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| Number | Title | Issue Date |
| 8178652 | Apparatus and method for separation of liquid phases of different density and for fluorous phase organic syntheses A simple, efficient apparatus and method for separating layers of immiscible or partially miscible liquids useful in methods of high-throughput combinatorial organic synthesis or parallel extraction of large libraries or megaarrays of organic compounds is disclosed.... | 05/15/2012 |
| 8173770 | Intermediates for LHRH antagonist synthesis, process for the production, and process for LHRH antagonist production The peptides Ac-D-2Nal-D-4ClPhe-D-3Pal-OH and Boc-D-2Nal-D-4ClPhe-D-3Pal-OH are intermediates useful in the synthesis of LHRH analogs by coupling with suitable heptapeptides, in particular with the heptapeptides P1-Ser(P2)-MMeTry(P3)... | 05/08/2012 |
| 8163874 | Beta helical peptide structures stable in aqueous and non-aqueous media and methods for preparing same Disclosed is a method of making peptide structures that are stable in aqueous and non-aqueous media where a first linear peptide chain comprising alternating D,L- or L,D-amino acids having an N and C termini is joined by... | 04/24/2012 |
| 8153761 | Microwave-assisted peptide synthesis An instrument and associated method are disclosed for the accelerated synthesis of peptides by the solid phase method. The instrument includes a microwave cavity, a microwave source in communication with the cavity, a column in the cavity formed of a material that i... | 04/10/2012 |
| 8124726 | Contoxin analogues and methods for synthesizing same According to the present invention, there is provided a range of new conotoxin derivatives and methods for synthesizing these analogues and other intramolecular dicarba bridge-containing peptides, including dicarba-disulfide bridge-containing peptides. ... | 02/28/2012 |
| 8063181 | Method for the production of cyclic molecules The invention at hand describes a method for the cyclization of peptides and proteins in which linear thioesters serve as substrates. The cyclization is catalyzed by thioesterase domains of NRPS or PKS cyclases. The substrates according to the present invention are ... | 11/22/2011 |
| 8058393 | Microwave-assisted peptide synthesis An instrument and method for accelerating the solid phase synthesis of peptides are disclosed. The method includes the steps of deprotecting a protected first amino acid linked to a solid phase resin by admixing the protected linked acid with a deprotecting solution... | 11/15/2011 |
| 8034900 | Water-soluble thioester and selenoester compounds and methods for making and using the same Water-soluble thioester and selenoester compounds, their generators, as well as methods for making and using the same, are provided. The subject thioester and selenoester compounds are characterized by including an amino acid synthon having a C-terminal group bonded... | 10/11/2011 |
| 8022181 | Composition and method for the release of protected peptides from a resin The present invention provides a composition and a method for cleaving a peptide from a solid support resin. Hydrochloric acid in an organic water miscible solvent is used to cleave the peptide-resin attachment. Optionally, trifluoroethanol or hexafluoroisopropanol ... | 09/20/2011 |
| 8008434 | Preparation of solid phase bound peptides or PNAs The invention relates to a process for the preparation of at least one solid phase bound peptide. PNA or a chimera. ... | 08/30/2011 |
| 7981999 | Triazole macrocycle systems The present invention provides novel peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and kits useful in their production. In various embodiments, the peptidomimetic macrocycles are o... | 07/19/2011 |
| 7977456 | Apparatus and method for separation of liquid phases of different density and for fluorous phase organic syntheses A simple, efficient apparatus and method for separating layers of immiscible or partially miscible liquids useful in methods of high-throughput combinatorial organic synthesis or parallel extraction of large libraries or megaarrays of organic compounds is disclosed.... | 07/12/2011 |
| 7968519 | Methods and compositions for controlled polypeptide synthesis Methods and compositions for the generation of polypeptides having varied material properties are disclosed herein. Methods include means for initiating the polymerization of aminoacid-N-carboxyanhydride (NCA) monomer by combining the monomer with an amido-containin... | 06/28/2011 |
| 7951773 | Ring-closing metathesis process for the preparation of macrocyclic peptides Disclosed is a process for preparing a compound of formula (I) by protecting the secondary amide nitrogen atom in the compound of formula (III) to obtain (IV) wherein PGN is a suitable nitrogen protecting group, ring-closing the compound of formula (IV) b... | 05/31/2011 |
| 7951912 | Poly-β-peptides from functionalized β-lactam monomers and antibacterial compositions containing same Disclosed is a method of making β-polypeptides. The method includes polymerizing β-lactam-containing monomers in the presence of a base initiator and a co-initiator which is not a metal-containing molecule to yield the product β-polypeptides. Specifically disclos... | 05/31/2011 |
| 7939629 | Method for solid phase peptide synthesis A novel method for synthesizing a Hirulog peptide is devised. ... | 05/10/2011 |
| 7939628 | Microwave-assisted peptide synthesis An instrument and process for accelerating the solid phase synthesis of peptides is disclosed. The method includes the steps of deprotecting a protected first amino acid linked to a solid phase resin by admixing the protected linked acid with a deprotecting solution... | 05/10/2011 |
| 7923533 | Methods for arbitrary peptide synthesis Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed. ... | 04/12/2011 |
| 7910695 | Methods for arbitrary peptide synthesis Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed. ... | 03/22/2011 |
| 7888465 | Methods for arbitrary peptide synthesis Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed. ... | 02/15/2011 |
| 7879973 | Methods for arbitrary peptide synthesis Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed. ... | 02/01/2011 |
| 7879975 | Methods for arbitrary peptide synthesis Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed. ... | 02/01/2011 |
| 7879974 | Methods for arbitrary peptide synthesis Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed. ... | 02/01/2011 |
| 7872099 | Camera device and monitor system A camera device includes: an iris unit for varying exposure; a shutter control unit for varying a shutter speed of an imaging element; and a control unit for controlling the signal processing unit and the entire device. The camera device further includes: an exposur... | 01/18/2011 |
| 7807782 | Method for linking molecular substances The invention relates to a method for linking two or more molecular substances, by means of adapter segments, which bring about a targeted interaction based upon the affinity of proline-rich amino acid sequences and protein domains of the type WW. ... | 10/05/2010 |
| 7777002 | Methods for arbitrary peptide synthesis Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed. ... | 08/17/2010 |
| 7754854 | Methods for arbitrary peptide synthesis Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed. ... | 07/13/2010 |
| 7718579 | Electrochemical deblocking using a hydrazine derivative A method for electrochemical removal of acid-labile protecting groups on an electrode microarray using an organic solution is disclosed. The solution comprises a hydrazine derivative and a salt in an organic solvent. The hydrazine derivative has at least one hydrazi... | 05/18/2010 |
| 7718769 | Tri-peptide hepatitis C serine protease inhibitors The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis c virus (HCV) NS3-NS... | 05/18/2010 |
| 7696311 | Process and systems for recovery of peptides The invention provides methods of obtaining a peptide that include steps of synthesizing a peptide intermediate having one or more side chain protecting groups; providing a solvent to the peptide intermediate to form a peptide intermediate composition; and providing... | 04/13/2010 |
| 7696312 | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can includ... | 04/13/2010 |
| 7662914 | Native chemical ligation with three or more components The invention provides a method of assembling oligopeptide intermediates in a native chemical ligation reaction that eliminates self-ligation of bi-functional intermediates. An important aspect of the invention is a bi-functional intermediate with an N-terminal cycl... | 02/16/2010 |
| 7649080 | Cross-linked glycopeptide-cephalosporin antibiotics This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacteria... | 01/19/2010 |
| 7612165 | Solid-phase synthesis is a capillary The invention provides, inter alia, methods for synthesizing a molecule on the channel surface of a capillary, comprising the steps of: (i) covalently attaching a first chemical entity to the channel surface of a capillary; and (ii) covalently attaching a second che... | 11/03/2009 |
| 7601802 | Cysteine-containing peptides having antioxidant properties Cysteine containing amphipathic alpha helices of the exchangeable apolipoproteins, as exemplified by apolipoprotein (apo) A-IMilano (R173C) and apoA-IParis, (R151C) were found to exhibit potent antioxidant activity on phospholipid surfaces. The... | 10/13/2009 |
| 7582728 | Microwave-assisted peptide synthesis An instrument and method for accelerating the solid phase synthesis of peptides is disclosed. The method includes the steps of deprotecting a protected first amino acid linked to a solid phase resin by admixing the protected linked acid with a deprotecting solution ... | 09/01/2009 |
| 7563865 | Microwave-assisted peptide synthesis An instrument and process for accelerating the solid phase synthesis of peptides is disclosed. The method includes the steps of deprotecting a protected first amino acid linked to a solid phase resin by admixing the protected linked acid with a deprotecting solution... | 07/21/2009 |
| 7550560 | Microwave-assisted peptide synthesis An instrument and process for accelerating the solid phase synthesis of peptides is disclosed. The method includes the steps of deprotecting a protected first amino acid linked to a solid phase resin by admixing the protected linked acid with a deprotecting solution... | 06/23/2009 |
| 7538190 | Methods for the synthesis of two or more dicarba bridges in organic compounds Described herein are methods for forming two or more dicarba bridges, as well as new compounds containing dicarba bridges. ... | 05/26/2009 |
| 7538189 | Methods of making deuterated cyclosporin analogs Cyclosporine derivatives are disclosed which possess enhanced efficacy and reduced toxicity over naturally occurring and other presently known cyclosporins and cyclosporine derivatives. The cyclosporine derivatives of the present invention are produced by chemical a... | 05/26/2009 |
