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| Number | Title | Issue Date |
| 8173605 | Kokumi-imparting agent The present invention encompasses a method for screening for a kokumi-imparting substance by using the calcium receptor activity as an index, a composition containing a kokumi-imparting substance obtained by the screening method, a method for producing food or drink... | 05/08/2012 |
| 8148322 | Method and carrier complexes for delivering molecules to cells The invention relates to carrier complexes and methods for delivering molecules to cells. The carrier complexes comprises a molecule and an aromatic cationic peptide in accordance with the invention. In one embodiment, the method for delivering a molecule to a cell ... | 04/03/2012 |
| 8106016 | Compounds and compositions for prevention of overdose of oxycodone The invention relates to pharmaceutical compounds and compositions comprised of a chemical moiety attached to an opioid such as oxycodone in a manner that substantially decreases the potential of the opioid to cause overdose. When delivered at the proper dosage the ... | 01/31/2012 |
| 8067537 | Composition and method for treatment of stomatitis A composition and a method effective in preventing or treating stomatitis are presented. The composition contains glutathione or a pharmaceutically acceptable salt thereof and/or orotic acid or a derivative thereof or a pharmaceutically acceptable salt thereof is pr... | 11/29/2011 |
| 8067379 | Sulfur compounds as inhibitors of hepatitis C virus NS3 serine protease The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of us... | 11/29/2011 |
| 8030448 | Polypeptide having collagen-like structure Disclosed is a peptide trimer in which three peptides of the same chain length having a repeating unit as a fundamental structure represented by the formula: -(-Gly-X-Y-)- wherein X and Y each represent any amino acid residue are tethered to one ... | 10/04/2011 |
| 8022041 | Prodrug of an ICE inhibitor This invention describes an ICE inhibitor prodrug (I) having good bioavailability. Compound I is useful for treating IL-1 mediated diseases such as rheumatoid arthritis, inflammatory bowel disease, Crohn's disease, ulcerative... | 09/20/2011 |
| 7919468 | Compounds useful as modulators of the proteasome activity Compounds of the following general formula (I): are provided. The compounds can be used as modulators of the proteasome activity, in the preparation of a medicament useful for the prevention or treatment of diseases wherein... | 04/05/2011 |
| 7906619 | 4-amino-4-oxobutanoyl peptides as inhibitors of viral replication The invention provides 4-amino-4-oxobutanoyl peptide compounds of Formula I and the pharmaceutically salts and hydrates thereof. The variables R1-R9, R16, R18, R19 | 03/15/2011 |
| 7888464 | Hepatitis C virus inhibitors Hepatitis C virus inhibitors having the general formula are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed. ... | 02/15/2011 |
| 7884186 | Isotopically labeled trapping agent and method for identifying reactive metabolites The present invention is directed to an isotopically labeled trapping agent, methods for detecting reactive metabolites and methods of identifying drug candidates. More specifically, the isotopically labeled trapping agent and methods for detecting reactive metaboli... | 02/08/2011 |
| 7863417 | Tripeptides and derivatives thereof for cosmetic application in order to improve skin structure The invention relates to compounds and to the cosmetically acceptable salts thereof, which correspond to general formula (I), wherein: R1 represents H, —C(O)—R6, —SO2—R6 or —C(O)—XR6; R2 a... | 01/04/2011 |
| 7858741 | Stabilization of the collagen triple helix by O-methylation of hydroxyproline residues This invention relates to a collagen polypeptide comprising a tripeptide motif having the formula (ProYaaGly)n, where Yaa is an O-methylated amino acid residue and “n” is the number of motif repeats. Preferred O-methylated amino acid residues at the Y... | 12/28/2010 |
| 7851449 | Peptide, pharmaceutical composition, and a method of treating microcirculation disorders The invention is related to the medicinal means of correction of metabolic vascular syndrome and diseases, associated with disordered vascular wall permeability and capillaries fragility, and can be used as a means of enhancing capillaries resistance. There is propo... | 12/14/2010 |
| 7741436 | Biologically active peptides and their use for repairing injured nerves The present invention relates to biologically active peptides derived from the neurite outgrowth-promoting domain of laminin-1, i.e. the γ1-chain of laminin-1. These peptides include the decapeptide RDIAEIIKDI (SEQ ID NO: 1) and the truncated peptides derived there... | 06/22/2010 |
| 7714105 | Use of fragments of oxytocin for the preparation of a pharmaceutical composition in order to create eustasis The present invention relates to the use di-, tri- and tetrapeptide fragments of oxytocin or mesotocin for the preparation of a pharmaceutical composition in order to create eustasis. The invention also relates to di-, tri- and tetrapeptide fragments of oxytocin or ... | 05/11/2010 |
| 7666986 | Biologically active peptide comprising tyrosyl-seryl-valine (YSV) The tripeptide Tyrosyl-seryl-valine is disclosed with its use as a nutritional supplement. A method of making a nutritional supplement comprising obtaining the tripeptide Tyrosyl-seryl-valine and mixing the tripeptide with a biologically or therapeutically acceptabl... | 02/23/2010 |
| 7576175 | Alpha-4 beta-1 integrin ligands for imaging and therapy The present invention provides α4β1 integrin ligands that display high binding affinity, specificity, and stability. The ligands comprise a peptide having n independently selected amino acids, wherein at least one amino acid is an unnatural a... | 08/18/2009 |
| 7550559 | Acylsulfonamide compounds as inhibitors of hepatitis C virus NS3 serine protease The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of us... | 06/23/2009 |
| 7507791 | Solid phase peptide synthesis of tri-peptide derivatives The present invention relates to a process for the preparation of a peptide derivative, and more preferably tri-peptide derivatives, of the formula wherein Tos has the meaning of p-toluenesulfonyl. ... | 03/24/2009 |
| 7427599 | Biologically active peptide comprising Tyrosyl-seryl-valine(YSV) The tripeptide Tyrosyl-seryl-valine is disclosed with its use as a pharmaceutical composition in treating a condition whose effects can be reduced by stimulating T-cell transformation and a cell proliferative disorder. A method is also disclosed making a pharmaceuti... | 09/23/2008 |
| 7425608 | Method of making metallopeptides Method of making metallopeptides is provided, for use in biological, pharmaceutical and related applications. The metallopeptides are made of peptides, peptidomimetics and peptide-like constructs, and include a metal ion-binding region thereof which includes at leas... | 09/16/2008 |
| 7423010 | Nonporous microparticle-prodrug conjugates for treatment of infection This invention provides novel methods and reagents for specifically delivering biologically active compounds to phagocytic mammalian cells. The invention also relates to specific uptake of such biologically active compounds by phagocytic cells and delivery of such c... | 09/09/2008 |
| 7423012 | Phosphinyloxy, oxime and carboxylic acid derivatives which are useful as carboxypeptidase U inhibitors The present invention relates to compounds of Formula I, and pharmaceutically acceptable salts or solvates thereof, or solvates of such salts, which compounds inhibit carboxypeptidase U and thus can be used in the preventio... | 09/09/2008 |
| 7417029 | Prodrug of an ice inhibitor This invention describes an ICE inhibitor prodrug (I) having good bioavailability Compound I is useful for treating IL-1 mediated diseases such as rheumatoid arthritis, inflammatory bowel disease, Crohn's disease, ulcerativ... | 08/26/2008 |
| 7417027 | Linear and cyclic melanocortin receptor-specific peptides Linear and cyclic peptides are provided specific to one or melanocortin receptors, and which exhibit agonist, antagonist, or mixed agonist-antagonist activity. In one embodiment, a linear peptide of the following general formula is provided: | 08/26/2008 |
| 7417030 | Indazole peptidomimetics as thrombin receptor antagonists The invention is directed to novel indazole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, athero... | 08/26/2008 |
| 7410951 | Biologically active peptides and compositions, their use Derivatives of hemiasterlin or Geodiamolide G having anti-mitotic activities and useful in treating cancer. These derivatives are represented by formula I wherein Y, n, R1, R2, R3, R7 | 08/12/2008 |
| 7404948 | Peptidic conjugates for alopecia prevention and treatment The invention relates to novel peptidic conjugates containing a Gly-His-Lys sequence and used for dermatology or cosmetology for stimulating hair growth or stopping hair fall. ... | 07/29/2008 |
| 7402556 | Prodrugs activated by plasmin and their use in cancer chemotherapy The product of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide having a plasmin peptide substrate of 2-4 amino acids and mono- or di-peptide linkage, a stabilizing group and, optionally, a linker group. The ... | 07/22/2008 |
| 7399749 | Substituted prolines as inhibitors of hepatitis C virus NS3 serine protease The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of us... | 07/15/2008 |
| 7396814 | Metallopeptide compositions for treatment of sexual dysfunction Metallopeptide compositions are provided for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction. The metallopeptides include at least one, and preferably two, aromatic amino acid... | 07/08/2008 |
| 7396812 | Method for modulating Nod1 activity, use of a MTP related molecule for modulating Nod1 activity, and therapeutic applications thereof A method for modulating Nod1 activity wherein said method comprises the steps of providing cells expressing a functional Nod1; and bringing said cells into contact with a molecule related to compositions comprising a molecule related to MTP and use of a molecule rel... | 07/08/2008 |
| 7390789 | Thio-containing inhibitors of aminopeptidase P, and compositions thereof The present invention is directed to an α thio-containing compound that is capable of inhibiting the enzyme, membrane aminopeptidase P (mAPP or APP), whose natural substrate is bradykinin. The compound is useful as a pharmaceutical agent because by inhibiting brady... | 06/24/2008 |
| 7385025 | Metallopeptide compounds Metallopeptides with a sequence of a biologically active alpha-melanocyte stimulating hormone (α-MSH), gamma-melanocyte stimulating hormone (γ-MSH), or bombesin sequence of length n residues, wherein a residue including a nitrogen atom and sulfur atom each availab... | 06/10/2008 |
| 7378397 | TRH-degrading ectoenzyme inhibitors Peptide derivatives useful as inhibitors of activity of thyrotropin-releasing hormone-degrading ectoenzyme (TRH-DE) are of formula Ia: wherein: R1 is an optionally su... | 05/27/2008 |
| 7375083 | Pharmaceutical compositions for prevention of overdose or abuse The invention relates to pharmaceutical compositions comprised of a chemical moiety attached to an active agent in a manner that substantially decreases the potential of the active agent to cause overdose or to be abused. When delivered at the proper dosage the phar... | 05/20/2008 |
| 7375085 | Melanocyte-stimulating hormone inhibitors In the present specification is disclosed a melanocyte-stimulating hormone inhibitory composition which comprises, as the active ingredient, a di- or tripeptide derivative having a certain naphthyl group or the salts thereof, or a melanocyte-stimulating hormone inhi... | 05/20/2008 |
| 7375082 | Abuse-resistant hydrocodone compounds The present invention decreases the potential for abuse of opioids, particularly hydrocodone, by covalent modification. The invention provides methods of delivering hydrocodone as conjugates that release the hydrocodone following oral administration while being resi... | 05/20/2008 |
| 7371871 | Inhibitors of glutaminyl cyclase The present invention relates to compounds that act as inhibitors of QC including those represented by the general formulae 1 to 9: and combinations thereof for the treatment of neuronal disorders, especially Alzheimer's di... | 05/13/2008 |
