Today In History
Six-year-old Robert W. Patch granted a patent for a "toy truck".
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7666987 | Bioluminescent caspase assay compounds A sensitive bioluminescent assay to detect proteases including caspases is provided which employs an aminoluciferin or a carboxy-terminal protected derivative thereof covalently linked via a peptide bond to a substrate for a caspase or an aminoluciferin or a carboxy... | 02/23/2010 |
| 7662915 | Peptides having protected amines of untargeted sites, methods for production thereof and of specifically conjugated PEG peptides using the same The present invention relates to synthetic peptides having selectively protected amines of untargeted sites and to methods for production thereof and for specifically conjugating PEG to targeted sites of the synthetic peptides using the same. The present invention p... | 02/16/2010 |
| 7425608 | Method of making metallopeptides Method of making metallopeptides is provided, for use in biological, pharmaceutical and related applications. The metallopeptides are made of peptides, peptidomimetics and peptide-like constructs, and include a metal ion-binding region thereof which includes at leas... | 09/16/2008 |
| 7423117 | Surface-functionalized carrier material and solid phase synthesis method The invention concerns a novel surface-functionalized carrier material with a polymeric surface and at least one linker compound according to the general formula (I), which is covalently bound to the surface. In the formula, P indicates the polymeric surface; R... | 09/09/2008 |
| 7414106 | Synthesis of peptide α-thioesters Disclosed herein is a new method for the solid phase peptide synthesis (SPPS) of C-terminal peptide α thioesters using Fmoc/t-Bu chemistry. This method is based on the use of an aryl hydrazine linker, which is totally stable to conditions required for Fmoc-SPPS. Wh... | 08/19/2008 |
| 7393920 | Microwave-assisted peptide synthesis An instrument and process for accelerating the solid phase synthesis of peptides is disclosed. The method includes the steps of deprotecting a protected first amino acid linked to a solid phase resin by admixing the protected linked acid with a deprotecting solution... | 07/01/2008 |
| 7354996 | Method and kit for quantitative analysis of protein The present invention provides a method for global quantitative analysis of protein that is effectively applied also for unpurified samples such as biological samples, and achieves better detection sensitivity and quantitativeness than the conventional NBS method. A... | 04/08/2008 |
| 7314708 | Method and apparatus for electronic synthesis of molecular structures A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridization, antibody/antig... | 01/01/2008 |
| 7256258 | Regioselective liquid phase pegylation A method is described for a method for the regioselective liquid-phase pegylation of GRF, which increases the yield of the GRF-PEG conjugate having 1 PEG molecule covalently bound to the e-amino group of Lys12. This method is characterized in that the rea... | 08/14/2007 |
| 7247701 | Amino amides, peptides and peptidomimetics Synthetic methods and compounds involving amino amides, peptides and peptidomimetics. Amino amide derivatives are prepared via the one-step three-component reaction of a glyoxamide, an amine, and an organoboron derivative. Conversion of the product to another glyoxa... | 07/24/2007 |
| 7238841 | Polymer-supported phosphorus ligands for catalysts Novel phosphine and phosphine oxide ligands are prepared using polymeric supports. These compounds can be easily cleaved from the support, and along with the corresponding supported compounds, used as ligands in the preparation of novel, metal-complexed catalysts. | 07/03/2007 |
| 7226905 | Process for the preparation of cyclosporin derivatives The invention concerns a novel method for preparing an intermediate polyanion for preparing cyclosporin derivatives by treating a cyclosporin with a hexamethyldisilazane metal salt, optionally in the presence of a metal halide. The treated cyclosporin has one or sev... | 06/05/2007 |
| 7214769 | Method for inverse solid phase synthesis of peptides The present invention provides a process for preparing a peptide of formula (I): Sub-[L]-[NH-A-C(O)]n+m—OH (I) comprising: (a) reacting an immobilized compound of formula (II): ... | 05/08/2007 |
| 7205384 | Process for preparing peptidyl heterocyclic ketone derivatives The present invention relates to novel processes for the preparation of peptidyl heterocyclic ketones of the general formula (I) wherein all variables are as herein defined. The present invention further relates to... | 04/17/2007 |
| RE39545 | Methods and apparatus for synthesizing labeled combinatorial chemistry libraries The present invention provides labeled synthetic libraries of random oligomers and methods and apparatus for generating labeled synthetic oligomer libraries. Each member of such a library is labeled with a unique identifier tag that specifies the structure or sequen... | 04/03/2007 |
| 7192713 | Stabilized compounds having secondary structure motifs The present invention provides novel stabilized crosslinked compounds having secondary structure motifs, libraries of these novel compounds, and methods for the synthesis of these compounds libraries thereof. The synthesis of these novel stabilized compounds involve... | 03/20/2007 |
| 7169576 | Method for identifying drug metabolites with dansylated glutathione The present application relates to a sensitive and quantitative method using dansylated glutathione as a trapping agent for the detection of reactive metabolites in the field of drug discovery. The fluorescent tag attached to the dansylated glutathione does not impe... | 01/30/2007 |
| 7163923 | Peptide deformylase activated prodrugs This invention provides a method for inhibiting the growth of a microorganism that expresses Peptide Deformylase by contacting the microorganism with an effective amount of the compound described herein. This method inhibits the growth of gram-positive and gram-nega... | 01/16/2007 |
| 7157255 | Process for the preparation of dihydroxy esters and derivatives thereof A process is provided for the preparation of a compound of formula (1) wherein R and R′ represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises ei... | 01/02/2007 |
| 7141648 | Synthesis of cyclosporin analogs The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine A. The mixtures possess enhanced efficacy and reduced toxicity over the individual isomers and over naturally occurring and other presently known c... | 11/28/2006 |
| 7138489 | Method for producing a modified peptide The present invention is a method for producing a peptide or a protein in which a side chain contains a modified amino acid residue, which comprises chemically producing a peptide fragment containing an amino acid residue having a modified side chain using an weak a... | 11/21/2006 |
| 7135564 | Reusable solid support for oligonucleotide synthesis A reusable linker arm for solid support oligonucleotide synthesis, the linker arm comprising formula (a) wherein Z is a linker moiety and T is an organic radical. A method for adding one or more nucleosides on the linker arm is also described | 11/14/2006 |
| 7122628 | Process for the synthesis of a peptide having a Trp residue A process for the solid phase synthesis of a peptide having at least one thyptophan residue, wherein said method comprises temporarily protecting the indole ring of said tryptophan residue with a side chain protecting group which is labile to a base wherein said pro... | 10/17/2006 |
| 7102023 | Protecting groups useful in the synthesis of polysaccharides, natural products, and combinatorial libraries One aspect of the present invention relates to optionally substituted halogenated benzyl halides and the like. These compounds are useful as halogenated benzyl ether-based protecting groups for a variety of functional groups. Another aspect of the present invention ... | 09/05/2006 |
| 7087732 | Nucleotides and analogs having photoremovable protecting groups A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are ut... | 08/08/2006 |
| 7053055 | Compounds of unstable DP IV-inhibitors Novel compounds of unstable inhibitors of the serine peptidase dipeptidyl peptidase IV, are used in the treatment of various disorders, especially of metabolic disorders. The compounds can be used in the treatment of impaired glucose tolerance, glucosuria, hyperlipi... | 05/30/2006 |
| 7049399 | Process for the preparation of polypeptide 1 A process for the preparation of a polypeptide designated in the present invention as 1, composed of the following amino acid units in the structure, namely: L-alanine, L-glutamic acid, L-lysine and L-tyrosine randomly arranged in the polypeptide 1, or pharmaceutica... | 05/23/2006 |
| 7045503 | Radiometal-binding peptide analogues Novel metal binding ligands are disclosed that may be coupled to peptides for use in methods of diagnosis and therapy. Peptides containing the ligands are produced using a method wherein ligand introduction or cyclization can be conducted at any point during the syn... | 05/16/2006 |
| 7026114 | Methods and compositions for monitoring polymer array synthesis VLSIPS™ manufacturing processes are of increasing commercial importance. The present invention provides methods and compositions for monitoring the efficiency and quality of polymer synthesis in VLSIPS™ arrays. Methods for monitoring polymer synthesis in an arra... | 04/11/2006 |
| 7019113 | Reversible modification of membrane interaction An process for the reversible modification of membrane interaction of a compound is described. Modification of membrane interaction can be used to facilitate delivery of molecules to cells in vitro and in vivo. The described modifiers, which are used to reversibly i... | 03/28/2006 |
| 7001982 | Non-natural C-linked carbo-β-peptides with robust secondary structures Nonnatural C-linked carbo-β-peptides with robust secondary structures, which involves the synthesis of a new class of β-peptides called C-linked carbo-β-peptides. The compounds are favorably disposed for the formation of stable helical structures and are useful a... | 02/21/2006 |
| 6995136 | Peptide fragments of murine epidermal growth factor as laminin receptor targets A peptide factor, its analogs and methods of using such peptide factor derived from murine epidermal growth factor peptide is disclosed wherein the peptide factor is modified to protect it from proteolytic degradation and the peptide binds to laminin receptors. ... | 02/07/2006 |
| 6955915 | Apparatus comprising polymers A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are ut... | 10/18/2005 |
| 6946542 | Amino amides, peptides and peptidomimetics Synthetic methods and compounds involving amino amides, peptides and peptidomimetics. Amino amide derivatives are prepared via the one-step three-component reaction of a glyoxamide, an amine, and an organoboron derivative. Conversion of the product to another glyoxa... | 09/20/2005 |
| 6921636 | Method and apparatus for conducting an array of chemical reactions on a support surface The invention provides apparatus and methods for determining the nucleotide sequence of target nucleic acids using hybridization to arrays of oligonucleotides. The invention further provides apparatus and methods for identifying the amino acid sequence of peptides t... | 07/26/2005 |
| 6919211 | Polypeptide arrays The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classif... | 07/19/2005 |
| 6887665 | Methods of array synthesis Radiation-activated catalysts (RACs), autocatalytic reactions, and protective groups are employed to achieve a highly sensitive, high resolution, radiation directed combinatorial synthesis of pattern arrays of diverse polymers. When irradiated, RACs produce catalyst... | 05/03/2005 |
| 6849714 | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components A method of synthesizing a modified therapeutic peptide capable of forming a peptidase-stabilized therapeutic peptide conjugate, the peptide having between 3 and 50 amino acids, is k. In a first step of the method, a therapeutic peptide having a carboxy terminal ami... | 02/01/2005 |
| 6841658 | Purification of human Troponin I The invention is directed to methods for purifying Troponin I, particularly recombinant Tropnin I produced in a bacterial expression system. Recombinant Tropnin I can be advantageously purified after reversibly protecting the free sulfhydryl groups, e.g., by forming... | 01/11/2005 |
| 6831066 | Modulators of β-amyloid peptide aggregation Compounds that modulate natural β amyloid peptide aggregation are provided. The modulators of the invention comprise a peptide, preferably based on a β amyloid peptide, that is comprised entirely of D-amino acids. Preferably, the peptide comprises 3-5 D-amino acid... | 12/14/2004 |
