Quotables
"The idea that cavalry will be replaced by these iron coaches is absurd. It is little short of treasonous."
Aide-de-camp to Field Marshal Haig ; At a tank demonstration, 1916
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7846915 | Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases The present disclosure provides non-naturally occurring polyphenol compounds that upregulate the expression of Apolipoprotein A-I (ApoA-I). The disclosed compositions and methods can be used for treatment and prevention of cardiovascular disease and related disease ... | 12/07/2010 |
| 7030103 | Sulfonamidomethyl phosphonate inhibitors of β-lactamase The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural product and... | 04/18/2006 |
| 7019024 | Pharmaceutical for treatment of neurological and neuropsychiatric disorders The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: or a pharmaceutically acceptable salt thereof. ... | 03/28/2006 |
| 6921756 | Inhibitors of β-lactamase The invention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural product and... | 07/26/2005 |
| 6884791 | Inhibitors of β-lactamase The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural product and... | 04/26/2005 |
| 6706698 | α-Substituted β-aminoethyl phosphonate derivatives The present invention relates to novel α-substituted-β-aminoethylphosphonate and α-substituted-β-aminovinylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and ver... | 03/16/2004 |
| 6632807 | (2R,4S)-(-)-[N-(4-diethoxyphosphorylmethyl)phenyl]-1,2,4,5- tetrahydro-4-methyl-7,8-methylenedioxy-5-oxo-3-benzothiepin-2-carboxamide This invention relates to an optically active benzothiepin derivative represented by the formula: ##STR1## wherein R represents a lower alkyl group; R1 and R2 independently represent a lower alkyl group, or may bind together to form ... | 10/14/2003 |
| 6355672 | Benzothiepin derivatives, process for the preparation of the same and uses thereof The invention provides compounds of the formula: ##STR1## wherein the ring A is an optionally substituted benzene ring; R1 is an optionally substituted non-aromatic heterocyclic group; R2 and R3 are independently hydrogen ... | 03/12/2002 |
| 6346521 | Optically active 2R, 4S benzothiepin isomer This invention relates to an optically active benzothiepin derivative represented by the formula: ##STR1## wherein R represents a lower alkyl group; R1 and R2 independently represent a lower alkyl group, or may bind together to form ... | 02/12/2002 |
| 6054448 | 2-amino-2-(3-substituted cyclobutyl) acetic acid derivatives Compounds of the formula ##STR1## in which R1 is Y or Y--C1-6 alkyl, where Y is carboxy, tetrazolyl, --SO2 H, --SO3 H, --OSO3 H, --CONHOH, or --P(OH)OR', --PO(OH)OR', --OP(OH)OR' or --OPO(OH)OR' ... | 04/25/2000 |
| 5958905 | Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin Phosphoramidates and phosphinic amides and related compounds are provided. Also provided are methods that use the compounds for modulating the activity of the endothelin family of peptides are provided. In particular, compounds having formula: ##STR1... | 09/28/1999 |
| 5910492 | Osteogenic promoting pharmaceutical composition This invention provides a pharmaceutical composition comprising a non-peptide osteogenic promoting substance and a biodegradable polymer, which can be safely used as a prophylactic/therapeutic agent for various bone diseases (e.g., bone fractures).... | 06/08/1999 |
| 5880111 | Therapeutic derivations of diphosphonates Novel chemotherapeutic agents having utility in treating infectious diseases such as periodontal disease, certain urinary tract infections, and infectious urinary tract stones, are obtained by combining chemically a diphosphonate compound with a therapeut... | 03/09/1999 |
| 5854227 | Therapeutic derivatives of diphosphonates Novel chemotherapeutic agents having utility in treating infectious diseases such as periodontal disease, certain urinary tract infections, infectious urinary tract stones, and bone cancer, are obtained by combining chemically a diphosphonate compound wit... | 12/29/1998 |
| 5837702 | 4-arylamino-benzopyran and related compounds Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein X is alkyl, Y is a single bond, --CH2 --, --C(O)--, --O--, --S-- or --N(R8)-- where R8 is hydrogen, alkyl, haloalkyl, aryl, a... | 11/17/1998 |
| 5578601 | Nonpeptide bradykinin antagonists Disclosed are nonpeptides having bradykinin antagonist activity of the formulae (I) and (II) ##STR1## or a pharmaceutically acceptable salt thereof therefor.... | 11/26/1996 |
| 5565440 | Methane diphosphonic acid derivative, its production process and its pharmaceutical applications The present invention discloses a methane diphosphonate derivative, a process for producing said derivative and its pharmaceutical applications, said methane diphosphonate derivative indicated with general formula (1): ##STR1## (wherein, R1 | 10/15/1996 |
| 5492925 | Thienyl-and furylpyrrole insecticidal and acaricidal agents There are provided thienyl- and furylpyrrole compounds of formula I ##STR1## and their use for the control of insects and acarina. Further provided are compositions and methods comprising those compounds for the protection of plants from attack by in... | 02/20/1996 |
| 5428027 | Substituted semicarbazone arthropodicieds Certain substituted semicarbazones, including all geometric and stereoisomers thereof, agricultural compositions containing them and their use as arthropodicides.... | 06/27/1995 |
| 5336671 | Fungicidal compositions containing benzyl-tris(aryl)phosphonium salts The invention provides fungicidal compositions containing benzyl-tris(aryl)-phosphonium salts of the general formula ##STR1## in which R1 represents an optionally substituted alkyl or alkoxy group; R2 represents a hydrogen atom ... | 08/09/1994 |
| 5268385 | Method for treating schizophrenia This invention provides a method for treating the symptoms of schizophrenia by interacting selectively with presynaptic dopaminergic D2 receptors without appreciably activating postsynaptic dopamine receptors which comprises administering to a ... | 12/07/1993 |
| 5268388 | Substituted semicarbazone arthropodicides Certain substituted semicarbazones, including all geometric and stereoisomers thereof, agricultural compositions containing them and their use as arthropodicides.... | 12/07/1993 |
| 5229375 | Phosphene oxide-terminated allene-ene-yne DNA-cleaving, antitumor and antibiotic molecules Phosphine oxide-terminated allene-ene-yne compounds are disclosed that possess DNA-cleaving, antimicobial and tumor growth-inhibiting properties. Methods of making and using those compounds are also disclosed.... | 07/20/1993 |
| 5204334 | Benzoheterocyclylalkylaminoalkanediphosphonic acids, compositions thereof, and use thereof in the treatment of calcium metabolism disorders Benzoheterocyclylalkylaminoalkanediphosphonic acids of formula I ##STR1## wherein R1 and R2, independently of one another, are hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, R3 is hydrogen or lower a... | 04/20/1993 |
| 5190929 | Cyclophosphamide analogs useful as anti-tumor agents Cyclophosphamides possessing anti-tumor activity and having the formula ##STR1## and salts thereof; wherein R is lower alkyl, aryl, aryl-lower alkyl or a nitrogen, sulfur or oxygen containing heterocyclic or heterocyclic lower alkyl, and R' is hydrog... | 03/02/1993 |
| 5169639 | Controlled release verapamil tablets Controlled release verapamil tablets are disclosed. The tablets include an excipient having a hydrophilic material, preferably containing a mixture of xanthan gum/locust bean gum, and an inert diluent.... | 12/08/1992 |
| 5158943 | Sulfur-containing heterocyclic compounds A sulfur-containing hetrocyclic compound of the formula (I) ##STR1## wherein the ring A is an optionally substituted benzene ring, R is a hydrogen atom or an optionally substituted hydrocarbon residue, B is a carboxyl group which may be esterified or... | 10/27/1992 |
| 5071841 | Sulfur-containing heterocyclic compounds useful for the treatment of osteoporosis, and their production The present invention provides a sulfur-containing heterocyclic compound of the formula (I) ##STR1## wherein ring A is a benzene ring which may be substituted; R is a hydrogen atom or a hydrocarbon group which may be substituted; B is a carboxyl ... | 12/10/1991 |
| 4963536 | Diphosphonic acid compounds, and pharmaceutical composition comprising the same useful for treating bone diseases A compound of the formula: ##STR1## wherein R1 -A- is a group of the formula: ##STR2## in which R1 is aryl or a heterocyclic group, each of which may be substituted with substituent(s) selected from the group consisting of ... | 10/16/1990 |
| 4963537 | Labdane compounds, pharmaceutical compositions and use Novel labdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure utilizing compounds or compositions thereof are disclosed.... | 10/16/1990 |
| 4962096 | Heterocyclic glycerol derivatives and their use as anti-hypertensive agents A novel glycerol derivative which is effective to reduce blood pressure has the formula: ##STR1## wherein R1 is an alkyl group having 10-22 carbon atoms, R2 is lower acyl, benzoyl, aryl, mono-, di- or triarylalkyl, alkyl, cycloa... | 10/09/1990 |
| 4897402 | 5-oxa, 5-thia, 5-aza HmG-CoA reductase inhibitors Novel HMG-CoA reductase inhibitors are useful as antihypercholesterolemic agents and are represented by stuctural formulae (I) and (II): ##STR1## wherein A is O, S(O)n or N--R13.... | 01/30/1990 |
| 4857513 | Diphosphonic acid compounds, processes for the preparation thereof and pharmaceutical composition comprising the same A compound of the formula: ##STR1## wherein R1 --A-- is a group of the formula: ##STR2## in which R1 is aryl or a heterocyclic group, each of which may be substituted with substituent(s) selected from the group consisting ... | 08/15/1989 |
| 4777163 | Diphosphonate derivatives, pharmaceutical compositions and methods of use for calcium disturbances The present invention produces alkyldiphosphonic acid derivative of the general formula: ##STR1## wherein Het is a heteroaromatic five-membered ring containing to 3 heteroatoms which can be partly hydrogenated and optionally substituted one or m... | 10/11/1988 |
| 4748160 | Angiotensin converting enzyme inhibitors and their formulation and use as pharmaceuticals There are described compounds of formula I, where the substituents are defined in the disclosure. There are also described methods for making the compounds, formulations containing them and their use, e.g. as antihypertensives.... | 05/31/1988 |
| 4722933 | Substituted 2-aminotetralins The invention provides compounds represented by the general formula ##STR1## where R2, R3 and R4 are each selected from the group consisting of H, and OA; A is H or ##STR2## R5 is selected from the gro... | 02/02/1988 |
| 4535075 | Dithiolane derivative, process for producing the same and use thereof Dithiolane derivatives represented by the formula (I): ##STR1## wherein R1 is an alkyl group, a cycloalkyl group, an alkenyl group, an alkynyl group, a benzyl group or an alkoxyalkyl group and R2 is a cyano group, an alkylcarbon... | 08/13/1985 |
| 4424213 | Biologically active heterobicyclic hydroximidates and thiolhydroximidates and carbamate ester derivatives thereof Novel heterobicyclic compounds of Formula I, processes for preparing same and pesticidal compositions and methods are described. ##STR1##... | 01/03/1984 |
| 4410518 | N-Phosphinoaminosulfinylcarbamate esters and their use as insecticides A novel class of chemical compounds useful as pesticides consists of N-phosphinoaminosulfinylcarbamate esters. The preparation of these compounds and their formulation to control insects are exemplified.... | 10/18/1983 |
| 4404220 | Xanthenone-yl esters of phosphoric and phosphonic acids Disclosed are new compounds of the formula ##STR1## wherein R1 and R2 are each independently selected from the group consisting of halogen, alkyl, haloalkyl, nitro, alkylsulfinyl, alkylsulfonyl and cyano; k and m are integers fr... | 09/13/1983 |
