Class 530/388.25 - Binds plasma protein, serum protein, or fibrin (e.g., clotting factor, fibrinolytic factor, complement factor, immunoglobulin, apolipoprotein, etc.)

Subclass of Class 530 - Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
Definition: Subject matter involving a monoclonal antibody or antigen-binding
No. of patents: 426
Last issue date: 02/28/2012

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Number	Title	Issue Date
8124742	Rh(D)-binding proteins The invention includes Rh(D) binding proteins, including antibodies, and DNA encoding such proteins. Methods of generating such proteins and DNAs are also included. ...	02/28/2012
8026345	Characterization and identification of unique human adiponectin isoforms and antibodies The invention pertains to methods for measuring different forms of human adiponectin that are present in human plasma/serum, and more specifically methods are based on an ELISA assay that utilizes different monoclonal antibodies directed against adiponectin, in comb...	09/27/2011
7999082	Anti-factor B antibodies Disclosed are novel inhibitors of the alternative complement pathway and particularly, novel anti-factor B antibodies. Also disclosed is the use of such inhibitors to reduce or prevent airway hyperresponsiveness and/or airway inflammation by selectively inhibiting t...	08/16/2011
7999081	Anti-C5 alpha antibodies The present invention refers to recombinant antibodies of human origin specific for the C5 component of the activated complement and characterised by the ability to inhibit the conversion of the C5 alpha chain to C5a and C5b. Moreover the present inven...	08/16/2011
7858758	Monoclonal antibodies for detection of urinary trypsin inhibitors Certain monoclonal antibodies are able to detect urinary trypsin inhibitors (UTIs) that are characteristic of disease in humans. In particular, the UTIs include AMBK, Bikunin, Uristatin, Uristatin-1, Uristatin-2, as defined herein, also including the fragments and a...	12/28/2010
7795403	Antibodies directed against prothrombin fragment F, the preparation and use thereof The invention relates to antibodies directed against F1+2, to the preparation and use thereof, especially in therapy and diagnosis. The antibodies bind to an epitope on the N-terminal half of the F2 fragment of prothrombin. ...	09/14/2010
7608695	Substance with antithrombotic activity and method for detecting glycokallidin A method for conveniently detecting binding between the von Willebrand factor and glycoprotein Ib and a means to be used therein. The von Willebrand factor fixed in a reactor immobilized in a reaction vessel in the presence of bottrocetin is bound to a chimeric prot...	10/27/2009
7589182	Anti-sulfotyrosine antibodies The invention provides anti-sulfotyrosine specific antibodies capable of detecting and isolating polypeptides that are tyrosine-sulfated. The sulfotyrosine antibodies and antibody fragments of the invention may be used to discriminate between the non-sulfated and su...	09/15/2009
7579447	Antibodies against LLG polypeptides of the triacylglycerol lipase family Lipoprotein Lipase like polypeptides, nucleic acids encoding said polypeptides, antisense sequences, and antibodies to said polypeptides are disclosed. Also disclosed are methods for the preparation of said polypeptides in a recombinant system and for the use of sai...	08/25/2009
7517965	Non-neutralizing anti-aPC antibodies The present invention provides anti-aPC antibodies that suppress the inactivation of activated protein C (aPC), and uses thereof. The present inventors screened anti-aPC antibodies, and succeeded in isolating anti-aPC antibodies comprising the activity of suppressin...	04/14/2009
7514539	Epitope directed selection of antibodies to murine tissue factor A tissue factor antibody which binds to non-human tissue factor and is useful as a surrogate in preclinical testing where the human therapeutic tissue factor candidate antibody does not interact with the homolog target protein in a manner that would provide meaningf...	04/07/2009
7438911	Antibody against human insulin-like growth factor For the effective treatment of diseases such as cancer in which hIGF participates, there have been desired to be developed antibodies which strongly bind to both factors hIGF-I and hIGF-II and inhibit their functions and fragments of these antibodies. The present in...	10/21/2008
7435413	Anti-tissue factor antibodies with enhanced anticoagulant potency The invention concerns anti-tissue factor (anti-TF) antibodies with enhanced anticoagulant potency, and methods and means for identifying, producing and using such antibodies. The anti-TF antibodies of the present invention are designed to comprise a region binding ...	10/14/2008
7432356	Complement pathway inhibitors binding to C5 and C5a without preventing formation of C5b The invention relates to inhibitors that bind to C5 and C5a, but which do not prevent the activation of C5 and do not prevent formation of or inhibit the activity of C5b. One example of such an inhibitor molecule is the monoclonal antibody designated MAb137-26, whic...	10/07/2008
7423128	Anti-properdin antibodies, and methods for making and using same The present invention is related to antibodies directed to the antigen properdin and uses of such antibodies. In particular, in accordance with the present invention, there are provided fully human monoclonal antibodies directed to the antigen properdin. Nucleotide ...	09/09/2008
7390490	Uses of anti-CX3CR1 antibody, anti-fractalkine antibody and fractalkine There are provided uses of an antibody directed to CX3CR1 and fractalkine. Killer lymphocytes can be readily identified, eliminated and separated by using an anti-CX3CR1 antibody. Further, there can be provided an antibody drug for suppressing chemotaxis and cytotox...	06/24/2008
7381802	Human antibodies that specifically recognize the toxin Cn2 from scorpion venom The present invention is directed to recombinant human antibodies specific for Cn2 toxin from C. noxius scorpion venom. The antibodies are able to recognize the toxin and preferably neutralize it as well as the whole venom of C. noxius scorpion. This i...	06/03/2008
7364735	Method for diagnosis and treatment of haemophilia A patients with an inhibitor A polynucleotide, comprising a contiguous nucleotide sequence coding for a human antibody with factor VIII specificity, or complementary to a nucleotide sequence coding for a human antibody for factor VIII specificity, or capable of selectively hybridizing under str...	04/29/2008
7354585	Methods of treating coagulapathic or thrombotic disorders The invention provides for the isolation, identification, synthesis, expression and purification of antibodies reactive with factor IX (FIX)/factor IXa (IXa). In particular aspects, the invention provides human antibodies reactive with the human FIX Gla domain. The ...	04/08/2008
7348412	Ouabain-specific monoclonal antibodies The invention relates to a monoclonal antibody or antigen binding fragment thereof having binding specificity for ouabain, wherein the antibody or antigen binding fragment does not crossreact with digoxin. Preferably the anti-ouabain monoclonal antibody can bind oua...	03/25/2008
7339035	Antibody recognizing GM1 ganglioside-bound amyloid β-protein and DNA encoding the antibody It is intended to provide an antibody efficacious in diagnosing, preventing or treating Alzheimer's disease, DNA encoding the antibody, a method of screening a drug and drugs. The amino acid sequence and the gene sequence of the variable region of an antibody, which...	03/04/2008
7332162	Cell lines, ligands and antibody fragments for use in pharmaceutical compositions for preventing and treating haemostasis disorders A ligand derived from, e.g. a Fab fragment of, a monoclonal antibody obtainable from the cell line deposited with the Belgian Coordinated Collections of Micro-organisms under accession number LMBP 5108CB binds to the human platelet glycoprotein GPib and prevents the...	02/19/2008
7329737	Antibodies that bind hK-1 The invention features hK1 binding polypeptides as well as compositions comprising such polypeptides and methods of making and using such polypeptides. ...	02/12/2008
7311913	Methods of treating thrombotic diseases with von Willebrand factor specific antibodies Anti-thrombotic agents containing humanized antibodies which bind to von Willebrand factor. ...	12/25/2007
7297336	Factor IXa specific antibodies displaying factor VIIIa like activity Ligands such as antibodies that can bind factor IX/factor IXa and increase the procoagulant activity of factor IXa (FIXa), pharmaceutical compositions containing such ligands, methods for treating patients afflicted with blood coagulation with such ligands, and a nu...	11/20/2007
7291333	Blockade of protein C activation reduces microvascular surgical blood loss A method of inhibiting microvascular bleeding is provided. Antibody to protein C administered to a patient in a pharmaceutically acceptable carrier prevents anticoagulation by greater than 90% of activated protein C in human plasma. ...	11/06/2007
7279161	Factor IX/factor IXa activating antibodies and antibody derivatives An antibody or antibody derivative against factor IX/activated factor IX (FIXa) which increases the procoagulant activity of FIXa. ...	10/09/2007
7279158	Methods for the treatment of inflammatory joint disease The use of compounds that block complement component C5 or its active fragments C5a and/or C5b (such compounds collectively referred to as “C5 blockers”) to treat established joint inflammation (arthritis) is disclosed. Administration of such C5 bl...	10/09/2007
7273925	Methods and products for regulating lectin complement pathway associated complement activation The invention relates to methods and products for regulating lectin complement pathway associated complement activation. The methods include both in vitro and in vivo methods for inhibiting lectin complement pathway associated complement activation. The methods are ...	09/25/2007
7258989	Carbohydrate deficient transferrin (CDT) -specific antibodies, their preparation and use The present invention relates to antibodies which, in agueous solution, selectively bind to a transferrin-homologous carbohydrate deficient transferrin (CDT) without the latter needing to be bound to a solid phase. CDT is characterized by at least one of the two oli...	08/21/2007
7250168	Tissue factor targeted thrombomodulin fusion proteins as anticoagulants This invention relates to novel fusion proteins which are comprised of a targeting protein that binds tissue factor (TF), which is operably linked to the thrombomodulin (TM) EGF456 domain alone or in combination with at least one other TM domain selected from the gr...	07/31/2007
7244580	Epsilon immunoglobulin chain derived peptides for induction of anti-IgE antibodies The present invention relates to identification of polypeptides useful for generating antibodies specific for non-human IgE, particularly equine IgE. The invention, therefore, also relates to antibodies that specifically bind to IgE and methods to detect IgE using t...	07/17/2007
7241578	Immunoassay method/equipment, biological component measurable toilet, anti-albumin monoclonal antibody, cell strain producing the same, and albumin detection kit The immunoassay method of this invention measures the content of a subject substance in a sample. The method includes the steps of: (a) preparing a mixed solution by mixing the sample and an antibody solution including a first monoclonal antibody and a second monocl...	07/10/2007
7235643	Antibodies and methods for generating genetically altered antibodies with high affinity Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more...	06/26/2007
7223848	Methods for purifying Fc-containing proteins The present invention provides a process for dissociating Fc-containing molecules from complexes of Protein A/Fc-containing molecules or mixtures containing Fc-containing molecules and Protein A. The association, e.g., by hydrophobic interactions, between the Fc-con...	05/29/2007
7214785	Human-type anti-blood coagulation factor VIII antibody The present invention provides a human antibody against blood coagulation factor VIII (hereinafter also referred to as “FVIII”) and an antibody fragment that binds to human FVIII and specifically inhibits the coagulation activity of human FVIII. ScFv display pha...	05/08/2007
7157085	Method for treating IgE-mediated disorders The present invention relates to a method for adjusting the affinity of a polypeptide to a target molecule by a combination of steps, including: (1) the identification of aspartyl residues which are prone to isomerization; (2) the substitution of alternative residue...	01/02/2007
7151169	Specific binding members for TGFβ The invention provides specific binding members, for example in the form of antibody variable domains, based on the CDR3 sequences of the antibody VH regions of SL15 (SEQ ID NO:4) and JT182 (SEQ ID NO:10). The antibodies have strong neutralising activity for TGFβ	12/19/2006
7138116	Antithrombotic agent and humanized anti-von Willebrand factor monoclonal antibody Anti-thrombotic agents containing humanized antibodies which bind to von Willebrand factor. ...	11/21/2006
7132510	Specific human antibodies for selective cancer therapy The present invention is directed to novel peptides and polypeptides that specifically bind to target cells and may have anti-cancer activity, especially blood-related cancers. The present invention includes a peptide or polypeptide comprising an Fv molecule, having...	11/07/2006

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Class 530/388.25 - Binds plasma protein, serum protein, or fibrin (e.g., clotting factor, fibrinolytic factor, complement factor, immunoglobulin, apolipoprotein, etc.)