Did You Know...
...that after Parker Brothers executives turned down the game of Monopoly because it had "52 fundamental errors" (including taking too long to play), a copy of the game wound up in the home of the company president who stayed up until 1 a.m. to finish playing it? He was so impressed by the game that the next day he wrote to inventor Charles Darrow and offered to buy it!
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| Number | Title | Issue Date |
| 7994280 | On-resin peptide cyclization A novel compound of formula I is devised. ... | 08/09/2011 |
| 7897724 | Solid phase Fmoc chemistry process to prepare peptides The present invention relates to an improved process for the preparation of N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-α-aspartyl-L-tryptophyl-L-prolyl-L-cysteinamide, cyclic(1→6)-disulfide of formula (1), which involv... | 03/01/2011 |
| 7608687 | Releasable linkage and compositions containing same A compound comprised of a hydrophilic polymer covalently yet reversibly linked to a amine-containing ligand through a dithiobenzyl linkage is described. ... | 10/27/2009 |
| 7488794 | High yield S-nitrosylation process A method for producing a S-nitrosylated species is provided. The method comprises: (a) providing a deoxygenated, alkaline aqueous solution comprising a thiol and a nitrite-bearing species; (b) acidifying the solution by adding acid to the solution while concurrently... | 02/10/2009 |
| 7425608 | Method of making metallopeptides Method of making metallopeptides is provided, for use in biological, pharmaceutical and related applications. The metallopeptides are made of peptides, peptidomimetics and peptide-like constructs, and include a metal ion-binding region thereof which includes at leas... | 09/16/2008 |
| 7393920 | Microwave-assisted peptide synthesis An instrument and process for accelerating the solid phase synthesis of peptides is disclosed. The method includes the steps of deprotecting a protected first amino acid linked to a solid phase resin by admixing the protected linked acid with a deprotecting solution... | 07/01/2008 |
| 7301006 | Methods and materials for the synthesis of modified peptides Methods and protected amino acids useful as building blocks (protected monomers) for the synthesis of peptides and proteins that are selectively modified at one or more side-chain hydroxyl groups. Azide-bearing protecting groups allow the selective deprotection of s... | 11/27/2007 |
| 7285622 | Releasable linkage and compositions containing same A compound comprised of a hydrophilic polymer covalently yet reversibly linked to a amine-containing ligand through a dithiobenzyl linkage is described. ... | 10/23/2007 |
| 7276248 | Conjugate having a cleavable linkage for use in a liposome Conjugates of a hydrophobic moiety, such as a lipid, linked through a cleavable dithiobenzyl linkage to a therapeutic agent are described. The dithiobenzyl linkage is susceptible to cleavage by mild thiolysis, resulting in release of the therapeutic agent in its ori... | 10/02/2007 |
| 7247701 | Amino amides, peptides and peptidomimetics Synthetic methods and compounds involving amino amides, peptides and peptidomimetics. Amino amide derivatives are prepared via the one-step three-component reaction of a glyoxamide, an amine, and an organoboron derivative. Conversion of the product to another glyoxa... | 07/24/2007 |
| 7238368 | Releasable linkage and compositions containing same A conjugate comprised of a hydrophilic polymer covalently yet reversibly linked to a amine-, hydroxy- or carboxyl-containing ligand is described. The resulting conjugate is capable of releasing the parent amine, hydroxy, or carboxyl-containing compound via thiol-med... | 07/03/2007 |
| 7226905 | Process for the preparation of cyclosporin derivatives The invention concerns a novel method for preparing an intermediate polyanion for preparing cyclosporin derivatives by treating a cyclosporin with a hexamethyldisilazane metal salt, optionally in the presence of a metal halide. The treated cyclosporin has one or sev... | 06/05/2007 |
| 7192713 | Stabilized compounds having secondary structure motifs The present invention provides novel stabilized crosslinked compounds having secondary structure motifs, libraries of these novel compounds, and methods for the synthesis of these compounds libraries thereof. The synthesis of these novel stabilized compounds involve... | 03/20/2007 |
| 7138489 | Method for producing a modified peptide The present invention is a method for producing a peptide or a protein in which a side chain contains a modified amino acid residue, which comprises chemically producing a peptide fragment containing an amino acid residue having a modified side chain using an weak a... | 11/21/2006 |
| 7094580 | Methods for producing pure perlecan and other heparan sulfate proteoglycans A method of perlecan isolation (from the EHS tumor) which produces “clean” (i.e. substantially “pure”) perlecan is disclosed. Clean perlecan is thus produced in sufficient quantities for use in a number of different in vitro and in vivo assays. In addition, ... | 08/22/2006 |
| 7049399 | Process for the preparation of polypeptide 1 A process for the preparation of a polypeptide designated in the present invention as 1, composed of the following amino acid units in the structure, namely: L-alanine, L-glutamic acid, L-lysine and L-tyrosine randomly arranged in the polypeptide 1, or pharmaceutica... | 05/23/2006 |
| 7045503 | Radiometal-binding peptide analogues Novel metal binding ligands are disclosed that may be coupled to peptides for use in methods of diagnosis and therapy. Peptides containing the ligands are produced using a method wherein ligand introduction or cyclization can be conducted at any point during the syn... | 05/16/2006 |
| 7019113 | Reversible modification of membrane interaction An process for the reversible modification of membrane interaction of a compound is described. Modification of membrane interaction can be used to facilitate delivery of molecules to cells in vitro and in vivo. The described modifiers, which are used to reversibly i... | 03/28/2006 |
| 6995136 | Peptide fragments of murine epidermal growth factor as laminin receptor targets A peptide factor, its analogs and methods of using such peptide factor derived from murine epidermal growth factor peptide is disclosed wherein the peptide factor is modified to protect it from proteolytic degradation and the peptide binds to laminin receptors. ... | 02/07/2006 |
| 6946542 | Amino amides, peptides and peptidomimetics Synthetic methods and compounds involving amino amides, peptides and peptidomimetics. Amino amide derivatives are prepared via the one-step three-component reaction of a glyoxamide, an amine, and an organoboron derivative. Conversion of the product to another glyoxa... | 09/20/2005 |
| 6921636 | Method and apparatus for conducting an array of chemical reactions on a support surface The invention provides apparatus and methods for determining the nucleotide sequence of target nucleic acids using hybridization to arrays of oligonucleotides. The invention further provides apparatus and methods for identifying the amino acid sequence of peptides t... | 07/26/2005 |
| 6906171 | Process for the deprotection of protected thiols The synthesis of peptides comprising disulphide bridges is challenging since it is difficult to ensure that the correct cysteine residues combine to form the desired disulphide bridges. The present invention describes novel protection techniques useful in the prepar... | 06/14/2005 |
| 6849270 | Releasable linkage and compositions containing same A compound comprised of a hydrophilic polymer covalently yet reversibly linked to a amine-containing ligand through a dithiobenzyl linkage is described. ... | 02/01/2005 |
| 6770436 | Chemical amplification for the synthesis of patterned arrays Radiation-activated catalysts (RACs), autocatalytic reactions, and protective groups are employed to achieve a highly sensitive, high resolution, radiation directed combinatorial synthesis of pattern arrays of diverse polymers. When irradiated, RACs produce catalyst... | 08/03/2004 |
| 6767718 | Lipodepsipeptide antibiotics and methods of preparation Novel cyclodepsipeptide intermediates have been prepared from the A21978 complex and used to synthesize new lipodepsipeptide antibiotics. The three intermediates can be readily derivatized to give new families of antibiotics that have potent antibacterial activity a... | 07/27/2004 |
| 6762282 | High yield S-nitrosylation process A method for producing a S-nitrosylated species is provided. The method comprises: (a) providing a deoxygenated, alkaline aqueous solution comprising a thiol and a nitrite-bearing species; (b) acidifying the solution by adding acid to the solution while concurrently... | 07/13/2004 |
| 6747009 | Peptidomimetic glutathione analogs The invention relates to peptidomimetic compounds with formula wherein Z═CH2 and Y═CH2, or Z═O and Y═O═O, which are novel analogs of glutathion and are inhibitors of glutathione S-transfer... | 06/08/2004 |
| 6703480 | Peptide dimers as agonists of the erythropoientin (EPO) receptor, and associated methods of synthesis and use Novel peptide dimers are provided that bind and activate the erythropoietin receptor (EPO-R) or otherwise act as an EPO agonist. The novel compounds have a first peptide chain R1 and a second peptide chain R2, wherein R1 a... | 03/09/2004 |
| 6605299 | Releasable linkage and compositions containing same A compound comprised of a hydrophilic polymer covalently yet reversibly linked to a amine-containing ligand through a dithiobenzyl linkage is described.... | 08/12/2003 |
| 6600016 | Multifunctionalized solid support resins for synthesis of combinatorial libraries and method for using the same Multifunctionalized support resin for the solid phase synthesis of combinatorial libraries is disclosed. The support resin comprises a resin backbone to which is attached a template containing at least two more attachment points which carry mutiple functi... | 07/29/2003 |
| 6566495 | Very large scale immobilized polymer synthesis A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techni... | 05/20/2003 |
| 6562944 | Amide library formation using a "by-product-free" activation/coupling sequence Disclosed is an improved method for preparing an activated carboxylic acid in the form of a pentafluorophenyl ester, an improved method for making a carboxamide from a pentaflourophenyl ester, and a carboxamide and carboxamide library prepared using both ... | 05/13/2003 |
| 6509189 | Nucleic acid molecules encoding the cytoplasmic domain of human Ob receptor The presention invention relates to the discovery, identification and characterization of nucleotides that encode Ob receptor (ObR), a receptor protein that participates in mammalian body weight regulation. The invention encompasses obR nucleotides, host ... | 01/21/2003 |
| 6504005 | Long-acting drugs and pharmaceutical compositions comprising them Disclosed are conjugates of a polypeptide or oligopeptide with a low molecular weight lipophilic compound, the peptide and lipophilic group being covalently linked to one another either directly or via a connecting element, with the exception of (a) conju... | 01/07/2003 |
| 6492491 | Method of making hypusine peptides The invention relates to novel peptides synthesized according a method utilizing the hypusine reagent: ##STR1## wherein: Q1 Q2 and Q3 may be the same or different and are amino protective groups, provided that Q3 | 12/10/2002 |
| 6458923 | Modified position (7) bradykinin antagonist peptides The substitution of the L-Pro at the 7-position of the peptide hormone bradykinin or other substituted analogs of bradykinin with an isoquinoline derivative which converts bradykinin agonists into bradykinin antagonists. The invention further includes the... | 10/01/2002 |
| 6426184 | Method and apparatus for chemical and biochemical reactions using photo-generated reagents This invention provides method and apparatus for performing chemical and biochemical reactions in solution using in situ generated photo-products as reagent or co-reagent. Specifically, the method and apparatus of the present invention have applications i... | 07/30/2002 |
| 6417347 | High yield S-nitrosylation process A method for producing a S-nitrosylated species is provided. The method comprises: (a) providing a deoxygenated, alkaline aqueous solution comprising a thiol and a nitrite-bearing species; (b) acidifying the solution by adding acid to the solution while c... | 07/09/2002 |
| 6380358 | Guanidinylation reagents Trisubstituted N-protected guanidines and methods for use as guanidinylating reagents to yield N-protected guanidine derivatives.... | 04/30/2002 |
| 6376649 | Methods for the synthesis of - hydroxy-ଲ-amino acid and amide derivatives Methods for the synthesis of -hydroxy-ଲ-amino acid and amide derivatives and -ketoamide derivatives and novel derivatives made by these methods are provided. These methods involve reacting a N-terminally blocked (protected) aminoaldehy... | 04/23/2002 |
