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| Number | Title | Issue Date |
| 8168762 | Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9) Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 ... | 05/01/2012 |
| 8168761 | Antibody to SOST peptides The present invention is directed to isolated polypeptides and antibodies suitable for producing therapeutic preparations, methods, and kits relating to bone deposition. One objective of the present invention is to provide compositions that improve bone deposition. ... | 05/01/2012 |
| 8106167 | Human anti-NGF neutralizing antibodies as selective NGF pathway inhibitors This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also provides pharmaceutical compositions of these antibodies and methods for neutralizing NGF function, and pa... | 01/31/2012 |
| 8106164 | Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof The invention pertains to the development of antibodies that specifically bind amyloid beta protein (Abeta) in its protofibril conformation. The invention also comprises methods of using anti-Abeta protofibril antibodies to diagnose or treat Alzheimer's disease, Dow... | 01/31/2012 |
| 8106166 | Antibodies that bind specifically to phosphorylated β-catenin The present invention relates to a purified molecules, including antibodies, that bind specifically to murine β-catenin phosphorylated at amino acid position Serine552 and to orthologs thereof, such as mammalian orthologs, including human orthologs. Meth... | 01/31/2012 |
| 8106165 | Antibodies to HNFIP24 polypeptides The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted prote... | 01/31/2012 |
| 8030457 | Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9) Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 ... | 10/04/2011 |
| 7994294 | Nucleic acids and polypeptides related to a guanine exchange factor of Rho GTPase The present invention relates to all aspects of a guanine exchange factor (GEF), for example, a Rho-GEF, such as p115 Rho-GEF. A GEF modulates cell signaling pathways, both in in vitro and in vivo, by modulating the activity of a GTPase. By way of illustration, a p1... | 08/09/2011 |
| 7935796 | Monoclonal antibodies against ANGPTL3 Monoclonal antibodies that specifically bind to ANGPTL3 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL3 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided. ... | 05/03/2011 |
| 7897732 | Antibodies to heparin-binding growth factor (HBGF) polypeptides Substantially pure heparin-binding growth factor polypeptides (HBGFs), nucleic acids encoding the HBGFs and antibodies which bind to the HBGFs of the invention are provided. The HBGF polypeptides are useful in methods for the induction of bone, cartilage and tissue ... | 03/01/2011 |
| 7893218 | Antibodies that specifically bind SOST peptides The present invention is directed to isolated polypeptides and antibodies suitable for producing therapeutic preparations, methods, and kits relating to bone deposition. One objective of the present invention is to provide compositions that improve bone deposition. ... | 02/22/2011 |
| 7888486 | Antagonist antibodies against GDF-8 The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure al... | 02/15/2011 |
| 7888485 | Anti-pleiotrophin antibodies and methods of use thereof The present invention concerns antibodies that neutralize at least one biological activity of pleiotrophin. The antibodies can inhibit cancer cell growth and angiogenesis in vitro or in vivo. The present invention provides for methods of inhibiting cancer cell growt... | 02/15/2011 |
| 7884071 | Administration form for pharmaceutically active peptides with sustained release and method for the production thereof The invention relates to pharmaceutical administration forms with sustained release comprising at least one pharmacologically active peptide. The invention also relates to a method for the production thereof, a kit comprising a lyophilised peptide and an aqueous sol... | 02/08/2011 |
| 7872106 | Sclerostin-binding antibodies Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided. ... | 01/18/2011 |
| 7851601 | Monoclonal antibody capable of binding to heparin-binding epidermal growth factor-like growth factor Medicaments for treating diseases related to HB-EGF escalation are in demand. The present invention provides a monoclonal antibody or an antibody fragment thereof which binds to a cell membrane-bound HB-EGF, a membrane type HB-EGF and a secretory HB-EGF. ... | 12/14/2010 |
| 7842790 | Antibodies against human parathyroid hormone related protein Disclosed are an antibody against human para-thyroid-hormone-related protein, a DNA coding for the antibody, a recombinant vector containing the DNA, a transformant transformed with the recombinant vector, a method for preparation of the antibody, and uses of the an... | 11/30/2010 |
| 7790864 | Antibody to BACE455, an alternative splice variant of the human beta-secretase The present invention relates generally to the fields of genetics, biochemistry, medicinal chemistry and medicine. The present invention more particularly discloses the identification of a human gene variant involved in neuropathological conditions, and methods for ... | 09/07/2010 |
| 7709611 | Antibodies to Dkk-1 The present invention provides antibodies and immunologically functional fragments thereof that specifically bind Dkk-1 polypeptides. The subject antibodies and fragments bind with high affinity to a conformational epitope located in the carboxy region of the Dkk-1 ... | 05/04/2010 |
| 7691979 | Anti-metastin antibody and its use The present invention aims at providing an antibody, by which metastin or its derivative can be quantified specifically with a high sensitivity, a method of detecting/quantifying metastin or its derivative using the antibody, and a diagnostic agent (e.g., a diagnost... | 04/06/2010 |
| 7649082 | Persephin specific antibodies A novel growth factor, persephin, which belongs to the GDNF/neurturin family of growth factors, is disclosed. The human, mouse and rat amino acid sequences have been identified. Human, mouse and rat persephin genomic DNA sequences have been cloned and sequenced and ... | 01/19/2010 |
| 7649083 | Hepatocyte growth factor (HGF) binding antibody The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic a... | 01/19/2010 |
| 7612183 | Humanised anti-mag antibody or functional fragment thereof The present invention relates to altered antibodies to myelin associated glycoprotein (MAG), pharmaceutical formulations containing them and to the use of such antibodies in the treatment and/or prophylaxis of neurological diseases/disorders. ... | 11/03/2009 |
| 7601818 | Human anti-NGF neutralizing antibodies as selective NGF pathway inhibitors This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing NGF function, and par... | 10/13/2009 |
| 7592429 | Sclerostin-binding antibody Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided. ... | 09/22/2009 |
| 7511123 | Immuno-interactive fragments of the alpha-C subunit of inhibin Novels immuno-interactive fragments of the (alpha)C portion of a mammalian inhibin alpha subunit are disclosed, together with their variants and derivatives for producing antigen-binding molecules that are interactive with said (alpha)C portion, which are chemically... | 03/31/2009 |
| 7438908 | Anti-human tenascin monoclonal antibody A novel anti-human tenascin ST2146 monoclonal antibody is described endowed with high affinity with the native antigen and high tumor selectivity. The cST2146 hybridoma is stably producing the antibody in high density culture conditions and is suitable for the indus... | 10/21/2008 |
| 7439329 | GEF-H1b: biomarkers, complexes assays and therapeutic uses thereof The present invention relates to diagnosing abnormal cell proliferation in biological samples and screening for drugs which inhibit, reduce or abolish cell growth, especially tumorigenic cell growth, by detecting a phosphovariant isoform of a guanine nucleotide exch... | 10/21/2008 |
| 7425329 | Methods for treating bone cancer pain by administering a nerve growth factor antagonist The invention features methods and compositions for preventing or treating bone cancer pain including cancer pain associated with bone metastasis by administering an antagonist of nerve growth factor (NGF). The NGF antagonist may be an anti-NGF (such as anti-hNGF) a... | 09/16/2008 |
| 7411049 | Hybridoma cell lines and monoclonal antibodies recognizing Prox1 Monoclonal antibodies to Prox1 of vertebrates (pfam05044.5; NM_002763.3) and two continuous cell lines for their production are disclosed. These antibodies are particularly useful in immunoassays to detect the presence of Prox1 protein in vertebrate tissues and cell... | 08/12/2008 |
| 7410639 | Vascular endothelial growth factor D(VEGF-D) antibodies and methods of use VEGF-D, a new member of the PDGF family of growth factors, which among other things stimulates endothelial cell proliferation and angiogenesis and increases vascular permeability, as well as nucleotide sequences encoding it, methods for producing it, antibodies and ... | 08/12/2008 |
| 7408043 | Neutralizing antibody against HGF The neutralizing antibody against HGF binding to the inventive neutralizable epitope of HGF is capable of neutralizing HGF as a single agent, and can be effectively used for preventing and treating intractable diseases and cancers that are caused by binding of HGF t... | 08/05/2008 |
| 7402313 | Method for controlling preeclampsia and eclampsia A method of controlling preeclampsia includes the steps of providing a supply of digoxin immune Fab (ovine), calculating an appropriate dosage of the digoxin immune Fab (ovine) based on a patient's weight and using an assumed endogenous digitalis-like factor level, ... | 07/22/2008 |
| 7399636 | Diagnostic kit for predicting pregnancy outcome The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early ... | 07/15/2008 |
| 7396917 | Rationally designed antibodies Antibodies or fragments thereof having at least two CDR regions replaced or fused with biologically active peptides are described. Compositions containing such antibodies or fragments thereof are useful in therapeutic and diagnostic modalities. ... | 07/08/2008 |
| 7393662 | Human EPO mimetic hinge core mimetibodies, compositions, methods and uses The present invention relates to at least one novel human EPO mimetic hinge core mimetibody or specified portion or variant, including isolated nucleic acids that encode at least one EPO mimetic hinge core mimetibody or specified portion or variant, EPO mimetic hing... | 07/01/2008 |
| 7371384 | Compositions and methods of using angiopoietin-like 4 protein antibody ANGPTL4 compositions and methods of using such compositions, and agonists or antagonists thereof, for the diagnosis and treatment of diseases or disorders are included, including methods to modulate cell proliferation, cell adhesion, and cell migration. ... | 05/13/2008 |
| 7364910 | Methods of inducing ovulation The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific admini... | 04/29/2008 |
| 7364736 | Antibodies to OPGL Antibodies that interact with osteoprotegerin ligand (OPGL) are described. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are described. Methods of detecting the amount of OPGL in a sample using an... | 04/29/2008 |
| 7342105 | Antibody and use thereof The antibody of the present invention, which specifically reacts with the N-terminal or C-terminal partial peptide of TGR23-2 ligand, is useful in detecting and quantifying the TGR23-2 ligand. Moreover, it is useful as a preventing/treating agent and a diagnostic ag... | 03/11/2008 |
