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| Number | Title | Issue Date |
| 8188222 | High molecular weight derivative of nucleic acid antimetabolite [Problems] A derivative of a nucleic acid antimetabolite is demanded which can show a higher therapeutic effect at a lower dose. [Means for Solving Problems] Disclosed is a high molecular weight derivative a nucleic acid antimetabolite, which is characterized... | 05/29/2012 |
| 7449546 | Method for extending storage of glutathione solutions and methods for treating Parkinson's disease with said stored glutathione solutions A method of storing solutions of reduced glutathione for extended periods of time, by dissolving reduced glutathione in an aqueous medium having a pH of between 5.0 and 8.0 to produce a reduced glutathione solution; reducing the temperature of the reduced glutathion... | 11/11/2008 |
| 7429639 | SSX-2 peptides presented by HLA class II molecules The invention describes HLA class II binding peptides encoded by the SSX-2 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating to the peptides. The peptides stimulate the activity and proliferation of CD4+ T lymp... | 09/30/2008 |
| 7423115 | ARTS C-terminus fragments and mimetics thereof This invention provides isolated peptides comprising a C-terminal fragment of an ARTS protein, isolated nucleotides encoding same, mimetics and small molecule analogues of same, and therapeutic applications comprising administering a peptide, nucleic acid, or mimeti... | 09/09/2008 |
| 7405267 | Method for purifying teicoplanin A Disclosed is a method for purifying teicoplanin A2 comprising: (i) a primary pre-purification step of purifying a filtrate of fermentation broth of a strain using a synthetic adsorbent; (ii) a secondary pre-purification step of purifying the primary pre-p... | 07/29/2008 |
| 7402556 | Prodrugs activated by plasmin and their use in cancer chemotherapy The product of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide having a plasmin peptide substrate of 2-4 amino acids and mono- or di-peptide linkage, a stabilizing group and, optionally, a linker group. The ... | 07/22/2008 |
| 7385029 | Method of making tetrapeptide derivative TZT-1027 crystal The invention provides crystals of N2-(N,N-dimethyl-L-valyl)-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[(2-phenylethyl)amino]propyl]-1-pyrrolidinyl]-1-[(S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide or salts thereof which p... | 06/10/2008 |
| 7368421 | Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis The present invention provides a new use of DP IV-inhibitors. The compounds of the present invention, and their corresponding pharmaceutically acceptable acid addition salt forms, are useful in treating conditions mediated by DP IV or DP IV-like enzymes, such as imm... | 05/06/2008 |
| 7354723 | Assay of isomerised and/or optically inverted proteins and protein fragments Disclosed are compositions and methods for performing an immuno-assay that includes measuring the amount of an isomerised or optically inverted non-collagen protein derived from cartilage. ... | 04/08/2008 |
| 7345020 | Mimetics of CD4 that inhibit immune response The application concerns a method of identifying compounds that can be used to inhibit undesired human CD4+ T cell immune responses by identifying compounds that block the interaction of CD4 and MHC, class II, gene products and a method of treatment which... | 03/18/2008 |
| 7335644 | Anti-hypertensive molecules and process for preparation thereof The present invention relates to novel anti-hypertensive molecules. The present invention also provides a process for the preparation of novel antihypertensive molecules. The present invention particularly relates to the preparation of novel Angiotensin Converting E... | 02/26/2008 |
| 7332161 | Treatment of disease with antibodies against high molecular weight kininogen domain 5 Antibodies directed against an antigenic determinant of high molecular weight kininogen domain 5, particularly a determinant located in the region formed by light chain amino acids Gly(440) to Lys(502), inhibit angiogenesis. ... | 02/19/2008 |
| 7285525 | Suppression of immune response via inhibition of cathepsin S Methods and products for suppressing a class II MI-IC-restricted immune response in a mammal, or in mammalian cells, are described. The methods depend upon inhibiting invariant chain proteolysis by cathepsin S from class II MHC/invariant chain complexes, thereby red... | 10/23/2007 |
| 7276484 | Dipeptide inhibitors of β-secretase Dipeptide derived inhibitors of the β-secretase enzyme are provided which are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of Aβ peptide in a mammal. The compounds of the invention provide useful methods of treatmen... | 10/02/2007 |
| 7250401 | Therapeutic compositions A method is provided for the preparation of compounds of the formula (R1)(R2)NC(═X)S(O)nR3 or (R1)(R2)NC(═X)OS(O)nR3, wherein R1, R2 and R3, ... | 07/31/2007 |
| 7223846 | Urocortin proteins and uses thereof A human urocortin-related peptide with significant sequence homology to the CRF neuropeptide family was identified. A mouse cDNA was isolated from whole brain poly (A+) RNA that encodes a predicted 38 amino acid peptide protein designated herein as urocortin II. Bot... | 05/29/2007 |
| 7198791 | Compositions and methods for the generation of protective immune responses against malaria The invention presents vaccine formulations comprising highly antigenic epitopes identified within the semi-conserved loop-I of domain III that are capable of eliciting parasite growth inhibitory antibodies. The cyclized or linear peptides can be applied by known ad... | 04/03/2007 |
| 7192713 | Stabilized compounds having secondary structure motifs The present invention provides novel stabilized crosslinked compounds having secondary structure motifs, libraries of these novel compounds, and methods for the synthesis of these compounds libraries thereof. The synthesis of these novel stabilized compounds involve... | 03/20/2007 |
| 7186695 | Treatment of arthritis with arsenoxide compounds The present invention provides a method of treatment and/or prophylaxis of arthritis in a vertebrate comprising administering to said vertebrate in need of said treatment and/or prophylaxis a therapeutically effective amount of a compound of Formula (I) or a pharmac... | 03/06/2007 |
| 7176185 | Short peptide carrier system for cellular delivery of agent A dipeptide or tripeptide carrier system for active agent delivery to cells has an N-terminus natural amino acid and an active agent covalently bonded to a side chain of one of the remaining amino acid bases. The system is amenable to formulation as an oral administ... | 02/13/2007 |
| 7173013 | Treatment of tuberculosis using immunomodulator compounds Tuberculosis in an animal is treated by administration of a therapeutically effective amount of an immunomodulator of formula A. In formula (A), n is 1 or 2, R is hydrogen, acyl, alkyl or a peptide fragment, and X is an aromatic or heterocyclic amino acid or a deriv... | 02/06/2007 |
| 7157091 | MAGE-A1 peptides presented by HLA class II molecules The invention provides isolated HLA DRB1*15-binding peptides consisting of the amino acid sequence set forth as SEQ ID NO:7 with 0–10 amino acids added to either or both ends of the amino acid sequence set forth as SEQ ID NO:7, and an endosomal targeting signal co... | 01/02/2007 |
| 7094870 | Crystals of oxidized glutathione and process for producing the same The present invention provides crystals of glutathione oxidized n hydrate (wherein n is an integer or a fraction of not less than 0 and less than 8) useful, for example, as final products of, as raw materials for, or as intermediates of health foods, pharmaceuticals... | 08/22/2006 |
| 7081495 | Cationic compounds and their use as macro molecular carriers Dendrimers comprising a dentritic polypeptide with one dendron having terminal cationic groups and a lipidic anchor, preferably comprising C6-24-alkyl group containing α-amino acyl groups, preferably joined to the focal group, are used to assist transfec... | 07/25/2006 |
| 7074892 | Thrombin generation inhibitors Peptides derived from amino acids 307 to 356 of the human blood coagulation factor Va are provided. Such peptides comprise: i) a length of between 3 and 50 amino acids, ii) a minimum of 3 contiguous amino acids from the 307–356 heavy chain region of factor Va, exc... | 07/11/2006 |
| 7074620 | Controlling protein levels in eucaryotic organisms Method for reducing the level and/or activity of a target protein in a eukaryotic cell via activation of ubiquitination of the target protein wherein the cell is contacted with the compound having a ubiquitination recognition element covalently linked to a target pr... | 07/11/2006 |
| 7074766 | Substantially cell membrane impermeable compound and use thereof The present invention relates to a compound according to Formula (I): A-(L-Y)p, wherein A comprises at least one substantially cell-membrane impermeable pendant group; L comprises any suitable linker and/or spacer group; Y comprises at least one arsenoxid... | 07/11/2006 |
| 7060678 | Peptides comprising furanoid sugar amino acids for the treatment of cancer Anticancer peptides which incorporate furanoid sugar amino acids and compositions made using these peptides are described. Methods for synthesis of the peptides and for preparing the furanoid sugar amino acids are disclosed. The peptides and compositions made using ... | 06/13/2006 |
| 7012129 | Antiviral composition comprising glycine amide Embodiments relate to the discovery that certain tripeptide amides and glycine amide can be used to inhibit viral infection, including human immunodeficiency virus (HIV) infection. More specifically, medicaments comprising said tripeptide amides and/or glycine amide... | 03/14/2006 |
| 7001982 | Non-natural C-linked carbo-β-peptides with robust secondary structures Nonnatural C-linked carbo-β-peptides with robust secondary structures, which involves the synthesis of a new class of β-peptides called C-linked carbo-β-peptides. The compounds are favorably disposed for the formation of stable helical structures and are useful a... | 02/21/2006 |
| 6994852 | Inhibition of angiogenesis by antibodies against high molecular weight kininogen domain 5 Antibodies directed against an antigenic determinant of high molecular weight kininogen domain 5, particularly a determinant located in the region formed by light chain amino acids Gly(440) to Lys(502), inhibit angiogenesis. ... | 02/07/2006 |
| 6960565 | Compound for inhibiting the influx of polymorphonuclear leukocytes (PMNS) in a tissue, its selection, pharmaceutical compositions and use The invention relates to a compound suitable for inhibiting the influx of polymorphonuclear leukocytes (PMNs) into a tissue involved in a chronic inflammatory disease. The compound according to the invention is capable of forming a complex with N-acetyl-Pro-Gly-Pro.... | 11/01/2005 |
| 6958384 | Polypeptides containing γ-amino acids Disclosed are polypeptide compounds containing at least one residue comprising a cyclically-constrained γ-amino acid residue. The compounds have the formula where A is a hydrogen, hydroxy, amino- or carboxy-protecting... | 10/25/2005 |
| 6921747 | Basic amino acid derivatives The present invention provides a basic amino acid derivative represented by the formula (1): The present invention also provides a method of making a gelled product by employing the aforementioned compound, as well as ... | 07/26/2005 |
| 6914048 | Method for delivery of molecules to intracellular targets Disclosed are β-peptides and β-peptide conjugates that are capable of diffusing or otherwise being transported across the cell membranes of living cells. The β-peptides contain at least six β-amino acid residues, at leastsix of which are preferably β3 | 07/05/2005 |
| 6906199 | Process for preparing distamycin derivatives It is described a process for preparing, in high yields and purity and without the need of carrying out several steps and/or isolating many intermediates which could lead to undesired by-products, a distamycin derivative of formula | 06/14/2005 |
| 6906171 | Process for the deprotection of protected thiols The synthesis of peptides comprising disulphide bridges is challenging since it is difficult to ensure that the correct cysteine residues combine to form the desired disulphide bridges. The present invention describes novel protection techniques useful in the prepar... | 06/14/2005 |
| 6867284 | Peptide inhibitors of hepatitis C virus NS3 protease Fluorinated oligopeptides, especially those having 4,4-difluoro-2-amino butyric acid at the C terminus, may be effective inhibitors of hepatitis C virus NS3 protease. Examples of hexapeptides of the invention, optimized for binding in the S1 specificity pocket of th... | 03/15/2005 |
| 6864240 | Dipeptide inhibitors of β-secretase Dipeptide derived inhibitors of the β-secretase enzyme are provided which are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of Aβ peptide in a mammal. The compounds of the invention provide useful methods of treatmen... | 03/08/2005 |
| 6858114 | Laser hydrolysis of polypeptides The present invention relates to methods of hydrolyzing a protein (or peptide) by treating a protein (or peptide)-containing sample with a laser and associated apparatus for effectuating the hydrolysis. ... | 02/22/2005 |
