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| Number | Title | Issue Date |
| 8110661 | Anti-IP-10 antibodies and methods of use thereof The invention relates to fully human antibodies, and fragments thereof, that bind to interferon-inducible-protein-10 (IP-10, CXCL10), thereby modulating the interaction between IP-10 and its receptor, CXCR3, and/or modulating the biological activities of IP-10. The ... | 02/07/2012 |
| 8106161 | Binding domain-immunoglobulin fusion proteins The invention relates to novel binding domain-immunoglobulin fusion proteins that feature a binding domain for a cognate structure such as an antigen, a counterreceptor or the like, a hinge region polypeptide having either zero or one cysteine residue, and immunoglo... | 01/31/2012 |
| 8101719 | Humanized anti-CD47 antibody The present invention relates to humanized antibodies binding to CD47; diabodies binding to human CD47, characterized in that a disulfide bond exists between diabody-forming fragments; genes encoding any one of said antibodies; vectors containing said genes; host ce... | 01/24/2012 |
| 8101720 | Immunoglobulin insertions, deletions and substitutions An Fc variant of a parent Fc polypeptide, wherein said Fc variant exhibits altered binding to one or more FcγRs, wherein said Fc variant comprises at least one amino acid insertion in the Fc region of said parent Fc polypeptide. ... | 01/24/2012 |
| 8101721 | Antibodies blocking fibroblast growth factor receptor activation and methods of use thereof The present invention is related to antibodies with binding affinity to fibroblast growth factor receptor 2 (FGFR2) optionally with binding affinity to other FGF receptors, which block both ligand-dependent and constitutive ligand independent receptor activation. Sp... | 01/24/2012 |
| 8097704 | Antibody specifically binding to DR5 and composition for preventing or treating cancers comprising the same The present invention provides an antibody specifically binding to death receptor 5 (DR5), which is selected from the group consisting of: an antibody comprising a heavy chain variable region (VH) having the amino acid sequences of SEQ ID NOs: 1 to 3 at c... | 01/17/2012 |
| 8097703 | CD19 antibodies and their uses The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to CD19 with high affinity. Nucleic acid molecules encoding such CD19 antibodies, expression vectors, host cells and methods for expressin... | 01/17/2012 |
| 8093359 | Optimized Fc variants and methods for their generation The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants. ... | 01/10/2012 |
| 8093357 | Optimized Fc variants and methods for their generation The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants. ... | 01/10/2012 |
| 8093358 | Methods of treatment using anti-erbb antibody-maytansinoid conjugates The application concerns methods of treatment using anti-ErbB receptor antibody-maytansinoid conjugates, and articles of manufacture suitable for use in such methods. In particular, the invention concerns ErbB receptor-directed cancer therapies, using anri-ErbB rece... | 01/10/2012 |
| 8088896 | Generation and profiling of fully human gold-derived therapeutic antibodies specific for human CD38 The present invention provides novel antibodies and functional fragments thereof specific for CD38, and methods for using the same. These antibodies as well as the novel methods for using those antibodies can be used to treat, for example, hematological malignancies... | 01/03/2012 |
| 8088897 | Assay method for group transfer reactions An isolated antibody produced against a donor product of an enzymatically catalyzed group transfer reaction is disclosed. In one aspect, the antibody has the ability to preferentially recognize the donor-product guanosine diphosphate (GDP), in the presence of the do... | 01/03/2012 |
| 8088895 | Antibodies that bind CXCR7 epitopes Antibodies that bind CXCR7 epitopes, as well as methods of identifying CXCR7 modulators are described. ... | 01/03/2012 |
| 8084583 | RS7 antibodies This invention relates to monovalent and multivalent, monospecific binding proteins and to multivalent, multispecific binding proteins. One embodiment of these binding proteins has one or more binding sites where each binding site binds with a target antigen or an e... | 12/27/2011 |
| 8084582 | Optimized anti-CD20 monoclonal antibodies having Fc variants The present invention relates to optimized CD20 antibodies having Fc variants, methods for their generation, and method for their application, such as methods of enhancing macrophage activation, particularly for therapeutic purposes. ... | 12/27/2011 |
| 8080636 | BSL3 antibodies The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related p... | 12/20/2011 |
| 8076458 | Anti-claudin-4 antibody An object of the present invention is to provide a monoclonal antibody which is useful as a diagnostic agent or a therapeutic agent for a disease relating to a polypeptide encoded by Claudin-4 (hereinafter referred to as “CLDN4”) gene or a polypeptide encoded by... | 12/13/2011 |
| 8071729 | Anti-integrin antibodies, compositions, methods and uses The present invention relates to at least one novel anti-alpha-V subunit antibodies, including isolated nucleic acids that encode at least one anti-alpha-V subunit antibody, alpha-V subunit, vectors, host cells, transgenic animals or plants, and methods of making an... | 12/06/2011 |
| 8071730 | Anti-JAM-A antibodies The present invention relates to novel isolated antibodies, derived compounds, and functional isolated antibody fragments, capable of inhibiting the proliferation of tumor cells in vitro and/or in vivo and obtained by functional screening. More particularly, ... | 12/06/2011 |
| 8067545 | Isolated antibodies against biologically active leptin-related peptides The present invention relates to methods and compositions containing novel leptin peptides, preferably for the modulation of body mass (i.e., weight), more specifically for novel diagnostic and therapeutic applications in homeostasis of body weight and adipose tissu... | 11/29/2011 |
| 8067544 | Antibodies against T cell immunoglobulin domain and mucin domain 1 (TIM-1) antigen and uses thereof The invention described herein is related to antibodies directed to the antigen TIM-1 and uses of such antibodies. In particular, there are provided fully human monoclonal antibodies directed to the antigen TIM-1. Isolated polynucleotide sequences encoding, and amin... | 11/29/2011 |
| 8063186 | Antibodies to PRO7436 polypeptides The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 11/22/2011 |
| 8063187 | Methods and compositions for inhibiting CD32B expressing cells The present invention relates to immunoglobulins that bind FcγRIIb+ cells and coengage the antigen on the cell's surface and an FcγRIIb on the cell's surface, methods for their generation, and methods for using the immunoglobulins. ... | 11/22/2011 |
| 8058399 | Multispecific reagent for selectively stimulating cell surface receptors A multispecific reagent has at least one first binding site for a cell surface receptor which requires multimeric ligand binding to be stimulated. The reagent possesses a second binding site for a target antigen which is expressed on the same cell as the cell surfac... | 11/15/2011 |
| 8058400 | Composition and method for modulating dendritic cell-t cell interaction The present invention relates to the use of a compound that binds to a C-type lectin on the surface of a dendritic cell, in the preparation of a composition for modulating, in particular reducing, the immune response in an animal, in particular a human or another ma... | 11/15/2011 |
| 8058401 | Immunogenic compositions and uses thereof The present invention relates generally to a method of eliciting or otherwise inducing an effective immune response to a micro-organism and compositions for use therein. More particularly, the present invention relates to a method of inducing an immune response to a... | 11/15/2011 |
| 8048993 | Heparanase specific molecular probes and their use in research and medical applications According to the present invention there is provided an antibody that specifically binds an epitope of a heparanase protein, the heparanase protein including an amino acid sequence as set forth in SEQ ID NO:2, provided that phenylalanine replaces tyrosine at positio... | 11/01/2011 |
| 8048994 | C-type lectin polypeptide, polynucleotide and methods of making and use thereof Provided herein are polypeptide and polynucleotide sequences for a molecule having homology to the C-type lectin family of polypeptides. Also provided are methods of making and using the polypeptide and polynucleotides. ... | 11/01/2011 |
| 8048992 | Anti-IgSF4 antibody and utilization of the same It is intended to clarify a molecule which is available as a target in treating or diagnosing cancer and utilize the molecule in the medical field or the research field. By treating IgSF4, which has been identified as a molecule specifically expressed in lung cancer... | 11/01/2011 |
| 8048991 | Antibody to an integrin heterodimer and/or a subunit thereof A recombinant or isolated integrin heterodimer comprising a novel subunit α10 in association with a subunit β is described. The α10 integrin may be purified from bovine chondrocytes on a collagen-type-II affinity column. The integrin or the subunit of α10 can be... | 11/01/2011 |
| 8044180 | FcγRIIB specific antibodies and methods of use thereof The present invention relates to antibodies or fragments thereof that specifically bind FcγRIIB, particularly human FcγRIIB, with greater affinity than said antibodies or fragments thereof bind FcγRIIA, particularly human FcγRIIA. The invention provides methods ... | 10/25/2011 |
| 8044181 | Antibodies to the PcrV antigen of The current invention provides high-affinity antibodies to the Pseudomonas aeruginosa PcrV protein that have reduced immunogenicity when administered to treat Pseudomonas aeruginosa infections. ... | 10/25/2011 |
| 8044178 | Anti-5T4 antibodies and uses thereof Anti-5T4 antibodies, anti-5T4 antibody/drug conjugates, and methods for preparing and using the same. ... | 10/25/2011 |
| 8044179 | Methods and compositions for modulating tumor cell activity Antibodies which target clusterin, a protein involved in the epithelial-to-mesenchymal transition of carcinoma cells, are identified and characterized. The antibodies may be used to modulate tumour cell activity through binding to clusterin. ... | 10/25/2011 |
| 8039592 | Optimized Fc variants and methods for their generation The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants. ... | 10/18/2011 |
| 8039593 | Antibodies and immunotoxins that target human glycoprotein NMB The invention provides high affinity antibodies suitable for forming immunotoxins that inhibit the growth of cells expressing human glycoprotein NMB, including glioblastoma multiform cells, anaplastic astrocytoma cells, anaplastic oligodendroglioma cells, oligodendr... | 10/18/2011 |
| 8034902 | Recombinant antibodies against CD55 and CD59 and uses thereof The present invention relates to recombinant antibody molecules and functional fragments thereof, useful for neutralizing the complement regulatory proteins CD55 and CD59, compositions comprising the recombinant molecules and methods of using the recombinant molecul... | 10/11/2011 |
| 8030453 | Methods of making an antibody that binds a chemerin polypeptide The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful f... | 10/04/2011 |
| 8026342 | Compositions and methods for binding sphingosine-1-phosphate The present invention relates to anti-S1P agents, for example, humanized monoclonal antibodies, and their uses for detection of S1P or for treatment of diseases and conditions associated with S1P. ... | 09/27/2011 |
| 8022189 | Isolated antibodies against biologically active leptin-related peptides The present invention relates to methods and compositions containing novel leptin peptides, preferably for the modulation of body mass (i.e., weight), more specifically for novel diagnostic and therapeutic applications in homeostasis of body weight and adipose tissu... | 09/20/2011 |
