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| Number | Title | Issue Date |
| 8013122 | Method of purifying apolipoprotein A-1 A first method of purifying apolipoprotein A-1 includes mixing plasma fraction IV with a 1-8 M urea solution to form a pretreatment solution; loading the pretreatment solution to a first anion chromatography column, and then eluting to obtain an apoA-1 protein solut... | 09/06/2011 |
| 7838631 | Apparatus for measuring high density lipoproteins and method of separating high density lipoproteins The present invention provides a method of separating lipoproteins other than high density lipoproteins from a biological fluid. The method can quickly measure HDL cholesterol with a simple configuration and without the need of providing additional complicated devic... | 11/23/2010 |
| 7432355 | Apolipoprotein E stable folding intermediate and methods of use thereof The present invention provides isolated apolipoprotein E (apoE) stable folding intermediates. The invention further provides methods for identifying compounds that alter the structure or level or activity of an apoE stable folding intermediate, as well as methods of... | 10/07/2008 |
| 7427662 | Inhibition of angiogenesis and destruction of angiogenic vessels by apolipoprotein A-I and high density lipoprotein Apolipoprotein A-I-rich Lhigh-density Lipoprotein 2 (HDL2) and Apolipoprotein A-I (ApoA-I) was discovered to inhibit angiogenesis in an in vitro human angiogenesis model, the human placental vein angiogenesis model. Apolipoprotein A-I was able to destroy a pre-exist... | 09/23/2008 |
| 7420042 | Soluble neuropilin/growth factor receptor fusion proteins Complexes of a protein selected from the group consisting of VEGF-B167, VEGF-C, VEGF-D and processed VEGF-B186 and analogs thereof and the neuropilin-1 (NP-1) receptor, the extracellular domain or a ligand-binding fragment or analogue thereof; ... | 09/02/2008 |
| 7375191 | Methods and apparatus for creating particle derivatives of HDL with reduced lipid content The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content.... | 05/20/2008 |
| 7368247 | Diagnostic assay for transmissible spongiform encephalopathies Heart and brain fatty acid binding proteins (H-FABP, B-FABP) are markers for TSEs, especially CJD. The invention provides a diagnostic assay for either of these markers, preferably by enzyme immunoassay using a specific antibody thereto. Since H-FABP is also a marke... | 05/06/2008 |
| 7361739 | Methods and apparatus for creating particle derivatives of HDL with reduced lipid content The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content.... | 04/22/2008 |
| 7316996 | Bisacyloxypropylcysteine conjugates and the use thereof The invention provides lipopeptide conjugates in which a cysteine that is double-substituted by a fatty acid is bonded by means of the carboxyl group to a highly soluble, physiologically compatible and non-immunogenic, polymeric conjugate group. The conjugates exhib... | 01/08/2008 |
| 7312190 | Pharmaceutical compositions of apolipoprotein A-I agonists and their use to treat dyslipidemic disorders The present invention provides peptides and peptide analogues that mimic the structural and pharmacological properties of human ApoA-I. The peptides and peptide analogues are useful to treat a variety of disorders associated with dyslipidemia. ... | 12/25/2007 |
| 7309606 | Methods and compositions for treating hypercholesterolemia The present invention provides methods and compositions for treating hypercholesterolemia using therapeutic apoE proteins. A therapeutic apoE protein is a naturally-occurring apoE protein (e.g., apoE1, apoE2, apoE2*, apoE2**, apoE3, and apoE4) that has one or more a... | 12/18/2007 |
| 7285275 | Smooth muscle growth inhibitory composition, diagnostic method for arteriosclerosis, and kit therefor The invention provides not only a smooth muscle growth inhibitory composition and a composition for inhibiting expression of adhesion molecules in vascular endothelial cells, each comprising the adipose tissue-specific secretory factor apM1 as an active ingredient, ... | 10/23/2007 |
| 7276042 | Low hydraulic resistance cartridge A cartridge for treating medical or biological fluid includes a first cap having an inlet for the fluid, a container including a plurality of compartments and a second cap including an outlet for the fluid, wherein each compartment contains a plurality of particles,... | 10/02/2007 |
| 7238366 | Submicron liposome suspensions obtained from preliposome lyophilizates This invention provides an aqueous/t-butanol solvent-system, facile reconstitute, submicron-reconsitiute preliposome-lyophilaye and method of its preparation and use. In one embodiment this entails a modified method for the preparation of a submicron and stab... | 07/03/2007 |
| 7223726 | Apolipoprotein A-I mutant proteins having cysteine substitutions and polynucleotides encoding same Functional Apolipoprotein A-I mutant proteins, having one or more cysteine substitutions and polynucleotides encoding same, can be used to modulate paraoxonase's arylesterase activity. These ApoA-I mutant proteins can be used as therapeutic agents to combat cardiova... | 05/29/2007 |
| 7193056 | Process for purifying a compound The present invention relates to a process for purifying a hydrophobic or amphiphilic compound, by first mixing a starting material containing the hydrophobic or amphiphilic compound with a first polymeric material, water and at least one of a second polymeric mater... | 03/20/2007 |
| 7189411 | Peptide/lipid complex formation by co-lyophilization The invention relates to the formation of peptide/lipid vesicles and complexes through the co-lyophilization of peptides, preferably that are able to adopt an amphipathic alphahelical conformation, and one or more lipids. A single solution which solubilizes both the... | 03/13/2007 |
| 7129390 | Poultry Derived Glycosylated Interferon Alpha 2b This invention provides vectors and methods for the stable introduction of exogenous nucleic acid sequences into the genome of avians in order to express the exogenous sequences to alter the phenotype of the avians or to produce desired proteins. In particular, tran... | 10/31/2006 |
| 7053049 | Method for treating unstable angina pectoris The invention relates to the use of reconstituted HDL for improving the endothelial function in patients suffering from hypercholesterolaemia and for treating or preventing acute coronary diseases such as unstable angina pectoris. ... | 05/30/2006 |
| 7022744 | Ion exchanger for lipoproteins separation and lipoproteins separation method using the same A composition useful for separating lipoproteins, such as high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL) and modified lipoproteins with a high degree of accuracy by ion-exchange based procedures. The composition co... | 04/04/2006 |
| 6998388 | High density lipoprotein against organ dysfunction following haemorrhagic shock Use of high density lipoprotein and/or derivatives in the manufacture of a medicament for the prevention or treatment of organ dysfunction following ischaemia and reperfusion injury. In particular, the medicament may be for the treatment of end stage organ injury or... | 02/14/2006 |
| 6953840 | Methods of using non-human animal Apolipoprotein A-I protein The invention provides methods and compositions for treating disorders using non-human animal Apolipoprotein A-I (ApoA-I) protein. The invention provides methods and compositions for treating disorders in animals, including humans, associated with dyslipidemia, incl... | 10/11/2005 |
| 6936461 | Method for immobilizing multistranded nucleic acid molecules by modifying more than one strand thereof, and binding each strand to a solid support Various methodologies for the immobilization of molecules such, as multistranded nucleic acid molecules, are described. The methodologies include activation of solid supports, as well as treatment of, e.g. termini of nucleic acid molecules to render them more recept... | 08/30/2005 |
| 6897297 | Hydrophobically-modified protein compositions and methods Hydrophobically-modified proteins and methods of making them are described. A hydrophobic moiety is attached to a surface amino acid residue of the protein. The hydrophobic moiety can be a lipid or a peptide. Alternatively, the protein can be derivatized by a wide v... | 05/24/2005 |
| 6878817 | Low density lipoprotein binding proteins and their use in diagnosing and treating atherosclerosis Isolated polynucleotides encoding novel polypeptides which are capable of binding to native and methylated LDL (low density lipoprotein), the isolated polypeptides, called LBPs (LDL binding proteins), and biologically active fragments and analogs thereof, are descri... | 04/12/2005 |
| 6774215 | Method of separating and producing a lipid rich-lipid/protein complex and native proteins from oil seeds A method of producing separated lipid-rich lipid/protein complex and native proteins from oil seeds, by adding a substance having the ability to aggregate lipids with proteins to a water extract of oil seeds, sedimenting or floating a lipid/protein complex having a ... | 08/10/2004 |
| 6767994 | Process for purifying a compound The present invention relates to a process for purifying a hydrophobic or amphiphilic compound, by first mixing a starting material containing the hydrophobic or amphiphilic compound with a first polymeric material, water and at least one of a second polymeric mater... | 07/27/2004 |
| 6673555 | Methods of using SCAP antagonists The invention relates to a method for screening therapeutic agents, defined as SCAP antagonists, for use in combating diseases associated with elevated lipid levels, said method comprising detecting or assaying the extent or result of transcriptional acti... | 01/06/2004 |
| 6670452 | Non-naturally occurring lipoprotein particle Non-naturally occurring receptor competent LDL particle comprising at least one peptide component wherein the said peptide component comprises at least a binding site for an Apo B protein receptor and at least one lipophilic substituent.... | 12/30/2003 |
| 6652860 | Peptide, apoEp 1.B, compositions and uses thereof A peptide derived from apolipoprotein E termed apoEp1.B which includes amino acids 239-252 of the apolipoprotein E is described. The apoEp1.B peptide is a potent immune modulator that acts on a variety of immune cells. Interestingly, apoEp1.B is a dual mo... | 11/25/2003 |
| 6632923 | Low density lipoprotein binding proteins and their use in diagnosing and treating atherosclerosis Isolated polynucleotides encoding novel polypeptides which are capable of binding to native and methylated LDL (low density lipoprotein), the isolated polypeptides, called LBPs (LDL binding proteins), and biologically active fragments and analogs thereof,... | 10/14/2003 |
| 6583113 | Nitrosated and nitrosylated heme proteins Nitrosylation of proteins and amino acid groups enables selective regulation of protein function, and also endows the proteins and amino acids with additional smooth muscle relaxant and platelet inhibitory capabilities. Thus, the invention relates to nove... | 06/24/2003 |
| 6579682 | Methods and tools for identifying compounds which modulate atherosclerosis by impacting LDL-proteoglycan binding The present invention relates to the study and control of atherosclerosis through the modulation of LDL-proteoglycan binding at Site B (amino acids 3359-3369) of the apo-B100 protein in LDL. The invention encompasses methods of identifying compounds which... | 06/17/2003 |
| 6559284 | Process for purifying a protein The present invention relates to a composition for use in purification of apolipoprotein A (ApoA) or apolipoprotein E (ApoE), said composition comprising a first and a second polymeric material, wherein the first and second polymeric material are immiscib... | 05/06/2003 |
| 6528272 | Receptor-based assays for pathogens A rapid, simple, and inexpensive sandwich enzyme-linked receptor based immunodot assay detects pathogens or pathogenic products in test samples using receptors for a characteristic component of the pathogen. This assay is widely applicable because it is h... | 03/04/2003 |
| 6512093 | Method of preparing lipoproteins from fatty acids present in olive oil A method of preparing lipoproteins, lipoaminoacids, lipid esters, and glucolipids from olive oil or one or more of its constituting fatty acids which are condensed with vegetal protein hydrolyzates or aminoacids or esterificated with alcohols or sugars, s... | 01/28/2003 |
| 6506879 | Purified Apo A and Apo E compounds and methods for using them A substantially endotoxin-free ApoA or ApoE is produced by recombinant DNA technique, suitably in E. coli. Medicaments and methods for treatment of atherosclerosis or cardiovascular diseases employ ApoA or ApoE purified by a process comprising contacting ... | 01/14/2003 |
| 6506570 | Method of sorting birds in ovo A method of determining the gender of a bird in ovo comprises detecting the presence or absence of an elevated level of a sex-related hormone in the extra-embryonic fluid of the bird egg, and then determining the gender of the bird within the egg from the... | 01/14/2003 |
| 6506880 | Synthetic peptides that enhance atherogenic lipoprotein uptake and lower plasma cholesterol The present invention provides novel synthetic apolipoprotein E (ApoE)-mimicking peptides wherein the receptor binding domain of apolipoprotein E is covalently linked to 18A, the well characterized lipid-associating model class A amphipathic helical pepti... | 01/14/2003 |
| 6451543 | Lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides The present invention relates to methods and compositions for lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides that are incorporated in a lipid matrix. The invention is exemplified in production of a prefolded membrane polype... | 09/17/2002 |
