Did You Know...
...that the x-ray was discovered purely by accident? When German physicist Wilhelm Konrad von Roentgen was experimenting with cathode rays in 1895, he put an activated Crookes tube in a book and went out to lunch. When he returned, he discovered that a key that had also been placed in the book showed up as an image on the developed film!
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| Number | Title | Issue Date |
| 8110663 | Monoclonal antibodies for cartillage oligomeric matrix protein The present invention provides a new sensitive direct sandwich assay for determining the presence of COMP in a clinical sample. Two monoclonal antibodies directed against separate antigenic determinants of the COMP molecules are used in the assay. The invention also... | 02/07/2012 |
| 8101725 | Monoclonal antibodies to basic fibroblast growth factor The present invention is directed toward a neutralizing monoclonal antibody to basic fibroblast growth factor, a pharmaceutical composition comprising same, and methods of treatment comprising administering such a pharmaceutical composition to a patient. ... | 01/24/2012 |
| 8076460 | Antibody and inhibitor, and transfection method or kit using them The present invention provides a monoclonal antibody which specifically binds to human Toll-like receptor 3 and inhibits production of type 1 interferon. It also provides an inhibitor which (a) suppresses a double-stranded RNA-mediated immune response in a cell whic... | 12/13/2011 |
| 8071732 | Compositions and methods for the detection, diagnosis and therapy of hematological malignancies Disclosed are methods and compositions for the detection, diagnosis, prognosis, and therapy of hematological malignancies, and in particular, B cell leukemias, lymphomas and multiple myelomas. Disclosed are compositions, methods and kits for eliciting immune and T c... | 12/06/2011 |
| 8067550 | Hybridomas producing antibodies against non functional P2X7 receptor The present invention relates to the production of anti non functional P2X7 receptor monoclonal antibodies from hybridoma cell lines. ... | 11/29/2011 |
| 8058404 | MCM6 and MCM7 monoclonal antibodies and methods for their use in the detection of cervical disease Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to MCM6 or MCM7. Monoclonal antibodies having the b... | 11/15/2011 |
| 8058405 | Antibodies specific for N-terminal truncated and pyroglutamate modified amyloid-beta peptides The present invention pertains to novel diagnostic assays for the diagnosis of amyloidosis, in particular Alzheimer's disease, and related aspects. In particular, monoclonal antibodies and an antibody assay are provided. ... | 11/15/2011 |
| 8039596 | Alpha 5-beta 1 antibodies and their uses The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin α5β1 with high affinity. Nucleic acid molecules encoding the antibodies of the disclos... | 10/18/2011 |
| 8030456 | Nogo receptor antagonists Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are compositions comprising, and methods for... | 10/04/2011 |
| 8013128 | Antibodies and related molecules that bind to PSCA proteins Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA ... | 09/06/2011 |
| 8008448 | Cotinine neutralizing antibody The present application discloses monoclonal antibody against cotinine and nicotine. ... | 08/30/2011 |
| 8008447 | Crystallization of antibody or fragment thereof The present disclosure concerns methods of crystallization and/or concentration of antibody or antibody fragments. The methods comprise contacting an antibody or antibody fragment with a solution comprising a salt of a divalent cation. Crystals and/or protein gels o... | 08/30/2011 |
| 8003765 | Methods, antibodies and kits for detecting cerebrospinal fluid in a sample The present disclosure relates to detection of the presence or absence of cerebrospinal fluid (CSF) in a sample, in particular to the analysis of the CSF protein lipocalin-type prostaglandin D2 synthase (L-PGDS). The present disclosure provides assays for the analys... | 08/23/2011 |
| 8003766 | Monoclonal antibody specific to ochratoxin A This invention provides a monoclonal antibody specific to ochratoxin A and methods of assaying the level of ochratoxin A in food and feed. ... | 08/23/2011 |
| 7989595 | Compositions and methods for the diagnosis and treatment of tumor The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. ... | 08/02/2011 |
| 7989596 | Method of altering the binding specificity of monoclonal antibodies by oxidation-reduction reactions The binding specificity of a monoclonal antibody is altered by exposing the monoclonal antibody to an oxidizing agent or an electric potential. ... | 08/02/2011 |
| 7977463 | Polypeptide compounds for inhibiting angiogenesis and tumor growth In certain embodiments, this present invention provides polypeptide compositions (e.g., antibodies and antigen binding portions thereof that bind to EphB4), and methods for inhibiting EphB4 activity. In other embodiments, the present invention provides methods and c... | 07/12/2011 |
| 7973140 | Antibodies directed to angiopoietin-2 and uses thereof Antibodies directed to the antigen Ang-2 and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the antigen Ang-2. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobul... | 07/05/2011 |
| 7968690 | Agonist anti-trkC antibodies and methods using same The invention concerns agonist anti-trkC antibodies, polypeptides, and polynucleotides encoding the same. The invention further concerns use of such antibodies, polypeptides and/or polynucleotides in the treatment and/or prevention of neuropathies, such as sensory n... | 06/28/2011 |
| 7964707 | Anti-IL2 antibodies The invention relates to a humanized monoclonal antibody or fragment thereof which specifically binds to human interlukin-2 (IL2), whereby said humanized monoclonal antibody neutralizes the activity of human IL2 by binding to the human IL2 prior to, during, and/or s... | 06/21/2011 |
| 7964708 | Anti-TSG101 antibodies and their uses for treatment of viral infections The present invention provides antibodies that bind to the C-terminal region of TSG101. The invention also provides methods of using the TSG101 antibodies for the treatment of viral infections, including HIV and Ebola virus infection. ... | 06/21/2011 |
| 7928204 | Spore specific antigen The invention relates to a Bacillus spore specific antigen. Compositions and methods relating to the antigen are provided along with antibodies against the antigen. The antigen is specific for Bacillus spores relative to the vegetative form of the cell... | 04/19/2011 |
| 7915389 | Anti-acharan sulfate antibody and its application An anti-acharan sulfate antibody, a hybridoma that produces the antibody, a detection method and a detection kit to which the antibody is applied are disclosed. The anti-acharan sulfate antibody can be produced by immunizing a mammal using as an antigen a substance ... | 03/29/2011 |
| 7893216 | Anti-human trail receptor DR5 monoclonal antibody (AD5-10), method thereof and use of the same The present invention discloses a monoclonal antibody against the extracellular domain of human tumor necrosis factor-related apoptosis-inducing ligand receptor DR5 (death receptor 5). The present invention also provides a method of producing the monoclonal antibody... | 02/22/2011 |
| 7888481 | Anti-interferon alpha monoclonal antibodies and methods for use The present invention includes compositions and methods that include antibodies that selectively neutralize a bioactivity of at least two interferon alpha (“IFNα”) protein subtypes for the protein subtypes A, 2, B2, C, F, G, H2, I, J1, K, 4a, 4b and WA, but doe... | 02/15/2011 |
| 7879983 | Binding member which binds to both Lewis-and Lewis-haptens, and its use for treating cancer The invention relates to the use of a binding member which binds to Lewisy and Lewisb haptens in the treatment of tumours and leukaemia. The binding member may be an antibody which binds to Lewisy and Lewisb haptens and ca... | 02/01/2011 |
| 7872105 | Anticarcinoma antibodies and uses thereof A novel single domain antibody AFAI and fragments thereof which has specific affinity for binding to carcinoma, and especially lung carcinoma. This antibody, and portions thereof, can be used, inter alia in the diagnosis and treatment of carcinoma. ... | 01/18/2011 |
| 7872104 | Antibody, immunoassay and method for prostate cancer detection This invention concerns an antibody which binds with high affinity to human single-chain intact, i.e. not internally cleaved, mature and/or zymogen forms of prostate specific antigen (SCINT PSA). The antibody does not bind to a nicked PSA (PSA-N), wherein said PSA-N... | 01/18/2011 |
| 7863425 | Compositions and methods for inhibiting infection The invention provides a gene transfer vector for inducing an immune response against Yersinia pestis in a mammal. The gene transfer vector comprises a nucleic acid sequence encoding an immunogenic portion of one or more proteins of Yersinia pestis and... | 01/04/2011 |
| 7858756 | Monoclonal antibodies that selectively recognize methamphetamine and methamphetamine like compounds The invention generally relates to monoclonal antibodies that recognize at least one compound from the group consisting of (+) methamphetamine, (+) amphetamine, and (+) 3,4-methylenedioxymethamphetamine ((+) MDMA). Generally speaking, the monoclonal antibodies do no... | 12/28/2010 |
| 7858755 | Monoclonal antibodies that bind Chemerin polypeptide The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful f... | 12/28/2010 |
| 7847070 | LUCA2 and antibodies that bind thereto The invention provides the identification and characterization of disease and cancer-associated antigen, LUCA2. The invention also provides a family of monoclonal antibodies that bind to antigen LUCA2, methods of diagnosing and treating various human cancers and dis... | 12/07/2010 |
| 7829678 | Recombinant monoclonal antibodies and corresponding antigens for colon and pancreatic cancers The present invention provides for recombinant monoclonal antibodies that bind to human colorectal and pancreatic carcinoma-associated antigens, along with nucleic acid sequences encoding the antibody chains, and the amino acid sequences corresponding to the nucleic... | 11/09/2010 |
| 7829677 | Antibodies that recognize hyperproliferative cells and methods of making and using same The invention relates to antibodies that bind to antigens, such as antigens associated with hyperproliferating cells, and methods of treating hyperproliferative disorders. The invention antibodies are useful for treating hyperproliferative disorders, such as neoplas... | 11/09/2010 |
| 7825222 | Therapeutic binding molecules A molecule comprising at least one antigen binding site, comprising in sequence the hypervariable regions CDR1, CDR2 and CDR3, said CDR1 having the amino acid sequence Asn-Tyr-Ile-Ile-His (NYIIH), said CDR2 having the amino acid sequence Tyr-Phe-Asn-Pro-Tyr-Asn-His-... | 11/02/2010 |
| 7820797 | Glycolipopeptide antibodies A glycolipopeptide comprising a carbohydrate component, a peptide component and a lipid component, for use as a therapeutic or prophylactic vaccine. Also provided are monoclonal and polyclonal antibodies that recognize the glycolipopeptide of the invention, as well ... | 10/26/2010 |
| 7812135 | GITR-binding antibodies The present invention provides binding molecules that specifically bind to GITR, e.g., human GITR (hGITR), on T cells and dendritic cells. Binding molecules of the invention are characterized by binding to hGITR with high affinity, in the presence of a stimulating a... | 10/12/2010 |
| 7807797 | Human monoclonal antibodies to CTLA-4 In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucleotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, ... | 10/05/2010 |
| 7790862 | IL-17 and IL-23 antagonists and methods of using the same The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17, IL-23 via it's p19 subunit or both IL-17 and IL-23 (via p19). IL-17 and IL-23 are cytokines that are involved in inflammatory processes and human dis... | 09/07/2010 |
| 7786273 | Macromolecules comprising a thioether cross-link The present invention provides macromolecules comprising at least one thioether cross-link. A thioether cross-link comprising a single thioether bond between two residues of a macromolecule. The macromolecules of the invention can display enhanced stability, pharmac... | 08/31/2010 |
