Quotables
"To place a man in a multi-stage rocket and project him into the controlling gravitational field of the moon where the passengers can make scientific observations, perhaps land alive, and then return to earth--all that constitutes a wild dream worthy of Jules Verne. I am bold enough to say that such a man-made voyage will never occur regardless of all future advances."
Lee deForest, American radio pioneer ; 1957
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| Number | Title | Issue Date |
| 7320867 | Linker compound, ligand, and producing method thereof A linker compound has a structure represented by general formula (1) below, where n is an integer of 1 to 6, and X has a structure serving as a multi-branched structure moiety including three or four hydrocarbon derivative chains each having an aromatic amino group ... | 01/22/2008 |
| 7282481 | Heparin-binding proteins modified with sugar chains, method of producing the same and pharmaceutical compositions containing same A heparin-binding protein functionalized by covalently bonding thereto a sugar chain, a method for producing the protein and a pharmaceutical composition containing the protein as an active ingredient, as well as a method of functionalizing a natural protein having ... | 10/16/2007 |
| 7202092 | Indinavir derivatives useful in immunoassay Derivatives and conjugates of indinavir for generation of antibodies and labeled conjugates for use for detection of indinavir in biological samples. The derivatives are synthesized out of the indane ring hydroxyl group or the pyridine ring nitrogen of indinavir. Al... | 04/10/2007 |
| 7183067 | Versatile linker compound, ligand, and producing method thereof A versatile linker compound has a structure represented by following general formula (1), wherein Y has a structure represented by O or NH, and X has a structure serving as a multi-branched moiety including four hydrocarbon derivative chains each of which has an aro... | 02/27/2007 |
| 7166708 | Process for preparing conjugate vaccines and the conjugate vaccines This invention relates to a process for preparing a hapten-protein-polysaccharide conjugate and a hapten-protein conjugate by reacting a protein with a hapten to produce a hapten-protein conjugate, followed by reacting the hapten-protein conjugate with a polysacchar... | 01/23/2007 |
| 7138373 | Polysaccharide-based polymers and methods of making the same Gels and polymers comprising a polypeptide bound to a polysaccharide are disclosed. Specific polypeptides include, but are not limited to, polypeptides that comprise glutamine or tyrosine residues. Specific polysaccharides include, but are not limited to, chitosan. ... | 11/21/2006 |
| 7135343 | Biomolecule resistant and their methods of use in assays The present invention relates to bio-molecule resistant surfaces for use in assays, particularly in assay devices such as arrays and microfluidic devices. The biomolecule resistant surface of the present invention are prepared by coating a substrate with hydrophilic... | 11/14/2006 |
| 7005415 | Heparin-binding proteins modified with sugar chains, method of producing the same and pharmaceutical compositions containing the same A heparin-binding protein functionalized by covalently bonding thereto a sugar chain, a method for producing the protein and a pharmaceutical composition containing the protein as an active ingredient, as well as a method for functionalizing a natural protein having... | 02/28/2006 |
| 7001991 | Targeted delivery of bioaffecting compounds for the treatment of cancer A homogeneous conjugate for targeting and treating diseased cells wherein the conjugate comprises an anti-cancer drug and a targeting protein, wherein said anti-cancer drug is selected from the group consisting of heat sensitizers, photosensitizers and apoptosis ind... | 02/21/2006 |
| 6815533 | Cryogranulation of activated protein C The present invention is directed at a method of processing an aqueous solution of protein C into a state suitable for storage, handling, and recovery. The present invention provides aqueous activated protein C solutions and an improved method of processing such sol... | 11/09/2004 |
| 6803053 | Lipidic microparticles linked to multiple proteins The invention provides lipidic microparticles stably associated with at least two different targeting moieties, which targeting moieties are attached to linker molecules comprising a hydrophilic domain and a hydrophobic domain. The targeting moieties can be antibodi... | 10/12/2004 |
| 6756041 | Process for preparing conjugate vaccines including free protein and the conjugate vaccines, immunogens, and immunogenic reagents produced by this process A process for preparing a protein-polysaccharide conjugate includes reacting a protein with a polysaccharide to produce a mixture including a protein-polysaccharide conjugate and free protein. At least one unreacted reagent or low molecular weight component is remov... | 06/29/2004 |
| 6723831 | Neoglycoproteins Polyamide conjugates comprising either (a) a xenoantigenic group; or (b) a biologically active group and a macromolecular, macro- or microscopic entity; bound to a polyamide backbone, processes for their preparation and the use of these conjugates in therapeutic com... | 04/20/2004 |
| 6512098 | Chemically modified proteins with a carbohydrate moiety The present invention relates to a chemically modified mutant protein including a cysteine residue substituted for a residue other than cysteine in a precursor protein, the substituted cysteine residue being subsequently modified by reacting the cysteine ... | 01/28/2003 |
| 6479264 | Reversible inactivation enzymes A method for reversibly inactivating thermostable DNA polymerase or ligase, which method comprises reacting a mixture of the thermostable DNA polymerase or ligase with a dicarboxylic acid anhydride, wherein the reaction is carried out using a dried DNA po... | 11/12/2002 |
| 6399071 | Neoglycoproteins Polyamide conjugates comprising either (a) a xenoantigenic group; or (b) a biologically active group and a macromolecular, macro- or microscopic entity, bound to a polyamide backbone, processes for their preparation and the use of these conjugates in ther... | 06/04/2002 |
| 6372890 | Water-soluble polypeptides In this invention there are provided a polypeptide having morphogenesis-accelerating activity or cell-proliferating activity against epithelial cells, said polypeptide being defined by the 1st to 103rd amino acids from the N-terminal of human epimorphin o... | 04/16/2002 |
| 6322996 | Protein modification method Transglutaminase is allowed to act upon both a physiologically active protein (inclusive of a fused protein thereof with a peptide through acid amide bonding) and an amino group donor containing the polyethylene glycol, polysaccharide, polyamino acid or b... | 11/27/2001 |
| 6323326 | Method of solubilizing, purifying, and refolding protein A method of modifying protein solubility employs polyionic polymers. These facilitate the solubilization, formulation, purification and refolding of proteins especially incorrectly folded proteins and aggregated proteins. Compositions are described that a... | 11/27/2001 |
| 6309633 | Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same The invention provides a drug-oligomer conjugate having the following general formula: ##STR1## wherein D is a therapeutic drug moiety; H and H' are each a hydrophilic moiety, independently selected from the group consisting of straight or branched P... | 10/30/2001 |
| 6299881 | Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts A method for producing a conjugate vaccine includes mixing a uronium salt reagent with a first moiety (e.g., a polysaccharide). According to the invention, the uronium salt reagent has a chemical structure corresponding to formula I: ##STR1## wherein... | 10/09/2001 |
| 6248334 | Process for preparing conjugate vaccines including free protein and the conjugate vaccines, immunogens, and immunogenic reagents produced by this process A process for preparing a protein-polysaccharide conjugate includes reacting a protein with a polysaccharide to produce a mixture including a protein-polysaccharide conjugate and free protein. At least one unreacted reagent or low molecular weight compone... | 06/19/2001 |
| 6107272 | Modified polypeptides with altered biological activity The invention relates to novel modified polypeptides, with or without variations in noncoding regions, with altered biological activity. The invention discloses methods of preparing the modified polypeptides and methods of use.... | 08/22/2000 |
| 6042822 | Interferon polymer conjugates Compositions containing alpha interferon conjugated to a substantially non-antigenic polymer are disclosed in which at least about 30% of the conjugates include covalent attachment of the alpha interferon to the substantially non-antigenic polymer at a hi... | 03/28/2000 |
| 5972385 | Collagen-polysaccharide matrix for bone and cartilage repair A matrix and a method for preparing it are provided to support the growth of tissue, such as bone, cartilage or soft tissue. A polysaccharide is reacted with an oxidizing agent to open sugar rings on the polysaccharide to form aldehyde groups. The aldehyd... | 10/26/1999 |
| 5951974 | Interferon polymer conjugates Compositions containing alpha interferon conjugated to a substantially non-antigenic polymer are disclosed in which at least about 30% of the conjugates include covalent attachment of the alpha interferon to the substantially non-antigenic polymer at a hi... | 09/14/1999 |
| 5919758 | Modified polypeptides with altered biological activity The invention relates to novel modified polypeptides, with or without variations in noncoding regions, with altered biological activity. The invention discloses methods of preparing the modified polypeptides and methods of use.... | 07/06/1999 |
| 5919753 | Cross-linking agent A method of crosslinking a crosslinkable protein or carbohydrate substrate to form a crosslinked substrate in which the crosslinking groups are biodegradable. The crosslinking groups may comprise methylene diacrylate and the substrate can be galactose.... | 07/06/1999 |
| 5886143 | Hepatic-directed compounds and reagents for preparation thereof Hepatic-directed compounds, reagents useful in making such compounds and associated methods and compositions are discussed. Hepatic-directed compounds are processed by metabolic mechanisms, which generally differ in degree or in kind from the metabolic me... | 03/23/1999 |
| 5866165 | Collagen-polysaccharide matrix for bone and cartilage repair A matrix and a method for preparing it are provided to support the growth of bone or cartilage tissue. A polysaccharide is reacted with an oxidizing agent to open sugar rings on the polysaccharide to form aldehyde groups. The aldehyde groups are reacted t... | 02/02/1999 |
| 5849301 | Producing immunogenic constructs using soluable carbohydrates activated via organic cyanylating reagents The invention relates to a process for producing an immunogenic construct comprising activating at least one first carbohydrate-containing moiety with CDAP, CTEA or pNPC, and covalently joining the activated first moiety to a second moiety. Preferably, th... | 12/15/1998 |
| 5747446 | Modified polypeptides with increased biological activity Modified polypeptides with increased biological activity exhibited as either increased potency or prolonged circulating half-life are disclosed with methods of preparing the modified polypeptides and methods of use.... | 05/05/1998 |
| 5693326 | Producing immunogenic constructs using soluble carbohydrates activated via organic cyanylating reagents The invention relates to a process for producing an immunogenic construct comprising activating at least one first carbohydrate-containing moiety with CDAP, and covalently joining the activated first moiety to a second moiety. Preferably, the first moiety... | 12/02/1997 |
| 5683699 | Meningococcal polysaccharide conjugate vaccine Neisseria meningitidis group B polysaccharide (GBMP) modified by having sialic acid residue N-acetyl groups replaced by N-acyl groups exhibits enhanced immuno response thereto. In addition, induction of antibodies which cross-react with unmodified group B... | 11/04/1997 |
| 5677276 | Immobilization of peptides to hyaluronate The present invention provides novel conjugates of a synthetic polypeptide containing RGD or (dR)GD and a biodegradable polymer, hyaluronate. The conjugates are prepared by any one of three different methods provided by the present invention: (1) an epoxi... | 10/14/1997 |
| 5663074 | Nucleophilic polysubstituted aryl acridinium ester conjugates and syntheses thereof This invention is directed to novel nucleophilic polysubstituted aryl acridinium conjugates and the methods for preparation thereof. The novel nucleophilic polysubstituted aryl acridinium conjugates are useful in biological assays, including novel assays ... | 09/02/1997 |
| 5659015 | Oligosaccharide oxazolines, oligosaccharide conjugates and methods of preparation thereof This invention relates to a method of producing peracetyloxazolines from peracetyl saccharides. The method involves reacting the starting material, a peracetyl saccharide, with a reagent combination, to directly produce the peracetyl oxazoline. This metho... | 08/19/1997 |
| 5643564 | Glycosylated cytokines Disclosed is a sugar-modified cytokine which ensures migration of almost all of the dose of cytokine to the liver rapidly after administration to the live body and which can be advantageously used to enhance the effect of liver disease therapy and mitigat... | 07/01/1997 |
| 5631221 | Pollenosis-inducing polypeptide, process for preparing the same, and uses thereof A polypeptide having a molecular weight of 40,000&#b1;5,000 daltons and an isoelectric point of 9.5&#b1;0.5 is prepared from a cedar pollen. The polypeptide which induces pollenosis can be suitably used as desensitization agent because it induces immunogl... | 05/20/1997 |
| 5580853 | Modified polypeptides with increased biological activity Modified polypeptides with increased biological activity exhibited as either increased potency or prolonged circulating half-life are disclosed with methods of preparing the modified polypeptides and methods of use.... | 12/03/1996 |
