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| Number | Title | Issue Date |
| 8148352 | Antimicrobial therapy for bacterial infections The disclosure provides compounds and methods to treat bacterial pathogenesis, and demonstrates that the S. aureus pigment is a virulence factor and potential novel target for antimicrobial therapy. ... | 04/03/2012 |
| 7468360 | Therapeutic amides and related compounds Disclosed herein is a compound having a structure: Therapeutic methods, compositions, and medicaments relating thereto are also disclosed. ... | 12/23/2008 |
| 7402262 | Electroconductive polymers Provided are novel polymerizable monomers allowing preparation of exceptionally useful surface coatings by polymerization. Embodiments include highly reticulated chiral nanoparticles useful, for example, for covalently grating biological ligands, epitaxial growth of... | 07/22/2008 |
| 7304046 | Phosphoramide compounds The invention provides a compound of formula I: wherein R1, Ra, Rb, Rc, and Rd have any of the values defined in the specification, as well as pharmaceutical... | 12/04/2007 |
| 7265148 | Substituted pyrrole-indoles The present invention relates generally to substituted pyrrole-indoles such as substituted pyrrole-indoles, and methods of using them. ... | 09/04/2007 |
| 7241904 | Pentafluorosulfanyl-substituted thienothiophene monomers and conducting polymers Disclosed are monomers of the formula: ... | 07/10/2007 |
| 7214701 | Active substance combinations having insecticidal and acaricdal properties The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) ... | 05/08/2007 |
| 7141592 | Substituted oxadiazolidinediones The present invention relates generally to substituted oxadiazolidinediones and methods of using them. ... | 11/28/2006 |
| 7101907 | Topical administration of statins for treatment of bone disorders The topical administration of statins for the treatment of bone disorders is disclosed. ... | 09/05/2006 |
| 7084126 | Methods and compositions for enhancing cellular function through protection of tissue components Methods and composisions for enhancing cellular function through protection of a tissue components such receptors, proteins, lipids, nucleic acids, carbohydrates, hormones, vitamins, and cofactors, by administering pyrophosphate analogs or related compounds. ... | 08/01/2006 |
| 7030103 | Sulfonamidomethyl phosphonate inhibitors of β-lactamase The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural product and... | 04/18/2006 |
| 7019024 | Pharmaceutical for treatment of neurological and neuropsychiatric disorders The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: or a pharmaceutically acceptable salt thereof. ... | 03/28/2006 |
| 6919322 | Phenyl Phosphonate Fructose-1,6-Bisphosphatase Inhibitors Novel FBPase inhibitors of the formula I are useful in the treatment of diabetes and other conditions associated with elevated blood glucose. ... | 07/19/2005 |
| 6903081 | Phosphoramidates and methods therefor Novel phosphoramidate derivatives of hydroxy functional or amino functional compounds, including amino acids, peptides, peptidomimetics and nucleotide analogs, are described. The compounds enable enhanced intracellular delivery of drugs as their corresponding phosph... | 06/07/2005 |
| 6864276 | Active substance combinations having insecticidal and acaricidal properties The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) in which W, X, Y, Z, A, B, D and G ... | 03/08/2005 |
| 6670330 | Cancer chemotherapy with 2-deoxy-D-glucose A class of glycolytic inhibitors is useful in the treatment of solid tumors by attacking anaerobic cells at the center on the tumor. 2-deoxyglucose, oxamate and various analogs thereof are identified as having a natural selective toxicity toward anaerobic... | 12/30/2003 |
| 6566304 | Biogenic control and limitation of the reproduction of parasitic earth nematodes in stock culture The invention relates to use of (a) compounds of phosphorus containing at least partly lipophilic organic radicals together with (b) urea and/or urea derivatives in selected quantity ratios of (a) to (b) as a soil additive for biologically controlling pla... | 05/20/2003 |
| 6521605 | Amidophosphate derivatives The present invention provides amidophosphate derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.... | 02/18/2003 |
| 6506737 | Antimicrobial phosphonium and sulfonium polyhalide compositions An oxidizing species is described herein as a reaction product through an in situ preparation combining a protonizable phosphorus or sulfur compound, and a halide source at controlled proportions in an aqueous, non-aqueous, gel, aerosol, solid-phase or po... | 01/14/2003 |
| 6503891 | Water emulsifiable formulations A composition comprising an organic carbonate such as propylene carbonate and O,O-diethyl-O-(2-isopropyl-4-methyl-6-pyrimidinyl)phosphorothioate, S-[1,2-bis(ethoxycarbonyl)ethyl]O,O-dimethylphosphorodithioate, or 6,7,8,9,10, 10-hexachloro-1,5,5a,6,9,... | 01/07/2003 |
| 6500811 | Sulfonylaminophosphinic and sulfonylaminophosphonic acid derivatives, methods for their preparation and use Compounds of the formula I ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading enzymes is involved.... | 12/31/2002 |
| 6479471 | NAALADase inhibitors The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives that inhibit N-Acetylated -Linked Acidic Dipeptidase (NAALADase) enzym... | 11/12/2002 |
| 6395718 | Pharmaceutical compositions and methods of inhibiting angiogenesis using naaladase inhibitors The present disclosure relates to a method of inhibiting angiogenesis comprising administering a N-Acetylated -Linked Acidic Dipeptidase (NAALADase) inhibitor to a patient in need thereof, and a pharmaceutical composition comprising an anti-angioge... | 05/28/2002 |
| 6280715 | Cosmetic composition useful notably for the skin whitening and melanogenesis inhibiting agent containing such a cosmetic composition Cosmetic composition useful notably in the whitening of skin which it includes, in association with any suitable excipient, at least one compound of the following general formula (I): ##STR1## wherein: R1 represents a hydrogen atom, a linear or... | 08/28/2001 |
| 6258801 | Fungicidal mixtures A fungicidal mixture, comprising a) a carbamate of the formula I, ##STR1## where T is CH or N, n is 0, 1 or 2 and R is halogen, C1 -C4 -alkyl or C1 -C4 -haloalkyl, and where the radicals R may be different if n... | 07/10/2001 |
| 6200961 | Concentrates of organophosphorous insecticides A low volatile organic compound co-solvent system is disclosed for preparing emulsion concentrates of low melting organophosphorous insecticides wherein the bioefficacy of the insecticide active is significantly enhanced. The co-solvent system comprises a... | 03/13/2001 |
| 6172061 | Pharmaceutical composition for antagonizing CCR5 comprising anilide derivative This invention is to provide a pharmaceutical composition for antagonizing CCR5 which comprises a compound of the formula: ##STR1## wherein R1 is an optionally substituted 5- to 6-membered ring; W is a divalent group of the formula: ##STR2... | 01/09/2001 |
| 6054444 | Phosphonic acid derivatives The present invention relates to phosphonic acid derivatives that inhibit N-Acetylated -Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives to inhibit... | 04/25/2000 |
| 6017903 | Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors The present invention relates to a method of treating a glutamate abnormality and a method of effecting a neuronal activity in an animal using a NAALADase inhibitor, and a pharmaceutical composition comprising an effective amount of a NAALADase inhibitor ... | 01/25/2000 |
| 6004946 | Treatment of global and focal ischemia using naaladase inhibitors The present invention includes compositions and methods of treatment for glutamate abnormalities and associated nervous tissue insult in a animal by inhibition of NAALADase enzyme. Compositions include glutamate-derived hydroxyphosphinyl derivative compou... | 12/21/1999 |
| 5998443 | Phosphorous containing benzothiophenes for treating estrogen deficiency This invention relates to the fields of pharmaceutical and organic chemistry and provides novel phosphorous-containing benzothiophene compounds which are useful for the treatment of the various medical indications associated with post-menopausal syndrome,... | 12/07/1999 |
| 5985858 | Phosphonic diester derivatives A phosphonic diester derivative represented by the following formula (1): ##STR1## wherein R1 represents a cycloalkyl group; a phenyl group which may have 1 to 3 substituents selected from the group consisting of a lower alkoxy group, a lo... | 11/16/1999 |
| 5968915 | Naaladase inhibitors The present disclosure relates to dipeptidase inhibitors, and more particularly, to N-Acetylated -Linked Acidic Dipeptidase (NAALADase) enzyme inhibitors which are proposed as novel agents for the treatment of prostate cancer. NAALADase is enzyme w... | 10/19/1999 |
| 5962439 | Fused benzeneoxyacetic acid derivatives Fused benzeneoxyacetic acid derivatives of the formula (I): ##STR1## or salts thereof possess an agonistic effect on the PGI2 receptor and thus are useful for preventing and/or treating thrombosis, arteriosclerosis, ischemic heart diseases... | 10/05/1999 |
| 5958905 | Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin Phosphoramidates and phosphinic amides and related compounds are provided. Also provided are methods that use the compounds for modulating the activity of the endothelin family of peptides are provided. In particular, compounds having formula: ##STR1... | 09/28/1999 |
| 5935927 | Compositions and methods for stimulating amyloid removal in amyloidogenic diseases using advanced glycosylation endproducts The present invention relates generally to methods and compositions for treating amyloidogenic diseases such as Alzheimer's disease and the development of type II diabetes, in which deposition of amyloid in organs such as the brain and pancreas interfere ... | 08/10/1999 |
| 5880111 | Therapeutic derivations of diphosphonates Novel chemotherapeutic agents having utility in treating infectious diseases such as periodontal disease, certain urinary tract infections, and infectious urinary tract stones, are obtained by combining chemically a diphosphonate compound with a therapeut... | 03/09/1999 |
| 5863536 | Phosphoramidate derivatives The present invention includes phosphoramidate derivatives, compositions containing the same, and methods of using them as NAALADase inhibitors, particularly for the treatment of glutamate abnormalities and associated nervous tissue insult in a animal and... | 01/26/1999 |
| 5856314 | Thio-substituted, Nitrogen-containing, heterocyclic phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism The present invention relates to thio-substituted, nitrogen-containing heterocyclic phosphonate compounds, including bisphosphonates, phosphonoalkylphosphinates, phosphonocarboxylates, and phosphonosulfonates, and the pharmaceutically-acceptable salts and... | 01/05/1999 |
| 5856323 | Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase 2,5-Diaryl tetrahydrofurans, 2,5-diaryl tetrahydrothiophenes, 2,4-diaryl tetrahydrofurans, 2,4-diaryl tetrahydrothiophenes, 1,3-diaryl cyclopentanes, 2,4-diaryl pyrrolidines, and 2,5-diaryl pyrrolidines are disclosed that reduce the chemotaxis and respira... | 01/05/1999 |
