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| Number | Title | Issue Date |
| 8084580 | Therapeutic human albumin solutions with low prekallikrein activator (PKA) activity and process for obtaining them The invention discloses a purified albumin solution of human origin with low prekallicrein activator (PKA) activity and stability over time characterized in that it has an antithrombin content equal to or greater than 0.03 mg/g of albumin, and a process for producti... | 12/27/2011 |
| 7939632 | Proteolytically cleavable fusion proteins with high molar specific activity The invention relates to therapeutic fusion proteins in which a coagulation factor is fused to a half-life enhancing polypeptide, and in which both are connected by a linker peptide that is proteolytically cleavable. The cleavage of such linkers liberates the coagul... | 05/10/2011 |
| 7435410 | Methods of treatment with interferson and albumin fusion protein Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucl... | 10/14/2008 |
| 7410779 | Fusion polypeptides of human serum albumin and a therapeutically active polypeptide The invention includes biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant of human serum albumin, methods for the preparation of such fusion polypeptides, nucleotide sequences encoding such fusi... | 08/12/2008 |
| 7358379 | Steroid conjugates, preparation thereof and the use thereof Conjugates comprising one or more steroids conjugated with one or more mammalian proteins are disclosed. The conjugates are useful for diagnosis or treatment of solid cancer and hematological malignancies. Further the conjugates exhibit a synergistic action together... | 04/15/2008 |
| 7345150 | Albumin-based colloid composition having at least one protected thiol region, methods of making, and methods of use A composition comprising an albumin-based colloid composition having at least one protected thiol region, method of making the same, and method for use, including treating hypovolemic conditions such as capillary leak syndrome and shock, are disclosed. The compositi... | 03/18/2008 |
| 7332577 | Therapeutic human albumin solutions with low prekallikrein activator (PKA) activity and process for obtaining them The invention discloses a purified albumin solution of human origin with low prekallicrein activator (PKA) activity and stability over time characterised in that it has an antithrombin content equal to or greater than 0.03 mg/g of albumin, and a process for producti... | 02/19/2008 |
| 7271149 | GLP-1 fusion proteins The present invention relates to glucagon-like-1 compounds fused to proteins that have the effect of extending the in vivo half-life of the peptides. These fusion proteins can be used to treat non-insulin dependent diabetes mellitus as well as a variety of other con... | 09/18/2007 |
| 7238667 | Albumin fusion proteins The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic ac... | 07/03/2007 |
| 7229961 | Compositions and methods for enhancing drug delivery across and into ocular tissues This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including into and across ocular tissues and the like. The compositions and methods are also useful for delivery across endothelial tissues, ... | 06/12/2007 |
| 7223561 | Process of high purity albumin production A process is provided for the preparation of albumin which has extremely low levels of or is essentially free of colorants, metal ions, human proteins, host proteins, fragments of albumin, polymers or aggregates of albumin and viruses, and which is essentially non-g... | 05/29/2007 |
| 7220552 | Bifunctional molecules and their use in the disruption of protein-protein interactions Bifunctional inhibitor molecules and methods for their use in the inhibition of protein—protein interactions are provided. The subject bifunctional inhibitor molecules are conjugates of a target protein ligand and a blocking protein ligand, where these two moietie... | 05/22/2007 |
| 7220596 | Real time detection of antigens Antigens can be captured and detected from complex samples, such as food and environmental samples, in about 30 minutes using apparatus and methods that include flow of the samples through a module containing antibodies coupled to beads. The samples flow through the... | 05/22/2007 |
| 7208580 | Atomic structure of the hemalbumin complex and its use in designing therapeutic compounds A high resolution structure of the hemalbumin binding complex is provided which includes the detailed atomic coordinates which reflect the binding site and the binding characteristics of the structure. This high resolution structure can be used in methods of determi... | 04/24/2007 |
| 7202210 | Modified and stabilized GDF propeptides and uses thereof Modified and stabilized propeptides of Growth Differentiation Factor proteins, such as GDF-8 and Bone Morphogenetic Protein-11, are disclosed. Also disclosed are methods for making and using the modified propeptides to prevent or treat human or animal disorders in w... | 04/10/2007 |
| 7202041 | Immunoreaction measurement method The present invention relates to an immunoreaction measuring method for measuring an antigen or antibody contained as a subject substance in a sample, wherein the sample was mixed with at least one compound selected from the group consisting of dicarboxylic acids ha... | 04/10/2007 |
| 7198949 | Compositions and methods for altering the biodistribution of biological agents The invention relates to a new and improved pharmaceutical composition and method for delivery of therapeutic agents. The methods and composition of the invention can be used with several therapeutic agents and can achieve site specific delivery of a therapeutic or ... | 04/03/2007 |
| 7189533 | Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 03/13/2007 |
| 7182962 | Immunostimulator for animals and humans, and method of preventing animal and human infectious diseases and cancer The goal of the present invention is to provide substances to prevent diseases by activating inherently possessed functions, for cultured fishes and shellfishes and livestock with tendency of decreased immune function due to densely populated breeding environment, a... | 02/27/2007 |
| 7163919 | Anticancer composition The present invention relates to an anticancer composition comprising a therapeutically effective amount of one or more active components selected from the group consisting of citric acid; citric acid and zinc; citric acid and albumin; and citric acid, zinc and albu... | 01/16/2007 |
| 7141547 | Albumin fusion proteins comprising GLP-1 polypeptides The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic ac... | 11/28/2006 |
| 7129210 | Tissue adhesive sealant A tissue adhesive sealant includes a cross-linkable protein in a solution that when combined with a cross-linking agent solution including an aldehyde and amino acid containing species reactive with the aldehyde cross-links to form a seal. The sealant is well suited... | 10/31/2006 |
| 7115583 | Microbubble compositions and methods for oligonucleotide delivery The invention relates to a new and improved pharmaceutical composition and method for delivery of therapeutic agents. The methods and composition of the invention can be used with several therapeutic agents and can achieve site specific delivery of a therapeutic or ... | 10/03/2006 |
| 7112563 | Therapies using hemoproteins Herein it is shown that hemoproteins (e.g., Ascaris hemoglobin, myoglobin, flavohemoglobins) have NO-consuming and deoxygenase activities. The invention provides a method of reducing the concentration of oxygen and/or nitric oxide in a mammal. The method of t... | 09/26/2006 |
| 7105160 | Antibody-serum protein hybrids Hybrid proteins are described which comprise one or more antigen-binding antibody fragments covalently linked to one or more serum carrier proteins. The hybrid proteins can bind antigens, have a long half-life in vivo and can be used in medicine for therapy and diag... | 09/12/2006 |
| 7094577 | Insulin and albumin fusion protein Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucl... | 08/22/2006 |
| 7094351 | Purification of substances by reaction affinity chromatography The invention relates to the separation of at least one target from a sample composition using a naturally reversible reaction comprising the formation of at least one covalent bond. One embodiment of the invention is a chromatographic method in which the affinity o... | 08/22/2006 |
| 7087719 | Method for the crystallization of human serum albumin The present invention relates to the purification and production of human albumin from various sources through crystallization and repeated crystallization. Basic features of the invented process include providing specific reaction conditions and precipitating reage... | 08/08/2006 |
| 7081354 | Interleukin and albumin fusion protein Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucl... | 07/25/2006 |
| 7078378 | Method of tissue repair II A substantially solid biomolecular solder for joining tissue comprising a partially denatured biomolecule. The solder can be formed into shapes to suit the needs of a user. The invention also relates to methods for joining tissue and methods for preparing the solder... | 07/18/2006 |
| 7057019 | Crosslinked albumin hydrogels Materials, methods, and compositions for making crosslinked albumin hydrogels are included in the application. Embodiments include a biocompatible material of albumin crosslinked with an n-functional crosslinking agent wherein n is at least 3. Other embodiments incl... | 06/06/2006 |
| 7056701 | Hormone and albumin fusion protein Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucl... | 06/06/2006 |
| 7045318 | Recombinant fusion proteins to growth hormone and serum albumin The invention describes methods of producing fusion proteins of albumin and growth hormone and products obtained by the methods. ... | 05/16/2006 |
| 7041478 | G-CSF and albumin fusion protein Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucl... | 05/09/2006 |
| 7026453 | Method of protein purification Purification methods are provided for proteins and peptides, employing silicon carbide to bind the proteins or peptides. The methods may also be used to recover and purify recombinantly expressed proteins sequestered in inclusion bodies. The method for purifying a p... | 04/11/2006 |
| 7008624 | Antagonists of interleukin-15 Antagonists of mammalian interleukin-15 (“IL-15”) are disclosed and include muteins of IL-15 and modified IL-15 molecules that are each capable of binding to the IL-15Rα-subunit and that are incapable of transducing a signal through either the β- or γ-subunit... | 03/07/2006 |
| 7005506 | Method for preparing an albumin isolate from a substance containing albumin For preparing an albumin isolate from a substance containing albumin, the substance is first ground to a flour. The flour is then suspended in an aqueous solution. The albumin is extracted from the flour into the solution by an at least two stage extraction process ... | 02/28/2006 |
| 6994857 | Albumin fusion proteins The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic ac... | 02/07/2006 |
| 6987006 | Erythropoietin and albumin fusion protein, nucleic acids, and methods thereof Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucl... | 01/17/2006 |
| 6972322 | Interferon and albumin fusion protein Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucl... | 12/06/2005 |
