Celebrity Inventors
Mark Twain (Samuel L. Clemens) received Patent No. 121,992 for "An Improvement in Adjustable and Detachable Straps for Garments." He later received two more patents: one for a self-pasting scrapbook and one for a game to help players remember important historical dates.
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| Number | Title | Issue Date |
| 8188044 | Anti-tumor drug, medicament, composition, and use thereof An active polypeptide comprising the amino acid sequence of SEQ ID NO: 3, or having at least 50%, preferably 70%, more preferably 90% identity with the amino acid sequence of SEQ ID NO: 3, or fragments thereof having at least 21 contiguous amino acids, or peptides h... | 05/29/2012 |
| 8188218 | Bi-functional peptides for multiple sclerosis treatment and diagnosis Novel bifunctional peptides useful in the treatment and/or diagnosis of EAE or MS. The peptides have a first peptide portion derived from an epitope of myelin proteolipid protein, myelin oligodendrocyte glycoprotein, or oligodendrocyte-specific peptide and a second ... | 05/29/2012 |
| 8173769 | Taste receptors of the T1R family from domestic cat The present invention relates to the discovery of several genes of the domestic cat (Felis catus) associated with taste perception. The invention provides, inter alia, the nucleotide sequence of the feline Tas1r1, Tas1r2, and Tas1r3 receptor genes, the amino ... | 05/08/2012 |
| 8163873 | Isolated microtubule-associated protein tau peptides and kit A monoclonal antibody which forms an immunological complex with a phosphorylated epitope of an antigen belonging to human abnormally phosphorylated tau proteine. The tau protein can be obtained from a brain homogenate, itself isolated from the cerebral cortex of a p... | 04/24/2012 |
| 8153760 | Rhinovirus vaccines The present invention relates generally to peptide vaccines. More specifically, the present invention relates to vaccines against rhinoviruses and other related and non-related pathogenic animal viruses. In addition, the present invention relates generally to method... | 04/10/2012 |
| 8153598 | PKD ligands and polynucleotides encoding PKD ligands The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate protein kinase D (PKD) activity. The ligands and polyligands are utilized as research tools or as therapeut... | 04/10/2012 |
| 8148492 | Synthetic pulmonary surfactant peptides The present invention is directed to a reconstituted surfactant comprising a lipid carrier, a polypeptide analog of the native surfactant protein SP-C, and a polypeptide analog of the native surfactant protein SP-B. The invention is also directed to the pharmaceutic... | 04/03/2012 |
| 8148320 | Peptide inhibitors of ABL kinases Provided are purified compounds comprising SEQ ID NO:1, where the tyrosine at residue (10) is phosphorylated. Also provided are purified compounds comprising SEQ ID NO:1, where the amino acid sequence of the compound is less than 400 amino acids. Additionally provid... | 04/03/2012 |
| 8143224 | Oxidant resistant apolipoprotein A-1 and mimetic peptides A purified polypeptide includes an ApoA1 mimetic or fragment thereof that are resistant to oxidation. ... | 03/27/2012 |
| 8143374 | Polypeptide derivatives of parathyroid hormone (PTH) The present invention is related to novel parathyroid hormone polypeptide derivatives, and to pharmaceutical composition containing the polypeptides, as well as synthetic and recombinant methods for producing the polypeptides. Also disclosed are methods for treating... | 03/27/2012 |
| 8143222 | Modular platform for targeted therapeutic delivery Pharmaceutical compounds, pharmaceutical compositions and methods of treatment are disclosed, wherein a compound comprises a targeting moiety which, in free form, binds a cell receptor with a dissociation constant Kd of less than about 10−7 M... | 03/27/2012 |
| 8138305 | Analogues of GLP-1 The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefore comprising said analogues. ... | 03/20/2012 |
| 8138146 | Antiviral peptide and antiviral agent Disclosed is an antiviral agent comprising a non-naturally occurring, artificially synthesized peptide as the main ingredient. The antiviral agent comprises an antiviral peptide, wherein the antiviral peptide has at least one unit of an amino acid sequence constitut... | 03/20/2012 |
| 8129330 | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof Methods are provided for the preparation of conjugates of a variety of bioactive components, especially proteins, with water-soluble polymers (e.g., poly(ethylene glycol) and derivatives thereof), which conjugates have reduced antigenicity and immunogenicity compare... | 03/06/2012 |
| 8129332 | Reagents and methods for smooth muscle therapies The present invention provides novel polypeptides comprising heat shock protein 20 (HSP20)-derived polypeptides to treat or inhibit smooth muscle vasospasm, as well to treat and inhibit smooth muscle cell proliferation and migration. ... | 03/06/2012 |
| 8129331 | Specific binding agents of human angiopoietin-2 Disclosed are peptides that bind to Ang-2. Also disclosed are peptibodies comprising the peptides, methods of making such peptides and peptibodies, and methods of treatment using such peptides and peptibodies. ... | 03/06/2012 |
| 8124579 | Heat shock protein 20-related polypeptides and uses therefor The present invention provides novel HSP20-based polypeptides and pharmaceutical compositions thereof, and methods for using such polypeptides and pharmaceutical compositions for various therapeutic uses. ... | 02/28/2012 |
| 8124725 | PDGF-Rβ binders Provided herein are PDGF-Rβ imaging agents that are polypeptides labeled with a signal generator (e.g., paramagnetic label, a radionuclide, or a fluorophore), wherein the imaging agents bind specifically to PDGFR-β. Also provided are in vivo imaging methods using ... | 02/28/2012 |
| 8119601 | Voltage dependent anion channel (VDAC1) compositions and methods of use thereof for regulating apoptosis The present invention relates generally to the mitochondrial protein, voltage-dependent anion channel (VDAC)5 polynucleotides encoding same and variants thereof, as well as peptide fragments, peptide derivatives and analogs. In particular, the present invention is d... | 02/21/2012 |
| 8119600 | Compositions containing lysozyme and C-1/C-4 polysaccharides and use thereof in oral care, cosmetology and dermatology, contraception, urology and gynecology A composition comprising a content of a lysozyme and a content of a C-1/C-4 polysaccharide is useful in oral care, cosmetology and dermatology, contraception, urology and gynecology. It is emphasized that this abstract is provided to comply with the rules requiring ... | 02/21/2012 |
| 8114960 | Heterologous expression of Neisserial proteins Alternative and improved approaches to the heterologous expression of the proteins of Neisseria meningitidis and Neisseria gonorrhoeae. These approaches typically affect the level of expression, the ease of purification, the cellular localization, and/... | 02/14/2012 |
| 8110655 | Method to promote hair growth and/or delay or treat hair loss by administering a TGF-β antagonist or inhibitor The present invention provides methods for promoting hair growth and/or treating or preventing hair loss (alopecia) by contacting the cells with a TGF-β antagonist or inhibitor either alone or in combination with other alopecia-inhibiting compounds. ... | 02/07/2012 |
| 8110656 | Compositions and methods of a phosphatidic acid binding protein TGD2 proteins of Arabidopsis are proposed to be a substrate binding component of a lipid transfer complex in the inner chloroplast envelope membrane. Loss of function of this protein or other components of this complex may disrupt the endoplasmic reticulum (E... | 02/07/2012 |
| 8101576 | Compounds and their effects on feeding behaviour The invention features peptides for the treatment or prevention of obesity, diabetes or co-morbidities of obesity; for reduction of appetite, food intake, calorie intake, body weight, or body weight gain; and for increase of energy expenditure in a subject. ... | 01/24/2012 |
| 8101577 | Oxidative DNA damage protection Provided herein are methods of screening compounds, gene sequences, and gene products in bacteria for agents that are protective against oxidative DNA damage in a human or animal. Gene sequences identified by these screens can also be used in diagnostic assays that ... | 01/24/2012 |
| 8097698 | Derivatives of GLP-1 analogs The present invention relates to a pharmaceutical composition comprising a GLP-1 derivative having a lipophilic substituent; and a surfactant. ... | 01/17/2012 |
| 8093209 | Methods of suppressing microglial activation and systemic inflammatory responses Methods of suppressing the activation of microglial cells in the Central Nervous System (CNS), methods of ameliorating or treating the neurological effects of cerebral ischemia or cerebral inflammation, and methods of combating specific diseases that affect the CNS ... | 01/10/2012 |
| 8088889 | Teneurin c-terminal associated peptides (TCAP) and uses thereof The invention provides a novel family of biologically active neuropeptides and the nucleic aid molecules coding for same. The peptides are derived for the C-terminus of the teneurin family peptides (Ten M1-4). These novel peptides, referred to as teneurin C-terminal... | 01/03/2012 |
| 8080632 | Peptide mimics of melanocyte stimulating hormone Provided are peptides having melanocyte stimulating hormone activity. Also provided are vectors encoding these peptides and transgenic cells comprising the above vectors. Additionally, methods of reducing or preventing release of an inflammatory cytokine from mammal... | 12/20/2011 |
| 8080522 | Polyethlene glycol modifications of thymosin alpha-1 Polyethylene glycol modifications of thymosin alpha 1 (T&agr; 1-PEGs), their preparation process, the medicine composition containing them, and their application in the medicine for preventing and treating diseases related with immune deficiency and hypoimmunity, in... | 12/20/2011 |
| 8076451 | Selective delivery of molecules into cells or marking of cells in diseased tissue regions using environmentally sensitive transmembrane peptide A polypeptide with a predominantly hydrophobic sequence long enough to span a membrane lipid bilayer as a transmembrane helix (TM) and comprising one or more dissociable groups inserts across a membrane spontaneously in a pH-dependant fashion placing one terminus in... | 12/13/2011 |
| 8076299 | Method for producing peptide thioester It is an object of the present invention to provide a novel method for producing a peptide thioester. In the present invention, general peptide synthesis is performed on a solid-phase resin, carboxylic acid obtained after cutout is allowed to react with p-toluenesul... | 12/13/2011 |
| 8076286 | Antimicrobial peptides and use thereof The invention relates to a molecule comprising at least the amino acid sequence X1 X2 X3 X4 X5 X6 W X8 X9 X10 wherein X4,6,9 is any amino acid residue, X | 12/13/2011 |
| 8076300 | FGF2-binding peptides and uses thereof FGF2-binding peptides are here described, which have been designed starting from the N-terminal region of PTX3, in particular spanning the PTX3(82-11O) region. Synthetic peptides related to this sequence are able to bind FGF2 | 12/13/2011 |
| 8067533 | Peptides and peptide derivatives, the production thereof as well as their use for preparing a therapeutically and/or preventively active pharmaceutical composition The invention relates to peptides and peptide derivatives of the following general Formulas (Ia) and (Ib) as well as in particular anti-inflammatory drugs containing these peptides. ... | 11/29/2011 |
| 8067532 | Modifications of peptide compositions to increase stability and delivery efficiency The disclosed invention relates to methods of modifying peptide compositions to increase stability and delivery efficiency. Specifically, the disclosed invention relates to methods to increase the stability and delivery efficiency of protein kinase C (PKC) modulator... | 11/29/2011 |
| 8048859 | Use of repeat sequence protein polymers in personal care compositions A personal care composition is provided and includes an effective amount of a repeat sequence protein polymer. The personal care composition may be a hair care composition, a skin care composition, a nail care composition, a cosmetic composition, or an over-the-coun... | 11/01/2011 |
| 8044022 | Hyaluronic acid binding peptides enhance host defense against pathogenic bacteria Several species of bacteria capable of invasive infections, such as S. pyogenes, S. equi and P. multocida, contain hyaluronic acid (HA) in their capsules. Bacterial species such as Staphylococcus aureus and related Staphylococci have capsules th... | 10/25/2011 |
| 8044174 | Thrombopoietic compounds The invention relates to the field of compounds, especially peptides or polypeptides, that have thrombopoietic activity. The peptides and polypeptides of the invention may be used to increase platelets or platelet precursors (e.g., megakaryocytes) in a mammal. ... | 10/25/2011 |
| 8044018 | Reagents and methods for smooth muscle therapies The present invention provides novel polypeptides comprising heat shock protein 20 (HSP20)-derived polypeptides to treat or inhibit smooth muscle vasospasm, as well to treat and inhibit smooth muscle cell proliferation and migration. ... | 10/25/2011 |
