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| Number | Title | Issue Date |
| 8067554 | Ion exchange chromatography of GLP-1, analogs and derivatives thereof The present invention relates to an ion exchange chromatography process for purifying GLP-1 or an analog or a derivative thereof from a mixture containing said GLP-1 and related impurities, and to an industrial method including such ion exchange chromatography proce... | 11/29/2011 |
| 8058411 | Method for producing mature VWF from VWF pro-peptide The present invention relates to a method for producing a mature von Willebrand Factor (VWF) from von Willebrand Factor pro-peptide comprising the steps: immobilizing VWF pro-peptide on an ion exchange resin, incub... | 11/15/2011 |
| 7906630 | Method for identifying peptides in a biological sample The invention provides a method for isolating a cargo peptide from a sample containing a cargo peptide-carrier protein complex. The method involves contacting a sample comprising a cargo peptide-carrier protein complex with a binding moiety selective for the carrier... | 03/15/2011 |
| 7531645 | Protein purification A method for purifying a polypeptide by ion exchange chromatography is described which involves changing the conductivity and/or pH of buffers in order to resolve a polypeptide of interest from one or more contaminants. ... | 05/12/2009 |
| 7476726 | Method of producing and purifying endostatin protein The present invention provides a method for recombinant production, recovery and purification of endostatin protein. This method may be employed for large scale recovery and purification of recombinantly-produced endostatin protein. ... | 01/13/2009 |
| 7470779 | Process for decreasing aggregate levels of pegylated protein The present invention is directed generally to recombinant methods for making a desired pegylated protein and pooling of same. The method(s) yield a polypeptide product containing reduced levels of aggregate thereof pooled to provide the desired pegylated isoforms t... | 12/30/2008 |
| 7385040 | Antibody purification The present invention relates to a method of separating antibodies from contaminants in a solution, which method comprises contacting the solution with a chromatography resin comprised of a support to which multi-modal ligands have been immobilised, wherein a multi-... | 06/10/2008 |
| 7375188 | Vegetarian protein a preparation and methods thereof The invention relates to methods of producing Protein A without contamination of the Protein A by animal products. The invention also relates to a vegetarian fermentation media in which Staphylococcus aureus is grown to produce a vegetarian Protein A. The inv... | 05/20/2008 |
| 7371581 | Process for the monitoring of contaminant removal during the purification process of a pharmaceutical product produced by a host cell We describe a process for the monitoring of contaminant removal during the purification process of a pharmaceutical product produced by a host cell, wherein at least two different samples taken during the purification process of the pharmaceutical product are incuba... | 05/13/2008 |
| 7368141 | Process of isolating lactoferrin A process for isolating lactoferrin from milk or a casein-containing component or product containing lactoferrin, comprising subjecting a precipitate of casein obtained from the milk of the casein-containing component or product, with which precipitate at least part... | 05/06/2008 |
| 7365173 | Method for the production of pure virally inactivated butyrylcholinesterase The present invention provides a method for purifying butyrylcholinesterase from various biological fluids. Biological fluids include, e.g., blood, blood fractions, plasma, and bioreactor broths, and other such mixtures containing butyrylcholinesterase. In one embod... | 04/29/2008 |
| 7355020 | Stimulus responsive affinity chromatographic material and separation/purification method A separation material characterized by supporting, in its surface, a linear or crosslinked stimulus responsive polymer to which a substance A having specific affinity for a target substance and a low-molecular substance B having specific affinity for the substance A... | 04/08/2008 |
| 7329409 | Compositions and methods for treatment of microbial infections The present invention relates to methods and compositions for treatment of microbial infections and for the enhancement of resistance to infection. The invention comprises administration of an effective amount of bacterial lysate compositions for the treatment of pa... | 02/12/2008 |
| 7300772 | BMP products Purified BMP-2 and BMP-4 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair. ... | 11/27/2007 |
| 7294614 | Phosphoprotein affinity resins and methods for making and using the same Phosphorylated protein (i.e., phosphoprotein) affinity resins and methods for making and using the same are provided. The subject resins include a substrate bonded to aspartate-based tetradentate ligand/metal ion complexes, where the tetradentate ligand/metal ion co... | 11/13/2007 |
| 7279309 | Process for manufacture of Nematode-extracted Anticoagulant Protein (NAP) The present invention provides a process for manufacture of purified Nematode-extracted Anticoagulant Proteins (NAPs), wherein the NAP manufactured by the claimed process method is a NAP drug substance that can be formulated as a NAP drug product. The present invent... | 10/09/2007 |
| 7276590 | Ion exchange chromatography of proteins and peptides The present invention relates to an ion exchange chromatography process for purifying a peptide from a mixture containing the peptide and related impurities, and to an industrial method including such ion exchange chromatography process. ... | 10/02/2007 |
| 7252973 | Protein and processes for producing the same A novel protein and a process of producing the protein is provided. The protein is a glycoprotein having activity of suppressing the differentiation and/or maturation of adipocyte, having a molecular weight of about 45 kD under non-reducing conditions and about 28 k... | 08/07/2007 |
| 7247331 | Milk protein isolate and method for preparing same The invention concerns a method for isolating milk proteins from milk or from whey comprising steps which consist in passing the milk or whey over a cation-ex-changing resin, eluting the fraction retained by an aqueous salted solution and desalting and sterilizing t... | 07/24/2007 |
| 7244706 | Antimicrobial/endotoxin neutralizing polypeptide The present invention provides a therapeutic method for treating or preventing a disease resulting from a microbial infection in an individual using an antimicrobial polypeptide. The present invention also provides a method of potentiating the therapeutic action of ... | 07/17/2007 |
| 7232893 | Method of manufacturing a stellate cell death factor The present invention provides compositions and methods for selectively inhibiting the proliferation of stellate cells, which are important for the development of liver fibrosis upon liver injury. The invention describes conditioned media from immortalized hepatocyt... | 06/19/2007 |
| 7229554 | Purification process comprising microfiltration at elevated temperatures Process for microfiltration at elevated temperature. ... | 06/12/2007 |
| 7229789 | Methods and compositions for extracting proteins from cells A process is disclosed for releasing proteins from cells and/or inactivating viruses. In the process, a host cell containing a protein of interest is contacted with a solution of an effective amount of a detergent. ... | 06/12/2007 |
| 7226609 | Sodium dodecyl sulfate compositions for inactivating prions An antiseptic composition useful in destroying the infectivity of infectious proteins such as prions is disclosed. The antiseptic composition is preferably maintained at either a low pH of 4.0 or less or a high pH of 10.0 or more either of which allows for an enviro... | 06/05/2007 |
| 7226757 | Formulation, solubilization, purification, and refolding of tissue factor pathway inhibitor Compositions are described that are suitable for formulating TFPI. Solubilizers and stabilizers facilitate the preparation of pharmaceutically acceptable compositions of TFPI at various concentrations. ... | 06/05/2007 |
| 7223561 | Process of high purity albumin production A process is provided for the preparation of albumin which has extremely low levels of or is essentially free of colorants, metal ions, human proteins, host proteins, fragments of albumin, polymers or aggregates of albumin and viruses, and which is essentially non-g... | 05/29/2007 |
| 7223848 | Methods for purifying Fc-containing proteins The present invention provides a process for dissociating Fc-containing molecules from complexes of Protein A/Fc-containing molecules or mixtures containing Fc-containing molecules and Protein A. The association, e.g., by hydrophobic interactions, between the Fc-con... | 05/29/2007 |
| 7217691 | Methods of treatment of periodontal disease Purified BMP-2 and BMP-4 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair. ... | 05/15/2007 |
| 7202211 | Methods of preventing or treating brain ischemia or brain injury The present invention relates to use of Narp inhibitor in order to promote or enhance recovery from ischemic events, particularly focal ischemia of the central nervous system, as well as for preventing or diminishing chronic degenerative changes. ... | 04/10/2007 |
| 7195923 | Ratiometric determination of glycated protein The present invention provides methods for determining a ratio of an amount of a glycated form of a protein to a total amount of the protein in a sample containing the glycated protein, the glycosylated protein, or the glycoprotein. The method incorporates lateral f... | 03/27/2007 |
| 7193066 | Preparation of highly pure toxin fragments Toxin derivatives are prepared by proteolytic treatment of holotoxin, and their toxicity is reduced by contacting the preparation with a ligand, which can be a metal or an antibody or another ligand. This ligand selectively binds to the toxin but not to the toxin de... | 03/20/2007 |
| 7189324 | High-affinity, low molecular-mass displacers for ion-exchange chromotography A method for separating one or more components of a biomolecule mixture by means of an ion exchange chromatographic system operated in the displacement mode includes sequentially perfusing the system with a first solution including the biomolecule mixture, and a sec... | 03/13/2007 |
| 7148048 | Process for purification of recombinant porphobilinogen deaminase A process for purification of recombinant porphobilinogen deaminase (rhPBGD) on an industrial scale by starting from a rhPBGD containing extract obtained from a fermentation of a recombinant cell capable of expressing the rhPBGD and the use of the purified product f... | 12/12/2006 |
| 7144855 | Protein complex from ion-exchange chromatography for treatment of bacterial infections The present invention relates to the use of alpha-lactalbumin in the preparation of preparations to be used in therapeutic or prophylactic treatment and/or for diagnostic use for infections, preferably of the respiratory tract, caused by bacteria, in particular S... | 12/05/2006 |
| 7138120 | Process for producing immunoglobulins for intravenous administration and other immunoglobulin products The present invention relates to a process for purifying immunoglobulin G from a crude immunoglobulin-containing plasma protein fraction. Said process includes a number of steps of which the anion exchange chromatography and the cation exchange chromatography are pr... | 11/21/2006 |
| 7135327 | Ribonucleic acid-enriched brewer's yeast cells and process for producing the same By using a medium containing an ingredient for activating brewer's yeast, a brewer's yeast cell body is immersed in the medium in the presence of an added inorganic salt; and the immersion is stirred at a predetermined temperature to concurrently carry out an aerobi... | 11/14/2006 |
| 7122344 | Methods for the production of purified recombinant human uteroglobin for the treatment of inflammatory and fibrotic conditions The present invention relates generally to the production of recombinant human uteroglobin (rhUG) for use as a therapeutic in the treatment of inflammation and fibrotic diseases. More particularly, the invention provides processes, including broadly the steps of bac... | 10/17/2006 |
| 7112453 | Retentate chromatography and protein chip arrays with applications in biology and medicine This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by d... | 09/26/2006 |
| 7109322 | Process for the depletion or removal of endotoxins A process for the depletion or removal of endotoxins from preparations containing active ingredients designated for therapeutical use which are obtained from natural sources by genetic engineering and/or biotechnology by treatment with chromatographic material where... | 09/19/2006 |
| 7098026 | Human desert hedgehog protein Disclosed are a novel hedgehog protein, i.e., a Desert hedgehog protein of human origin including mature and precursor forms, a DNA encoding the protein, a monoclonal antibody recognizing the protein, a process for producing the protein, and a method for detecting t... | 08/29/2006 |
