Did You Know...
...that several people are credited with the invention of the flush toilet? Most people have heard of Thomas Crapper (1837-1910), the sanitary engineer who invented the valve-and-siphon arrangement that made the modern toilet possible. Another claimant to "the throne" was British inventor Alexander Cumming who patented a toilet in 1775. Then there's a nameless Minoan (a native of ancient Crete) who lived 4,000 years ago who supposedly was ahead of his time and created the first flush toilet!
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| Number | Title | Issue Date |
| 8188213 | Purified polypeptide comprising or consisting of a C-terminus MSP1 antigen from carrying a Glycosyl-phosphatidyl-inositol group (GPI) The present invention relates to a purified polypeptide comprising or consisting of a C-terminus Merozoite Surface Protein 1 (MSP1) antigen from Plasmodium falciparum carrying a Glycosyl-phosphatidyl-inositol group (GPI), an immunogenic composition and a vacc... | 05/29/2012 |
| 8188214 | Brachyury polypeptides and methods for use It is disclosed herein that Brachyury is expressed in human tumors, specifically in tumors of the small intestine, stomach, kidney, bladder, uterus, ovary, and testes, as well as in lung, colon and prostate carcinomas. Immunogenic Brachyury polypeptides are disclose... | 05/29/2012 |
| 8188215 | Metal-binding compounds and uses therefor The invention provides a method of reducing the damage done by reactive oxygen species (ROS) in an animal. The invention also provides a method of reducing the concentration of a metal in an animal. These methods comprise administering to the animal an effective amo... | 05/29/2012 |
| 8188048 | Combination therapy The present invention relates generally to methods for inducing, promoting or otherwise facilitating pain relief. More particularly, the present invention relates to a synergistic combination of a selective inhibitor of the neuronal norepinephrine transporter and an... | 05/29/2012 |
| 8188053 | Anti-inflammatory peptides The present invention relates, inter alia, to a method of ameliorating an inflammatory skin condition. Thus, the present invention provides a peptide that includes the amino acid sequence KMIKP (SEQ ID NO: 20), wherein the peptide includes no more than 70 amino acid... | 05/29/2012 |
| 8183339 | Cell-permeable peptide inhibitors of the JNK signal transduction pathway The invention provides cell-permeable peptides that bind to JNK proteins and inhibit JNK-mediated effects in JNK-expressing cells. ... | 05/22/2012 |
| 8183203 | Methods for treating pulmonary hypertension and compositions comprising vasoactive intestinal peptide A method and device for discharging an electrical defibrillation pulse or an electrical demand pacer pulse or delivering at least one pharmaceutical agent to treat conditions such as cardiac arrest, bradycardia, arrhythmia, cardiac standstill, PEA, EMD and other hea... | 05/22/2012 |
| 8178649 | Immunostimulatory compositions and uses thereof The present invention provides novel immuno-stimulatory polypeptides, and methods for their use and identification. ... | 05/15/2012 |
| 8173767 | Synthetic peptide vaccines for HIV: the CBD epitope as an effective immunogen to elicit broadly neutralizing antibodies against HIV The present invention relates to peptides, referred to as CBD-1, CBD-2, CBM-1/TH-1, CBM-1/TH-2, CBM-2/TH-1, CBM-2/TH-2 and C-20 peptides, which are antigenic and elicit a protective immune response against HIV infection. Compositions, pharmaceutical compositions and... | 05/08/2012 |
| 8173768 | Peptides having antimicrobial and neurotrophic activity and uses thereof A method for preventing a break out of a neurodegenerative disease in an individual and for treating an individual suffering from a neurodegenerative disease comprising the administration of an effective amount of an antimicrobial and neurotrophic peptide. ... | 05/08/2012 |
| 8168746 | Biomimetic materials for protein storage and transport The invention provides a method for the insertion of protein in storage vehicles and the recovery of the proteins from the vehicles, the method comprising supplying isolated protein; mixing the isolated protein with a fluid so as to form a mixture, the fluid compris... | 05/01/2012 |
| 8163870 | Channel forming peptides The present invention provides a family of peptides based upon the M2GlyR sequence. These peptides are derivatives of the M2GlyR sequence and can be modified at their ends to include a plurality of polar amino acid residues to enhance their solubility. Particularly ... | 04/24/2012 |
| 8163871 | Enzymatic reactions in the presence of keto acids Conversion in vitro of X-Gly to X-alpha-hydroxy-Gly or X-NH2 (X being a peptide or any other compound having a carbonyl group capable of forming a covalent bond with glycine) is accomplished enzymatically in the presence of keto acids, or salts or esters ... | 04/24/2012 |
| 8158749 | Method for ameliorating pain by modification of NMDA receptors through inhibition of Src The present invention provides a method for ameliorating inflammatory and/or neuropathic pain in a subject by modifying the activity of N-methyl-D-aspartate (NMDA) receptors in cells of the subject by inhibition of the interaction of the unique domain of the tyrosin... | 04/17/2012 |
| 8153758 | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can includ... | 04/10/2012 |
| RE43309 | Immunoregulatory compositions The invention relates to compounds exhibiting immuno-regulatory activity as determined by measuring the compound's ability to modulate production of NO by a cell. Preferred compounds include or consist of a sequence AAL AAQ AAG AAV wherein AAL is... | 04/10/2012 |
| 8153593 | Transglutaminase inhibitors and methods of use thereof Transglutaminase inhibitors and methods of use thereof are provided. ... | 04/10/2012 |
| 8143210 | Enzyme treatment of foodstuffs for celiac sprue Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten. ... | 03/27/2012 |
| 8143372 | Synthetic regulators of ferritin protein nanocage pores and methods of use thereof The present invention provides synthetic regulators of ferritin pores, and compositions comprising the regulators. The regulators function to reduce ferritin demineralization rates. The regulators are useful for treating inflammatory conditions. The present inventio... | 03/27/2012 |
| 8143373 | Carbohydrate-containing pan cancer marker The effective epitope of CA215, a known cancer marker and antigen, has been demonstrated to include a carbohydrate moiety of defined composition and to be non-reactive with anti-human IgG, IgA and IgM, although CA215 is an immunoglobulin heavy chain-like molecule. T... | 03/27/2012 |
| RE43279 | Compositions capable of reducing elevated blood urea concentration The invention includes a method of reducing urea concentration in a subject's serum. Such a method comprises administering to the subject (e.g., a mammal such as a human) a composition comprising an oligopeptide (or oligopeptides) having activity in reducing urea co... | 03/27/2012 |
| 8138304 | Neural regeneration peptides and formulations thereof Neural regeneration peptide consisting of a sequence comprised in the sequence of REGRRAAPGRAGG(SEQ ID NO:1). ... | 03/20/2012 |
| 8133868 | Dipeptides for prevention of muscle breakdown and microbial infection The subject invention provides dipeptides useful in promoting healthy muscle tissues as well as effective immune responses. The dipeptides of the subject invention are particularly advantageous because they are stable, bioavailable, and can be formulated in an aqueo... | 03/13/2012 |
| 8133972 | IgE antigenic peptides Cytotoxic T lymphocytes (CTLs) specific for antigenic peptides derived from IgE molecule can be generated in vitro by stimulating resting naive CD8 T cells with IgE peptides presented by artificial antigen presenting cells. The IgE specific CTLs lyse the target cell... | 03/13/2012 |
| 8133971 | Polypeptide specifically bound to phosphatidylserine and the use thereof The present invention relates to a polypeptide specifically bound to phosphatidylserine and use thereof, and more particularly to a polypeptide having an amino acid sequence designated as sequence number 1 and specifically bound to phosphatidylserine, a phosphatidyl... | 03/13/2012 |
| 8129346 | Compounds for enzyme inhibition Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited b... | 03/06/2012 |
| 8129333 | Antigen delivery vectors and constructs The present invention relates to fluorocarbon vectors for the delivery of antigens to immunoresponsive target cells. It further relates to fluorocarbon vector-antigen constructs and the use of such vectors associated with antigens as vaccines and immunotherapeutics ... | 03/06/2012 |
| 8124721 | Peptides for modulating innate immunity In one aspect, the present invention provides isolated novel peptides that can be used to modulate innate immunity in a subject, and/or for the treatment of an immune-related disorder, including treating and preventing infection by modulating innate immunity. Also p... | 02/28/2012 |
| 8124723 | Circovirus sequences associated with piglet weight loss disease (PWD) The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods f... | 02/28/2012 |
| 8124722 | Soluble CD14 antigen There are provided a soluble CD14 antigen which is a novel in vivo protein useful as a marker for diagnosing sepsis and has the following characteristic features 1) to 3): 1) a molecular weight of 13±2 kDa when measured by SDS-PAG... | 02/28/2012 |
| 8114830 | Polypeptoid pulmonary surfactants The present invention provides spreading agents based on sequence-specific oligomers comprising a peptoid, a peptide-peptoid chimera, a retropeptoid or a retro(peptoid-peptide) chimera, and methods for using the same, including for the treatment of respiratory distr... | 02/14/2012 |
| 8110654 | T cell epitope peptides of ovarian cancer anti-idiotypic antibody 6B11 and use thereof The present invention provides two T-cell epitode peptides of anti-idiotype antibody 6B11 of ovarian cancer, the sequences of which are shown in SEQ ID NO:3 or 6. The present invention also provides the use of such T-cell epitope peptides in the manufacture of vacci... | 02/07/2012 |
| 8110541 | Antigen delivery vectors and constructs The present invention relates to fluorocarbon vectors for the delivery of antigens to immunoresponsive target cells. It further relates to fluorocarbon vector-antigen constructs and the use of such vectors associated with antigens as vaccines and immunotherapeutics ... | 02/07/2012 |
| 8110540 | Antigen delivery vectors and constructs The present invention relates to fluorocarbon vectors for the delivery of antigens to immunoresponsive target cells. It further relates to fluorocarbon vector-antigen constructs and the use of such vectors associated with antigens as vaccines and immunotherapeutics ... | 02/07/2012 |
| 8110653 | Collections of repeat proteins comprising repeat modules A collection of repeat proteins, each repeat protein comprising a repeat domain, which comprises a set of consecutive repeat modules, wherein each of the repeat modules is derived from one or more repeat units and wherein the repeat units comprise framework residues... | 02/07/2012 |
| 8106153 | Ex-vivo priming for generating cytotoxic T lymphocytes specific for non-tumor antigens to treat autoimmune and allergic disease Cytotoxic T lymphocytes (CTLs) specific for antigenic peptides derived from IgE molecule can be generated in vitro by stimulating resting naive CD8 T cells with IgE peptides presented by artificial antigen presenting cells. The IgE specific CTLs lyse the target cell... | 01/31/2012 |
| 8106006 | Modified defensins and their use This disclosure provides modified antimicrobial agents, for example modified defensin polypeptides. Compositions including a modified arginine residue, such as an ADP-ribosylated and/or ribosylated alpha defensin polypeptide, are provided. Also provided are methods ... | 01/31/2012 |
| 8106152 | Antimicrobial composition The present invention relates to novel antimicrobial composition comprising a peptide which can be obtained from the milk protein casein or chemically synthesised or produced by recombinant DNA technology and a divalent cation. ... | 01/31/2012 |
| 8101572 | Methods for promoting wound healing and/or reducing scar formation The present invention provides methods for promoting wound healing and/or reducing scar formation, by administering to an individual in need thereof one or more of the heat shock protein 20-derived polypeptides disclosed herein. ... | 01/24/2012 |
| 8097697 | Tumor antigen protein SART-3 and tumor antigen peptides thereof A novel tumor antigen protein and gene therefor, tumor antigen peptides derived from said tumor antigen protein or derivatives thereof as well as medicaments, prophylactics, or diagnostics for tumors using such tumor substances in vitro or in vitro are provided.... | 01/17/2012 |
