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| Number | Title | Issue Date |
| 7820801 | Highly purified proteinase K A method for producing solid proteinase K which is insoluble in water and has high purity, the method comprising the steps of adding to an aqueous solution of proteinase K ammonium sulfate in an amount of 0.1 to 0.2 M per 5 minutes up to a final amount of 1.5 to 2 M... | 10/26/2010 |
| 7439336 | Process for the purification of IL-18 binding protein The invention relates to a process for the purification of IL-18 binding protein (IL-18BP) from a fluid using aqueous two-phase partitioning. ... | 10/21/2008 |
| 7381789 | Synthesis of inorganic structures using templation and catalysis by self assembled repeat protein polymers Methods for forming repeat protein polymers and utilizing the repeat protein polymers to form inorganic structures are provided. The inorganic structures may have features on the nanoscale, and the structures generally do not have the repeat protein polymer incorpor... | 06/03/2008 |
| 7262058 | Method for determining lipid associated sialoprotein in body fluids The amount of lipid associated sialoprotein (LSP) in body fluids such as cerebrospinal fluid, peritoneal fluid, pleural fluid, bronchial washings, saliva and sputum samples, may be determined by a method which may be automated, involving the following steps to be pe... | 08/28/2007 |
| 7244828 | Agent for protein precipitation, a method of protein precipitation, a method of protein assay using protein precipitation agent, and a kit for protein assay A method of protein precipitation, concentration and removal of non-protein agents from the protein solution wherein the protein solution is treated with a protein-precipitation agent containing an acidic agent, a salt and a precipitate forming agent. After precipit... | 07/17/2007 |
| 7232894 | Method for the production of recombinant peptides with a low amount of trisulfides Methods for the production of recombinant peptides comprise fermenting cells to produce recombinant peptides. A metal salt is added to a concentrate of the fermented cells after the fermentation step, prior to peptide isolation, and the pH of the cell concentrate af... | 06/19/2007 |
| 7229952 | Additive packages for removing oil from solid materials recovered from a well bore An additive package for removing oil from solid material recovered from a well bore, e.g., drill cuttings and produced sand, is provided. The additive package includes an aqueous acidic solution containing a polymer substituted with an amino group, a halogenating ag... | 06/12/2007 |
| 7223561 | Process of high purity albumin production A process is provided for the preparation of albumin which has extremely low levels of or is essentially free of colorants, metal ions, human proteins, host proteins, fragments of albumin, polymers or aggregates of albumin and viruses, and which is essentially non-g... | 05/29/2007 |
| 7192527 | Processes for removing oil from solid wellbore materials and produced water Processes for removing oil from a solid wellbore material such as drill cuttings or water such as produced by a subterranean formation include contacting the solid material/water with an amino-substituted polymer such as chitosan and a halogenating agent. The oil se... | 03/20/2007 |
| 7183237 | Method for the use of distiller's grain as herbicide and fertilizer A method of weed control using a biological paradigm. A method for the use of dried distiller's grain and soluble as an herbicide and a fertilizer in the use of crop production. A method for the processing of corn and other crops including the re-use of the dried gr... | 02/27/2007 |
| 7025963 | Vaccine against Gram-negative bacterial infections A vaccine, effective in inducing the production of antibodies with which to immunize a second subject passively against infection by Gram-negative bacteria and LPS-mediated pathology, comprises a non-covalent polyvalent complex formed between purified, detoxified LP... | 04/11/2006 |
| 6998251 | Nanoporous membrane reactor for miniaturized reactions and enhanced reaction kinetics Reactors and methods for miniaturized reactions having enhanced reaction kinetics. In particular the subject matter is directed to chemical and biological reactions conducted in a nanoporous membrane environment. The subject matter contemplates methods for modifying... | 02/14/2006 |
| 6967239 | Method of filtering viruses from a factor VIII solution Method for preparing a factor VIII solution that is essentially free of viruses and essentially devoid of vWF (von Willebrand factor) and factor VIII-vWF complexes by (a) obtaining a starting factor VIII solution devoid of factor VIII-vWF complexes; and (b) filterin... | 11/22/2005 |
| 6894023 | Growth hormone crystals and a process for production of these GH-crystals A process for producing cation crystals of growth hormone or growth hormone derivatives, as well as growth hormone and growth hormone derivatives. The process of producing the growth hormone crystals includes the steps of (a) adding cations of inorganic or organic n... | 05/17/2005 |
| 6875617 | Agent for protein precipitation, a method of protein precipitation, a method of protein assay using protein precipitation agent, and a kit for protein assay A method of protein precipitation, concentration and removal of non-protein agents from the protein solution wherein the protein solution is treated with a protein-precipitation agent containing an acidic agent, a salt and a precipitate forming agent. After precipit... | 04/05/2005 |
| 6777538 | Binding protein A 24 kd protein capable of binding the E2 envelope protein of hepatitis C virus (HCV), and functionally equivalent variants or fragments of the 24 kd protein, are disclosed. Processes for production and purification of the 24 kd protein, and functionally equivalent ... | 08/17/2004 |
| 6759384 | Factor Xa inhibitors The invention provides compounds which specifically inhibit factor Xa activity having the structure A1—A2—(A3)m—B, where m is 0 or 1. A compound of the invention is characterized, in part, in that it exhibits a speci... | 07/06/2004 |
| 6756354 | Therapeutic compositions containing oligo (ethylene glycol)-terminated 1,2-dithiolanes and their conjugates The present invention provides biotechnologically useful oligo(ethylene glycol)-terminated 1,2-dithiolane compositions and conjugates of these compositions with biological or non-biological receptor, ligand, sequestering, or reporter moieties to provide physiologica... | 06/29/2004 |
| 6737233 | Method for preparing HCV E2 binding protein A 24 kd percent capable of binding the E2 envelope protein of hepatitis C virus (HCV), and functionally equivalent variants or fragments of the 24 kd protein, are disclosed. Processes for production and purication of the 24 kd protein, and functionally equivalent va... | 05/18/2004 |
| 6676840 | Fat and protein removal from process streams The precipitation and removal of suspended fat and protein components and other suspended solids from a given solution can be accomplished by the addition of an aluminate to complex with the fat and protein components and the addition of a flocculating ag... | 01/13/2004 |
| 6638740 | Process of high purity albumin production The present invention relates to a process for purifying the protein human serum albumin extracted from serum or recombinant human albumin produced by transforming a microorganism with a nucleotide coding sequence encoding the amino acid sequence of human... | 10/28/2003 |
| 6635746 | Chlamydial vaccines and immunogenic compositions containing an outer membrane antigen and methods of preparation thereof Immunogenic compositions including vaccines are described that comprise an outer membrane antigen extract of a strain of Chlamydia and are effective in protection against disease caused by Chlamydia infection The immunogenic compositions may comprise the ... | 10/21/2003 |
| 6610630 | Chromatography adsorbents utilizing mercapto heterocyclic ligands A pseudobioaffinity chromatography adsorbent adapted for use in selectively adsorbing immunoglobulins. In one embodiment, the adsorbent includes: (a) a solid support material; and (b) a ligand immobilized on the surface of the solid support material, said... | 08/26/2003 |
| 6566329 | Freeze-dried preparation of human growth hormone A readily-soluble freeze-dried solid preparation of hGH with a minimal content of degradation products in terms of deamidation, dimers, polymers, and sulphoxide forms, obtainable by a method comprising a single lyophilization of an aqueous slurry of an am... | 05/20/2003 |
| 6461604 | Crystalline IL-6 and models of the molecular structure of IL-6 Crystallographic and NMR solution structures of human IL-6 are reported. The invention provides models and systems incorporating such structures which are useful for identifying IL-6/IL-6 receptor interactions and for identification of agonists and antago... | 10/08/2002 |
| 6448374 | Production of phosphopeptides from casein A method for the preparation of selected phosphopeptides having anticariogenic and other activities, comprising the steps of completely digesting a soluble monovalent cation salt of casein in solution with a proteolytic enzyme, adding a mineral acid to th... | 09/10/2002 |
| 6444211 | Purification of a pertussis outer membrane protein Pertactin (formerly 69 kDa protein) is recovered in stable biologically pure form having no detectable adenylate cyclase activity from fermentation broth from the fermentation of Bordetella pertussis as well as from the cells. The broth is processed to se... | 09/03/2002 |
| 6437101 | Methods for protein purification using aqueous two-phase extraction Methods are provided in this invention for the isolation of human growth hormone, growth hormone antagonist, or a homologue of either, from a biological source. The methods of the invention use multi-phase extraction.... | 08/20/2002 |
| 6372145 | Fat and protein removal from process streams The precipitation and removal of suspended fat and protein components and other suspended solids from a given solution can be accomplished by the addition of an aluminate to complex with the fat and protein components and the addition of a flocculating ag... | 04/16/2002 |
| 6335430 | Process of producing polyphenolic adhesive proteins and proteins produced in accordance with the process The invention relates to a process of producing MAP-products from mussel feet. The process is characterised by extracting the mussel feet in a weakly acid aqueous solution containing, for instance, 1-10 percent by weight of a weak acid and 0.5-3 percent b... | 01/01/2002 |
| 6284874 | Process for separating 댑-proteinase inhibitor from cohn fraction IV1 and IV4 paste The present invention is directed to a process for purifying 댑 -proteinase inhibitor. The process comprises providing an impure protein fraction which comprises 댑 -proteinase inhibitor. The impure protein fraction is pr... | 09/04/2001 |
| 6281336 | Process for producing immunoglobulins for intravenous administration and other immunoglobulin products The present invention relates to a process for purifying immunoglobulin G from a crude immunoglobulin-containing plasma protein fraction. Said process includes a number of steps of which the anion exchange chromatography and the cation exchange chromatogr... | 08/28/2001 |
| 6239261 | Pasteurized, purified von Willebrand factor concentrate and a process for the preparation thereof A process for the preparation of a concentrate of von Willebrand factor is described, entailing a solution of a complex of this factor with factor VIII:C being optionally pasteurized and treated with an anion exchanger, there being no binding of the von W... | 05/29/2001 |
| 6166187 | Method of concentrating prion proteins in blood samples A sample is prepared from blood in a manner which makes it possible to further analyze proteins in the sample, e.g. to detect prions in the sample. Blood is extracted, allowed to clot and subjected to separation processing (e.g. centrifugation) to obtain ... | 12/26/2000 |
| 6160092 | Crystal of the core portion of a signal transducer and activator of transcription (STAT) The present invention provides a crystal of the core portion of the STAT protein in dimeric form with an 18-mer duplex DNA that contains a binding site for the STAT-dimer. The crystal is of sufficient quality to perform X-ray crystallographic studies. Met... | 12/12/2000 |
| 6140469 | Protein isolate having an increased level of isoflavone compounds and process for producing the same The present invention relates to the production of an isoflavone enriched vegetable protein isolate in which the weight ratio of material to extractant is controlled and washing of the acid precipitated protein curd is avoided or minimized to provide an i... | 10/31/2000 |
| 6117984 | Growth hormone crystals and a process for production of these GH-crystals Divalent cation crystals of human growth factor (hGH) or derivatives thereof, and pharmaceutical preparations comprising divalent cation crystals of hGH. In specific embodiments, the divalent cation is Zn++ and the molar ration Zn++ and hGH is about 0.2 t... | 09/12/2000 |
| 6080844 | Process for the recovery and purification of a recombinant protein from a cell The present invention involves a process of purifying and recovering a recombinant protein from a suspension of cells. The process of the present invention involves extracting a recombinant protein from a concentrated suspension of cells using a water-mis... | 06/27/2000 |
| 6051694 | Method for size reduction of proteins Liquefied gases, compressed gases, and supercritical fluids are used to form protein particles without first dissolving the protein. The product material is expected to retain full activity and be devoid of residual processing chemicals such as solvents, ... | 04/18/2000 |
| 6051687 | Purification of liquid protein hydrolysate and the resultant products A method for removing excess salts, sulfites, sulfates and fatty components from liquid protein hydrolysate is described. Purified liquid protein products having reduced concentrations of salts, sulfites, sulfates and fatty material are also described. Th... | 04/18/2000 |
