Did You Know...
...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8008262 | β-peptides β-peptide regions of polypeptides can serve as structural mimics of α-helices in wild type proteins. Because α-helices of one protein often bind to a target protein in a biological pathway, a polypeptide that contains a helical β-peptide region can be used to di... | 08/30/2011 |
| 7351787 | Process for the preparation of activated polyethylene glycols A process for preparing activated polyethylene glycols is disclosed. In some embodiments, the process includes reacting a molten polyethylene glycol with an activator. In other embodiments, the process includes reacting a polyethylene glycol with an activator in the... | 04/01/2008 |
| 7332566 | Biocompatible crosslinked polymers with visualization agents Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and cros... | 02/19/2008 |
| 7323298 | Microarray for determining the relative abundances of polynuceotide sequences A method of determining the relative amounts of individual polynucleotides in a complex mixture of different-sequence polynucleotides is disclosed. The polynucleotides, after fluorescent labeling, are contacted under hybridization conditions with an array of differe... | 01/29/2008 |
| 7319003 | Arrays of probes for positional sequencing by hybridization This invention is directed to methods and reagents useful for sequencing nucleic acid targets utilizing sequencing by hybridization technology comprising probes, arrays of probes and methods whereby sequence information is obtained rapidly and efficiently in discret... | 01/15/2008 |
| 7314865 | Compositions and methods for promoting lipid mobilization in humans The invention provides methods of using polypeptide compounds based on the structures of insect peptides of the adipokinetic hormone family to mobilize lipids in humans. The compositions and methods described in the application are useful for modulating human body w... | 01/01/2008 |
| 7285422 | Systems and methods for preparing and analyzing low volume analyte array elements The invention provides methods for dispensing tools that can be employed to generate multi-element arrays of sample material on a substrate surface. The substrates surfaces can be flat or geometrically altered to include wells of receiving material. The tool can dis... | 10/23/2007 |
| 7285427 | Raman-active particles and methods of making and using them A Raman-active particle as well as a method of making a Raman-active particle are described. The Raman-active particle includes a core particle and a coating. The coating substantially covers the core particle. A Raman-active analyte is at least partially within the... | 10/23/2007 |
| 7232688 | Systems and methods for preparing and analyzing low volume analyte array elements Methods for dispensing tools that can be employed to generate multi-element arrays of sample material on a substrate surface. The resulting substrates are also provided. The substrates surfaces can be flat or geometrically altered to include wells of receiving mater... | 06/19/2007 |
| 7230068 | Polymer derivatives The invention provides water-soluble compounds that include a polymer and at least one terminal azide or acetylene moiety. Also provided are highly efficient methods for the selective modification of proteins with PEG derivatives, which involves the selective incorp... | 06/12/2007 |
| 7211651 | Proteinaceous gels having visualization agents and methods of use thereof Proteinaceous gels having visualization agents and methods of use thereof are disclosed herein. Further, polymeric crosslinking agents are disclosed that have an inert water soluble polymeric component, biodegradable components, functional components reactive with c... | 05/01/2007 |
| 7208171 | Injectable and bioadhesive polymeric hydrogels as well as related methods of enzymatic preparation The invention is related to biomimetic gels that are prepared enzymatically, using a transglutaminase to cross-link polymer-peptide conjugates of rational design. ... | 04/24/2007 |
| 7198893 | DNA diagnostics based on mass spectrometry Fast and highly accurate mass spectrometry-based processes for detecting a particular nucleic acid sequence in a biological sample are provided. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromo... | 04/03/2007 |
| 7195867 | Method for detection of multiple test materials in a sample A method for sequentially detecting multiple target nucleic acid fragments in a sample includes steps of adding a sample into a column having a test snare which has thereon multiple single strand capture DNA sequences; wherein each capture sequence binds specificall... | 03/27/2007 |
| 7195782 | Concentrated aqueous bromine solutions and their preparation Described is a process of producing a concentrated liquid biocide formulation. Mixed together are (a) bromine chloride or bromine and (b) an aqueous solution of alkali metal salt of sulfamic acid having a pH of at least about 7, in amounts such that (i) the active b... | 03/27/2007 |
| 7196059 | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith Pharmaceutical compositions that include insulin, an insulin drug-oligomer conjugate, a fatty acid component, and a bile salt component or a bile salt component without a fatty acid component are described. The insulin drug is covalently coupled to an oligomeric moi... | 03/27/2007 |
| 7192558 | Multi-well rotary synthesizer An apparatus for synthesizing polymer chains includes a controller, a plurality of precision fit vials circularly arranged in multiple banks on a cartridge, a drain corresponding to each bank of vials, a chamber bowl, a plurality of valves for delivering reagents to... | 03/20/2007 |
| 7183050 | Gradient resolved information platform Methods and devices for the detection and identification in a sample of one or more target molecules which bind to nucleic acid probe molecules are provided. The method includes contacting the sample with a surface that is coated with one or more gradients of nuclei... | 02/27/2007 |
| 7169889 | Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin The present invention relates generally to hydrolyzable drug-oligomer conjugates, pharmaceutical compositions comprising such conjugates, and to methods for making and using such conjugates and pharmaceutical compositions. For example, a conjugate of insulin, PEG, a... | 01/30/2007 |
| 7163736 | Rubber reinforcing fiber cord, method of manufacturing the same, and radial pneumatic tire for passenger car using the same Disclosed is a rubber reinforcing fiber cord in which an eco-friendly silk material is made usable for applications in an automobile pneumatic tire and the like acted upon by large loads. The rubber reinforcing fiber cord of the present invention is characterized in... | 01/16/2007 |
| 7150998 | Multi-well rotary synthesizer An apparatus for synthesizing polymer chains includes a controller, a plurality of precision fit vials circularly arranged in multiple banks on a cartridge, a drain corresponding to each bank of vials, a chamber bowl, a plurality of valves for delivering reagents to... | 12/19/2006 |
| 7144700 | Photolithographic solid-phase polymer synthesis Methods, employing a polycyclic hydrocarbon or a polycyclic heteroaromatic compound as sensitizers, are provided to increase the efficiency of removing, by irradiation, photolabile protecting groups that mask reactive sites on synthesis intermediaries. Preferred gro... | 12/05/2006 |
| 7132519 | Releasable nonvolatile mass-label molecules Releasable tag reagents for use in the detection and analysis of target molecules, particular in mass spectrometric analyses are provided. Also provided are methods of detection that employ releasable tag reagents. ... | 11/07/2006 |
| 7125558 | Process for the preparation of activated polyethylene glycols The present invention relates to a process for the preparation of activated polyethylene glycols, or PEG(NPC)2s, comprising reacting polyethylene glycol with an activator while in the presence of an aromatic nitrogen containing heterocyclic base. The proc... | 10/24/2006 |
| 7118737 | Polymer-modified synthetic proteins The present invention relates to methods and compositions for modifying peptides, polypeptides and proteins with polymers, especially glyco-mimetic polymers, so as to improve their biological activity or pharmacokinetic properties. The invention further provides met... | 10/10/2006 |
| 7115766 | Nucleophilic approach for preparing radiolabeled imaging agents and associated compounds Radiolabeled fluorinated compounds useful for imaging in the diagnosis of Parkinson's Disease are disclosed. Methods and kits for their synthesis are also disclosed. ... | 10/03/2006 |
| 7112449 | Combinatorial chemical synthesis Combinatorial synthesis methods obtain a plurality of compositions having materially different characteristics using an apparatus having a plurality of collectors. A first quantity of fluid reactants are reacted to form a first quantity of product composition. Follo... | 09/26/2006 |
| 7097972 | Method and composition for regulating apoptosis This invention provides non-naturally occurring and isolated naturally occurring nucleic acid molecules which encode proteins designated pro-Yama, p11 Yama and p20 Yama. This invention also provides recombinant polynucleotides coding for these proteins. Also provide... | 08/29/2006 |
| 7094256 | Coatings for implantable medical device containing polycationic peptides Coatings for implantable medical devices and methods for fabricating the same are disclosed. The coatings include carboxylated acrylates and polycationic peptides, for example R7. ... | 08/22/2006 |
| 7087251 | Control of biofilm A method of eradicating or at least substantially reducing biofilm on a surface in contact with water, or which comes in contact with water, which method comprises introducing into such water a concentrated aqueous biocidal composition formed from bromine chloride a... | 08/08/2006 |
| 7087732 | Nucleotides and analogs having photoremovable protecting groups A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are ut... | 08/08/2006 |
| 7084114 | Mixtures of insulin drug-oligomer comprising polyalkylene glycol A mixture of conjugates in which each conjugate in the mixture comprises an insulin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may exhibit higher in vivo activity than a polydispersed mixture of similar conjugate... | 08/01/2006 |
| 7084121 | Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same A mixture of conjugates in which each conjugate in the mixture comprises a calcitonin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may lower serum calcium levels in a subject by 10, 15 or even 20 percent or more. M... | 08/01/2006 |
| 7081495 | Cationic compounds and their use as macro molecular carriers Dendrimers comprising a dentritic polypeptide with one dendron having terminal cationic groups and a lipidic anchor, preferably comprising C6-24-alkyl group containing α-amino acyl groups, preferably joined to the focal group, are used to assist transfec... | 07/25/2006 |
| 7074563 | Mass spectrometric methods for detecting mutations in a target nucleic acid Provided herein are mass spectrometric methods for detecting a mutation in a target nucleic acid. In an embodiment, provided is a method which comprises digesting a target nucleic acid molecule; capturing digested fragments on a solid support that comprises oligonuc... | 07/11/2006 |
| 7070922 | Surface treatment Described is a process for producing a biomolecular monolayer on a biosensor surface comprising the steps of: reacting a biosensor surface with a solution of heterobifunctional reagent having a first functional group and a second functional group, the first function... | 07/04/2006 |
| 7070798 | Coatings for implantable medical devices incorporating chemically-bound polymers and oligomers of L-arginine A coating for an implantable medical device is disclosed. The coating comprises a polymer and an amino acid chemically bonded, attached or conjugated to the polymer. In one embodiment, the coating can include a therapeutic substance. In lieu of bonding the amino aci... | 07/04/2006 |
| 7067623 | Volatilizable solid phase supports for compound synthesis A solid phase synthetic method is disclosed in which the usual solid phase synthetic steps are carried out and the spent solid phase support is reacted to form a volatilizable compound upon cleavage of the reaction product from the solid phase support. The cleaved p... | 06/27/2006 |
| 7056523 | Implantable medical devices incorporating chemically conjugated polymers and oligomers of L-arginine An implantable medical device, such as a stent, is disclosed comprising an amino acid or a polypeptide bonded to a plasma polymerized film layer formed on the device. A method of manufacturing the same is also disclosed. ... | 06/06/2006 |
| 7057019 | Crosslinked albumin hydrogels Materials, methods, and compositions for making crosslinked albumin hydrogels are included in the application. Embodiments include a biocompatible material of albumin crosslinked with an n-functional crosslinking agent wherein n is at least 3. Other embodiments incl... | 06/06/2006 |
