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Felix Hoffmann, a German chemist, was searching for something to relieve his father's arthritis. In doing so, he "rediscovered" acetylsalicylic acid and in 1900, patented a stable process for developing it. Hence, we have aspirin.
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| Number | Title | Issue Date |
| 8058409 | Method of serum pre-treatment for glycomic analysis A means for pre-treatment in glycomic analysis of a glycoprotein is provided by the present invention. A salt of the general formula (I): wherein Z, X, R1, R2, M, m and n are the same as describ... | 11/15/2011 |
| 7423131 | Busulfan immunoassay Novel conjugates of busulfan and novel busulfan immunogens derived from α-substituted derivatives of busulfan and antibodies generated by these busulfan linked immunogens are useful in immunoassays for the quantification and monitoring of busulfan in biological flu... | 09/09/2008 |
| 7420035 | Purification of polypeptides This invention relates to a process for purifying a polypeptide, a capture tag useful for purifying a polypeptide and a periodate-cleavable amino acid derivative useful for purifying a polypeptide. The polypeptide to be purified comprises a vicinal-amino-thiol, vici... | 09/02/2008 |
| 7417021 | Biologically active conjugate of a biopolymer and therapeutic agent A biologically active conjugate is disclosed comprising a biopolymer and a therapeutic agent joined by a disulfide bond. The conjugate, when formulated in a pharmaceutical composition with a suitable carrier, has improved in vivo stability and activity, and can be t... | 08/26/2008 |
| 7393828 | Modified MscL protein channel The invention relates to the field of drug delivery, in particular, to compounds and methods for the chemical modification of a proteinaceous channel to be used in pharmaceutical delivery vehicles for controlled and/or localized release of therapeutic molecules (e.g... | 07/01/2008 |
| 7381572 | Reagents and procedures for multi-label high-specificity labeling A detectable complex and methods for use thereof are provided herein. The detectable complex includes: at least one target material; a first peptide tag bound to the at least one target material; and a second peptide tag bound to the at least one target material. Th... | 06/03/2008 |
| 7351807 | Cyanine-sulfenates for dual phototherapy Dye-sulfenate derivatives and their bioconjugates for dual phototherapy of tumors and other lesions. The compounds comprise sulfenates having the formula, t,0080 where E is selected from the group consisting of somatostatin receptor binding molecules, heat se... | 04/01/2008 |
| 7306931 | Method for refolding proteins containing free cysteine residues The present invention relates to novel methods for making and refolding insoluble or aggregated proteins having free cysteines in which a host cell expressing the protein is exposed to a cysteine blocking agent. The soluble, refolded proteins produced by the novel m... | 12/11/2007 |
| 7282373 | Ultra-high specificity fluorescent labeling A self-assembled relay probe for detecting a target material is provided including: a first peptide tag bound to the target material; and a first fluorescent conjugate including a first fluorochrome and a first tag binding group; wherein the first fluorescent conjug... | 10/16/2007 |
| 7282481 | Heparin-binding proteins modified with sugar chains, method of producing the same and pharmaceutical compositions containing same A heparin-binding protein functionalized by covalently bonding thereto a sugar chain, a method for producing the protein and a pharmaceutical composition containing the protein as an active ingredient, as well as a method of functionalizing a natural protein having ... | 10/16/2007 |
| 7265213 | Methodology of conjugating chelators to biomolecules A novel method of conjugating chelators to biomolecules such as proteins is provided. More particularly, the invention provides compositions and methods of using those compositions for the detection, purification and transport of divalent metal cation binding biomol... | 09/04/2007 |
| 7220405 | Peptide-based conditioners and colorants for hair, skin, and nails Peptides have been identified that bind with high affinity to hair, skin, and nails. Peptide-based hair conditioners, hair colorants, skin conditioners, skin colorants, and nail colorants are described. The peptide-based hair conditioners and hair colorants consist ... | 05/22/2007 |
| 7193042 | Methods for purifying authentic IGF from yeast hosts Methods for purifying authentic, properly folded IGF polypeptides from yeast transformants are disclosed. The methods include a refolding step and provide for high yields of authentic IGF from a variety of yeast strains. ... | 03/20/2007 |
| 7189694 | Inhibitors of autophosphorylation protein kinases The subject invention concerns peptide molecules that specifically inhibit the enzymatic function of tyrosine kinases, including the JAK and EGF receptor (EGFR) family of kinases, to autophosphorylate, i.e., to transfer a phosphate group from ATP to an amino acid in... | 03/13/2007 |
| 7172905 | Polypeptide immobilization A substrate comprises a surface, and a plurality of moieties, on at least a portion of the surface. The moieties are moieties of formula: Surf-L—Q—T, where —T comprises a reactant ligand, and Surf- designates where the moiety attaches to th... | 02/06/2007 |
| 7166708 | Process for preparing conjugate vaccines and the conjugate vaccines This invention relates to a process for preparing a hapten-protein-polysaccharide conjugate and a hapten-protein conjugate by reacting a protein with a hapten to produce a hapten-protein conjugate, followed by reacting the hapten-protein conjugate with a polysacchar... | 01/23/2007 |
| 7153836 | Active hedgehog protein conjugate A hedgehog conjugate which is characterized in that it contains: a) a polypeptide composed of 10 to 30 hydrophobic amino acids and/or amino acids which form transmembrane helices and are positively charged, b) 1 to 4 aliphatic, saturated or unsaturated hydrocarbon r... | 12/26/2006 |
| 7144743 | Preparation and use of mixed mode solid substrates for chromatography adsorbents and biochip arrays For certain mixed mode resins having anionic character, a ligand is joined to a solid support via a linkage that includes a mercapto-, ether- or amino-containing moiety. A suitable ligand comprises an aromatic group, a heteroaromatic group, or a heterocyclic group, ... | 12/05/2006 |
| 7141655 | Reagents and procedures for high-specificity labeling A molecule with two pendant phenylarsine moieties according to the general structural Formula (I) and tautomers, acids, and salts thereof: wherein: (i) R1 or R2, are each independently O | 11/28/2006 |
| 7138103 | Use of bi-specific antibodies for pre-targeting diagnosis and therapy The present invention relates to targetable constructs which may be bound by a bi-specific antibody or antibody fragment having at least one arm that specifically binds construct. The targetable construct comprises a carrier portion which comprises or bears at least... | 11/21/2006 |
| 7135343 | Biomolecule resistant and their methods of use in assays The present invention relates to bio-molecule resistant surfaces for use in assays, particularly in assay devices such as arrays and microfluidic devices. The biomolecule resistant surface of the present invention are prepared by coating a substrate with hydrophilic... | 11/14/2006 |
| 7091325 | Fibrin/fibrinogen-binding conjugate A fibrin/fibrinogen binding conjugate for forming a depot for the sustained release of a pharmaceutically active substance from a fibrin clot. The conjugate comprises a fibrin/fibrinogen binding moiety bound to a pharmaceutically active substance either directly or ... | 08/15/2006 |
| 7078496 | Thioester-terminated water soluble polymers and method of modifying the N-terminus of a polypeptide therewith The invention provides reagents and methods for conjugating a polymer specifically to the α-amine of a polypeptide. The invention provides monofunctional, bifunctional, and multifunctional PEGs and related polymers having a terminal thioester moiety capable of spec... | 07/18/2006 |
| 7071313 | Methods of purifying authentic IGF from yeast hosts Methods for purifying authentic, properly folded IGF polypeptides from yeast transformants are disclosed. The methods include a refolding step and provide for high yields of authentic IGF from a variety of yeast strains. ... | 07/04/2006 |
| 7067485 | IGF-I composition and its use A highly concentrated, low salt-containing, biologically active syrup form of IGF-I or variant thereof and methods for its preparation are provided. This novel syrup form of IGF-I has an IGF-I concentration of at least about 250 mg/ml, a density of about 1.0 g/ml to... | 06/27/2006 |
| 7064192 | High pressure refolding of protein aggregates and inclusion bodies The present disclosure provides an effective method for the refolding of denatured proteins in solution so that properly folded, biologically active protein in solution is recovered in high yield. The refolding takes place at pressures between about 0.25 kbar to abo... | 06/20/2006 |
| 7057016 | Process for the production of biologically active protein The present invention relates to a folding process for the preparation of biologically active, dimeric, TGF-β (Transforming Growth Factor type β)-like protein in a detergent-free folding buffer. ... | 06/06/2006 |
| 7052915 | Selective labeling and isolation of phosphopeptides and applications to proteome analysis A method for selective labeling of phosphate groups in natural and synthetic oligomers and polymers in the presence of chemically related groups such as carboxylic acid groups. The method is specifically applicable to biological oligomers and polymers, including pho... | 05/30/2006 |
| 7001738 | Method for assaying protein nitrosylation Many of the effects of nitric oxide are mediated by the direct modification of cysteine residues resulting in an adduct called a nitrosothiol. A method to detect proteins which contain nitrosothiols involves several steps. Nitrosylated cysteines are converted to tag... | 02/21/2006 |
| 6964769 | Molecular antigen array The invention provides compositions and processes for the production of ordered and repetitive antigen or antigenic determinant arrays. The compositions of the invention are useful for the production of vaccines for the prevention of infectious diseases, the treatme... | 11/15/2005 |
| 6953838 | Urocortin-III and uses thereof A search of the public human genome database identified a human EST, GenBank accession number AW293249, which has high homology to known pufferfish urocortin sequences. The full length sequence was amplified from human genomic DNA and sequenced. Sequence homology co... | 10/11/2005 |
| 6916909 | Collagen peptides modified by grafting mercapto functions, method for the production thereof and uses thereof as biomaterials The invention relates to novel collagen peptides that are modified by grafting free or substitued thiol functions carried by mercaptoamine radicals. The aim of the invention is to provide thiol collagens that can be cross-linked in a sufficient and controlled manner... | 07/12/2005 |
| 6916914 | Purification of somatotropin from transformed microorganisms This invention discloses a commercially advantageous process for extraction and purification of protein from microorganisms. The initial steps of the process are useful for purifying many insoluble proteins while later steps are designed to renature denatured somato... | 07/12/2005 |
| 6844175 | Methods of inhibition using glycosyl sulfotransferase-3 A novel human glycosylsulfotransferase expressed in high endothelial cells (GST-3) and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid find use in a variety of applications... | 01/18/2005 |
| 6833276 | Polymer brushes for immobilizing molecules to a surface and having water-soluble or water-dispersible segments therein and probes bonded thereto Sensors for determining the presence and concentration of bio-molecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface that is modified with a water-dispersible or water-soluble polymer segment having ... | 12/21/2004 |
| 6824997 | Process and materials for the rapid detection of streptococcus pneumoniae employing purified antigen-specific antibodies A process is disclosed for obtaining a C-polysaccharide cell wall antigen containing not more than about 10% protein from Streptococcus pneumoniae bacteria. The antigen thus obtained is conjugated to a spacer molecule, and the free end of the latter is then c... | 11/30/2004 |
| 6821948 | Conjugate for mediating cell, compartment or membrane-specific transport of active substances The present invention relates to conjugates for mediating a cell-specific, compartment-specific or membrane-specific to methods of active substances. The invention also relates to methods of preparing these conjugates as well as their use. The conjugates comprise: | 11/23/2004 |
| 6818454 | Phosphoprotein binding agents and methods of their use The invention provides reagents and methods for characterizing (i.e., identification and/or quantitation) the phosphorylation states of proteins. Proteins may be post-transcriptionally modified such that they contain phosphate groups at either some or all of their s... | 11/16/2004 |
| 6818623 | Active hedgehog protein conjugate A hedgehog conjugate which is characterized in that it contains: a) a polypeptide composed of 10 to 30 hydrophobic amino acids and/or amino acids which form transmembrane helices and are positively charged, b) 1 to 4 aliphatic, saturated or unsaturated hydrocarbon r... | 11/16/2004 |
| 6815162 | Passivation of porous semiconductors A method is disclosed for stabilizing porous silicon. A porous silicon structure having a surface terminated with hydrogen atoms is subjected to organic thermal processing to substitute the hydrogen atoms with a protective organic layer. The resulting structure are ... | 11/09/2004 |
