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| Number | Title | Issue Date |
| 8158762 | Anti-factor B antibodies and their uses The invention concerns the prevention and treatment of complement-associated eye conditions, such as choroidal neovascularization (CNV) and age-related macular degeneration (AMD), by administration of factor B antagonists. ... | 04/17/2012 |
| 8114968 | Metalloproteinase-12 specific monoclonal antibody Proteins that bind to matrix metalloproteinase 12 and methods of using such proteins are described. ... | 02/14/2012 |
| 8106168 | Metalloproteinase binding proteins Proteins that bind to matrix metalloproteinase 14 and methods of using such proteins are described. ... | 01/31/2012 |
| 8048995 | Human skeletal muscle-specific ubiquitin-conjugating enzyme The present invention provides novel human genes, for example a novel human gene comprising a nucleotide sequence coding for the amino acid sequence shown under SEQ ID NO:1. The use of the genes makes it possible to detect the expression of the same in various tissu... | 11/01/2011 |
| 8008452 | Phosphorylated Ndr kinase The present invention relates to the phosphorylated form of nuclear serine/threonine protein kinase, designated nuclear, Dbf2-related kinase (Ndr), and provides assays and materials for identifying modulators thereof. The invention relates to the fields of molecular... | 08/30/2011 |
| 7989597 | Immunogenic memapsin 2 β-secretase peptides and methods of use This application pertains to antibodies which specifically bind to immunogenic memapsin 2β-secretase peptides for use in the treatment of Alzheimer's disease and memapsin 2β-secretase disorders. The application also pertains to immunogenic compositions comprising ... | 08/02/2011 |
| 7973143 | Sphingosine-1-phosphate lyase polypeptides, polynucleotides and modulating agents and methods of use therefor Compositions, methods and kits for diagnosing and treating cancer are provided. Therapeutic compositions may comprise agents that modulate the expression or activity of a sphingosine-1-phosphate lyase (SPL). Such compositions may be administered to a mammal afflicte... | 07/05/2011 |
| 7973142 | Antibodies that bind human protein tyrosine phosphatase beta (HPTPβ) Antibodies and antigen binding fragments thereof that bind to human protein tyrosine phosphatase beta (HPTPβ), and uses thereof. ... | 07/05/2011 |
| 7902340 | Antibodies binding to the extracellular domain of the receptor tyrosine kinase ALK The present invention concerns an antibody specific for human ALK (Anaplastic Lymphoma Kinase), in particular a scFv, a nucleic acid sequence encoding it, its production and its use as a pharmaceutical or for diagnostic purposes. Said antibody is suitable for the lo... | 03/08/2011 |
| 7816499 | Antibodies that selectively bind HDAC9 The present invention features, inter alia, purified antibodies that selectively bind an isolated or recombinant histone deacetylase polypeptide comprising the amino acid sequence as set forth in SEQ ID NO: 2, which comprises a histone deacetylase catalytic domain a... | 10/19/2010 |
| 7759466 | Monoclonal antibodies to alpha-amylase Monoclonal antibody that specifically binds to alpha-amylase and is useful for detecting weather damage (i.e. pre-harvest sprouting) in cereal grain. ... | 07/20/2010 |
| 7745587 | Antibodies that bind MMP-14 Proteins that bind to matrix metalloproteinase 14 and methods of using such proteins are described. ... | 06/29/2010 |
| 7662929 | Antibody that specifically binds hyaluronan synthase Modulation of Hyaluronan (HA) synthesis and degradation is disclosed by compounds and compositions that are capable of reducing the level of hyaluronan synthase (HAS) or hyaluronidase (HYAL) or the function or activity of HAS or HYAL. The compounds and compositions ... | 02/16/2010 |
| 7550569 | Antibodies that specifically bind to GMAD The present invention relates to antibodies and related molecules that immunospecifically bind to GMAD. Such antibodies have uses, for example, in the prevention and treatment of both insulin- and non insulin-dependent diabetes mellitus (i.e. Type I and Type II diab... | 06/23/2009 |
| 7524938 | Antibodies and pharmaceutical compositions containing same useful for inhibiting activity of metalloproteins A method of producing a metalloprotein inhibitor, the method comprising generating antibodies directed at a composition including a metal ion-bound chelator, wherein the composition is selected having structural and electronic properties similar to a functional doma... | 04/28/2009 |
| 7439331 | Inhibition of complement activation The invention relates to factor D inhibitors, which bind to factor D and block the functional activity of factor D in complement activation. The inhibitors include antibody molecules, as well as homologues, analogues and modified or derived forms thereof, including ... | 10/21/2008 |
| 7423128 | Anti-properdin antibodies, and methods for making and using same The present invention is related to antibodies directed to the antigen properdin and uses of such antibodies. In particular, in accordance with the present invention, there are provided fully human monoclonal antibodies directed to the antigen properdin. Nucleotide ... | 09/09/2008 |
| 7416853 | Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds. ... | 08/26/2008 |
| 7378090 | Alleviation of the memory deficits and memory components of psychiatric dysfunctions by altering atypical PKM activity Methods have been developed for alleviating memory problems or psychiatric dysfunctions that have a memory formation component. These methods are based on the finding that a truncated form of an aPKCζ protein is intimately involved in memory formation in animals. T... | 05/27/2008 |
| 7371828 | Extracellular signal-regulated kinase sequences and methods of production and use The present invention relates, in general, to an extracellular signal regulated kinase, ERK-5. In particular, the present invention relates to nucleic acid molecules coding for ERK-5; ERK-5 polypeptides; recombinant nucleic acid molecules; cells containing the recom... | 05/13/2008 |
| 7368237 | Cell death-related nucleases and their uses An assay uses apoptotic nucleases to screen for apoptosis modulators, in a method of modulating apoptosis, and in a method of aiding in a diagnosis of a disease, among other methods. materials for use in the assay include isolated or recombinant polypeptides and pol... | 05/06/2008 |
| 7361741 | Antibody, or fragment thereof, capable of binding specifically to human pancreatic lipase An antibody, or fragment thereof, capable of binding specifically to one or more human dietary enzymes, said antibody or fragment thereof comprising a heavy chain variable domain derived from an immunoglobulin naturally devoid of light chains, or a functional equiva... | 04/22/2008 |
| 7358352 | Nucleic acids encoding human TNF-α convertase The present invention provides isolated human and bovine TNF-α convertases, nucleic acids and; recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods for making the convertases using the host cells. This invention fu... | 04/15/2008 |
| 7355015 | Matriptase, a serine protease and its applications The invention is directed to a method of detecting a malignancy or a pre-malignant lesion in breast or other tissue, or a pathologic condition, by detecting the presence of single-chain or two-chain forms of matriptase in the tissue. The invention is further directe... | 04/08/2008 |
| 7339031 | Modified bouganin proteins, cytotoxins and methods and uses thereof The invention provides modified forms of bouganin protein having biological activity and a reduced propensity to activate human T cells as compared to the non-modified bouganin protein. The invention also provides T-cell epitope peptides of bouganin, and modified T-... | 03/04/2008 |
| 7311906 | Anti-viral activity of an anti-thymidine kinase monoclonal antibody Monoclonal antibodies to thymidine kinase 1 are disclosed which are useful in methods of detecting, diagnosing, and treating viral infection. ... | 12/25/2007 |
| 7312321 | Antibody to human enzymes of the metalloprotease family This invention relates to newly identified polypeptides which have zinc metalloprotease activities and are referred to as IGS5, and polynucleotides encoding such polypeptides, to their use in therapy and in identifying compounds which may be stimulators and/or inhib... | 12/25/2007 |
| 7309779 | Antibodies directed to the testis-specific tubulin tyrosine-ligase-like protein, BGS42 The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relat... | 12/18/2007 |
| 7297336 | Factor IXa specific antibodies displaying factor VIIIa like activity Ligands such as antibodies that can bind factor IX/factor IXa and increase the procoagulant activity of factor IXa (FIXa), pharmaceutical compositions containing such ligands, methods for treating patients afflicted with blood coagulation with such ligands, and a nu... | 11/20/2007 |
| 7294154 | Microorganism staining agent and use thereof A microorganism staining agent characterized in that an alkali substance and a diazo dye or xanthene dye are contained therein; and a method of detecting microorganisms with the use of the agent. There are provided a microorganism staining agent which resolves the p... | 11/13/2007 |
| 7294705 | Anti-PRO3580 antibodies The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 11/13/2007 |
| 7279274 | Method for diagnosing diabetes in a mammal Provided are mammalian secreted and non-secreted diabetes mediating proteins, including protective and deleterious diabetes-mediating proteins, as well as polynucleotides encoding same, drug screening methods for identifying a test compound capable of altering the e... | 10/09/2007 |
| 7279290 | ATM kinase compositions and methods The present invention provides methods for detecting activation of ATM kinase, DNA damage, and DNA damaging agents. Further provided are antibodies which specifically recognize the phosphorylation state of Ataxia Telangiectasia-Mutated (ATM) kinase. Methods of ident... | 10/09/2007 |
| 7273610 | Endotheliase-2 ligands Proteins that bind to ET2, such as immunoglobulins that inhibit ET2 with high affinity and selectivity, are provided. The ET2 binding proteins can be used to treat a variety of disorders, including angiogenesis-associated disorders. ... | 09/25/2007 |
| 7264932 | Nuclease inhibitor cocktail Methods and compositions for inhibiting and/or inactivating nucleases by using nuclease inhibitors are provided. The nuclease inhibitors comprise anti-nuclease antibodies and non-antibody nuclease inhibitors. ... | 09/04/2007 |
| 7247442 | Antibodies to HHPEN62 polypeptide The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted prote... | 07/24/2007 |
| 7232661 | Diagnostic agents for the prenatal diagnosis of preterm delivery, fetal infection, and fetal damage, and diagnostic kit containing the same This invention is about a method for the prenatal diagnosis of preterm delivery, fetal infection, and fetal damage, and diagnostic reagent system and diagnostic kit for the diagnosis. The method, diagnostic reagent system, and kit are based on the finding that the l... | 06/19/2007 |
| 7214373 | Methods, compositions and kits relating to chitinases and chitinase-like molecules and inflammatory disease The present invention includes compositions and methods for the treatment of inflammatory disease (e.g., asthma, COPD, inflammatory bowel disease, atopic dermatitis, atopy, allergy, allergic rhinitis, scleroderma, and the like), relating to inhibiting a chitinase-li... | 05/08/2007 |
| 7195926 | Antibodies to a cathepsin C homolog The present invention provides nucleotide and amino acid sequences that identify and encode a new cathepsin C homolog (RCP) expressed in THP-1 cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode RCP, expression... | 03/27/2007 |
| 7189823 | Antibody against illfdyfnr Proteins useful in the diagnosis of proliferative disorders of the colon are present in nuclear matrix protein preparations and can be characterized by molecular weight, isoelectric point, and amino acid sequence. The proteins may be identified, for example, by 2D-g... | 03/13/2007 |
