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| Number | Title | Issue Date |
| 8178617 | Antimicrobial constructs The invention is based on the recognition that known antimicrobial compounds, such as nisin or other lantibiotics, can be made to form a long lasting antimicrobial surface coating by linking the peptide with a block polymer, such as PLURONIC® F108 or an end group a... | 05/15/2012 |
| 8173597 | Modified recombinant factor VIII and von Willebrand factor and methods of use The present invention provides novel methods of increasing the survival of a coagulation protein by inhibiting the interaction with a clearance receptor. The invention also provides methods of preparing compositions that inhibit coagulation protein clearance recepto... | 05/08/2012 |
| 8143347 | Pegylation of recombinant blood coagulation factors in the presence of bound antibodies The present invention relates to a proteinaceous construct comprising a blood coagulation factor, e.g., Factor VIII (FVIII), being bound to at least one water soluble polymer, including a poly(alkylene oxide) such as polyethylene glycol (PEG). Further the present in... | 03/27/2012 |
| 8138265 | Hydroxyphenyl cross-linked macromolecular network and applications thereof A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or syn... | 03/20/2012 |
| 8088340 | Polymer compound for biomedical use and biochip substrate using such a polymer compound A biochip substrate capable of realizing the high detection accuracy by restricting a nonspecific adsorption or bonding of a substance to be detected, when used for a detection or analysis of protein, nucleic acids and the like. The biochip substrate is for fixing a... | 01/03/2012 |
| 8071678 | Thioester-terminated water soluble polymers and method of modifying the N-terminus of a polypeptide therewith The invention provides reagents and methods for conjugating a polymer specifically to the α-amine of a polypeptide. The invention provides monofunctional, bifunctional, and multifunctional PEGs and related polymers having a terminal thioester moiety capable of spec... | 12/06/2011 |
| 8053520 | Conjugation reactions An initiator for the terminal group of the polymer product of an atom or group radical transfer polymerisation has an activated carboxyl or an amine group which is reacted with an amine or carboxyl (respectively) group containing biologically active compound. The in... | 11/08/2011 |
| 7897684 | Conjugated polymers suitable for strand-specific polynucleotide detection in homogeneous and solid state assays The invention further relates to polycationic multichromophores, which may be conjugated polymers, and methods, articles and compositions employing them as described herein. In some aspects, the invention relates to methods, articles and compositions for the detecti... | 03/01/2011 |
| 7884075 | Polymer-factor VIII-von Willebrand factor-conjugates The present invention relates to a proteinaceous construct (also designated as polymer-VWF-conjugate) comprising plasmatic and/or recombinant von Willebrand factor (VWF), said VWF being bound to at least one physiologically acceptable polymer molecule, as well as to... | 02/08/2011 |
| 7872072 | Branched polymers and their conjugates The present invention is directed to branched reactive water-soluble polymers comprising at least two polymer arms, such as poly(ethylene glycol), attached to a central aliphatic hydrocarbon core molecule through heteroatom linkages. The branched polymers bear at le... | 01/18/2011 |
| 7868087 | Graft copolymers, methods for grafting hydrophilic chains onto hydrophobic polymers, and articles thereof The present invention relates to synthetic methods for grafting hydrophilic chains onto polymers, particularly hydrophobic polymers such as poly(vinyl chloride) (PVC), poly(vinylidene fluoride) (PVDF), and chlorinated polypropylene (cPP). Resulting polymers include ... | 01/11/2011 |
| 7847019 | Functionalized polymers using protected thiols A process for the preparation of functional molecules using the thiol-ene coupling reaction and a process for the preparation of protected functional thiols, specifically thioesters is provided. The methods may be used to make functional polymers and other molecules... | 12/07/2010 |
| 7834088 | Thioester-terminated water soluble polymers and method of modifying the N-terminus of a polypeptide therewith The invention provides reagents and methods for conjugating a polymer specifically to the α-amine of a polypeptide. The invention provides monofunctional, bifunctional, and multifunctional PEGs and related polymers having a terminal thioester moiety capable of spec... | 11/16/2010 |
| 7820759 | Micellar preparation containing sparingly water-soluble anticancer agent and novel block copolymer A novel micellar preparation in which the solubility of a sparingly water-soluble anticancer agent has been heightened and which after intravenous administration, enables a high blood concentration to be maintained. The preparation has high medicinal activity and/or... | 10/26/2010 |
| 7786213 | Biomacromolecule polymer conjugates Chemical polymerization procedures initiated by, and proceeding from, a biomolecule, particularly a protein, for the formation of biomolecule-polymer conjugates, particularly protein-polymer conjugates, which have therapeutic uses, are intermediates for forming othe... | 08/31/2010 |
| 7767756 | Composite materials containing keratin The application describes materials derived from keratin proteins in combination with polymers, either as intimate mixtures with water soluble polymers, or as chemically bound copolymers. The keratin protein is a specific keratin protein fraction, and is preferably ... | 08/03/2010 |
| 7728069 | Reactive cyclic carbonates and ureas used for modifying biomolecules, polymers, and surfaces Disclosed are reactive cyclic carbonates and ureas of formula (I) or (II), wherein R and X have the meaning indicated in the description. Said carbonates and ureas allow functional groups to be specifically introduced into biomolecules, polymers, and surfaces in mil... | 06/01/2010 |
| 7714063 | Solid support for Fmoc-solid phase synthesis of peptides The present invention provides compositions and processes for the solid phase synthesis of polypeptides. In particular, the present invention provides solid supports and processes for preparing solid supports for the synthesis of polypeptides. ... | 05/11/2010 |
| 7635734 | Photochemical activation of surfaces for attaching biomaterial A water-soluble photo-activatable polymer including: a photo-activatable group adapted to be activated by an irradiation source and to form a covalent bond between the water-soluble photo-activatable polymer and a matrix having at least one carbon; a reactive group ... | 12/22/2009 |
| 7615593 | Bifunctional-modified hydrogels Disclosed are hydrogels wherein a polymer matrix is modified to contain a bifunctional poly(alkylene glycol) molecule covalently bonded to the polymer matrix. The hydrogels can be cross-linked using, for example, glutaraldehyde. The hydrogels may also be crosslinked... | 11/10/2009 |
| 7598318 | Thermosensitive and biocompatible amphiphilic poly(organophosphazenes) and preparation method thereof The present invention relates to a thermosensitive and biocompatible poly(organophosphazenes) represented by Formula 1, and a preparation method thereof: wherein R is a methyl or ethyl group; R′ i... | 10/06/2009 |
| 7511095 | Thioester-terminated water soluble polymers and method of modifying the N-terminus of a polypeptide therewith The invention provides reagents and methods for conjugating a polymer specifically to the α-amine of a polypeptide. The invention provides monofunctional, bifunctional, and multifunctional PEGs and related polymers having a terminal thioester moiety capable of spec... | 03/31/2009 |
| 7465766 | Hydroxyphenyl cross-linked macromolecular network and applications thereof A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic, implantable tissue matrix material for a wide variety of tissue types. In particular, arti... | 12/16/2008 |
| 7442370 | Polymer conjugates of mutated neublastin A dimer comprising a mutated neublastin polypeptide coupled to a polymer is disclosed. Such dimers exhibit prolonged bioavailability and, in preferred embodiments, prolonged biological activity relative to wild-type forms of neublastin. ... | 10/28/2008 |
| 7432331 | Hydrolytically stable maleimide-terminated polymers The present invention is directed to hydrolytically stabilized maleimide-functionalized water soluble polymers and to methods for making and utilizing such polymers and their precursors. ... | 10/07/2008 |
| 7432330 | Hydrolytically stable maleimide-terminated polymers The present invention is directed to hydrolytically stabilized maleimide-functionalized water soluble polymers and to methods for making and utilizing such polymers and their precursors. ... | 10/07/2008 |
| 7419600 | Method for purifying a branched water-soluble polymer Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure wherein Z is a moiety that can be activated for attachment to biologically active molecules such as proteins and wherein P a... | 09/02/2008 |
| 7378469 | Method for the preparation of 1-benzotriazolyl carbonate esters of poly(ethylene glycol) The invention provides a method for preparing a 1-benzotriazolylcarbonate ester of a water-soluble and non-peptidic polymer by reacting a terminal hydroxyl group of a water-soluble and non-peptidic polymer with di(1-benzotriazolyl)carbonate in the presence of an ami... | 05/27/2008 |
| 7371345 | Sterilization of medical adhesive kits Adhesive compositions, particularly medical adhesive compositions, often include several components that may react differently to different sterilization processes, particularly when combined with one another. The present invention is directed to methods of steriliz... | 05/13/2008 |
| 7371836 | PRO526 nucleic acids The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host ceolls comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of... | 05/13/2008 |
| 7371406 | Preparation of injectable suspensions having improved injectability Injectable compositions having improved injectability. The injectable compositions include microparticles suspended in an aqueous injection vehicle having a viscosity of at least 20 cp at 20° C. The increased viscosity of the injection vehicle that constitutes the ... | 05/13/2008 |
| 7368502 | Hydroxyphenyl cross-linked macromolecular network and applications thereof A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, such as artificial or synthetic cartilage. The network is made by first providing a polyamine or polycarboxylate macromolecule ... | 05/06/2008 |
| 7368505 | Graft copolymers This invention relates to methods of making graft copolymers, and articles having such graft copolymers. The methods may provide better control than in radicalization or photoinitiated polymerization techniques. For example, a graft copolymer can be prepared by reac... | 05/06/2008 |
| 7364748 | Controlled morphologies in polymer drug for release of drugs from polymer films The present invention includes a drug release system. The drug release system comprises a bulk polymer phase and a polymeric drug-enriched phase within the bulk polymer phase. At least one drug is incorporated into the drug-enriched phase. ... | 04/29/2008 |
| 7365127 | Process for the preparation of polymer conjugates A process for efficiently preparing polymer conjugates such as branched PEG-polypeptide conjugates, in large scale without column chromatography clean up of the activated PEG linkers to remove impurities is disclosed. ... | 04/29/2008 |
| 7364859 | Methods of using bioelastomers Bioelastomers are disclosed for use in methods of binding compounds including immunoassay methods, in biosensors and methods or regenerating biosensors, and in methods for targeting the delivery of a compound to a particular location within an animal subjects. In ge... | 04/29/2008 |
| 7363074 | Coatings comprising self-assembled molecular structures and a method of delivering a drug using the same A coating for an implantable medical device is disclosed, the coating including a self-assembled molecular structure. The coating can be used for altering the release rate of a therapeutic substance from the implantable device. ... | 04/22/2008 |
| 7361715 | Polymer additives for powder coatings Star polymers prepared by reacting a highly branched polymer and either a lactone or lactam are disclosed. These star polymers find particular application as additives for powder coating compositions, to improve various performance properties thereof. Powder coating... | 04/22/2008 |
| 7361726 | Poly(hydroxyalkanoate-co-ester amides) and agents for use with medical articles Polymers containing poly(hydroxyalkanoate-co-ester amides) and agents for use with medical articles are disclosed along with methods of fabricating medical articles comprising these polymers. The medical articles generally comprise an implantable substrate having a ... | 04/22/2008 |
| 7351332 | Chromatography cartridge and method for manufacturing a chromatography cartridge A chromatography cartridge and method of manufacturing same. A chromatography cartridge of the present invention can include a tubular housing having an open end and an inner surface, and a plug. The plug can be positioned within the open end of the tubular housing ... | 04/01/2008 |
