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Class 530/316 - Angiotensin; related peptides


Subclass of Class 530 - Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
Definition: Peptides containing at least half the amino acid residues
No. of patents: 61
Last issue date: 06/30/2009


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NumberTitleIssue Date
7553928Use of des-Aspartate-angiotensin I as an agent for the treatment and prevention of glomerulosclerosis and renal failure
The present invention relates generally to a method for the treatment and/or prophylaxis of renal-related disorders. More particularly, the present invention contemplates a method for the treatment and/or prophylaxis of glomerulosclerosis and/or end stage renal fail...
06/30/2009
7378489Angiotensin derivatives
An angiotensin derivative comprising at least one angiotensin peptide moiety coupled to a peptide carrier-binding moiety which can be used for therapy and prophylaxis of conditions associated with the renin activated angiotensin system. ...
05/27/2008
7338938Methods for treating a patient undergoing chemotherapy
The present invention provides improved methods, kits, and pharmaceutical compositions for increasing hematopoietic cell survival and/or reducing or preventing the side effects of chemotherapy, and mobilizing hematopoietic progenitor cells from bone marrow into peri...
03/04/2008
7335722Peptides used as angiotensin converting enzyme inhibitor and preparation process thereof
The invention discloses five peptides which can be used as angiotensin converting enzyme inhibitor. The subject invention also discloses a process for the preparation of the products having angiotensin converting enzyme inhibitory activity, which comprises the follo...
02/26/2008
7288522Method of promoting erythropoiesis
The present invention provides methods, compounds, pharmaceutical compositions, and kits for the augmentation of erythropoiesis by potentiating erythropoietin-induced differentiation with angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues ...
10/30/2007
7276251Sustained-release composition of drugs encapsulated in microparticles of hyaluronic acid
A sustained-release drug composition consisting essentially of microparticles of hyaluronic acid having a high molecular weight or an inorganic salt thereof and a protein or peptide drug encased in said microparticles, wherein the average size of said microparticles...
10/02/2007
7176183Methods for treating and preventing damage to mucosal tissue
The present invention provides improved methods, kits, and pharmaceutical compositions for treating and preventing damage to mucosal tissue by administering an effective amount of angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof,...
02/13/2007
7138393Biologically active vasopressin agonist metabolites
Novel compounds of Formula (I) and pharmaceutically acceptable salts thereof, and pharmaceutical formulations containing such compounds which are useful as anti-aquaretic agents in the treatment of nocturnal urin...
11/21/2006
7125702Process for the preparation of angiotensis converting enzyme (ACE) inhibitors and its use
The invention is a process for the preparation of angiotensin converting enzyme (ACE) inhibitors and the use thereof. ...
10/24/2006
7118747AT4 receptor ligands as angiogenic, anti-angiogenic, and anti-tumor agents
AT4 receptor agonists are potent activators of angiogenesis and can be used to treat diseases that are characterized by vascular insufficiency. AT4 receptor antagonists, which are potent inhibitors of angiogenesis, and can be used as anti-angio...
10/10/2006
6995236Sphingomyelin detecting probe
An object of the present invention is to provide a protein useful as a sphingomyelin detecting probe, which specifically recognizes sphingomyelin and has low cytotoxicity. The present invention provides a protein which has an amino acid sequence having, as the amino...
02/07/2006
6989363Angiotensin converting enzyme homolog and therapeutic and diagnostic uses therefor
The present invention relates to the discovery of novel genes encoding an angiotensin converting enzyme, Angiotensin Converting Enzyme-2 (ACE-2). The invention provides therapeutics, prognostic and diagnostics methods for treating blood pressure related disorders as...
01/24/2006
6919314Bioactive whey protein hydrolysate
The invention relates to a partial hydrolysate of whey protein which contains bioactive peptides but does not have a bitter flavor. The hydrolysate is carried out using selective enzymes which produce the active peptides and is terminated at a degree of hydrolysis b...
07/19/2005
6762167Methods for treating a patient undergoing chemotherapy
The present invention provides improved methods, kits, and pharmaccutical compositions for increasing hematopoietic cell survival and/or reducing or preventing the side effects of chemotherapy, and mobilizing hematopoietic progenitor cells from bone marrow into peri...
07/13/2004
6730775Methods for limiting scar and adhesion formation
The present invention provides methods, kits, and pharmaceutical compositions for limiting scar or adhesion formation by administration of angiotensinogen, AI, AI analogues, and/or AI fragments and analogues thereof, AII analogues, AII fragments or analogues thereof...
05/04/2004
6514941Method of preparing a casein hydrolysate enriched in anti-hypertensive peptides
The present invention relates, in general, to a casein hydrolysate, and, in particular, to a method of preparing a casein hydrolysate enriched in antihypertensive peptides....
02/04/2003
6495338Drug screening and diagnosis based on paracrine tubular renin-angiotensin system
The present invention relates to a method for screening drugs for use in treating hypertension using the tubular renin-angiotensinogen system identified by the present invention. The invention further relates to a method to diagnose sodium status and sens...
12/17/2002
6444646Use of angiotensin II type 2 receptor agonists in tissue repair
Angiotensin II Type 2 receptor agonists (AT2 receptor subtype agonists) are useful in accelerating wound healing. These compounds form the basis of compositions useful for accelerating wound healing, in which the active agent is present in an amount effec...
09/03/2002
6335195Method for promoting hematopoietic and mesenchymal cell proliferation and differentiation
The present invention provides methods, improved cell culture medium and kits for promoting hematopoietic and mesenchymal stem and lineage-specific cell proliferation and differentiation by growth in the presence of angiotensinogen, angiotensin I (AI); AI...
01/01/2002
6239109Method of promoting erythropoiesis
The present invention provides methods, compounds, pharmaceutical compositions, and kits for the augmentation of erythropoiesis by potentiating erythropoietin-induced differentiation with angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and...
05/29/2001
6197505Methods for assessing cardiovascular status and compositions for use thereof
The present invention provides methods for assessing cardiovascular status in an individual, which comprise determining the sequence at one or more polymorphic positions within the human genes encoding angiotensin converting enzyme (ACE), angiotensinogen ...
03/06/2001
6177407Methods to increase blood flow to ischemic tissue
The present invention provides methods and kits for increasing blood flow to ischemic tissue, comprising the administration of an effective amount of angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II (AI...
01/23/2001
6110895Method of promoting healing in skin grafts
Angiotensin II angiotensin II fragments, angiotensin II analogs, Angiotensin II Type 2 receptor agonists, angiotensin I or analogs thereof, and angiotensin or analogs thereof are useful in promoting the incorporation of skin grafts into the underlying tis...
08/29/2000
6022696Methods of identifying agonists or antagonists of angiotensin IV
A unique and novel angiotensin AT4 receptor and AIV ligand system for binding a small N-terminal hexapeptide fragment of Angiotensin II (referred to as AIV, with amino acid sequence Val1 -Tyr2 -Ile3 -His4 -Pro
02/08/2000
6011015Angiotensin II for improving fertilization
Angiotensin II, or an analog thereof, can be used for promoting the fertilization of mammalian eggs. A method is disclosed for promoting in vitro fertilization of mammalian eggs using angiotensin II or a salt or an analogue thereof....
01/04/2000
5972387Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof
Modified hydrolyzed vegetable protein microspheres and methods for their preparation and use as oral delivery systems for pharmaceutical agents are described....
10/26/1999
5955430Use of angiotensin II fragments and analogs thereof in tissue repair
Angiotensin II fragments and analogs thereof are useful in accelerating wound healing. These compounds form the basis of compositions useful for accelerating wound healing, in which the active agent is present in an amount effective to accelerate wound he...
09/21/1999
5843903Targeted cytotoxic anthracycline analogs
This invention is in the field of the chemistry of targeting anticancer anthracycline derivatives. More particularly, it concerns doxorubicin (DOX) or its daunosamine modified derivatives (DM-DOX) linked covalently to analogs of peptide hormones such as L...
12/01/1998
5834432Use of angiotensin II Type 2 receptor agonists in tissue repair
Angiotensin II Type 2 receptor agonists (AT2 receptor subtype agonists) are useful in accelerating wound healing. These compounds form the basis of compositions useful for accelerating wound healing, in which the active agent is present in an amount effec...
11/10/1998
5723307Fluorogenic substrates for assay of angiotensin converting enzyme
Disclosed are new fluorogenic substrates for assay of angiotensin converting enzyme, a process for preparing them and methods for using them to assay angiotensin converting enzyme and to screen antihypertensive agents which inhibit angiotensin converting ...
03/03/1998
5482925Complexes of nitric oxide with cardiovascular amines as dual acting cardiovascular agents
Novel complexes of nitric oxide (NO) and amines are described where the amine is a known cardiovascular agent having at least one or more primary or secondary amino groups and whereby the resulting complex is capable under physiological conditions of rele...
01/09/1996
5459077Methods for modelling tertiary structures of biologically active ligands and for modelling agonists and antagonists thereto
Disclosed are methods for modelling the three-dimensional structure (tertiary structure) of a ligand having one or more active sites employing a charge-transfer interaction. Also disclosed is a model for Angiotensin II derived from such method....
10/17/1995
5369015Method for producing an angiotensin converting enzyme inhibitor-containing composition
Disclosed is a method for producing an angiotensin converting enzyme inhibitor composition from natural materials, which composition is of use as an antihypertensive drug or diet. The method comprises heating a meat in water at a temperature not lower tha...
11/29/1994
5151502Method for solubilizing membrane receptor proteins
A process for solubilizing membrane receptor proteins which includes exposing an outer membrane having the desired protein to an oxidizing agent, treating the membrane with a detergent and treating with an inhibitory material lowering agent. This method m...
09/29/1992
5147857Glycolic acid derivatives
New glycolic acid derivatives of the formula I X--O--CR1 R2 --CO--Y--NR3 --CHR4 --CR5 --CH2 --CR6 R7 --Z I in which R1 to R7, X, Y and Z have the meanings ...
09/15/1992
5015629Tissue repair
A method for increasing the rate of healing in mammalian tissue includes the administration of a solution of angiotensin II....
05/14/1991
4966964Inhibitors of angiogenin
An inhibitor of angiogenin and method of use of the inhibitor, wherein the inhibitor inhibits the angiogenic activity of angiogenin. The inhibitor is dispensed at a suitable concentration within a physiologically compatable medium, suitable for administra...
10/30/1990
4911909Method of controlling hypertension using monoclonal antibodies to angiotensin-II
Monoclonal antibodies to angiotensin II and the continuous hybrid monoclonal cell lines for their production are provided. These antibodies are useful in the diagnosis and treatment of angiotensin II-induced hypertension....
03/27/1990
4897379N-[N -(1(S)-carboxy-3-cyclohexylpropyl)-L-lysyl]-N-cyclopentylglycine as antihypertensives
The invention relates to N-[N଱ -(1(S)-carboxy-3-cyclohexylpropyl)-L-lysyl]-N-cyclopentylglycine which is useful as antihypertensives....
01/30/1990
4785080Labeled analytes
A highly sensitive, immunoassay method for determining the amount of an analyte in a sample containing a known analyte in an unknown concentration is provided. Sample; a polypeptide-labeled analog of the analyte, an antibody specific for said analyte, a p...
11/15/1988
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