Did You Know...
...that in the early 1940s GE engineer James Wright was charged with a task of utmost importance to the war effort: develop a cheap substitute for rubber that could be used to produce tires, gas masks and a whole host of military gear. Wright tackled the task diligently -- and wound up inventing Silly Putty.
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| Number | Title | Issue Date |
| 7410771 | Reagent and method for detecting a sporozoite antigen A reagent and method for the specific and highly sensitive detection of C. parvum in which the reagent is an antibody for a soluble C. parvum sporozoite antigen and the method is an immunoassay in which the antibody is used to detect or quantify C. ... | 08/12/2008 |
| 7354583 | Antibody-induced apoptosis Anti-Her2 antibodies which induce apoptosis in Her2 expressing cells are disclosed. The antibodies are used to “tag” Her2 overexpressing tumors for elimination by the host immune system. Also disclosed are hybridoma cell lines producing the antibodies, methods f... | 04/08/2008 |
| 7342101 | Compositions and methods comprising a protective antigen of Disclosed are protein and peptide antigen and DNA compositions effective in generating immune responses against the pathogenic fungi Coccidioides spp., the causative agents of coccidioidomycosis and Valley Fever. The invention thus provides protein and peptid... | 03/11/2008 |
| 7317094 | Process for the in vitro culture of different stages of tissular parasites The process of the invention comprises the implementation of axenic conditions, with use of a liquid single-phase culture medium. For obtaining the amastigote forms, this medium is buffered at a pH of 5.5 to 6.5 and has an osmolarity of at least 400 milliosmoles/kg ... | 01/08/2008 |
| 7285639 | Antibody to telomerase reverse transcriptase The present invention is directed to monoclonal or recombinant antibodies or fragments thereof that bind to human telomerase reverse transcriptase (hTRT) protein. The present invention is also directed to methods of identifying or detecting hTRT polypeptides in biol... | 10/23/2007 |
| 7226594 | Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer A novel gene 0161P2F10B (also designated 161P2F10B) and its encoded protein, and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberranty expressed in the cancers listed in Table I. Consequently, ... | 06/05/2007 |
| 7211256 | antigens inducing protective antibodies The present invention relates, in part, to a purified polyclonal or monoclonal antibody which recognizes an epitope of a protein of 48,000 dalton, where the protein recognizes is a surface protein of a merozoite of Plasmodium falciparum which has a peptide of... | 05/01/2007 |
| 7025961 | Anti-plasmodium composition and methods of use Compositions that inhibit the binding of Plasmodium falciparum to erythrocytes are provided. More particularly, antibodies specific for Plasmodium falciparum binding proteins and blocking peptides that prevent the binding of Plasmodium falciparum | 04/11/2006 |
| 6969602 | Production of an immunovariant strain of contributes to strain cross-protection with other An immunovariant strain of Eimeria maxima was isolated. Vaccines incorporating the immunovariant strain are effective in eliciting immunological protection against coccidial infection. ... | 11/29/2005 |
| 6891024 | Monoclonal antibodies to Sarcocystis neurona and uses therefor The present invention is directed to particular monoclonal antibodies that find use in the identification and purification of Sarcocystis neurona and related antigens. In particular, these antibodies permit the diagnosis of Sarcocystis related diseases... | 05/10/2005 |
| 6828416 | Recombinant multivalent malarial vaccine against Plasmodium falciparum A recombinant protein is provided which comprises peptides derived from different stages in the life cycle of parasite Plasmodium falciparum. The protein is useful as a reagent and, when combined with a pharmaceutically-acceptable vehicle or carrier, is usefu... | 12/07/2004 |
| 6825325 | Molecular pathogenicide mediated plant disease resistance The present invention is drawn to a fusion protein containing at least one binding domain that specifically recognizes an eptitope of a plant pathogen and at least one additional domain made from a protein or peptide sequence which is toxic to the pathogen or detrim... | 11/30/2004 |
| 6790630 | DNA and protein from Dirofilaria immitis In accordance with the present invention, a 31-33 kDa glycoprotein of D. immitis (DiT33) is provided which represents another member of the family of putative pepsin inhibitors. Other known members include Ov33 (a.k.a. Ov33.3, Oc3.6, OvD 5B), Bm33 and Av33. T... | 09/14/2004 |
| 6790937 | Recombinant scFV antibodies specific to Eimeria spp. responsible for coccidiosis The present invention relates to (a) variable regions of heavy and light chains of an antibody specific to a surface antigen in sporozoite of Eimeria spp.; (b) a recombinant scFV (single chain variable fragment) antibody prepared using the variable regions; (c) a me... | 09/14/2004 |
| 6730307 | Anti-cryptosporidium parvum preparations Compositions and methods useful for conferring passive or active immunity to the parasite, C. parvum. A high molecular weight glycoprotein antigen isolated from C. parvum, capable of binding the mAb 3E2, was shown to harbor an epitope critical for trig... | 05/04/2004 |
| 6682737 | Anti-cryptosporidium parvum preparations Compositions and methods useful for conferring passive or active immunity to the parasite, C. parvum. A high molecular weight glycoprotein antigen isolated from C. parvum, capable of binding the mAb 3E2, was shown to harbor an epitope critical for trigger... | 01/27/2004 |
| 6673345 | Anti-parasite astacin metalloendopeptidase antibodies The present invention relates to parasite astacin metalloendopeptidase proteins, nucleic acid molecules having sequences that encode such proteins, antibodies raised against such proteins and compounds that can inhibit the activities of parasite astacin m... | 01/06/2004 |
| 6632621 | G protein-coupled receptor-like receptors and modulators thereof The invention provides neuropeptide ligands, G protein-coupled receptors and methods of screening for modulators of receptor activity. Identified modulators, including neuropeptide ligand mimetics, are useful as biostatic and biocidal agents of varying sc... | 10/14/2003 |
| 6551594 | Ex vivo animal or challenge model as method to measure protective immunity directed against parasites and vaccines shown to be protective in said method The invention relates to an ex vivo animal or challenge model as a method to identify protective (recombinant) proteins and rapidly measure protective immunity in intestinal segments directed against parasites and vaccines directed against parasitic infec... | 04/22/2003 |
| 6521229 | 41 kDa Cryptosporidium parvum oocyst wall protein Recombinant proteins have been developed for the immunization of animals against cryptosporidiosis. The proteins are effective for the immunization of a variety of animals against Cryptosporidium parvum, particularly for the production of hyperimmune colo... | 02/18/2003 |
| 6489448 | Antiparasitic helminth larval thiol specific antioxidant-antibodies, and uses thereof The present invention relates to parasitic helminth thiol specific antioxidant (TSA) larval proteins; to parasitic helminth larval TSA nucleic acid molecules, including those that encode such TSA proteins; to antibodies raised against such TSA proteins; a... | 12/03/2002 |
| 6489148 | Immunoassay for equine protozoal myeloencephalitis in horses An immunoassay for Sarcocystis neurons antibodies in equines is described. The immunoassay uses blocking of Sarcocystis antigens by antibodies to Sarcocystis sp. other than Sarcocystis neurona in connection with the immunoassay.... | 12/03/2002 |
| 6451984 | Chicken monoclonal antibodies specific for coccidial antigens involved in invasion of host lymphocytes A stable chicken hybridoma secreting a monoclonal antibody (mAb) that detects the conoid structure of Eimeria acervulina (E. acervulina) sporozoites has been developed. The hybridoma is made by fusing a thymidine kinase (TK)-deficient chicken myeloma with... | 09/17/2002 |
| 6440416 | Vaccines against cancer and infectious diseases A method of stimulating an immune response in a human against malignant cells or an infectious agent comprises the step of administering to the human an immunogenic amount of a primate anti-idiotype antibody or antibody fragment that acts as an immunogeni... | 08/27/2002 |
| 6419925 | Toxoplasma gondii antigens, the preparation thereof and the use thereof The present invention relates to the identification of toxoplasma gondii antigens and the preparation thereof by genetic engineering. A cDNA expression gene bank of this parasite was prepared. Recombinant clones which are of diagnostic interest were ident... | 07/16/2002 |
| 6413721 | Methods of isolating common and specific antigens from excretory-secretory products of protostrongylidae Novel Protostrongylidea antigens and early and accurate diagnostic methods for Protostrongylidae infection are disclosed. Novel P. tenuis-specific antigens and methods of discriminating between P. tenuis infection and infection with other closely-related ... | 07/02/2002 |
| 6403103 | Trypanosoma cruzi antigen, gene encoding therefore, and methods of detecting and treating chagas disease The nucleotide sequence of Tc100, a gene encoding a new antigenic protein from Trypanosoma cruzi called PTc100, is disclosed. The amino acid sequence of the PTc100 protein is also disclosed, along with the amino acid sequence of the dominant antigenic epi... | 06/11/2002 |
| 6399062 | Murine monoclonal antibody protective against Plasmodium vivax malaria The invention relates to a passive protective agent against P. vivax. The passive protective agent is an antibody that, when a concentration of the antibody is injected intravenously, protects a subject to the limits of that concentration of antibody from... | 06/04/2002 |
| 6392014 | Cloning of gene encoding the GP28.5 protein of Toxoplasma gondii; peptide fragments of said protein and their applications The invention relates to cloning of the gene for the toxoplasma GP28.5 antigen. It also encompasses purified GP28.5 antigen preparations and antigenic polypeptides derived from said antigen, and their applications.... | 05/21/2002 |
| 6391569 | Method to detect Dirofilaria immitis infection The present invention includes a method to detect D. immitis infection in a host animal using a D. immitis Di33 protein to detect anti-D. immitis Di33 antibodies in a bodily fluid of the animal. Also included is a method to detect D. immitis infection in ... | 05/21/2002 |
| 6344337 | Antigen test to detect equine protozoal myeloencephalitis in horse serum and cerebrospinal fluid The present invention provides an immunoassay to detect identifying antigens in horses that are infected with Sarcocystis neurona. The immunoassay is preferably an antigen-capture-based assay that relies upon polyclonal or monoclonal antibodies against a ... | 02/05/2002 |
| 6303755 | Therapeutic multispecific compounds comprised of anti-FCA receptor antibodies Therapeutic multispecific compounds comprised of anti-Fc receptor antibodies and methods of use are provided.... | 10/16/2001 |
| 6270767 | Trypanosoma cruzi antigen, gene encoding therefor and methods of detecting and treating chagas disease The nucleotide sequence of Tc100, a gene encoding PTc100, a new Trypanosoma antigen, and the amino acid sequence of PTc100 are described. Tc100 and PTc100, or fragments thereof, modified or otherwise, can be used directly or indirectly for the detection o... | 08/07/2001 |
| 6248326 | Regulation of osteoclast formation by inhibition of osteoblastic stem cell factor The present invention provides an inhibitor of osteoblastic stem cell factor binding and/or activity, for example, an antibody or an antisense oligonucleotide. Also provided are pharmaceutical compositions comprising these inhibitors of osteoblastic stem ... | 06/19/2001 |
| 6165735 | Parasitic helminth asparaginase proteins, nucleic acid molecules, and uses thereof The present invention relates to: parasitic helminth asparaginase proteins; parasitic helminth asparaginase nucleic acid molecules, including those that encode such asparaginase proteins; antibodies raised against such asparaginase proteins; and compounds... | 12/26/2000 |
| 6114142 | Parasitic helminth nucleic acid molecules/and uses thereof The present invention relates to parasitic helminth proteins of about 39 kD (i.e., P39 proteins); to parasitic helminth P39 nucleic acid molecules, including those that encode such proteins; and to antibodies raised against such proteins. The present inve... | 09/05/2000 |
| 6110463 | Anti-Cryptosporidium parvum preparations Compositions and methods useful for conferring passive or active immunity to the parasite, C. parvum. A high molecular weight glycoprotein antigen isolated from C. parvum, capable of binding the mAb 3E2, was shown to harbor an epitope critical for trigger... | 08/29/2000 |
| 6066503 | Recombinant DNA molecules encoding aminopeptidase enzymes and their use in the preparation of vaccines against helminth infections The present invention provides nucleic acid molecules containing nucleotide sequences encoding helminth aminopeptidase enzymes, and antigenic fragments and functionally-equivalent variants thereof, their use in the preparation of vaccines for use against ... | 05/23/2000 |
| 6022546 | Toxoplasma gondii antigens, the preparation thereof and the use thereof The present invention relates to the identification of Toxoplasma gondii antigens and the preparation thereof by genetic engineering. A cDNA expression gene bank of this parasite was prepared. Recombinant clones which are of diagnostic interest were ident... | 02/08/2000 |
| 6007814 | Therapeutic uses of the hypervariable region of monoclonal antibody M195 and constructs thereof Therapeutic agents and methods for treating and diagnosing leukemia are provided. Such agents comprises monoclonal antibody M195, a polypeptide capable of binding to the antigen of M195, or a chimeric antibody such a peptide, conjugated to a cytotoxic age... | 12/28/1999 |
