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...that Kleenex tissue was originally designed to be a gas mask filter? It was developed at the beginning of World War I to replace cotton, which was then in short supply as a surgical dressing.
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| Number | Title | Issue Date |
| 7232805 | Cobalamin conjugates for anti-tumor therapy The present invention provides a cobalamin-drug conjugate suitable for the treatment of tumor related diseases. Cobalamin is indirectly covalently bound to an anti-tumor drug via a cleavable linker and one or more optional spacers. Cobalamin is covalently bound to a... | 06/19/2007 |
| 7229967 | Oxygenated albumin for use as blood and blood extender The compositions described herein comprise oxygenated albumin in an aqueous sterile physiological or serum solution. The albumin is oxygenated to increase the oxygen content up to O2 saturation with clinically useful oxygen gas. The preferred oxygen-satur... | 06/12/2007 |
| 7208528 | Polyamine analogues as therapeutic and diagnostic agents Novel inhibitors of polyamine transport having inhibition constants two orders of magnitude lower than those of known compounds are disclosed. These polyamine analogues are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine t... | 04/24/2007 |
| 7198958 | Method for increasing hydrophilicity of fluorescent label compounds A fluorescent label compound of formula where Z is a reactive group that can be used for covalent coupling of the fluorescent label compound to other molecule. Either the fluorophore is a dipyrrometheneboron difl... | 04/03/2007 |
| 7160923 | Polyamine analogues as therapeutic and diagnostic agents Novel inhibitors of polyamine transport having inhibition constants two orders of magnitude lower than those of known compounds are disclosed. These polyamine analogues are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine t... | 01/09/2007 |
| 7150967 | Fluorescent tags for amino acid and nucleic acid analysis Methods and kits for labeling and detecting thiol containing species and nucleic acids using mercurimethyl-dihydropsoralen compounds and derivatives thereof which intercalate nucleic acids and are highly reactive with thiol containing species are provided. Fluoresce... | 12/19/2006 |
| 7129210 | Tissue adhesive sealant A tissue adhesive sealant includes a cross-linkable protein in a solution that when combined with a cross-linking agent solution including an aldehyde and amino acid containing species reactive with the aldehyde cross-links to form a seal. The sealant is well suited... | 10/31/2006 |
| 6995252 | PT32 sperm protein, sperm c-Yes, oocyte cytoplasmic c-Yes and uses thereof The perinuclear theca 32 (PT32) protein is disclosed and shown to interact with tyrosine kinase c-Yes. PT32, c-Yes, fragments thereof, and molecules that bind thereto can be used in methods of enhancing fertility, treating or diagnosing diminished fertility and abno... | 02/07/2006 |
| 6905884 | Fluorescent cobalamins and uses thereof The present invention relates to fluorescent cobalamins and uses of these compounds. More particularly, this invention relates to fluorescent cobalamins that comprise a fluorescent, phosphorescent, luminescent or light-producing compound covalently linked to cobalam... | 06/14/2005 |
| 6620778 | Cysteine/glycine rich peptides Described is a method for the preparation of a mixture of peptides having a cysteine content between 7-20 w/w % from a protein source, comprising cysteine containing proteins, comprising the steps of: a) cleaving the proteins of the protein source into pep... | 09/16/2003 |
| 6506570 | Method of sorting birds in ovo A method of determining the gender of a bird in ovo comprises detecting the presence or absence of an elevated level of a sex-related hormone in the extra-embryonic fluid of the bird egg, and then determining the gender of the bird within the egg from the... | 01/14/2003 |
| 6495344 | Phenylalanine-free protein and DNA coding therefor A DNA molecule coding for a food protein, such as ovalbumin or casein, modified so that the codons for phenylalanine have been omitted or replaced by codons for one or more other metabolisable amino acids. Also a modified edible protein coded for by such ... | 12/17/2002 |
| 6429297 | Modified avidin and streptavidin and methods of use thereof The present invention relates to a compound of the formula ##STR1## These modified streptavidin compounds have are useful as part of a delivery system to deliver a molecule to a target site for use in diagnosis or therapy.... | 08/06/2002 |
| 6391047 | Repair of ruptured membrane by injection of naturally occurring protein in amniotic fluid sac The present invention provides compositions and methods for use in treatment of premature rupture of membrane. The compositions of the invention include a therapeutic amount of an avian thick egg white composition. Preferably, the compositions include the... | 05/21/2002 |
| 6270983 | Surfaces coated with streptavidin/avidin The invention relates to surfaces coated with streptavidin and avidin for use in immunoassays, wherein the surfaces comprise a layer of streptavidin and avidin which are bonded on a surface of a solid supporting material through a biotinylated adhering ag... | 08/07/2001 |
| 6217869 | Pretargeting methods and compounds Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed.... | 04/17/2001 |
| 6214974 | Avidin-biotin immunoconjugates The present invention provides a non-viral vector, comprising a cell binding component having a biotin-binding element conjugated to a biotinylated moiety. Also, provided is a method of introducing genetic material inside a specific cell comprising the ad... | 04/10/2001 |
| 6083926 | Water soluble vitamin B12 receptor modulating agents and methods related thereto Vitamin B12 receptor modulating agents capable of modulating cell surface receptors by affecting the cell surface receptor trafficking pathway are disclosed. The vitamin B12 receptor modulating agents are comprised of a covalently bo... | 07/04/2000 |
| 6045799 | Chimeric contraceptive vaccines The invention is directed to contraceptive vaccines comprising a carrier protein or fragment thereof in peptide linkage with a reproduction related polypeptide, protein or fragment thereof, and to DNAs encoding the chimeric proteins. The invention also in... | 04/04/2000 |
| 6046024 | Method of producing a fibrin monomer using a biotinylated enzyme and immobilized avidin Compositions and methods for avidin immobilized on an inert support material, e.g. agarose, are disclosed. The compositions have high activity levels of avidin and may further include a bulking agent, e.g., maltose, and a protectant to maintain the stabil... | 04/04/2000 |
| 6013770 | Chimeric contraceptive vaccines The invention is directed to contraceptive vaccines comprising a carrier protein or fragment thereof in peptide linkage with a reproduction related polypeptide, protein or fragment thereof, and to DNAs encoding the chimeric proteins. The invention also in... | 01/11/2000 |
| 5998155 | Stable composition of immobilized protein having affinity for biotin Compositions and methods for avidin or protein having affinity for biotin immobilized on an inert support material, e.g., agarose, are disclosed. The compositions have high activity levels for binding biotin and may include a bulking agent, e.g., maltose,... | 12/07/1999 |
| 5973124 | Modified avidin and streptavidin molecules and use thereof Biotin-binding modified avidin-type molecules are provided in which the essential tyrosine residue in the biotin-binding site is modified in such a way that its pKa is decreased in comparison to the pKa of the unmodified tyrosine residue in the correspond... | 10/26/1999 |
| 5922302 | Detection and therapy of lesions with biotin/avidin-metal chelating protein conjugates Improved methods of detecting and/or treating lesions in a patient are provided. The improved methods comprise the steps of (a) parenterally injecting a subject with a targeting composition comprised of a conjugate of biotin and targeting protein or of an... | 07/13/1999 |
| 5914312 | Pretargeting methods and compounds Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, methods for radiometal labeling of biotin and for improved radiohalogenation of biotin, as well as related com... | 06/22/1999 |
| 5911969 | Pretargeting protocols for enhanced localization of active agents to target sites Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, methods for radiometal labeling of biotin and for improved radiohalogenation of biotin, as well as related com... | 06/15/1999 |
| 5883231 | Artificial menses fluid There is provided a bodily fluid simulant made from red blood cells in an amount between about 10 and about 60 weight percent, egg white in an amount between 20 and 50 weight percent, and plasma.... | 03/16/1999 |
| 5863740 | Interference eliminating agent for application in immunoassays The invention concerns interference-eliminating agents for avoiding unspecific interactions in immunoassays in which avidin or streptavidin or a derivative thereof are used as the interference-eliminating agents.... | 01/26/1999 |
| 5851795 | Soluble CTLA4 molecules and uses thereof The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybri... | 12/22/1998 |
| 5739287 | Biotinylated cobalamins A biotinylated cobalamin, formed from a vitamin B12 molecule coupled to a biotin molecule, is disclosed. In a preferred embodiment, the vitamin B12 molecule is cyanocobalamin. The biotin molecule can also be coupled to a rerouting mo... | 04/14/1998 |
| 5736119 | Detection and therapy of lesions with biotin/avidin-metal chelating protein conjugates Improved methods of detecting and/or treating lesions in a patient are provided. The improved methods comprise the steps of (a) parenterally injecting a subject with a targeting composition comprised of a conjugate of biotin and targeting protein or of an... | 04/07/1998 |
| 5707844 | Immunoassay reagents and methods for detecting brequinar and analogs The present invention is directed to immunoassay reagents including specific antibodies to quinoline carboxylic acids, such as brequinar; novel quinoline carboxylic acid haptens useful as standards in immunoassays or for conjugating to large molecular wei... | 01/13/1998 |
| 5698405 | Method of reducing immunogenicity The immunogenicity of avidin, a therapeutic agent moiety of a conjugate, or a targeting composition is reduced by coupling the immunogenic agent with a carbohydrate polymer or polyol groups, such as polysaccharides (e.g. dextran), polyethylene glycol and ... | 12/16/1997 |
| 5670629 | Ovoglycoprotein and agents for chromatographic separation containing same An ovoglycoprotein has a molecular weight of 30,000 daltons which is determined by a matrix-assisted laser desorption ionization time-of-flight type mass spectrometer, an amino acid sequence of 15 residues from the N-terminal represented by Thr-Glu-S... | 09/23/1997 |
| 5648468 | Process for identifying sex associated egg proteins and methods for increasing the probability that the avian offspring will be the desired sex A method for Avian sex-preselection by identifying sex-specific proteins for maternal immunization to embryonic proteins is described. Sex-preselection proteins are used in sexing offsprings.... | 07/15/1997 |
| 5578577 | Method for storing labile proteins The present invention relates to improved specific binding assay methods, kits and devices utilizing chromatographically mobile specific binding reagents labelled with colloidal particles. Specific binding reagents labelled with colloidal particles such a... | 11/26/1996 |
| 5545620 | Synthetic fibronectin fragments as inhibitors of retroviral infection The invention includes methods for inhibiting retroviral infections such as HIV. The methods of this invention involve the use of certain fragments of fibronectin and such fragments conjugated to carrier molecules such as ovalbumin to inhibit retroviral i... | 08/13/1996 |
| 5492839 | Immunogenic ryanodine derivative and related uses Disclosed is a novel photo-activatable derivative of ryanodine 9-hydroxy-21-(4-azidobenzoyloxy)-9-epiryanodine. This novel ryanodine derivative has been conjugated to keyhole limpet hemocyanin (KLH) and used for the production of antibodies with high affi... | 02/20/1996 |
| 5480973 | Gel products and a process for making them A proteinaceous product comprises a stable, substantially clear, thermally irreversible gel formed by the reaction product of protein and reducing sugar, preferably containing from 2 to 25% gel-forming protein by weight. Particles or pieces of edible mate... | 01/02/1996 |
| 5468486 | Vaccine containing a protein alkaloid conjugate for the treatment of fescue toxicosis A method for the treatment of the symptoms of fescue toxicosis in mammals comprising injecting a subject mammal with a vaccine which includes from about 5 μg to about 1 mg of a protein-alkaloid conjugate per mL of a physiologically acceptable carrier. Th... | 11/21/1995 |
