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...When G.G. Hubbard learned of his future son-in-law's invention, he called it "only a toy." His daughter was engaged to a young man named Alexander Graham Bell.
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| Number | Title | Issue Date |
| 8383591 | Peptides for treating cancer The present invention relates to peptide from 4 to 50 amino acids comprising a phosphorylated pYX1X2X1 motif (SEQ ID NO: 1), wherein each X1 independently is M or Nle and X2 is any amino acid, pharmaceutical com... | 02/26/2013 |
| 8383772 | Ang-(1-7) receptor agonist The application provides Ang-(1-7) receptor agonist peptides and their use for treating acute lung injury. ... | 02/26/2013 |
| 8377880 | Therapeutic agents for reducing parathyroid hormone levels Compounds having activity for lowering parathyroid hormone levels are described. In one embodiment, the compounds are comprised of a contiguous sequence of subunits, X1—X2—X3—X4—X5—X6—X | 02/19/2013 |
| 8362203 | Non-natural peptides as models for the development of antibiotics Described herein are methods of screening one of the RNA hairpins in the small ribosomal subunit of bacteria to identify peptides that bind to it. The RNA hairpin target may be the 970 loop (aka helix 31 (h31)) or a modified version thereof. The identified peptides ... | 01/29/2013 |
| 8354373 | Compounds having an isolated peptide consisting of structure (I) A new compound inhibiting phosphorylation of Ser727 of STAT3, a phosphorylation inhibitor containing the new compound, an insulin resistance improving agent and a preventive or therapeutic agent for diabetes; and a screening method for at least one of the insulin re... | 01/15/2013 |
| 8344102 | Nanoparticle and magnetic resonance imaging contrast agent A nanoparticle contains a core including superparamagnetic nanoparticles and having an outer surface, and siloxanyl moieties covalently coupled to the outer surface of the core and having Formula (I): In formula (I): X... | 01/01/2013 |
| 8299215 | Methods and compositions for treating brain diseases The present disclosure provides targeting peptides and vectors containing a sequence that encodes targeting peptides that deliver agents to the brain. ... | 10/30/2012 |
| 8293702 | Phenolic binding peptides The present application relates to peptides which bind to tannin, polyphenolic or anthocyanin compounds, and particularly to tea and wine stains on a fabric or other surface. The invention also concerns binding peptide conjugates which includes a binding peptide cou... | 10/23/2012 |
| 8288511 | Nuclear targeting sequence The present provides nuclear localization signaling (NLS) sequences derived from titin, comprised of amino acids 181-220: SVGRATSTAE LLVQGEEEVP AKKTKTIVST AQISESRQTR and fragments thereof, such as amino acids 193-208: VQGEEEVP AKKTKTIV; amino acids 199-208: VPAKKTKT... | 10/16/2012 |
| 8268962 | Molecules for targeting compounds to various selected organs or tissues The invention provides conjugates, comprising an organ, tissue or tumor cell homing molecule linked to a moiety. Such a moiety can be, for example, an oligonucleotide, small interfering RNA, gene, virus, protein, pharmaceutical or detectable agent. In addition the i... | 09/18/2012 |
| 8236762 | Peptide-cytotoxic conjugates The invention features targeted cytotoxic compounds and methods relating to their therapeutic use for the treatment of neoplasia and other conditions. ... | 08/07/2012 |
| 8222215 | Methods for the use of inhibitors of antigen presentation by MHC class II molecules The present invention relates to compounds, pharmaceutical compositions containing such compounds and methods for their use. In particular, the compounds of the invention are useful for the treatment or prevention of diseases associated with T cell proliferation suc... | 07/17/2012 |
| 8217011 | Peptides, compositions and uses thereof Described is an N-terminal hexapeptide fragment of maximakinin, QUB 698.8, which exhibits potent tissue selective actions on smooth muscle. It demonstrates a high degree of selectivity for arterial smooth muscle over small intestinal smooth muscle, causing potent re... | 07/10/2012 |
| 8207296 | Approach to treat intraocular hypertension The present invention relates to the use of antisecretory factors, such as antisecretory proteins, homologues, derivatives and/or fragments thereof having antisecretory activity, for the manufacture of a pharmaceutical composition for use in the treatment and/or pre... | 06/26/2012 |
| 8193155 | Method and compositions for treating skin A skin care composition comprising at least one keratinocyte CLOCK or PER1 gene activator and at least one DNA repair enzyme; a method for inhibiting damage to human keratinocytes due to environmental aggressors by applying a composition comprising at least one kera... | 06/05/2012 |
| 8106019 | CHEC-7 a novel sPLA2 inhibitor The present invention relates to the discovery of a composition including a seven-amino acid peptide that promotes neuronal survival, inhibits inflammation, and is a potent inhibitor of sPL2A, and uses thereof. ... | 01/31/2012 |
| 8097582 | Peptide derivatives useful as antimicrobial agents and for treating wounds A compound having the general formula (I) R1—NH—CH[(CH2)n—NH—C(NH)—NH2]-CO—R2-A-R4; a pharmaceutical composition comprising the compound and use of the compound for the manufacturing of a ... | 01/17/2012 |
| 8063180 | Antibodies directed against prothrombin fragment F1+2, the preparation and use thereof The invention relates to antibodies directed against F1+2, to the preparation and use thereof, especially in therapy and diagnosis. The antibodies bind to an epitope on the N-terminal half of the F2 fragment of prothrombin. ... | 11/22/2011 |
| 8053415 | Compounds having RD targeting motifs The present invention provides compounds that have motifs that target the compounds to cells that express integrins. In particular, the compounds have peptides with one or more RD motifs conjugated to an agent selected from an imaging agent and a targeting agent. Th... | 11/08/2011 |
| 8034781 | Angiotensin-(1-7) and angiotensin-(1-7) agonists for inhibition of cancer cell growth The present invention describes the use of angiotensin-(1-7) peptide as an anti-cancer therapeutic. Thus, in one embodiment, the present invention comprises a composition to inhibit the growth of cancer cells in an individual comprising a pharmaceutically effective ... | 10/11/2011 |
| 8030447 | Substrate peptide sequences for plague plasminogen activator and uses thereof The present invention is directed to peptide sequences that were identified from combinatorial libraries and could serve as substrates of plague plasminogen activator (Pla). Another aspect of the present invention is drawn to peptides derived from the substrates for... | 10/04/2011 |
| 8017572 | Immune-modulating peptide Disclosed are peptides having SEQ ID NOs: 1 to 24 that induce superoxide generation by human monocytes or neutrophils; that induce an intracellular calcium increase by human peripheral blood monocytes or neutrophils; binds to formyl peptide receptor or formyl peptid... | 09/13/2011 |
| 7960508 | Peptide having cytotoxicity inhibitory activity and method of screening these peptide having cytotoxicity inhibitory activity A peptide fragment or a series of peptide fragments containing one or more selenocysteine that has a lowered toxicity than selenocystine and that exhibits a cytotoxicity-inhibitory activity. The peptide fragment or a series of peptide fragments according to the pres... | 06/14/2011 |
| 7919466 | Lymphatic zip codes in tumors and pre-malignant lesions Disclosed herein are compositions and methods for and involving selectively targeting tumor lymphatics. ... | 04/05/2011 |
| 7919582 | Neuregulin-β isoform The invention relates, inter alia, to the use of neuregulin-β as a target in a screening method for active compounds, in particular for exerting an influence on changes in calcium concentration which are mediated by glutamate receptors. The invention furthermore re... | 04/05/2011 |
| 7915220 | Peptidomimetic agents from dextrorotatory amino acids as well as pharmaceutical agents that contain the latter for treatment of neurodegenerative diseases A peptidomimetic agent from dextrorotatory amino acids includes vGek with Dval-gly-Dglu-Dlys as a central D-amino acid sequence, whereby gly is equal to D-glycine, which is equal to L-glycine. Pharmaceutical agents for use in the treatment of neurodegenerative disea... | 03/29/2011 |
| 7910694 | Homing peptides to receptors of heart vasculature The present invention relates to peptides which selectively or preferentially home to areas of a heart. The invention further relates to conjugates of the homing peptides and uses thereof. ... | 03/22/2011 |
| 7906477 | Activation of peptide prodrugs by hK2 The invention provides novel peptide prodrugs that contain cleavage sites specifically cleaved by human kallikrein 2 (hK2). These prodrugs are useful for substantially inhibiting the non-specific toxicity of a variety of therapeutic drugs. Upon cleavage of the prodr... | 03/15/2011 |
| 7875701 | Diagnostic compounds The invention relates to conjugates of formula (III) or (IIIa), or a salt thereof, their use as radiopharmaceuticals, processes for their preparation, and synthetic intermediates used in such processes. ... | 01/25/2011 |
| 7863416 | Nociceptin-based analgesics The invention relates to a family of hexapeptide compounds exhibiting activity with regard to the ORL-1 receptor. The compounds share a general formula of Arg-Tyr-Tyr-Arg-Trp-Arg, and may be constructed having modifications or substitutions at any position, and may ... | 01/04/2011 |
| 7863415 | Amino acid and peptide conjugates of amiloride and methods of use thereof The present invention provides compositions comprising amiloride amino acid and peptide conjugates. Efficient methods are also provided for administering the amiloride conjugates of the present invention for treating cancer or a central nervous system disease or dis... | 01/04/2011 |
| 7816489 | Methods for making intermediates and oxytocin analogues More efficient and/or economical methods for synthesizing heptapeptide alcohol analogs of oxytocin are provided along with novel intermediates which are useful in synthesizing such oxytocin analogs. Efficient and economical methods for synthesizing intermediates use... | 10/19/2010 |
| 7777001 | Agonist polypeptide of receptor for ZOT and zonulin Agonist polypeptide of a receptor protein has been identified. The agonist can be used to facilitate drug and antigen absorption. Suitable routes of administration include oral, nasal, transdermal, and intravenous. Pharmaceutical formulations may comprise a therapeu... | 08/17/2010 |
| 7622551 | Leukocyte stimulating peptides The present application describes peptides that stimulate arachidonic acid release in target cells. The application also discloses peptides that cause intracellular calcium release. The application also discloses methods of using the disclosed peptides. ... | 11/24/2009 |
| 7544774 | Mimotopes and anti-mimotopes of human platelet glycoprotein Ib/IX The present invention is directed to an isolated peptide that functionally mimics a binding site for a monoclonal antibody, the monoclonal antibody recognizing an epitope within the human platelet glycoprotein Ib/IX complex. This peptide is called a mimotope. The in... | 06/09/2009 |
| 7544773 | Antimicrobials against pathogenic bacteria and method for screening them The present invention provides antimicrobials for efficient therapy of infections caused by bacterial pathogens. The antimicrobials include peptides corresponding to the active site of N-terminal extension of subunits composing specific adhesive organelles of virule... | 06/09/2009 |
| 7538188 | Method for fabricating an olfactory receptor-based biosensor A biosensor, a method of making a biosensor, and a method of using a biosensor are described. A biosensor includes a transducer and a peptide encoding the most probable binding domain of an olfactory receptor protein. In embodiments, the transducer is a piezoelectri... | 05/26/2009 |
| 7531624 | Nuclear targeting sequence The present provides nuclear localization signaling (NLS) sequences derived from titin, comprised of amino acids 181-220: SVGRATSTAE LLVQGEEEVP AKKTKTIVST AQISESRQTR and fragments thereof, such as amino acids 193-208: VQGEEEVP AKKTKTIV; amino acids 199-208: VPAKKTKT... | 05/12/2009 |
| 7521530 | Peptides and peptidomimetics useful for inhibiting the activity of prostaglandin Freceptor The invention relates to compositions which are useful for inhibiting prostaglandin F2αreceptor. The compositions include, but are not limited to, linear peptides, peptide analogs, and peptidomimetics. Methods of using the compositions of the invention t... | 04/21/2009 |
| 7442763 | Compositions for treating abnormalities in glomerular filtration, patent ductus arteriosus and osteoporosis The present invention relates to a composition of matter comprising novel prostaglandin E2 receptor antagonists, and their use in treatments for regulating the fluid filtration in the kidney, preventing bone mineral loss in osteoporosis and dental disease and additi... | 10/28/2008 |
