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| Number | Title | Issue Date |
| 8168763 | Ferritin 2 for the host immunization against ticks Ferritin 2 is a tick secreted protein, which serves in the tick plasma as a non-heme iron transporter from the gut to the peripheral tissues. It can be exploited as an antigen for raising up host antibodies, which can reversely block this antigen in the tick and the... | 05/01/2012 |
| 8058408 | Transcription factor having zinc finger domains Using an undifferentiated mouse CL6 cell line, DMSO was added to induce its differentiation into cardiac muscular cells in order to obtain gene fragments whose expression elevated upon the induction. The isolated gene had zinc finger domains and showed a significant... | 11/15/2011 |
| 7919596 | Method of arranging ferritin and method of arranging inorganic particles To provide a method of arranging ferritin by which a high rate of the number of the molecular film spots on which sole ferritin molecule was arranged in effect, with respect to total number of the molecular film spots provided for arranging ferritin (sole arrangemen... | 04/05/2011 |
| RE42211 | Relating to binding proteins for recognition of DNA Disclosed are libraries of DNA sequences encoding zinc finger binding motifs for display on a particle, together with methods of designing zinc finger binding polypeptides for binding to a particular target sequence and, inter alia, use of designed zinc finger polyp... | 03/08/2011 |
| 7834160 | Process for producing zinc oxide-protein complex An object of the present invention is to obtain a zinc oxide-protein complex which can be a source of nanoparticles of zinc oxide utilizing a protein having a cavity inside thereof. The process for producing a zinc oxide-protein complex according to the present inve... | 11/16/2010 |
| 7439334 | Method of arrangement of titanium-binding ferritin and inorganic particles A method for selectively arranging ferritin modified with a peptide, which specifically binds to titanium, to titanium formed on a substrate surface is provided. The method for arranging ferritin of the present invention is characterized in that ferritin is s... | 10/21/2008 |
| 7393935 | Method of selective arrangement of ferritin A method for selectively arranging ferritin in a specified inorganic material part formed on a substrate is provided. The method for arranging ferritin of the present invention is characterized in that ferritin is selectively arranged on a part including titanium or... | 07/01/2008 |
| 7371579 | Nickel-based reagents for detecting DNA and DNA-protein contacts The invention relates to a compound comprising a labeled nickel complex (FIG. 1) that is used to detect and purify nucleic acid sequences by forming an adduct between a specific nucleic acid base and the labeled nickel complex. The adduct can also be purified... | 05/13/2008 |
| 7368570 | Organometallic complexes as singlet oxygen sensitizers A series of organometallic complexes and the singlet oxygen sensitization properties of these complexes are provided. Complexes with acetylacetonate ligands give singlet oxygen quantum yields near unity, whether exciting the ligand-based state or the lowest energy e... | 05/06/2008 |
| 7358342 | Preparation derived from shark cartilage for treatment of diseased related to excessive PHF or excessive intracellular calcium A preparation derived from shark cartilage for the treatment of diseases related to excessive PHF or Excessive intracellular calcium. ... | 04/15/2008 |
| 7326775 | Treatments for contaminant reduction in lactoferrin preparations and lactoferrin-containing compositions A method of preparing an ultra-cleansed lactoferrin preparation, termed treatment for contaminant reduction (TCR) is provided which includes the steps of treating commercial lactoferrin preparation with at least one each of surfactants, antioxidants and polyphenols ... | 02/05/2008 |
| 7323443 | Lactoferrin in the reduction of pain The present invention relates to methods of using lactoferrin (LF) to reduce pain in conditions associated with severe or intractable pain by administering a composition of lactoferrin either alone or in combination with other therapy for pain. ... | 01/29/2008 |
| 7318957 | Organic material-coated semiconductor nanoparticle with excellent durability, and method of manufacturing the same The resistance of a semiconductor nanoparticle provided with a surface treatment, such as an OH coating or ammonia treatment, against external factors is improved. A semiconductor nanoparticle provided with a surface treatment such as an OH coating or ammonia treatm... | 01/15/2008 |
| 7314857 | Synergistic antimicrobial compositions and methods of inhibiting biofilm formation A synergistic antimicrobial composition for inhibiting biofilm formation includes an iron-sequestering glycoprotein, a cationic polypeptide and a chelating agent, or an iron-sequestering glycoprotein and a chelating agent, or an iron-sequestering glycoprotein and a ... | 01/01/2008 |
| 7262279 | Lactoferrin in the treatment of diabetes mellitus The present invention relates to methods of using a composition of lactoferrin for the treatment of diabetes mellitus as manifested by a reduction in the levels of serum glucose, blood pressure, obesity, or glycosylated hemoglobin (HbA1c). ... | 08/28/2007 |
| 7259249 | Method for preparing conjugates of proteins and chelating agents Improved synthesis methods are provided for preparing conjugates of proteins and chelating agents. In the synthesis methods, non-stable bonds are hydrolyzed after the conjugate is synthesized, for example by treating the conjugate with a quenching agent. The synthes... | 08/21/2007 |
| 7241449 | Transferrin receptor genes of Purified and isolated nucleic acid molecules are provided which encode Tbp2 proteins of M. catarrhalis strains M35, 3 and LES1. The nucleic acid sequence may be used to produce recombinant Tbp2 proteins of the strain of Moraxella free of other proteins... | 07/10/2007 |
| 7238791 | 6-monoacetylmorphine derivatives useful in immunoassay Analogs of 6-monoacetyl morphine (6-MAM) are described. These include analogs derivatized at either the C-3 position, the C-6 position, or the nor position of the molecule. These analogs allow for elaboration with linkers terminated by a functional group such as an ... | 07/03/2007 |
| 7223847 | Method for producing cobalt-protein complex A method for obtaining a cobalt-apoferritin complex according to the present invention includes: the step a) of preparing a solution including a Co2+ ion, a protein, a pH buffer agent and a Co2+ associating agent; and the step b) of adding an o... | 05/29/2007 |
| 7220719 | Modulation of endogenous gene expression in cells Disclosed herein are methods and compositions for modulating expression of endogenous cellular genes using recombinant zinc finger proteins. ... | 05/22/2007 |
| 7176278 | Modified transferrin fusion proteins The present invention discloses fusion proteins comprising transferrin, lactoferrin or melanotransferrin fused to glucagon-like peptide 1 (GLP-1). In one embodiment of the invention, the fusion protein displays increased serum half-life as compared to a GLP-1 peptid... | 02/13/2007 |
| 7164010 | Molecular magnetic protein A highly magnetically aligned metallothionein (MT) containing manganese (Mn) and cadmium (Cd) has been synthesized. The metallotionein has a formula of Mnx Cd7−x MT with x being in the range of 1 to 6. Its size and biological functions are si... | 01/16/2007 |
| 7160855 | Enhancement of iron chelation therapy The present invention provides methods of enhancing the rate of iron release from ferritin. By increasing the amount of iron available for chelation, the invention also provides methods of treating conditions associated with iron overload. The invention also provide... | 01/09/2007 |
| 7144992 | Synergistic antimicrobial compositions and methods for reducing biofilm formation The present invention provides novel compositions comprising: (a) a thiol-specific reagent and a cationic polypeptide or (b) a thiol-specific reagent and an iron-sequestering glyocoprotein; and uses thereof for the preparation of devices, and in particular medical d... | 12/05/2006 |
| 7129329 | Heme proteins hemAT-Hs and hemAT-Bs and their use in medicine and microsensors The present invention provides an isolated archael and bacterial heme binding protein which reversibly binds oxygen with a low affinity. The heme binding protein may be utilized as a blood substitute. The invention also provides a method for controlled storage of ox... | 10/31/2006 |
| 7125963 | Treatments for contaminant reduction in lactoferrin preparations and lactoferrin containing compositions A method of preparing an ultra-cleansed lactoferrin preparation, termed treatment for contaminant reduction (TCR) is provided which includes the steps of treating commercial lactoferrin preparation with at least one each of surfactants, antioxidants and polyphenols ... | 10/24/2006 |
| 7119065 | Metal complex-protein composite and oxidation catalyst We claim a metal complex-protein composite comprising a salen metal complex and an apoprotein having a cavity, wherein the salen metal complex has a structure given by the following formula: R1 and R | 10/10/2006 |
| 7105323 | Recombinant cage-like protein, method for producing the same, precious metal-recombinant cage-like protein complex, method for producing the same and recombinant DNA The present invention relates to a precious metal-recombinant apoferritin complex produced by recombination technique, wherein the precious metal is gold (Au) or platinum (Pt), and wherein the residues of glutamic acid and aspartic acid in a channel of apoferritin c... | 09/12/2006 |
| 7097841 | Ferritin fusion proteins for use in vaccines and other applications An isolated ferritin fusion protein is provided in which ferritin is fused with a protein or peptide capable of being fused to ferritin without interfering with the polymeric self-assembly of the resulting fusion protein, and the protein may be of the endocapsid for... | 08/29/2006 |
| 7060803 | Metal complex-protein composite and hydrogenation catalyst A metal complex-protein composite comprising apohemoglobin, apoheme oxygenase, apocatalase or apoferrin having cavity and a metal complex has a specific structure that the metal complex is received in the cavity of the apoprotein. The metal complex is prepared by co... | 06/13/2006 |
| 7034113 | Bacteriocin-metal complexes in the detection of pathogens and other biological analytes Complexes of bacteriocins and metals are provided that are useful in detecting bacteria, fungi and other biological analytes, and are particularly useful in detecting gram positive bacteria. The complexes are preferably chelated complexes wherein the bacteriocin is ... | 04/25/2006 |
| 7034134 | Polynucleotide encoding a novel metalloprotease highly expressed in the testis, MMP-29 The present invention provides novel polynucleotides encoding MMP-29 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relat... | 04/25/2006 |
| 7033613 | Recombinant cage-like protein, method for producing the same, precious metal-recombinant cage-like protein complex, method for producing the same and recombinant DNA Using a gene recombination technique, a glutamic acid and an aspartic acid positioned in a channel of apoferritin are substituted with serine having a small size and no charges. Then, a glutamic acid positioned in a holding portion is substituted with a basic amino ... | 04/25/2006 |
| 7034126 | Lactoferrin in the treatment of diabetes mellitus The present invention relates to methods of using a composition of lactoferrin for the treatment of diabetes mellitus as manifested by a reduction in the levels of serum glucose, blood pressure, obesity, or glycosylated hemoglobin (HbAlc). ... | 04/25/2006 |
| 7001991 | Targeted delivery of bioaffecting compounds for the treatment of cancer A homogeneous conjugate for targeting and treating diseased cells wherein the conjugate comprises an anti-cancer drug and a targeting protein, wherein said anti-cancer drug is selected from the group consisting of heat sensitizers, photosensitizers and apoptosis ind... | 02/21/2006 |
| 6992203 | Metal complexes produced by Maillard Reaction products A method is disclosed for the formation of metal chelates which are able to remain stable in high alkaline environments when compared to metal chelates produced from a reaction with amino acids. The method involves the reaction of sugars, amino groups, and metal com... | 01/31/2006 |
| 6984624 | Composition containing an iron complexing protein and a precursor of nitrogen monoxide metabolism and/or a chemical donor of nitrogen monoxide and uses thereof The invention concerns a pharmaceutical composition or a food supplement containing at least an iron complexing protein optionally in the presence of at least an iron salt, and at least a precursor of nitrogen monoxide metabolism and/or at least a chemical donor of ... | 01/10/2006 |
| 6977160 | Sensor protein and use thereof The object of the present invention is to utilize, as a sensor protein, a molecular recognizing ability of a protein that scarcely undergoes any structural change by the binding of a target substance. According to the present invention, there is provided a sensor pr... | 12/20/2005 |
| 6960559 | Neurite growth regulatory factors The present invention relates to genes and their encoded proteins which regulate neurite growth and the diagnostic and therapeutic use of such proteins (termed herein neurite growth regulatory factors). The proteins of the present invention include metalloproteases ... | 11/01/2005 |
| 6887676 | Method to type prion proteins The invention relates to methods and materials for use in the typing, diagnosis, prevention and/or treatment of prion disease. ... | 05/03/2005 |
