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| Number | Title | Issue Date |
| 8148501 | Absorbent protein meal base hydrogels Absorbent hydrogels are formed by reacting a protein meal base, a radical initiator and a polymerizable monomer. Optionally, a cross-linking agent and/or a radical accelerant, such as tetramethylethylenediamine (TMEDA) or sodium bisulfite (NaHSO3), is als... | 04/03/2012 |
| 7420035 | Purification of polypeptides This invention relates to a process for purifying a polypeptide, a capture tag useful for purifying a polypeptide and a periodate-cleavable amino acid derivative useful for purifying a polypeptide. The polypeptide to be purified comprises a vicinal-amino-thiol, vici... | 09/02/2008 |
| 7390875 | Method for binding, in solution, a peptide and a lipophilic vector and uses thereof The invention concerns a method for binding, in solution, at least a peptide composition and at least a lipophilic vector bearing an aldehyde function, the coupling comprising a step which consists in producing a hydrazone bond between the peptide compound and the l... | 06/24/2008 |
| 7335751 | Aryl carbamate oligomers for hydrolyzable prodrugs and prodrugs comprising same The present invention provides a compound having a formula: where R1 is selected from the group consisting of alkyl, —CH2(OC2H4)OCH3, and —(OC2H4)OCH | 02/26/2008 |
| 7288319 | Forming a chemically cross-linked particle of a desired shape and diameter Chemically cross-linked polymeric particles are formed using mechanical rather than chemical processes, facilitating production of small-diameter particles in a manner largely independent of the viscosity or density of the polymer. For example, an uncross-linked res... | 10/30/2007 |
| 7279181 | Method for preparation of particles from solution-in-supercritical fluid or compressed gas emulsions The present invention provides a method of producing particles from solution-in-supercritical fluid or compressed gas emulsions. In accordance with the method of the invention, a solution that includes a solute dissolved in a solvent is contacted with supercritical ... | 10/09/2007 |
| 7265213 | Methodology of conjugating chelators to biomolecules A novel method of conjugating chelators to biomolecules such as proteins is provided. More particularly, the invention provides compositions and methods of using those compositions for the detection, purification and transport of divalent metal cation binding biomol... | 09/04/2007 |
| 7220405 | Peptide-based conditioners and colorants for hair, skin, and nails Peptides have been identified that bind with high affinity to hair, skin, and nails. Peptide-based hair conditioners, hair colorants, skin conditioners, skin colorants, and nail colorants are described. The peptide-based hair conditioners and hair colorants consist ... | 05/22/2007 |
| 7202092 | Indinavir derivatives useful in immunoassay Derivatives and conjugates of indinavir for generation of antibodies and labeled conjugates for use for detection of indinavir in biological samples. The derivatives are synthesized out of the indane ring hydroxyl group or the pyridine ring nitrogen of indinavir. Al... | 04/10/2007 |
| 7193084 | Polymorphic form of itraconazole The present invention provides a polymorphic form of itraconazole. ... | 03/20/2007 |
| 7186797 | Polypeptide conjugates with extended circulating half-lives The present invention relates to compounds and methods for synthesizing compounds wherein the compounds exhibit extended circulating half-life in the blood. The increase in circulating half-life is achieved by conjugating polypeptides to binding groups that exhibit ... | 03/06/2007 |
| 7166708 | Process for preparing conjugate vaccines and the conjugate vaccines This invention relates to a process for preparing a hapten-protein-polysaccharide conjugate and a hapten-protein conjugate by reacting a protein with a hapten to produce a hapten-protein conjugate, followed by reacting the hapten-protein conjugate with a polysacchar... | 01/23/2007 |
| 7164005 | Microencapsulation and sustained release of biologically active polypeptides This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invent... | 01/16/2007 |
| 7153836 | Active hedgehog protein conjugate A hedgehog conjugate which is characterized in that it contains: a) a polypeptide composed of 10 to 30 hydrophobic amino acids and/or amino acids which form transmembrane helices and are positively charged, b) 1 to 4 aliphatic, saturated or unsaturated hydrocarbon r... | 12/26/2006 |
| 7141655 | Reagents and procedures for high-specificity labeling A molecule with two pendant phenylarsine moieties according to the general structural Formula (I) and tautomers, acids, and salts thereof: wherein: (i) R1 or R2, are each independently O | 11/28/2006 |
| 7135343 | Biomolecule resistant and their methods of use in assays The present invention relates to bio-molecule resistant surfaces for use in assays, particularly in assay devices such as arrays and microfluidic devices. The biomolecule resistant surface of the present invention are prepared by coating a substrate with hydrophilic... | 11/14/2006 |
| 7129327 | Polypeptide and protein derivatives and process for their preparation Protein and polypeptid derivatives and their salts are claimed characterized in that a protein or polypeptide is conjugated via an intermediate grouping containing at least one radical of the formula —C(R)═N— (or —N═C(R)—) or —CH(R)—NH— (or —NH... | 10/31/2006 |
| 7118737 | Polymer-modified synthetic proteins The present invention relates to methods and compositions for modifying peptides, polypeptides and proteins with polymers, especially glyco-mimetic polymers, so as to improve their biological activity or pharmacokinetic properties. The invention further provides met... | 10/10/2006 |
| 7112340 | Compositions of and method for preparing stable particles in a frozen aqueous matrix The present invention discloses a composition of a stable suspension of a poorly water soluble pharmaceutical agent or cosmetic in the form of particles of the pharmaceutical agent or cosmetic suspended in a frozen aqueous matrix and method for its preparation. The ... | 09/26/2006 |
| 7094369 | Processes for manufacturing polymeric microspheres Processes of manufacturing polymeric microspheres facilitate the generation of polymeric microspheres of size ranges smaller than 600 microns diameter by forming beads of a predetermined size from a starting material which may include a template polymer, and subsequ... | 08/22/2006 |
| 7091325 | Fibrin/fibrinogen-binding conjugate A fibrin/fibrinogen binding conjugate for forming a depot for the sustained release of a pharmaceutically active substance from a fibrin clot. The conjugate comprises a fibrin/fibrinogen binding moiety bound to a pharmaceutically active substance either directly or ... | 08/15/2006 |
| 7067279 | Cell culture performance with betaine This invention relates generally to the field of cell culture. More particularly, the invention relates to improving viability of recombinant cell cultures and the yields of secreted polypeptides therefrom by the addition of betaine to the tissue culture medium.... | 06/27/2006 |
| 7060298 | Implantable particles for the treatment of gastroesophageal reflux disease The invention encompasses the treatment of urinary incontinence, gastroesophageal reflux disease and the amelioration of skin wrinkles using biocompatible hydrophilic cationic microparticles and a cell adhesion promoter. ... | 06/13/2006 |
| 7057016 | Process for the production of biologically active protein The present invention relates to a folding process for the preparation of biologically active, dimeric, TGF-β (Transforming Growth Factor type β)-like protein in a detergent-free folding buffer. ... | 06/06/2006 |
| 7052915 | Selective labeling and isolation of phosphopeptides and applications to proteome analysis A method for selective labeling of phosphate groups in natural and synthetic oligomers and polymers in the presence of chemically related groups such as carboxylic acid groups. The method is specifically applicable to biological oligomers and polymers, including pho... | 05/30/2006 |
| 7045365 | Supported aldehydic silanes and method of manufacture A method for producing a derivatized aldehydic support matrix material includes activating surface hydroxyl groups on the support matrix material and reacting the activated hydroxyl groups with an aldehydic alkoxy silane. The derivatized aldehydic support matrix mat... | 05/16/2006 |
| 7037528 | Microprecipitation method for preparing submicron suspensions The present invention provides a method for preparing submicron sized particles of an organic compound, the solubility of which is greater in a water-miscible first solvent than in a second solvent which is aqueous, the process including the steps of: (i) dissolving... | 05/02/2006 |
| 7034127 | Hydrophilic biopolymer-drug conjugates, their preparation and use Disclosed are methods of conjugating biologically active substances, particularly, alpha-interferon, with a hyaluronan or a mixture of a hyaluronan with at least one other hydrophilic polymer having a functional group capable of reacting with divinyl sulfone. Also d... | 04/25/2006 |
| 7030084 | Drug-oligomer conjugates with polyethylene glycol components The present invention relates generally to hydrolyzable drug-oligomer conjugates, pharmaceutical compositions comprising such conjugates, and to methods for making and using such conjugates and pharmaceutical compositions. For example, a conjugate of insulin, PEG, a... | 04/18/2006 |
| 7022673 | Method for increasing the serum half-life of a biologically active molecule A method is provided for preparing a biologically active molecule having an increased serum half-life. The method involves conjugating a polymer such as polyethylene glycol to the biologically active molecule. Also provided are polypeptide drugs having an increased ... | 04/04/2006 |
| 7001987 | Hydrogel with controllable mechanical, chemical, and biological properties and method for making same Networks, hydrogels, and methods for networks and hydrogels comprising proteinaceous material consisting essentially of water soluble proteins and covalent interprotein crosslinks other than disulfide crosslinks. ... | 02/21/2006 |
| 7001991 | Targeted delivery of bioaffecting compounds for the treatment of cancer A homogeneous conjugate for targeting and treating diseased cells wherein the conjugate comprises an anti-cancer drug and a targeting protein, wherein said anti-cancer drug is selected from the group consisting of heat sensitizers, photosensitizers and apoptosis ind... | 02/21/2006 |
| 6989436 | Stabilization of cardiac troponin I subunits and complexes The present invention provides methods for preparing, and compositions comprising, stabilized protein-polymer conjugates. More particularly, the present invention relates to the stabilization of individual and complexed subunits of multisubunit protein complexes by ... | 01/24/2006 |
| 6989437 | Methods for producing, films comprising, and methods for using heterogeneous crosslinked protein networks Methods for producing biocompatible heterogeneous proteinaceous networks crosslinked with a heterogeneous crosslinking agent, and novel heterogeneous crosslinked networks. Preferred heterogeneous crosslinking agents are silicone-based. ... | 01/24/2006 |
| 6977085 | Method for preparing submicron suspensions with polymorph control The present invention provides a method for preparing a suspension of a pharmaceutically-active compound, the solubility of which is greater in a water-miscible first organic solvent than in a second solvent which is aqueous. The process includes the steps of: (i) d... | 12/20/2005 |
| 6960345 | Oral vaccinia formulation This invention relates to methods and systems for generating a safe and effective oral smallpox vaccine for humans using a genetically defective strain of vaccinia virus to confer immunity following oral delivery of the vaccine. This invention is one that expands on... | 11/01/2005 |
| 6958148 | Linkage of agents to body tissue using microparticles and transglutaminase Methods, products and kits are provided for attaching agents to a body tissue surface via microparticles using endogenous or exogenous transglutaminase. The microparticles have surface available transglutaminase substrate reactive groups. In an embodiment, the group... | 10/25/2005 |
| 6916909 | Collagen peptides modified by grafting mercapto functions, method for the production thereof and uses thereof as biomaterials The invention relates to novel collagen peptides that are modified by grafting free or substitued thiol functions carried by mercaptoamine radicals. The aim of the invention is to provide thiol collagens that can be cross-linked in a sufficient and controlled manner... | 07/12/2005 |
| 6914126 | Methods for producing, films comprising, and methods for using heterogenous crosslinked protein networks Methods for producing biocompatible heterogeneous proteinaceous networks crosslinked with a heterogeneous crosslinking agent, and the novel crosslinked networks. ... | 07/05/2005 |
| 6884780 | Method for increasing the serum half-life of a biologically active molecule A method is provided for preparing a biologically active molecule having an increased serum half-life. The method involves conjugating a polymer such as polyethylene glycol to the biologically active molecule. Also provided are polypeptide drugs having an increased ... | 04/26/2005 |
