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| Number | Title | Issue Date |
| 7361516 | Field of modular multifunctional ligands This invention pertains to a surface ligand; preparation of the ligand; colloidal nanoparticle, such as quantum dot bearing one or more of the ligand; and a bioconjugate characterized by a nanoparticle bearing one or more of the ligand conjugated to a biomolecule. T... | 04/22/2008 |
| 7347617 | Mixing in microfluidic devices Mixing of liquids in a microfluidic device is accomplished by dispensing the liquids into a first chamber to produce combined liquid. The liquids are thereafter discharged through at least one capillary from the first chamber into a second chamber for complete mixin... | 03/25/2008 |
| 7326776 | Preparation and use of mixed mode solid substrates for chromatography adsorbents and biochip arrays For certain mixed mode resins having anionic character, a ligand is joined to a solid support via a linkage that includes a mercapto-, ether- or amino-containing moiety. A suitable ligand comprises an aromatic group, a heteroaromatic group, or a heterocyclic group, ... | 02/05/2008 |
| 7320867 | Linker compound, ligand, and producing method thereof A linker compound has a structure represented by general formula (1) below, where n is an integer of 1 to 6, and X has a structure serving as a multi-branched structure moiety including three or four hydrocarbon derivative chains each having an aromatic amino group ... | 01/22/2008 |
| 7282481 | Heparin-binding proteins modified with sugar chains, method of producing the same and pharmaceutical compositions containing same A heparin-binding protein functionalized by covalently bonding thereto a sugar chain, a method for producing the protein and a pharmaceutical composition containing the protein as an active ingredient, as well as a method of functionalizing a natural protein having ... | 10/16/2007 |
| 7279165 | Amyloid β1-6 antigen arrays The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an Aβ1-6 peptide-VLP-composit... | 10/09/2007 |
| 7279562 | Rapamycin conjugates Provided are rapamycin conjugates which are useful as immunogenic molecules for the generation of antibodies specific for rapamycin, for measuring levels of rapamycin or derivatives thereof; for isolating rapamycin binding proteins; and detecting antibodies specific... | 10/09/2007 |
| 7229782 | Antibodies specific to multiple beta blockers and methods for their use The present invention is directed antibodies specific to multiple beta blockers, as well as immunogens used to produce the antibodies and immunoassay kits and methods for using the antibodies. ... | 06/12/2007 |
| 7223406 | Methods and compositions for preventing and treating male erectile dysfunction and female sexual arousal disorder The invention provides a method for preventing or treating male erectile dysfunction or female sexual arousal disorder by administering an effective amount of one or more factors from a group of factors including vascular endothelial growth factor, brain-derived neu... | 05/29/2007 |
| 7208148 | Chemically modified cytokines The invention concerns a derivative of viral regulatory protein or a fragment of viral regulatory protein or of the alpha interferon or a fragment of alpha interferon, which is carboxymethylated, a method for preparing, use of the resulting product in a method of tr... | 04/24/2007 |
| 7205161 | Polymer brushes for immobilizing molecules to a surface or substrate having improved stability Sensors for determining the presence and concentration of biomolecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface modified with a hydrophobic polymer segment, attached to which is a water-dispersib... | 04/17/2007 |
| 7195882 | Monoclonal antibodies specific for buprenorphine and metabolites thereof The present invention relates to monoclonal antibodies that specifically bind buprenorphine and/or at least one metabolic product thereof. The present invention further relates to buprenorphine metabolite conjugates for the production of monoclonal antibodies that s... | 03/27/2007 |
| 7169392 | serogroup B glycoconjugates and methods of producing the same The present invention pertains generally to novel Neisseria meningitidis serogroup B glycoconjugates. More particularly, the invention pertains to glycoconjugates formed from a Neisseria meningitidis serogroup B capsular oligosaccharide derivative (Men... | 01/30/2007 |
| 7166708 | Process for preparing conjugate vaccines and the conjugate vaccines This invention relates to a process for preparing a hapten-protein-polysaccharide conjugate and a hapten-protein conjugate by reacting a protein with a hapten to produce a hapten-protein conjugate, followed by reacting the hapten-protein conjugate with a polysacchar... | 01/23/2007 |
| 7161031 | Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders Compounds useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula I: wherein: Ar, X, X1, g, R and R3 are as defined herein. ... | 01/09/2007 |
| 7157561 | Methods of inhibiting transmission of a costimulatory signal of lymphocytes Activated haptens useful for generating immunogens to the HIV protease inhibitor atazanavir, immunogens useful for producing antibodies to atazanavir, and antibodies and labeled conjugates useful in immunoassays for determination of atazanavir. The haptens feature a... | 01/02/2007 |
| 7148029 | Immunoassay for neonicotinyl insecticides The present invention provides immunogens for generating anti-neonicotinoid antibodies as well as antibodies, methods, reagents and kits for determining the presence of one or more neonicotinoid insecticides in a sample by immunoassay. The present invention has part... | 12/12/2006 |
| 7132397 | Bone morphogenetic protein antagonist based on the mature protein The purpose is to provide a mature protein having an antagonistic activity against bone morphogenetic proteins. The mature protein having an antagonistic activity against bone morphogenetic proteins is obtained by converting at least one residue among methionine res... | 11/07/2006 |
| 7128911 | Antigen arrays for treatment of bone disease The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular a RANKL protein, RANKL fragmen... | 10/31/2006 |
| 7125711 | Method and apparatus for splitting of specimens into multiple channels of a microfluidic device A microliter liquid sample, particularly a biological sample, is analyzed in a device employing centrifugal and capillary forces. The sample is moved by capillary forces into one or more metering wells which define the amount of the sample to be analyzed in subseque... | 10/24/2006 |
| 7115383 | Assays for amphetamine and methamphetamine Methods, compositions and kits are disclosed. The compounds disclosed comprise an amphetamine moiety and a methamphetamine moiety linked together by a first linking group. A second linking group depends from the first linking group and comprises a functional group. ... | 10/03/2006 |
| 7115266 | Angiotensin peptide-carrier conjugates and uses thereof The present invention provides conjugates of peptide derivatives of the mammalian peptide hormones angiotensinogen, angiotensin I and angiotensin II, presented in a repetitive scaffold by coupling the peptide derivatives to a carrier, particularly a virus-like parti... | 10/03/2006 |
| 7101980 | Derivatives, conjugates, and antibodies for detecting ecstasy-class analytes Compounds including haptens, intermediates, and immunogens that are useful in the production of antibodies specific for the methylenedioxy class of amphetamine derivatives are described. Antibodies specific for the methylenedioxy class of amphetamine derivatives, re... | 09/05/2006 |
| 7094354 | Method and apparatus for separation of particles in a microfluidic device A microfluidic device provides separation of particles in a liquid sample, particularly, separation of a sample of whole blood into its components for further analysis. Separation into red blood cells and plasma occurs within a few seconds after the blood sample has... | 08/22/2006 |
| 7078496 | Thioester-terminated water soluble polymers and method of modifying the N-terminus of a polypeptide therewith The invention provides reagents and methods for conjugating a polymer specifically to the α-amine of a polypeptide. The invention provides monofunctional, bifunctional, and multifunctional PEGs and related polymers having a terminal thioester moiety capable of spec... | 07/18/2006 |
| 7060708 | Active agent delivery systems and methods for protecting and administering active agents The present invention relates to active agent delivery systems and more specifically to compositions that comprise amino acids, as single amino acids or peptides, covalently attached to active agents and methods for administering conjugated active agent compositions... | 06/13/2006 |
| 7048930 | Expression of core-glycosylated HCV envelope proteins in yeast The present invention relates to the general field of recombinant protein expression, purification of recombinant proteins, diagnosis of HCV infection, prophylactic treatment against HCV infection and to the prognosing/monitoring of the clinical efficiency of treatm... | 05/23/2006 |
| 7037669 | Assays for amphetamine and methamphetamine using stereospecific reagents Methods, compositions and kits are disclosed. Enzyme conjugates of Formula I may be employed in assays for the determination of an amphetamine and/or a methamphetamine. Immunogenic conjugates of Formula I may be employed to prepare antibodies for an amphetamine and/... | 05/02/2006 |
| 7026134 | Haptens, immunogens and antibodies to oxycodone and its metabolites Novel haptens, which can be conjugated to form immunogens, are of formula I, II or III wherein R is a divalent alkyl, cycloalkyl or aryl group having 1 to 10 carbon atoms, and X is a functional group. ... | 04/11/2006 |
| 7022492 | Ecstasy haptens and immunogens Methods, compositions and kits are disclosed. Enzyme conjugates of Formula I are employed in assays for the determination of an methylenedioxyamphetamine, a methylene-dioxyethamphetamine, and/or a methylenedioxymethamphetamine. Immunogenic conjugates of Formula I ar... | 04/04/2006 |
| 7018637 | Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines Multivalent immunogenic molecules comprise a carrier molecule containing at least one functional T-cell epitope and multiple different carbohydrate fragments each linker to the carrier molecule and each containing at least one functional B-cell epitope. The carrier ... | 03/28/2006 |
| 7011968 | Fragments of virus protein 2 or 3 of the polyoma virus, used for transporting active ingredients The invention relates to a synthetic, biologically active molecule for fixing an active ingredient to the virus protein 1 (VP1) of the polyoma virus. According to the invention, an amino acid sequence A1 which is derived from the C-terminal end of virus protein 2 (V... | 03/14/2006 |
| 7005415 | Heparin-binding proteins modified with sugar chains, method of producing the same and pharmaceutical compositions containing the same A heparin-binding protein functionalized by covalently bonding thereto a sugar chain, a method for producing the protein and a pharmaceutical composition containing the protein as an active ingredient, as well as a method for functionalizing a natural protein having... | 02/28/2006 |
| 6964769 | Molecular antigen array The invention provides compositions and processes for the production of ordered and repetitive antigen or antigenic determinant arrays. The compositions of the invention are useful for the production of vaccines for the prevention of infectious diseases, the treatme... | 11/15/2005 |
| 6960653 | Method and kit for detecting, or determining the quantity of, beta-lactam penicillins The invention provides a hapten comprising a 6-[D-α-aminoacetamido] penicillin derivative crosslinked at the α-amino group with a substituted or unsubstituted phenyldicarbaldehyde. In addition, the invention provides an immunogen comprising the aforementioned hapt... | 11/01/2005 |
| 6932971 | Hapten-carrier conjugates and uses thereof The present invention provides compositions comprising a conjugate of a hapten with a carrier in an ordered and repetitive array, and methods of making such compositions. The conjugates and compositions of the invention may comprise a variety of haptens, including h... | 08/23/2005 |
| 6913936 | Immunological test kit comprising an immunologically invisible peg copolymer conjugated to one or more immunologically reactive substances A novel compound comprising an immunologically invisible polyethylene glycol copolymer is used to carry one or more immunologically reactive substances. The novel compounds may be used as part of kits for immunological assays. ... | 07/05/2005 |
| 6858211 | Vaccines against Escherichia coli O157 infection This invention relates to conjugates of the O-specific polysaccharide of E. coli O157 with a carrier, and compositions thereof, and to methods of using of these conjugates and/or compositions thereof for eliciting an immunogenic response in mammals, including... | 02/22/2005 |
| 6814971 | Adjuvants for use in vaccines The invention relates to adjuvants that contain a lecithin, an oil and an amphiphilic surfactant and that are capable of forming a stable oil-in-water emulsion vaccine so as to minimize local reactions to the vaccine in the injected animal. ... | 11/09/2004 |
| 6794496 | Immunoassay for LSD and 2-oxo-3-hydroxy-LSD The present invention provides hapten derivatives useful for the preparation of antigens, antibodies and reagents for use in immunoassays for the detection of LSD and 2-oxo-3-hydroxy LSD. In the present invention, the 2-oxy LSD nucleus is derivatized out of the indo... | 09/21/2004 |
