanine methylester A method for preparing an -L-aspartyl-L-phenylalanine alkyl ester, which method comprises: reacting a divalent alkali salt of aspartic acid, having an amino-protective group, with an organic halo ester compound, to form a monovalent, alkali-salt, m... | 06/08/1982 |
