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| Number | Title | Issue Date |
| 8106169 | Plant production of immunoglobulins with reduced fucosylation This invention provides for the plant production of immunoglobulins, wherein at least a portion of the glycans attached to the immunoglobulins lack fucose. The invention also provides the constructs; plasmids; vectors; transformed plant cells, transformed plant call... | 01/31/2012 |
| 7629443 | Neutralizing monoclonal antibodies against severe acute respiratory syndrome-associated coronavirus The present invention provides an isolated antibody capable of binding to the receptor-binding domain of the spike protein of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) so as to competitively inhibit the binding of the SARS-CoV to host c... | 12/08/2009 |
| 7442497 | Methods of determining chronic hepatitis C infection Methods for determining chronic hepatitis C infection are provided by the present invention. The methods generally involve determining the optical density of fluid samples which have tested positive for hepatitis C infection using an antibody-based assay. The optica... | 10/28/2008 |
| 7402561 | Compositions and methods for inhibiting abnormal cell growth In the US about ⅓ of college women show evidence of HPV infection. The clinical problem may be even larger in developing countries. There are currently no effective therapies for HPV infections, aside from therapeutic cone biopsies, which often are followed by rec... | 07/22/2008 |
| 7396914 | SARS nucleic acids, proteins, antibodies, and uses thereof Codon-optimized nucleic acids, polypeptides, and antibodies are described herein. ... | 07/08/2008 |
| 7364737 | Human neutralizing monoclonal antibodies to respiratory syncytial virus Human monoclonal antibodies and fragments thereof which bind, neutralize and provide passive immunotherapy to respiratory syncytial virus (RSV) antigenic subgroups A and B are disclosed. Also disclosed are diagnostic and immunotherapeutic methods of using the monocl... | 04/29/2008 |
| 7345152 | Monoclonal antibody specific for an epitope of inactivated feline immunodeficiency-encoded glycoprotein The present invention provides a monoclonal antibody specific for an epitope which is unique to the surface protein component of an inactivated feline immunodeficiency virus (FIV) envelope glycoprotein. Said antibody is useful for the quantification of inactivated F... | 03/18/2008 |
| 7314622 | Recombinant monoclonal antibodies and corresponding antigens for colon and pancreatic cancers The present invention provides for purified or highly pure recombinant monoclonal antibodies that bind to human colorectal and pancreatic carcinoma-associated antigens (CPAA), along with nucleic acid sequences encoding the antibody chains, and the amino acid sequenc... | 01/01/2008 |
| 7311906 | Anti-viral activity of an anti-thymidine kinase monoclonal antibody Monoclonal antibodies to thymidine kinase 1 are disclosed which are useful in methods of detecting, diagnosing, and treating viral infection. ... | 12/25/2007 |
| 7294703 | PRO6093 Antibodies The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 11/13/2007 |
| 7282205 | Anti-hepatitis A virus antibodies Chimpanzee monoclonal antibodies and antigen binding fragments including a γ1-chain CDR3 region that bind hepatitis A virus (HAV) antigen are disclosed herein. The antibodies neutralize HAV. Also disclosed are methods for using these antibodies and antigen binding ... | 10/16/2007 |
| 7264802 | Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV) The present invention provides a purified preparation containing, for example, at least one polypeptide selected from the group consisting of proteins encoded by one or more open reading frames (ORF's) of an Iowa strain of porcine reproductive and respiratory syndro... | 09/04/2007 |
| 7255986 | Compositions for the diagnosis and treatment of epizootic catarrhal enteritis in ferrets The present invention relates to the use of novel nucleotide sequences for the M and N region peptide of the ferret coronavirus and derivative products for the diagnosis and treatment of epizootic catarrhal enteritis (ECE) in ferrets. ... | 08/14/2007 |
| 7247301 | Human monoclonal antibodies to epidermal growth factor receptor (EGFR) Isolated human monoclonal antibodies which specifically bind to human EGFR, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, ca... | 07/24/2007 |
| 7217801 | Nucleic acids and new polypeptides associated with and/or overlapping with hepatitis C virus core gene products DNA encoding core+1 polypeptides of hepatitis C virus (HCV), nucleotides encoding the polypeptides, and methods for using the nucleotides and the encoded polypeptides are disclosed. ... | 05/15/2007 |
| 7208151 | Tweak receptor agonists as anti-angiogenic agents The present invention relates to methods of modulating angiogenesis and inhibiting tumor progression by using TWEAK receptor (Fn14) agonists. In particular, methods for inhibiting angiogenesis are disclosed. ... | 04/24/2007 |
| 7195765 | Sequences of hepatitis C virus genotypes and their use as therapeutic and diagnostic agents The present invention relates to a polynucleic acid composition comprising or consisting of at least one polynucleic acid containing 8 or more contiguous nucleotides corresponding to a nucleotide sequence from the region spanning positions 417 to 957 of the Core/E1 ... | 03/27/2007 |
| 7132100 | Stabilized liquid anti-RSV antibody formulations The present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof that immunospecifically bind to a respiratory syncytial virus (RSV) antigen, which formulations exhibit stability, low to undetectable levels of aggregation, and v... | 11/07/2006 |
| 7108967 | Hepatitis C viral antigen immunoassay detection systems Immunoassays for detecting hepatitis C virus protein and immune complexes between hepatitis C virus protein and antibodies in biological samples, methods of screening blood products for hepatitis C virus, and kits employed therefor are provided. ... | 09/19/2006 |
| 7101554 | Picornaviruses, vaccines and diagnostic kits A new group of picornaviruses is disclosed. The picornaviruses of the invention comprise in the non-coding region of their viral genome a nucleotide sequence which corresponds to cDNA sequence (I) or homologous sequences having at least 75% homology to the SEQ ID NO... | 09/05/2006 |
| 7101551 | Remedies for hepatitis C The present invention provides a substance which inhibits the binding between E2/NS1 protein of hepatitis C virus and a cell infectious with hepatitis C virus, a cell expressing CD81, or CD81. The present invention can provide a novel medicament which has an anti-vi... | 09/05/2006 |
| 7091324 | Prevention and treatment of HCV infection employing antibodies directed against conformational epitopes Conformational epitopes of the envelope protein E2 of the Hepatitis C virus (HCV) have been identified and characterized using a panel of monoclonal antibodies derived from patients infected with HCV. These conformational epitopes have been determined to be importan... | 08/15/2006 |
| 7087377 | Method and kit for detection of tat protein with anti-tat oyi antibodies The invention relates to an anti HIV 1 vaccine comprising the entire or part of the Tat HIV 1 protein, in addition to the identification of said protein in individuals affected by HIV. The Tat protein is a protein of the HIV 1 Oyi variant. ... | 08/08/2006 |
| 7071301 | Chimeric viral receptor polypeptides, human viral receptor polypeptides and uses thereof Target cell specificity of delivery vectors is provided by incorporation of a target cell specific binding domain by the use of any binding domain, which binds specifically to a binding site on the target cell. The binding site may be endogenous to the target cell, ... | 07/04/2006 |
| 7067638 | Small round structured virus (SRSV) detection kit This invention relates to an SRSV detection kit comprising all antibodies against SRSV-related which makes it possible to detect most SRSV-related viruses and further to distinguish their serotypes and genogroups. ... | 06/27/2006 |
| 7060799 | Antibody for ligand capture assay The present invention provides a novel method for the identification and clonal isolation of antibodies that bind to unique epitopes. The method is based on the use of antibodies as solid phase capture reagents to bind a known capture antibody epitope, thereby precl... | 06/13/2006 |
| 7052830 | Hepatitis C virus peptides and uses thereof Novel hepatitis C virus (HCV) polypetides are provided which are not encoded by the standard HCV open reading frame. These alternate reading frame polypeptides are useful, inter alia, in vaccine compositions, in diagnosing HCV infection, and as therapeutic targets. | 05/30/2006 |
| 7049060 | HCV anti-core monoclonal antibodies Monoclonal antibodies that specifically bind to HCV core antigen. Also provided are hybridoma cell lines which secrete these antibodies, methods for making and using these antibodies, including kits that include these antibodies. ... | 05/23/2006 |
| 7041293 | HIV env antibodies The invention provides antibodies specific for HIV env, including monoclonal antibodies and related hybridomas. The antibodies block CD4/g120 binding and reduce reverse transcriptase activity in vitro. ... | 05/09/2006 |
| 7026457 | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use The present invention relates to a method for purifying recombinant HCV single or specific oligomeric envelope proteins selected from the group consisting of E1 and/or E1/E2 characterized in that upon lysing the transformed host cells to isolate the recombinantly ex... | 04/11/2006 |
| 6984721 | Immunological reagents and diagnostic methods for the detection of human immunodeficiency virus type 2 utilizing multimeric forms of the envelope proteins GP300, P200, and P90/80 Immunological reagents obtained from multimeric forms of the HIV-2 and SIV envelope glycoproteins and their use in the detection of HIV-2, particularly, the HIV-2 proteins gp300, p200, p90, and p80, and gp300 of SIV. ... | 01/10/2006 |
| 6982156 | Compositions and methods modulating variola and vaccinia virus Antibodies directed to SPICE and VCP which may be used for detection, prevention, and treatment of variola virus or vaccinia virus are provided. Recombinant SPICE and VCP proteins are also provided which are used for enhancing the immune response to variola or vacci... | 01/03/2006 |
| 6949628 | ANTICYTOMEGALOVIRUS MONOCLONAL ANTIBODIES AND PROCESSES FOR THE IN VITRO DIAGNOSIS OF INFECTIONS BY HUMAN CYTOMEGALOVIRUSES AND A PROTEIN-KINASE INDUCIBLE BY CYTOMEGALOVIRUSES AND RECOGNIZABLE BY AFORESAID MONOCLONAL ANTIBODIES The invention relates to a process for in vitro diagnosis of an infection by human cytomegaloviruses. The process consists of contacting cells, possibly carrying the infection, with a monoclonal antibody reacting with a polypeptide of molecular weight 68,000, induce... | 09/27/2005 |
| 6946129 | Recombinant anti-CD40 antibody and uses thereof The present invention relates to methods and compositions for the prevention and treatment of cancer, inflammatory diseases and disorders or deficiencies of the immune system. The methods of the invention comprise administering a CD40 binding protein that potentiate... | 09/20/2005 |
| 6927281 | Adeno-associated virus-its diagnostic use with early abortion The present invention relates to a method of detecting a causative agent of the so-called spontaneous early abortion by investigating patients' samples for the presence of adeno-associated virias DNA (AAV DNA), or AAV antigen or antibodies, preferably of the IgM typ... | 08/09/2005 |
| 6924095 | Retrovirus isolated from mantle histiocytes in mantle cell lymphoma The present invention features an isolated, intact virus associated with human lymphoma, and originally isolated from a mantle cell lymphoma, referred to herein as a mantle histiocyte retrovirus (MHRV). The invention also features compositions and methods for detect... | 08/02/2005 |
| 6924362 | Monoclonal antibodies specific for the E2 glycoprotein of hepatitic C virus and their use in the diagnosis, treatment, and prevention of hepatitis C The present invention describes the identification and characterization of five human HC E1-specific monoclonal antibodies isolated from a phage display library and their use in the diagnosis, treatment, and prevention of HCV in mammals, preferably humans. ... | 08/02/2005 |
| 6890532 | Rabies virus-specific neutralizing human monoclonal antibodies and nucleic acids and related methods Human monoclonal rabies virus neutralizing antibodies represent a safe and efficacious post-exposure prophylactic therapy for individuals exposed to a rabies virus. The nucleic acid and encoded amino acid sequences of the heavy and light chain immunoglobulins of hum... | 05/10/2005 |
| 6870032 | Assay for the diagnosis of flaviviral infection using antibodies with high affinity for NS1 protein of flavivirus in hexameric form The invention concerns a method for early detection of a flavivirus-induced infection, comprising the detection of the flavivirus non-structural glycoprotein NS1 in a biological sample during the clinical phase of the infection, by an immunological met... | 03/22/2005 |
| 6824778 | Prophylactic and therapeutic monoclonal antibodies In this application are described monoclonal antibodies which recognize E3 glycoprotein of alphavirus and epitopes recognized by these monoclonal antibodies. Also provided are mixtures of antibodies of the present invention, as well as methods of using individual an... | 11/30/2004 |
