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| Number | Title | Issue Date |
| 7417024 | Template-fixed peptidomimetics as inhibitors of serine proteases Template-fixed β-hairpin peptidomimetics of the general formulae (I), wherein Z is a template-fixed chain of 7 to 11 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or of cer... | 08/26/2008 |
| 7368425 | Cyclic peptides for modulating growth of neo-vessels and their use in therapeutic angiogenesis The present disclosure teaches analogs of human chemokines and methods of using them in the prevention, treatment, and ameliorization of diseases that can benefit from therapeutic angiogenesis. The teachings are generally directed to compositions comprising SDF-1 mi... | 05/06/2008 |
| 7368426 | Methods for the therapeutic use of cyclosporine components Methods of treating humans or animals having rheumatoid arthritis are disclosed which include topically administering a therapeutically effective amount of a cyclosporine component to the human or animal, thereby treating the rheumatoid arthritis. ... | 05/06/2008 |
| 7361636 | Cyclosporin alkynes and their utility as pharmaceutical agents The compounds of the present invention are represented by the chemical structure found in Formula I: or a pharmaceutically acceptable salt thereof, with X, R0, and R1 defined herein. ... | 04/22/2008 |
| 7358229 | Deuterated cyclosporin analogs and their use as immunomodulating agents Cyclosporine derivatives are disclosed which possess enhanced efficacy and reduced toxicity over naturally occurring and other presently known cyclosporins and cyclosporine derivatives. The cyclosporine derivatives of the present invention are produced by chemical a... | 04/15/2008 |
| 7355216 | Fluidic nanotubes and devices Fluidic nanotube devices are described in which a hydrophilic, non-carbon nanotube, has its ends fluidly coupled to reservoirs. Source and drain contacts are connected to opposing ends of the nanotube, or within each reservoir near the opening of the nanotube. The p... | 04/08/2008 |
| 7345144 | Cyclic peptides for treatment of cachexia A highly selective melanocortin-4 receptor antagonist cyclic hexapeptide of the formula where R1, R2, R3a, R3b, R4, R5, x, y and z are as defined in the spec... | 03/18/2008 |
| 7342089 | Cyclic peptides for treatment for cachexia A highly selective melanocortin-4 receptor antagonist cyclic peptide of the formula where R1, R2, R3, R4a, R4b, R5, R6, R7, x, y and z ... | 03/11/2008 |
| 7332472 | Cyclosporine analogue mixtures and their use as immunomodulating agents The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine A. The mixtures possess enhanced efficacy and reduced toxicity over the individual isomers and over naturally occurring and other presently known c... | 02/19/2008 |
| 7288623 | Cyclic peptide tube Cyclic homodetic peptides having a repeating D-L-chirality motif are shown to have a stable disk conformation with the amino acid side chains extending radially outward and the carbonyl and amino groups extending axially upward or downward. Such cyclic peptides can ... | 10/30/2007 |
| 7262268 | Lipopeptide stereoisomers, methods for preparing same, and useful intermediates The present invention provides daptomycin stereoisomeric compounds, methods and intermediates for preparing daptomycin and daptomycin stereoisomoeric compounds, as well as pharmaceutical compositions of these compounds and methods of using these compositions as anti... | 08/28/2007 |
| 7262269 | Method for screening combinational bead library; ligands for cancer cells The invention includes a cell-growth-on-bead assay for screening a one-bead-one-compound combinatorial bead library to identify synthetic ligands for cell attachment and growth or proliferation of epithelial and non-epithelial cells. Cells are incubated with a compo... | 08/28/2007 |
| 7253146 | Template-fixed peptidomimetics with antimicrobial activity Template-fixed β-hairpin peptidomimetics of the general formulae (I) and (II) wherein Z, Z1 and Z2 are template-fixed chains of 8 to 16 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly... | 08/07/2007 |
| 7235625 | Multiple agent therapy for sexual dysfunction Multiple agent therapy for treatment of sexual dysfunction, including male erectile dysfunction, with sequential administration a type V phosphodiesterase inhibitor (PDE-5), such as sildenafil, preferably wherein the PDE-5 inhibitor is administered by oral dose mean... | 06/26/2007 |
| 7235626 | Structured peptide scaffold for displaying turn libraries on phage The invention is directed to a model system for structure-activity analysis of peptide or protein molecules involved in important biological processes. Provided by the invention are combinatorial peptide libraries comprising disulfide-constrained cyclic peptides wit... | 06/26/2007 |
| 7226905 | Process for the preparation of cyclosporin derivatives The invention concerns a novel method for preparing an intermediate polyanion for preparing cyclosporin derivatives by treating a cyclosporin with a hexamethyldisilazane metal salt, optionally in the presence of a metal halide. The treated cyclosporin has one or sev... | 06/05/2007 |
| 7226906 | Cyclosporin analogs for the treatment of immunoregulatory disorders and respiratory diseases Provided are novel cyclosporin analogs, methods for their production, and their use for treating immunoregulatory and respiratory diseases, disorders, and conditions. ... | 06/05/2007 |
| 7217690 | Compositions of sunflower trypsin inhibitors The present invention provides methods of using small cyclic peptides that can inhibit or prevent skin irritation caused by proteolytic activity. ... | 05/15/2007 |
| RE39496 | Kahalalide F and compositions and uses thereof Kalahide Kahalalide F, of formula I below, may be isolated from a sacoglossan. The compound may be used in the manufacture of pharmaceutical compositions or in the treatment of tumors or viral conditions ... | 02/27/2007 |
| 7176279 | Cyclic peptide compositions and methods for treatment of sexual dysfunction A cyclic peptide with a C-terminus —OH group. Further provided are compositions and methods for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction, by administration of a cycli... | 02/13/2007 |
| 7153834 | Pharmaceutical compositions Disclosed is a pharmaceutical composition suitable for oral administration in the form of a homogeneous solution which on exposure to water or gastrointestinal fluids forms an emulsion having a particle size of less than 5 microns, the solution containing: ... | 12/26/2006 |
| 7133725 | Method and related composition employing nanostructures A composition of microscopic devices utilizable in a medical diagnostic or therapeutic procedure. Each microscopic device includes a nanostructure provided with a ligand for effectively coupling the nanostructure to a predetermined chemical or molecular site. A medi... | 11/07/2006 |
| 7091039 | Kunitz domain polypeptide zkun6 Proteinase inhibitors comprising a Kunitz domain are disclosed. The Kunitz domain comprises a sequence of amino acid residues as shown in SEQ ID NO:3, wherein the sequence is at least 80% identical to residues 6 through 56 of SEQ ID NO:2. Also disclosed are methods ... | 08/15/2006 |
| 7056935 | Rotamase enzyme activity inhibitors This invention relates to methods of using neurotrophic compounds having an affinity for FKBP-type immunophilins to stimulate or promote neuronal growth or regeneration and to prevent neuronal degeneration. ... | 06/06/2006 |
| 7053041 | Methods and compositions useful for inhibition of αβmediated angiogenesis The present invention describes methods for inhibiting angiogenesis in tissues using vitronectin αvβ5 antagonists. The αvβ5-mediated angiogenesis is correlated with exposure to cytokines including vascular endothelial ... | 05/30/2006 |
| 7045133 | VEGF-D/VEGF-C/VEGF peptidomimetic inhibitor Monomeric monocyclic peptide inhibitors and dimeric bicyclic peptide inhibitors based on exposed loop fragments of a growth factor protein, such as loop 1, 2 or 3 of VEGF-D, and methods of making them are described as well as pharmaceutical compositions containing t... | 05/16/2006 |
| 7012064 | Cyclosporins for the treatment of immune disorders The present invention relates to methods of treating or preventing an inflammatory or immune disorder in a subject while eliminating or reducing the toxicity associated with the administration of cyclosporin A, comprising systemically administering to said subject a... | 03/14/2006 |
| 7012065 | Cyclosporins for the treatment of immune disorders The present invention relates to novel semi-synthetic cyclosporin analogs for the prevention of organ transplantation rejection and the treatment of immune disorders and inflammation, their use as pharmaceuticals and pharmaceutical composition comprising them, as we... | 03/14/2006 |
| 6998385 | Cyclosporine analogue mixtures and their use as immunomodulating agents The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine A. The mixtures possess enhanced efficacy and reduced toxicity over the individual isomers and over naturally occurring and other presently known c... | 02/14/2006 |
| 6995139 | Cyclic undecapeptide pro-drugs and uses thereof A pro-drug comprising a cyclic undecapeptide wherein the peptide chain thereof comprises at least one amino acid residue, useful as a medicinal product, including use for treatment of pathological conditions of the eye. ... | 02/07/2006 |
| 6987090 | Use of 3-position cyclosporin derivatives for hair growth The present invention discloses a hair growth promoting agent comprising a cyclosporin derivative as an active ingredient, and more particularly, a hair growth promoting agent comprising a cyclosporin A derivative in which sarcosine is substituted with thiosarcosine... | 01/17/2006 |
| 6979671 | Cyclosporins for the treatment of immune disorders The present invention relates to a cyclosporin analog of the following formula (I) or its pro-drug or pharmaceutically acceptable salt: In formula I, the formula for residue A is: ... | 12/27/2005 |
| 6972281 | Histogranin-like peptides and non-peptides, processes for their preparation and uses thereof The invention relates to new basic amino acid derivatives of general formula I and the preparation and use thereof in treatment of pain. The compounds have histogranin-like antinociceptive, morphine potentiating and COX-2 induction modulating activities. | 12/06/2005 |
| 6903074 | Neuromedin b and somatostatin receptor agonists A novel class of analogs which exhibit both high affinity and selectivity for Neuromedin B and Somatostann receptors are claimed. One example is Nal-Tyr-cyclo(D-Cys-D-Trp-Lys-D-Cys)-Abu-Nal-NH2. ... | 06/07/2005 |
| 6902720 | Cyclic peptide structures for molecular scale electronic and photonic devices The present invention discloses a family of cyclic peptide monomers and supramolecular cyclic peptide structures comprising chromophore residues which possess electronic and electro-optic properties for producing molecular scale electronic and photonic devices made ... | 06/07/2005 |
| 6884774 | Cyclic hexapeptide derivatives This invention relates to new polypeptide compound represented by the general formula (I) wherein R1, R2, R3, R4, R5 and R6 are as defined in the description or a salt thereof which has antimicrobial ... | 04/26/2005 |
| 6855692 | Histogranin peptides and their analgesic use The invention relates to linear and cyclic peptide and pseudopeptide compounds useful as analgesics, pharmaceutical compositions comprising such compounds, the use of the compounds and the compositions in the treatment of pain, and commercial packages containing suc... | 02/15/2005 |
| 6849709 | Aerothricin derivatives The present invention relates to novel Aerothricins represented by the Formula (I), and pharmaceutically acceptable salts thereof. The present invention also relates to a pharmaceutical composition comprising a... | 02/01/2005 |
| 6794489 | Compositions and methods for treatment of sexual dysfunction Compositions and methods are provided for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction. In one embodiment, a peptide-based composition including the peptide sequence Ac-Nle... | 09/21/2004 |
| 6790830 | Use of 3-position cyclosporin derivatives for hair growth The present invention discloses a hair growth promoting agent comprising a cyclosporin derivative as an active ingredient, and more particularly, a hair growth promoting agent comprising a cyclosporin A derivative substituted in the 3-position as an active ingredien... | 09/14/2004 |
