Bizarre Patents
A method of swing on a swing is disclosed, in which a user positioned on a standard swing suspended by two chains from a substantially horizontal tree branch induces side to side motion by pulling alternately on one chain and then the other.
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| Number | Title | Issue Date |
| 8188037 | Microparticles comprising somatostatin analogues Disclosed are microparticles comprising a somatostatin analogue embedded in a biocompatible pharmacologically acceptable polymer matrix for a long acting release and pharmaceutical compositions comprising such microparticles. ... | 05/29/2012 |
| 8188216 | Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery A library of macrocyclic compounds of the formula (I) where part (A) is a bivalent radical, a —(CH2)y | 05/29/2012 |
| 8188217 | Methods for the synthesis of dicarba bridges in organic compounds The present invention relates to methods for forming dicarba bridges in organic compounds. This involves the use of a pair of complementary metathesisable groups on the organic compound, and subjecting the compound to cross-metathesis under microwave radiation condi... | 05/29/2012 |
| 8183202 | Use of type-B lantibiotic-based compounds having antimicrobial activity A method for the treatment or prophylaxis of a microbial infection of the lower intestine or colon in a subject is described, wherein the method comprises administration to the subject of a type-B lantibiotic, wherein the type-B lantibiotic may include compounds sel... | 05/22/2012 |
| 8183341 | Antibacterial compounds and processes for its production This invention relates to a novel antibiotic compounds, pharmaceutically acceptable salts and derivatives thereof, and to methods for obtaining such compounds. ... | 05/22/2012 |
| 8178650 | Cyclic depsipeptides The present application relates to cyclic depsipeptides, or derivatives thereof, having the structure of formula (I), and uses thereof, e.g. as inhibitors of kallikrein 7 and human neutrophil elastase. ... | 05/15/2012 |
| 8168747 | On-growth inhibiting compounds An on-growth inhibiting agent, for the inhibition and/or prevention of on-growth of biological organisms on objects or living beings, includes at least one cyclotide, and a suitable carrier medium. A plant extract containing a mixture of cyclotides is also usable. | 05/01/2012 |
| 8153594 | Tacrolimus standard and methods of using same A composition and kit useful as a tacrolimus standard solution for immunoassays, and methods for making and using same. The composition and kits include a known amount of tacrolimus or a derivative thereof, and a non-specific protein capable of forming a complex wit... | 04/10/2012 |
| 8148319 | Peptidic vasopressin receptor agonists The present invention relates to novel compounds, pharmaceutical compositions comprising the same, use of said compounds for the manufacture of a medicament for treatment of inter alia shock conditions as well as to a method for treatment of said conditions, wherein... | 04/03/2012 |
| 8119592 | Compounds and methods for inhibiting hepatitis C viral replication Macrocyclic compounds having the structures described herein are useful for inhibiting replication of the hepatitis C virus (HCV). In preferred embodiments, the compounds are active against both the NS3 protease and the NS3 helicase of HCV. ... | 02/21/2012 |
| 8114831 | Guanylate cyclase receptor agonists for the treatment of tissue inflammation and carcinogenesis A method of treatment of inflamed, pre-cancerous or cancerous tissue or polyps in a mammalian subject is disclosed. The treatment involves administration of a composition of at least one peptide agonist of a guanylate cyclase receptor and/or other small molecules th... | 02/14/2012 |
| 8110552 | Antagonists against interaction of PF4 and RANTES The invention relates to polypeptides of amino acid sequence SEQ ID NO: 1 according to formula (1), the use thereof for producing a medicament, and medicaments for the treatment of diseases related to monocyte recruitment. ... | 02/07/2012 |
| 8088733 | Methods of using macrocyclic agonists of the ghrelin receptor for treatment of gastrointestinal motility disorders The present invention provides novel conformationally-defined macrocyclic compounds that have been demonstrated to be selective agonists of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and variants thereof). Such compoun... | 01/03/2012 |
| 8076285 | Lysobactin amides The invention relates to lysobactin amides and methods for their preparation, as well as their use for manufacturing medicaments for the treatment and/or prophylaxis of diseases, in particular bacterial infectious diseases. ... | 12/13/2011 |
| 8058240 | Biological active ligands of melanocortin receptors Disclosed are novel ligands based on an AGRP template that can rescue endogenous melanocortin agonist and/or antagonist dysfunction at MCR polymorphisms. In particular, the present invention provides novel synthetic ligands based on AGRP templates that can rescue en... | 11/15/2011 |
| 8048858 | Use of poly-α2,8-sialic acid mimetic peptides to modulate NCAM functions A peptide consisting of 5 to 30 amino acid residues, preferably 9 to 15, most preferably about 12 amino acid residues, comprising a B epitope of a poly-α2,8 sialic acid attached to NCAM which is recognized by an anti-poly-α2,8 sialic acid (PSA) antibody, the use t... | 11/01/2011 |
| 8048853 | Process for preparing pharmaceutical compound and intermediates thereof The present invention relates to novel intermediates of formula VII, or an acid addition salt or a solvate thereof, wherein R1 is —(CO)NH2, —CH2NH2 or —CN; R... | 11/01/2011 |
| 8044173 | Asymmetric synthesis of peptides A process comprising substitution of an acceptor molecule comprising a group —XC(O)— wherein X is O, S, or NR8, where R8 is C1-6 alkyl, C6-12 aryl or hydrogen, with a nucleophile, wherein the acceptor molecule is cycli... | 10/25/2011 |
| 8039435 | Melanocortin receptor ligands The present invention is directed to compounds according to formula, (R2R3)-A1-c(A2-A3-A4-A5-A6-A7-A8-A9)-A10-R1... | 10/18/2011 |
| 8034782 | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a gastrointestinal cancer). The peptides can be administered either alone or in com... | 10/11/2011 |
| 8034898 | Methods of collagen imaging Diagnostic compositions and methods for imaging and/or assessing collagen are described. The diagnostic compositions can include collagen binding peptides. ... | 10/11/2011 |
| 8030445 | Glycopeptide derivative Disclosed are derivatives of glycopeptide compounds having at least one substituent of the formula: —Ra—Y—Rb—(Z)x where Ra, Rb, Y, Z and x are as defined, and pharmaceutical composit... | 10/04/2011 |
| 8022176 | FAS peptide mimetics and uses thereof Exocyclic peptide mimetics that disable Fas were developed. A three dimensional model of the Fas receptor-ligand complex was constructed and structurally predicted regions of the receptor that were relevant to binding ligand were used to create constrained peptide m... | 09/20/2011 |
| 8022033 | Echinocandin/carbohydrate complexes A complex of an echinocandin compound with a carbohydrate is described having improved thermal stability and water solubility. A process for making the echinocandin/carbohydrate complex is also described as well as the use of the complex in pharmaceutical formulatio... | 09/20/2011 |
| 8013115 | Use of stabilised synthetic compounds in immunoassay The invention concerns the use of at least a synthetic compound comprising: a carrier molecule having at least a hydrocarbon chain comprising at least 10, advantageously at least 12, preferably at least 14 and not more than 300, advantageously not more than 100, pre... | 09/06/2011 |
| 8003598 | Peptide anti-tumor agent Disclosed herein are isolated, purified peptides, biologically active fragments and analogs of the peptides having anti-tumor activity in mammals, pharmaceutical formulations comprising the peptides, fragments and analogs and methods of treating mammals suffering fr... | 08/23/2011 |
| 7999068 | Process for the preparation of bicyclic peptide compounds A new process for the preparation of bicyclic peptide compounds Formula (I) in high yields of high purity, useful as intermediates for preparing compounds with pharmacological activity, is described. ... | 08/16/2011 |
| RE42624 | Methods of using macrocyclic modulators of the ghrelin receptor The present invention provides novel conformationally-defined macrocyclic compounds that have been demonstrated to be selective modulators of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and variants thereof). Methods of... | 08/16/2011 |
| 7989416 | Lantibiotic biosynthetic gene clusters from and Characterization of the biosynthetic gene cluster for the lantibiotic actagardine, identification of a novel variant of actagardine and its biosynthetic cluster, and methods of production and use of actagardine are described. ... | 08/02/2011 |
| 7981998 | Bis-sulfhydryl macrocyclization systems Peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and kits useful in their production, are provided. ... | 07/19/2011 |
| 7968518 | Use of modified cyclosporins for the treatment of HCV disorders Disclosed are non-immunosuppressive cyclophilin-binding cyclosporins, e.g., of formula (I, Ia or II) as defined herein, having useful properties in the prevention of Hepatitis C infections. ... | 06/28/2011 |
| 7960506 | Bis-sulfhydryl macrocyclization systems Peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and kits useful in their production, are provided. ... | 06/14/2011 |
| 7956158 | Fusion proteins with cleavable spacers and uses thereof A polypeptide comprising a first protein domain, a second protein domain, and a dithiocyclopeptide spacer containing at least one protease cleavage site, wherein the dithiocyclopeptide is exogenous relative to the first or second protein domain, and wherein the firs... | 06/07/2011 |
| 7951780 | Antitumor agent An antitumor agent containing, in combination, at least one kind of antitumor agent selected from the group consisting of an antitumor agent that forms a cross-link with DNA and shows an antitumor effect, an antimetabolite antitumor agent and a taxane antitumor agen... | 05/31/2011 |
| 7947654 | Pharmaceutical formulations Good bioavailability of desmopressin can be obtained by means of an orodispersible pharmaceutical dosage form. Preferred dosage forms comprise desmopressin and an open matrix network which is an inert water-soluble or water-dispersible carrier material. Desmopressin... | 05/24/2011 |
| 7939625 | Somatostatin analogues The invention provides cyclo[{4-(NH2—C2H4—NH—CO—O—)Pro}-Phg-DTrp-Lys-Tyr(4-Benzyl)-Phe], optionally in protected form, or a pharmaceutically acceptable salt or complex thereof, which has interesting pharmaceutical propertie... | 05/10/2011 |
| 7910693 | Prostate cancer diagnosis and treatment The present invention relates to novel mimetopes of anti-PSMA antibodies and their use for detecting, imaging, staging, treating and monitoring of prostate cancer, and/or metastatis thereof. The present invention also relates to novel pharmaceutical compositions for... | 03/22/2011 |
| 7897721 | Cyclic peptide compositions for treatment of sexual dysfunction A cyclic peptide of the structural formula: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, m and p are as defined. Further pr... | 03/01/2011 |
| 7872096 | Methods for cyclizing synthetic polymers The invention provides methods and compositions for production of a cyclic polymer in a cell free system. In general, the methods of the invention involve ligating first and second recombinant intein domains to a linear synthetic polymer to form a compound containin... | 01/18/2011 |
| 7872097 | Cyclic peptide compounds The present invention relates to a new cyclic peptide compound or a salt thereof, which has anti-hepatitis C virus activities based on inhibitory activity against the RNA replication of hepatitis C virus replicon, to a process for preparation thereof comprising a re... | 01/18/2011 |
