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| Number | Title | Issue Date |
| 8071540 | Virus derived antimicrobial peptides Described herein are peptides having antimicrobial activity (antimicrobial peptides). The antimicrobial peptides, designated LBU, WLBU and WR, are analogs of the Lentivirus Lytic Peptide 1 (LLP1) amino acid sequence. The antimicrobial peptides are monomers or multim... | 12/06/2011 |
| 7998928 | Method of treatment of type-1 diabetes with a humanin analogue The present invention is based on the discovery that Humanin and humanin analogues protect pancreatic beta cells in vitro and in vivo from apoptosis. Accordingly, humanin and its analogues are useful for preventing and treating diabetes and promoting beta cell survi... | 08/16/2011 |
| 7943580 | Polypeptide and the use thereof The present invention provides a variety of useful polypeptides. In particular, a polypeptide comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3, its amide, or a salt... | 05/17/2011 |
| 7879794 | Methods for controlling binge eating disorders Compositions and methods for preventing, treating or controlling conditions or disorders associated with obesity, diet, and nutrition are provided. The methods provided generally involve the administration of an amylin or an amylin agonist to a subject in order to p... | 02/01/2011 |
| 7786257 | Signal-1/signal-2 bifunctional peptide inhibitors A novel peptide sequence having the general formula AB wherein each of A and B represent a chain of amino acid residues and wherein said A chain is capable of binding with a major histocompatibility complex on an antigen presenting cell, and wherein said B chain is ... | 08/31/2010 |
| 7700720 | Antibodies against and methods for producing vaccines for respiratory syncytial virus The present invention relates to novel respiratory syncytial virus (RSV) F peptides and compositions comprising them. The present invention also relates to methods of evaluating anti-RSV antibody binding to F peptides. The present invention also relates to antibodie... | 04/20/2010 |
| 7598343 | Pharmaceutical formulations of bivalirudin and processes of making the same Pharmaceutical batch(es) or pharmaceutical formulation(s) comprising bivalirudin as the active ingredient, and a method of preparing the pharmaceutical batch(es) or pharmaceutical formulation(s). The pharmaceutical batch(es) or pharmaceutical formulation(s) may have... | 10/06/2009 |
| 7507790 | Fiber-shaping peptides capable of interacting with self-assembling peptides The present invention relates to a fiber-shaping peptides that are capable of interacting with self-assembling peptides to form protein structures. The present invention also relates to methods of forming protein structures using the fiber-shaping peptides of the pr... | 03/24/2009 |
| 7438917 | Peptide sequences specific for the hepatic stages of bearing epitopes capable of stimulating the T lymphocytes The present invention relates to an in vitro diagnostic method for malaria in an individual comprising placing a tissue or a biological fluid taken from an individual in contact with a molecule or polypeptide composition, wherein said molecule or polypeptide composi... | 10/21/2008 |
| 7432342 | Kinase anchor protein muteins, peptides thereof and related documents A-kinase anchor protein (AKAPs) muteins, peptides thereof, and nucleic acids encoding the peptides are provided herein. Also provided are transgenic animals, cells comprising transgenes and various methods employing such peptides. ... | 10/07/2008 |
| 7427658 | Chicken anemia virus mutants and vaccines and uses based on the viral proteins VP1, VP2 and VP3 or sequences of that virus coding therefor The coding information for three putative chicken anemia virus proteins (VP1, VP2, VP3) was inserted into a baculovirus vector and expressed in insect cells. Only lysates of insect cells which have synthesized equivalent amounts of all three recombinant CAV proteins... | 09/23/2008 |
| 7422862 | Methods for identifying modulators of apoptosis The invention provides a method of identifying an effective compound that modulates the binding of Humanin to Bax or Bid. The invention also provides a method of identifying an effective compound that modulates an activity of Bax or Bid. In addition, the invention p... | 09/09/2008 |
| 7417025 | Use of poly-α2,8-sialic acid mimetic peptides to modulate NCAM functions The invention relates to the use of a peptide consisting of 5 to 30 amino acid residues, preferably 9 to 15, most preferably about 12 amino acid residues, said peptide comprising a B epitope of a poly-α2,8 sialic acid attached to NCAM, which is recognized by an ant... | 08/26/2008 |
| 7414107 | Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis The invention is directed to a pharmacologically active peptide conjugate having a reduced tendency towards enzymatic cleavage comprising a pharmacologically active peptide sequence (X) and a stabilizing peptide sequence (Z) of 4-20 amino acid residues covalently bo... | 08/19/2008 |
| 7411039 | GLP-2 compounds, formulations, and uses thereof The present invention relates to novel human glucagon-like peptide-2 (GLP-2) peptides and human glucagon-like peptide-2 derivatives which have a protracted profile of action as well as polynucleotide constructs encoding such peptides, vectors and host cells comprisi... | 08/12/2008 |
| 7408031 | Peptide epitopes recognized by disease promoting CD4+ T lymphocytes The invention provides methods for identifying peptide epitopes that activate CD4+ T cells involved in the pathogenesis of diseases, e.g., autoimmune diseases, susceptibility to which is determined by expression of particular class II MHC genes. The invention includ... | 08/05/2008 |
| 7408029 | Peptide epitopes recognized by disease promoting CD4+ T lymphocytes The invention provides methods for identifying peptide epitopes that activate CD4+ T cells involved in the pathogenesis of diseases, e.g., autoimmune diseases, susceptibility to which is determined by expression of particular class II MHC genes. The invention includ... | 08/05/2008 |
| 7388072 | MAGE peptides presented by HLA class II molecules The invention describes HLA class II binding peptides encoded by the MAGE tumor associated genes, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes.... | 06/17/2008 |
| 7387779 | Anti-angiogenic proteins and fragments and methods of use thereof Proteins with anti-angiogenic properties are disclosed, and fragments thereof, and methods of using those proteins and fragments to inhibit or promote angiogenesis. ... | 06/17/2008 |
| 7381705 | Inhibitors of hepatitis C virus The present invention relates to methods that employ peptides or peptide derivatives to inhibit hepatitis C virus infection. The present invention is based in part on the discovery that E2 envelope glycoprotein of hepatitis C virus has previously undescribed domains... | 06/03/2008 |
| 7371812 | Antiangiogenic peptides The present invention provides an antiangiogenic polypeptide having the amino acid sequence set forth in SEQ ID NO: 1, or a fragment thereof, which is effective to inhibit endothelial cell proliferation as determined by the capillary EC proliferation assay. Preferab... | 05/13/2008 |
| 7368119 | Compositions and methods for WT1 specific immunotherapy Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that sp... | 05/06/2008 |
| 7368527 | HADDE71 polypeptides The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind thes... | 05/06/2008 |
| 7354992 | Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention. ... | 04/08/2008 |
| 7351792 | Recombinant C140 receptor, its agonists and antagonists, and nucleic acids encoding the receptor Nucleic acid molecules encoding the C140 cell surface receptor have been cloned and sequenced. The availability of C140 receptor DNA permits the recombinant production of the C140 receptor which can be produced on the surface of a cell, including an oocyte. The nucl... | 04/01/2008 |
| 7342093 | Compounds that inhibit Hsp90 protein-protein interactions with IAP proteins Disclosed herein are compounds that inhibit Hsp90 interactions with IAP proteins, such as Survivin, XIAP, cIAP1, or cIAP2, and methods for identifying and using such compounds. ... | 03/11/2008 |
| 7335636 | SPRR1A and axonal regeneration The present invention provides polynucleotides, polypeptides, pharmaceutical compositions, and methods for modulation of nerve growth and regeneration. ... | 02/26/2008 |
| 7335727 | Pharmaceutical used for treating HIV infection, the composition and uses thereof A fusion inhibitor used to treat HIV infection, has an amino acid sequence as follows: X-SWETWEREIENYTKQIYKILEESQEQQDRNEKDLLE-Z, wherein X is either an amino group or -X1-X2, wherein X1 is an imino group, and X2 is either an acetyl group, a hydro... | 02/26/2008 |
| 7335724 | Peptides immunoreactive with autoantibodies from patients suffering from rheumatoid arthritis The invention relates to a peptide derived from an antigen recognized by autoantibodies, which peptide is reactive with autoimmune antibodies from a patient suffering from rheumatoid arthritis. The peptide according to the invention possesses a modified arginine res... | 02/26/2008 |
| 7332567 | Fret protease assays for clostridial toxins The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of all serotypes as well as tetanus toxins. A clostridial toxin substrate of the invention contains a donor ... | 02/19/2008 |
| 7326535 | Immunoreactive peptides from Epstein-Barr virus Epstein-Barr virus (EBV) specific polypeptides are disclosed. Also disclosed are the use of these polypeptides for the production of polypeptide-specific antibodies and the diagnosis and treatment of EBV-associated disease. ... | 02/05/2008 |
| 7326688 | Analogs of gastric inhibitory polypeptide and their use of treatment for diabetes The present invention provides peptides which stimulate the release of insulin. The peptides, based on GIP 1-42 include substitutions and/or modifications which enhance and influence secretion and/or have enhanced resistance to degradation. The invention also provid... | 02/05/2008 |
| 7326767 | Immunotherapeutic methods using epitopes of WT-1 and GATA-1 A peptide comprising the amino acid sequence RMFPNAPYL (SEQ ID NO:1) or a portion or variant thereof provided that the peptide is not intact human WT-1 polypeptide or a peptide comprising the amino acid sequence CMTWNQMNL (SEQ ID NO:2) or a portion or variant thereo... | 02/05/2008 |
| 7314856 | Adrenomedullin agonists A method for promoting bone growth in a patient (e.g., a mammal such as a human) said method including the step of administering a therapeutically effective amount of adrenomedullin or an adrenomedullin agonist to said patient. ... | 01/01/2008 |
| 7312190 | Pharmaceutical compositions of apolipoprotein A-I agonists and their use to treat dyslipidemic disorders The present invention provides peptides and peptide analogues that mimic the structural and pharmacological properties of human ApoA-I. The peptides and peptide analogues are useful to treat a variety of disorders associated with dyslipidemia. ... | 12/25/2007 |
| 7306804 | HIV-specific T-cell induction This invention discloses diagnostic, preventative, and treatment therapies of AIDS involving determining whether a subject exhibits an HLA-Cw7-restricted CTL response. Some methods are directed to the use of HLA-Cw7 as a genetic marker for long-term non-progression ... | 12/11/2007 |
| 7282199 | Adeno-associated virus (AAV) serotype 8 sequences, vectors containing same, and uses therefor Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. rAAV8-mediated delivery of therapeutic and immunogen... | 10/16/2007 |
| 7276251 | Sustained-release composition of drugs encapsulated in microparticles of hyaluronic acid A sustained-release drug composition consisting essentially of microparticles of hyaluronic acid having a high molecular weight or an inorganic salt thereof and a protein or peptide drug encased in said microparticles, wherein the average size of said microparticles... | 10/02/2007 |
| 7271148 | Inhibition of cellular proteases The invention provides a method of decreasing viral replication in cells, the method comprising decreasing levels of functional cellular protease in the cells. The invention further provides a method of treating or preventing a viral infection in a subject, the meth... | 09/18/2007 |
| 7267823 | peptides and immunogenic compositions containing same Using CTL epitopes to the Ebola GP, NP, VP24, VP30, VP35 and VP40 virion proteins, a method and composition for use in inducing an immune response which is protective against infection with Ebola virus is described. ... | 09/11/2007 |
