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| Number | Title | Issue Date |
| 7973144 | Method for refolding protein It has been required to refold an inactive protein into an active protein with high efficacy. This problem can be solved by the method for producing a protein including a step of providing a porous body supporting an inactive protein in its mesopores, a step of appl... | 07/05/2011 |
| 7829681 | High-pressure inclusion body solubilization and protease clipping of recombinant fusion proteins Described herein are methods for the solubilization and proteolytic cleavage of fusion protein aggregates, including autocatalytic fusion proteins, at pressures greater than atmospheric pressure to yield soluble target polypeptides. ... | 11/09/2010 |
| 7767795 | High pressure refolding of protein aggregates and inclusion bodies The present disclosure provides an effective method for the refolding of denatured proteins in solution so that properly folded, biologically active protein in solution is recovered in high yield. The refolding takes place at pressures between about 0.25 kbar to abo... | 08/03/2010 |
| 7589184 | Stable protein storage and stable nucleic acid storage in recoverable form The invention provides compositions and methods for storage of biomolecules. The biomolecules are stored via absorption to a substrate. Absorbed biomolecules can be eluted or recovered from the substrate at a future time, and optionally be subjected to a subsequent ... | 09/15/2009 |
| 7538198 | Methods for protein refolding The present invention discloses improved methods of disaggregating protein aggregates, and refolding denatured proteins, using high pressure. In particular, the present invention provides for the use of agitation, high temperature, “stepped” depressurization, di... | 05/26/2009 |
| 7423132 | Method for the enrichment and characterization of phosphorylated peptides or proteins A method for the separation and assay of phosphorylated peptides or proteins from complex mixtures of proteins and peptides is described. The method uses a diazo moiety linked by an organic group to a substrate. Kits for performing the assay are also described. The ... | 09/09/2008 |
| 7411044 | Polymerized hemoglobin solutions having reduced amounts of tetramer and method for preparing A substantially tetramer free hemoglobin solution and a method for producing a substantially tetramer free hemoglobin solution. The method includes polymerizing a solution of hemoglobin, treating the polymerized hemoglobin solution to partially degrade the polymer t... | 08/12/2008 |
| 7385037 | Method for the preparation of gliadin- and glutenin-rich fractions out of gluten in an aqueous medium and in the presence of an acid Method for the preparation of gliadin- and glutenin-rich fractions from gluten in an aqueous medium and in the presence of an acid, wherein the gluten are dispersed continuously or not in water up to a dry substance varying between 5 and 30%, by which the pH of the ... | 06/10/2008 |
| 7368542 | Method of altering the binding specificity of plasma proteins by oxidation-reduction reactions The binding specificity of at least one plasma protein suspended or dissolved in a liquid medium is altered by exposing the protein to an oxidizing agent or an electric current sufficient to alter its binding specificity. A masked protein such as an autoantibody can... | 05/06/2008 |
| 7358342 | Preparation derived from shark cartilage for treatment of diseased related to excessive PHF or excessive intracellular calcium A preparation derived from shark cartilage for the treatment of diseases related to excessive PHF or Excessive intracellular calcium. ... | 04/15/2008 |
| 7244828 | Agent for protein precipitation, a method of protein precipitation, a method of protein assay using protein precipitation agent, and a kit for protein assay A method of protein precipitation, concentration and removal of non-protein agents from the protein solution wherein the protein solution is treated with a protein-precipitation agent containing an acidic agent, a salt and a precipitate forming agent. After precipit... | 07/17/2007 |
| RE39497 | Storage of materials A material or mixture of materials which is not itself storage stable is rendered storage stable by incorporation into a water-soluble or swellable glassy or rubbery composition which can then be stored at ambient temperature. Recovery is by adding aqueous solution ... | 02/27/2007 |
| 7135553 | Polymerized hemoglobin solutions having reduced amounts of tetramer and method for preparing A substantially tetramer free hemoglobin solution and a method for producing a substantially tetramer free hemoglobin solution. The method includes polymerizing a solution of hemoglobin, treating the polymerized hemoglobin solution to partially degrade the polymer t... | 11/14/2006 |
| 7122642 | Method for producing crystal polymorphs and crystal polymorphs produced thereby A method to prepare new or unexpected polymorphs of materials which have not been observed, or to obtain a known polymorph under different conditions than those in which it is usually made, by using a laser to cause nucleation and crystal growth to occur in a supers... | 10/17/2006 |
| 7119166 | Universal procedure for refolding recombinant proteins A universal folding method that has been demonstrated to be effective in refolding a variety of very different proteins expressed in bacteria as inclusion bodies has been developed. Representative proteins that can be dissolved and refolded in biologically active fo... | 10/10/2006 |
| 7115719 | Formulations and methods for denaturing proteins Reagents, methods and kits for denaturation of protein are provided. ... | 10/03/2006 |
| 7109300 | Extraction of collagen from calcified tissues A method is disclosed for extracting collagen from calcified tissue without a prior decalcification step. The method may be used with calcified tissues such as fish skin with scales, alligator skeletons, and crustacean exoskeletons. It does not require the use of ED... | 09/19/2006 |
| 7098315 | Method of preparing a collagen sponge, a device for extracting a part of a collagen foam, and an elongated collagen sponge A method of preparing a collagen sponge comprises mixing air into a collagen gel, so as to obtain a collagen foam which is dried. From the dried product thereby obtained, collagen sponge is obtained by isolating parts of sponge with a chamber diameter of more than 0... | 08/29/2006 |
| 7064192 | High pressure refolding of protein aggregates and inclusion bodies The present disclosure provides an effective method for the refolding of denatured proteins in solution so that properly folded, biologically active protein in solution is recovered in high yield. The refolding takes place at pressures between about 0.25 kbar to abo... | 06/20/2006 |
| 7034128 | Method for recovering proteins from the interstitial fluid of plant tissues A method for extracting proteins from the intercellular space of plants is provided. The method is applicable to the large scale isolation of many active proteins of interest synthesized by plant cells. The method may be used commercially to recover recombinantly pr... | 04/25/2006 |
| 7022822 | Highly purified gonadotropin compositions and process for preparing them Purification process of humanPurification process of human urinary gonadotropins of high biological activity and chemical purity absolutely free of foreign contaminating materials derived from the use of biological reagents or chromatography dyes, from crude of gona... | 04/04/2006 |
| 7015041 | Automated method for setting up multiple crystallization experiments in submicroliter volumes A method is provided for performing array microcrystallizations to determine suitable crystallization conditions for a molecule, the method comprising: forming an array of microcrystallizations, each microcrystallization comprising a drop comprising a mother liquor ... | 03/21/2006 |
| 6995246 | Methods for removing suspended particles from soluble protein solutions The present invention provides soluble protein solutions, free of suspended particles in high yield. More particularly, the current invention provides a method for removing suspended particles from soluble protein solutions by filtering the soluble protein solution ... | 02/07/2006 |
| 6967239 | Method of filtering viruses from a factor VIII solution Method for preparing a factor VIII solution that is essentially free of viruses and essentially devoid of vWF (von Willebrand factor) and factor VIII-vWF complexes by (a) obtaining a starting factor VIII solution devoid of factor VIII-vWF complexes; and (b) filterin... | 11/22/2005 |
| 6951575 | Method for performing high density submicroliter crystallization experiments A method is provided for performing array microcrystallizations to determine suitable crystallization conditions for a molecule, the method comprising: forming an array of microcrystallizations, each microcrystallization comprising a drop comprising a mother liquor ... | 10/04/2005 |
| 6932845 | Method for performing submicroliter crystallization experiments A method is provided for performing crystallization experiments for a molecule, the method comprising performing a plurality of crystallization experiments where the crystallization experiments have volumes of less than 1 microliter, the crystallization experiments ... | 08/23/2005 |
| 6924151 | Stable factor VIII/vWF-complex There are disclosed a stable factor VIII/vWF-complex, particularly comprising high-molecular vWF multimers, being free from low-molecular vWF molecules and from proteolytic vWF degradation products, as well as a method of producing this complex. ... | 08/02/2005 |
| 6911056 | Method for diffracting crystals formed by submicroliter crystallization experiments A method is provided for characterizing a crystal structure of a molecule, the method comprising performing a plurality of crystallization experiments where the crystallization experiments have volumes of less than 1 microliter, the crystallization experiments compr... | 06/28/2005 |
| 6894029 | Use of jellyfish collagen (type II) in the treatment of rheumatoid arthritis Compositions of substantially homogeneous type II-like collagen from invertebrates belonging to the class Scyphozoa, phylum Coelenterata, i.e., jellyfish, particularly Stomolophus meleagris, and methods for its extraction are provided. Methods for the treatme... | 05/17/2005 |
| 6875617 | Agent for protein precipitation, a method of protein precipitation, a method of protein assay using protein precipitation agent, and a kit for protein assay A method of protein precipitation, concentration and removal of non-protein agents from the protein solution wherein the protein solution is treated with a protein-precipitation agent containing an acidic agent, a salt and a precipitate forming agent. After precipit... | 04/05/2005 |
| 6844424 | Method for obtaining avian biological products This invention provides a method for separating and extracting biological products of avian origin. The method allows for the production of avian cartilages and of active ingredients which can be extracted from the cartilages thus obtained. ... | 01/18/2005 |
| 6844321 | Crystallization of a GLP-1 analogue Crystals of glucagon-like peptide-1 (GLP-1) and GLP-1 analogues, and processes for preparation of crystals of GLP-1 and GLP-1 analogues. ... | 01/18/2005 |
| 6841659 | Method for recovering proteins from the interstitial fluid of plant tissues A method for extracting proteins from the intercellular space of plants is provided. The method is applicable to the large scale isolation of many active proteins of interest synthesized by plant cells. The method may be used commercially to recover recombinantly pr... | 01/11/2005 |
| 6780979 | Method for purifying PrPres from a biological sample and applications The invention concerns a method for purifying PrPres from a biological sample to be used for qualitative and/or quantitative determination of the PrPres in said sample. The method essentially consists in: (1) incubating, during 30 seconds to 2 hours, at a temperatur... | 08/24/2004 |
| 6759521 | Polarization switching to control crystal form A method to select and prepare polymorphs of materials by switching the polarization state of light employing non-photochemical laser-induced nucleation. ... | 07/06/2004 |
| 6756482 | Purified human activin and process for producing the same The present invention provides a process for purifying human activin by cation exchange chromatography and chaotropic ion concentration gradient elution. ... | 06/29/2004 |
| 6747132 | Methods for the synthesis of a modified hemoglobin solution The present invention employs a filtration step during the hemoglobin purification process that substantially decreases viral contamination of a hemoglobin solution. The filtration means can be used to separate hemoglobin and several endogenous antioxidant enzymes f... | 06/08/2004 |
| 6740740 | Process for isolating and purifying proteins and peptides from plant sources The present invention features a method for isolating and purifying proteins and peptides of interest from a plant host, which is applicable on a larger scale. Moreover, the present invention provides a more efficient method for isolating proteins and peptides of in... | 05/25/2004 |
| 6734210 | Therapeutically improved salts of azelaic acid Stable salts of azelaic acid with polycations such as chitosan are described. The salts according to the invention are water-soluble, therapeutically more efficacious and are valuable for use as active constituents in pharmaceutical as well as cosmeceutical composit... | 05/11/2004 |
| 6670454 | Method for crosslinking porous biodegradable polymers The present invention relates to crosslinking of porous materials made of biodegradable polymers. The method comprises: (a) placing a porous biodegradable polymer in a chamber; (b) introducing a supercritical fluid containing a crosslinking agent into the... | 12/30/2003 |
