Did You Know...
...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
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| Number | Title | Issue Date |
| 7777012 | Method of preparing a protein aggregate and a pharmaceutical preparation The invention relates to a method of preparing a protein aggregate, wherein an aqueous protein solution is acidified with a pH that lies above the isoelectric point of the protein. In accordance with the invention, a first protein, which through acidification is abl... | 08/17/2010 |
| 7517968 | Rapid and inexpensive method for the purification of proteorhodopsin A method for purifying a membrane protein is disclosed which includes providing a test sample potentially including a target membrane protein; adding incremental amounts of a precipitating agent to the test sample to form one or more mixtures; and treating the one o... | 04/14/2009 |
| 7442308 | Process for removing viruses in fibrinogen solutions and fibrinogen obtained by said process A process for removing viruses in fibrinogen solutions and fibrinogen obtained thereof wherein the process starts with an adjusted purified fibrinogen solution, the adjusted purified solution is frozen and then thawed at a temperature between 5 and 20° C., the undi... | 10/28/2008 |
| 7411044 | Polymerized hemoglobin solutions having reduced amounts of tetramer and method for preparing A substantially tetramer free hemoglobin solution and a method for producing a substantially tetramer free hemoglobin solution. The method includes polymerizing a solution of hemoglobin, treating the polymerized hemoglobin solution to partially degrade the polymer t... | 08/12/2008 |
| 7385037 | Method for the preparation of gliadin- and glutenin-rich fractions out of gluten in an aqueous medium and in the presence of an acid Method for the preparation of gliadin- and glutenin-rich fractions from gluten in an aqueous medium and in the presence of an acid, wherein the gluten are dispersed continuously or not in water up to a dry substance varying between 5 and 30%, by which the pH of the ... | 06/10/2008 |
| 7361734 | S8 rRNA-binding protein from the small ribosomal subunit of A Staphylococcus aureus S8 native crystalline structure and a Staphylococcus aureus S8 mode of binding with rRNA were identified. ... | 04/22/2008 |
| 7351798 | Stabilized protein crystals, formulations comprising them and methods of making them This invention relates to methods for the stabilization, storage and delivery of biologically active macromolecules, such as proteins, peptides and nucleic acids. In particular, this invention relates to protein or nucleic acid crystals, formulations and composition... | 04/01/2008 |
| 7259243 | Process for isolation of osteopontin from milk A process for isolation of milk osteopontin from a material containing milk osteopontin by optionally mixing the milk material with a calcium source and separate the osteopontin containing phase from the rest of the milk material by pH adjustment. ... | 08/21/2007 |
| 7244828 | Agent for protein precipitation, a method of protein precipitation, a method of protein assay using protein precipitation agent, and a kit for protein assay A method of protein precipitation, concentration and removal of non-protein agents from the protein solution wherein the protein solution is treated with a protein-precipitation agent containing an acidic agent, a salt and a precipitate forming agent. After precipit... | 07/17/2007 |
| 7232894 | Method for the production of recombinant peptides with a low amount of trisulfides Methods for the production of recombinant peptides comprise fermenting cells to produce recombinant peptides. A metal salt is added to a concentrate of the fermented cells after the fermentation step, prior to peptide isolation, and the pH of the cell concentrate af... | 06/19/2007 |
| 7229789 | Methods and compositions for extracting proteins from cells A process is disclosed for releasing proteins from cells and/or inactivating viruses. In the process, a host cell containing a protein of interest is contacted with a solution of an effective amount of a detergent. ... | 06/12/2007 |
| 7226609 | Sodium dodecyl sulfate compositions for inactivating prions An antiseptic composition useful in destroying the infectivity of infectious proteins such as prions is disclosed. The antiseptic composition is preferably maintained at either a low pH of 4.0 or less or a high pH of 10.0 or more either of which allows for an enviro... | 06/05/2007 |
| 7214778 | Glycoprotein with antidiabetic, antihypertensive, antiobesity and antihyperlipidemic effects from , and a method for preparing same A glycoprotein extracted from the fruiting body of Grifola frondosa is demonstrated to have antidiabetic, antihypertensive, antiobesity and antihyperlipidemic effects, and has great potential as an active component for pharmaceuticals, dietary supplements or ... | 05/08/2007 |
| 7208106 | Method of forming particles The present invention provides a method of forming particles that involves contacting a solution, which includes a solute and/or other material to be precipitated dissolved or dispersed in a solvent, with a first compressed or liquefied gas at an initial temperature... | 04/24/2007 |
| 7193084 | Polymorphic form of itraconazole The present invention provides a polymorphic form of itraconazole. ... | 03/20/2007 |
| 7186796 | Method for drying water-borne materials Provided is a method of isolating a bio-molecule from a water-borne mixture, the method comprising: contacting the water-borne mixture with dimethyl ether to form solid particles of the bio-molecule. ... | 03/06/2007 |
| 7166471 | Misfolded protein sensor method in body fluids A catalytic conformational sensor method for detecting abnormal proteins and proteinaceous particles. The method is based on the interaction of a peptide fragment or probe with an abnormal proteinaceous particle. The interaction catalyzes transformation of the probe... | 01/23/2007 |
| 7166477 | Muscle sample prepared for prion assay A method of preparing a sample of muscle tissue and of assaying the prepared sample to determine the presence of prions in the sample is disclosed. The muscle tissue is homogenized and mixed with a complexing agent which forms a complex with a higher specific gravit... | 01/23/2007 |
| 7151000 | Method of concentrating proteins from serum A sample is prepared from blood in a manner which makes it possible to further analyze proteins in the sample, e.g. to detect prions in the sample. Blood is extracted, allowed to clot and subjected to separation processing (e.g. centrifugation) to obtain serum. The ... | 12/19/2006 |
| 7144988 | Method of structure-based drug design to create or improve modulators of IL-1 activity which bind to the interleukin-1 type 1 receptor Crystals comprising a modified interleukin-1 type 1 receptor (IL-1R1) and one or more modulators of IL-1 activity are described. Methods of identifying potential inhibitors of IL-1 activity are also described. Compositions and methods for the treatment of IL-1 media... | 12/05/2006 |
| 7141262 | Method for obtaining a TGF-beta enriched protein fraction in activated form, protein fraction and therapeutic applications The invention concerns a method for obtaining a highly enriched TGF-beta protein fraction in activated form, from a liquid solution rich in proteins said to be soluble in the aqueous phase of milk and/or of whey, said method comprising the following steps; a) adjust... | 11/28/2006 |
| 7135553 | Polymerized hemoglobin solutions having reduced amounts of tetramer and method for preparing A substantially tetramer free hemoglobin solution and a method for producing a substantially tetramer free hemoglobin solution. The method includes polymerizing a solution of hemoglobin, treating the polymerized hemoglobin solution to partially degrade the polymer t... | 11/14/2006 |
| 7125566 | Particulate drug-containing products and method of manufacture Provided is a compressed anti-solvent technique for manufacture of drug-containing powders for pulmonary delivery. The drug is processed in a cosolvent system including two or more mutually soluble organic solvents. Also provided are powders manufacturable by the ma... | 10/24/2006 |
| 7122642 | Method for producing crystal polymorphs and crystal polymorphs produced thereby A method to prepare new or unexpected polymorphs of materials which have not been observed, or to obtain a known polymorph under different conditions than those in which it is usually made, by using a laser to cause nucleation and crystal growth to occur in a supers... | 10/17/2006 |
| 7122344 | Methods for the production of purified recombinant human uteroglobin for the treatment of inflammatory and fibrotic conditions The present invention relates generally to the production of recombinant human uteroglobin (rhUG) for use as a therapeutic in the treatment of inflammation and fibrotic diseases. More particularly, the invention provides processes, including broadly the steps of bac... | 10/17/2006 |
| 7115719 | Formulations and methods for denaturing proteins Reagents, methods and kits for denaturation of protein are provided. ... | 10/03/2006 |
| 7112340 | Compositions of and method for preparing stable particles in a frozen aqueous matrix The present invention discloses a composition of a stable suspension of a poorly water soluble pharmaceutical agent or cosmetic in the form of particles of the pharmaceutical agent or cosmetic suspended in a frozen aqueous matrix and method for its preparation. The ... | 09/26/2006 |
| 7098026 | Human desert hedgehog protein Disclosed are a novel hedgehog protein, i.e., a Desert hedgehog protein of human origin including mature and precursor forms, a DNA encoding the protein, a monoclonal antibody recognizing the protein, a process for producing the protein, and a method for detecting t... | 08/29/2006 |
| 7087197 | Particle formation Method for preparing a target substance in particulate form, comprising introducing into a particle formation vessel, through separate first and second fluid inlets respectively, (a) a “target solution/suspension” of the substance in a fluid vehicle and (b) a co... | 08/08/2006 |
| 7087719 | Method for the crystallization of human serum albumin The present invention relates to the purification and production of human albumin from various sources through crystallization and repeated crystallization. Basic features of the invented process include providing specific reaction conditions and precipitating reage... | 08/08/2006 |
| 7037528 | Microprecipitation method for preparing submicron suspensions The present invention provides a method for preparing submicron sized particles of an organic compound, the solubility of which is greater in a water-miscible first solvent than in a second solvent which is aqueous, the process including the steps of: (i) dissolving... | 05/02/2006 |
| 7022822 | Highly purified gonadotropin compositions and process for preparing them Purification process of humanPurification process of human urinary gonadotropins of high biological activity and chemical purity absolutely free of foreign contaminating materials derived from the use of biological reagents or chromatography dyes, from crude of gona... | 04/04/2006 |
| 6995242 | Process for producing insoluble and soluble collagen protein products from poultry skins and use thereof A method of extracting and fractionating collagen-rich proteinaceous materials and derivatives from poultry skin tissue and the development of the proteinaceous materials to collagen-based protein ingredients that can function as meat replacer, texturizer, binder/fi... | 02/07/2006 |
| 6989438 | Process for the purification of EPI-HNE proteins The present invention concerns a process for the purification of EPI-HNE proteins, from the culture medium of a host strain for the expression of said proteins, comprising the steps of: (a) passing a derived part of the culture medium over an expanded bed of cationi... | 01/24/2006 |
| 6989436 | Stabilization of cardiac troponin I subunits and complexes The present invention provides methods for preparing, and compositions comprising, stabilized protein-polymer conjugates. More particularly, the present invention relates to the stabilization of individual and complexed subunits of multisubunit protein complexes by ... | 01/24/2006 |
| 6977085 | Method for preparing submicron suspensions with polymorph control The present invention provides a method for preparing a suspension of a pharmaceutically-active compound, the solubility of which is greater in a water-miscible first organic solvent than in a second solvent which is aqueous. The process includes the steps of: (i) d... | 12/20/2005 |
| 6967239 | Method of filtering viruses from a factor VIII solution Method for preparing a factor VIII solution that is essentially free of viruses and essentially devoid of vWF (von Willebrand factor) and factor VIII-vWF complexes by (a) obtaining a starting factor VIII solution devoid of factor VIII-vWF complexes; and (b) filterin... | 11/22/2005 |
| 6924151 | Stable factor VIII/vWF-complex There are disclosed a stable factor VIII/vWF-complex, particularly comprising high-molecular vWF multimers, being free from low-molecular vWF molecules and from proteolytic vWF degradation products, as well as a method of producing this complex. ... | 08/02/2005 |
| 6908985 | HspBP polypeptides and peptide fragments that bind Hsp 70 Human heat-shock protein-binding proteins (HspBP-1 and HspBP-2) and fragments thereof are disclosed with the polynucleotides which identify and encode them. Genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding heat-... | 06/21/2005 |
| 6903202 | DNA encoding proteins that inhibit Hsp70 function Human heat-shock protein-binding proteins (HspBP-1 and HspBP-2) are disclosed with the polynucleotides which identify and encode them. Genetically engineered expression vectors and host cells comprising nucleic acid sequences encoding heat-shock protein-binding prot... | 06/07/2005 |
