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| Number | Title | Issue Date |
| 8178513 | Heterocyclic aspartyl protease inhibitors Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein W, U, X, R1, R2, R3, and R4 are as defined he... | 05/15/2012 |
| 8003626 | Pyrazole-4-carboxamide derivatives as microbiocides Compounds of the formula I in which the substituents are as defined in claim 1 are suitable for use as microbiocides. ... | 08/23/2011 |
| 8003625 | Phosphoramidate alkylator prodrugs Phosphoramidate alkylator prodrugs can be used to treat cancer when administered alone or in combination with one or more anti-neoplastic agents. ... | 08/23/2011 |
| 7977323 | C-C-alkyl-imidazole-bisphosphonates C2-C5-Alkyl-substituted [(imidazol-1-yl)-1-hydroxy-1-phosphono-ethyl]-phosphonic acids, as well as methods or processes for their manufacture, their use in the manufacture of pharmaceutical formulations, their use in the treatment of diseases, ... | 07/12/2011 |
| 7947665 | LPA receptor agonists and antagonists and methods of use Disclosed are compounds according to formula (I) as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including inhi... | 05/24/2011 |
| 7763596 | Selective glucocorticoid receptor agonists This invention is directed to a method for treating an inflammatory condition, treating haematological and other malignancies, causing immunosuppression, or preventing or treating transplant rejection in man or other animals which comprises administering to a patien... | 07/27/2010 |
| 7687481 | Cannabinoid receptor antagonists/inverse agonists useful for treating obesity The present invention provides novel pyrazoles that are useful as cannabinoid receptor antagonists and pharmaceutical compositions thereof and methods of using the same for treating obesity, diabetes, and/or cardiometabolic disorders. ... | 03/30/2010 |
| 7354911 | 1,3-benzodioxol compound and use of same Containing the 1,3-benzodioxol compound represented by the formula (I): together with a pesticidal active ingredient in a pesticidal composition enhances a pest control effect of the pesticidal composition. ... | 04/08/2008 |
| 7238709 | Therapeutic carbamates This invention relates to hindered carbamate derivatives that are muscarinic receptor antagonists, pharmaceutical compositions comprising such compounds, and methods of preparing these compounds. ... | 07/03/2007 |
| 7235666 | Process for the preparation of sodium fosphenytoin Phosphoric acid diester 2,5-dioxo-4,4-diphenylimidazolidin-1-ylmethyl esters, both of whose ester groups can be selectively cleaved, are obtained by converting 3-(hydroxymethyl)-5,5-diphenylimidazolidine-2,4-dione to an alkylsulfonate or arylsulfonate and reacting t... | 06/26/2007 |
| 7217704 | LPA receptor agonists and antagonists and methods of use The present invention relates to compounds according to formula (I) as disclosed herein as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA... | 05/15/2007 |
| 7211267 | Methods of treating acne A method of treating acne in a human in need thereof comprising administering systemically to said human a tetracycline compound in an amount that is effective to treat acne but has substantially no antibiotic activity, without administering a bisphosphonate compoun... | 05/01/2007 |
| 7208481 | Aminodiphosphonate apolipoprotein E modulators The present invention relates to methods of use of aminodiphosphonate to modulate apolipoprotein E levels and the use of such compounds in therapy, including cardiovascular and neurological disease states. ... | 04/24/2007 |
| 7172873 | Methods of detecting early renal disease in animals The present invention provides a method for the detection of early renal disease in animals. The method includes the steps of (a) obtaining a sample from an animal to be tested and (b) determining the amount of albumin in the sample. An amount of albumin in the rang... | 02/06/2007 |
| 7105556 | Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method Compounds are provided which have the structure wherein Q is C or N, X1 is C or N, and R1, R2, R2a, R2b, R2c, R3, Y, A, m, n, X2 | 09/12/2006 |
| 7030103 | Sulfonamidomethyl phosphonate inhibitors of β-lactamase The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural product and... | 04/18/2006 |
| 7014858 | Use methods of treating acne and telangiectasia A method of treating telangiectasia in a human in need thereof comprising administering to said human a tetracycline compound in an amount that is effective to treat telangiectasia, but has substantially no antibiotic activity. ... | 03/21/2006 |
| 6965033 | Bisamidate phosphonate prodrugs Novel bisamidate phosphonate prodrugs of FBPase inhibitors of the Formula IA: and their use in the treatment of diabetes and other conditions associated with elevated blood glucose. ... | 11/15/2005 |
| 6919322 | Phenyl Phosphonate Fructose-1,6-Bisphosphatase Inhibitors Novel FBPase inhibitors of the formula I are useful in the treatment of diabetes and other conditions associated with elevated blood glucose. ... | 07/19/2005 |
| 6762227 | Inhibition of marine biofouling of surfaces The use of an aromatic compound substituted with at least one heterocyclic amine and possibly additional substituents, such as medetomidine and clonidine, or a functionally analogous derivative thereof, as an agent for the inhibition of marine biofouling on a surfac... | 07/13/2004 |
| 6756391 | Antiviral compounds The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV-infected cells as well as othe... | 06/29/2004 |
| 6703368 | Peptide-containing -ketoamide cysteine and serine protease inhibitors This invention relates to peptide-containing -ketoamide inhibitors of cysteine and serine proteases, methods for making these compounds, and methods for using the same.... | 03/09/2004 |
| 6514952 | Hydantoin derivatives as inhibitors of leucocyte adhesion and as VLA-4 antagonists Compounds of the formula I ##STR1## in which B, D, E, R, W, Y, Z, b, c, d, e, f, g and have the meanings indicated in the claims, are inhibitors of the adhesion and migration of leucocytes and/or antagonists of the adhesion receptor VLA-4 which belongs ... | 02/04/2003 |
| 6500811 | Sulfonylaminophosphinic and sulfonylaminophosphonic acid derivatives, methods for their preparation and use Compounds of the formula I ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading enzymes is involved.... | 12/31/2002 |
| 6498151 | Aryldifluoromethylphosphonic acids with sulfur-containing substituents as PTP-1B inhibitors The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme. ##STR1## The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated d... | 12/24/2002 |
| 6492410 | Combinations of protein farnesyltransferase and HMG CoA reductase inhibitors and their use to treat cancer Novel combinations of inhibitors of protein farnesyltransferase enzymes and HMG CoA reductases enzymes are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in preventing or treating cancer, re... | 12/10/2002 |
| 6425881 | Therapeutic mixture useful in inhibiting lesion formation after vascular injury Vessels are treated with a mixture of L-arginine and an agent which enhances the biotransformation of L-arginine into NO. The incidents associated with restenosis are expected to be substantially reduced and prevented providing for a reduced incidence of ... | 07/30/2002 |
| 6352985 | Benzimidazole compounds A benzimidazole compound represented by the formula (I): ##STR1## wherein R3 is a carboxyl group, a esterified carboxyl group, an amidated carboxyl group, an amino group, an amido group, or a sulfonyl group, or their pharmaceutically acceptable... | 03/05/2002 |
| 6300356 | Method for decreasing QT dispersion or inhibiting the progression of QT dispersion with an angiotensin II receptor antagonist Angiotensin II receptor antagonists are useful for decreasing QT dispersion or inhibiting the progression of QT prolongation in patients. Also disclosed is a method for monitoring the reduction in die risk of experiencing an adverse cardiac event, such as... | 10/09/2001 |
| 6201002 | Method for reducing mortality with an angiotensin II antagonist Angiotensin II receptor antagonists are useful in reducing and preventing mortality and sudden cardiac death in symptomatic heart failure patients. Losartan potassium has been shown to reduce mortality and sudden cardiac death in this patient population. ... | 03/13/2001 |
| 6200961 | Concentrates of organophosphorous insecticides A low volatile organic compound co-solvent system is disclosed for preparing emulsion concentrates of low melting organophosphorous insecticides wherein the bioefficacy of the insecticide active is significantly enhanced. The co-solvent system comprises a... | 03/13/2001 |
| 6187752 | Method for treating schizophrenia employing an ace inhibitor A method is provided for treating schizophrenia in a mammalian species by administering an ACE inhibitor, such as captopril, alone or with a neuroleptic such as cholecystokinin, fluphenazine or haloperidol.... | 02/13/2001 |
| 6162820 | Method for removing parasites and in particular ectoparasites of vertebrates, in particular of mammals, and compositions for the implementation of this method Methods for removing parasites and in particular ectoparasites of vertebrates, in particular of mammals, and compositions for the implementation of this method. Methods for removing parasites of vertebrates, and in particular arthropods, mainly insects an... | 12/19/2000 |
| 6121296 | Transition-state inhibitors for nucleoside hydrolase and transferase reactions This invention is directed to transition-state analog compounds and to the use of said compounds as inhibitors of nucleoside hydrolase and transferase enzyme activity of parasites. This invention is further directed to the use of said compounds to treat i... | 09/19/2000 |
| 5998390 | Combination of bisphosphonate and tetracycline Tissue-destructive conditions related to excess proteinase activity in a biological system are treated or prevented by administering to the system a composition which combines a tetracycline and a bisphosphonate in synergistic proteinase inhibiting amount... | 12/07/1999 |
| 5998447 | Heterocycles as inhibitors of leucocyte adhesion and as VLA-4 antagonists Compounds of the formula I ##STR1## in which B, D, E, R, W, Y, Z, b, c, d, e, f, g and have the meanings indicated in the claims, are inhibitors of the adhesion and migration of leucocytes and/or antagonists of the adhesion receptor VLA-4 which belon... | 12/07/1999 |
| 5972915 | Pesticide containing a synergistic combination of active ingredients A pesticide comprising an active ingredient combination consisting of a) tetrahydro-3,5-dimethyl-1,3,5-thiadiazine-2-thione of the formula ##STR1## and b) O-(O-ethyl-S-n-propylphosphoryl)-O-(N-methylcarbamoyl)pyrocatechol of the formula ##STR2## ... | 10/26/1999 |
| 5958905 | Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin Phosphoramidates and phosphinic amides and related compounds are provided. Also provided are methods that use the compounds for modulating the activity of the endothelin family of peptides are provided. In particular, compounds having formula: ##STR1... | 09/28/1999 |
| 5952305 | Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims The invention involves a method for treating a human survivor of a heart attack and provides further improvement in survival following the heart attack by the early initiation and long-term administration of a renin-angiotensin system inhibitor, preferabl... | 09/14/1999 |
| 5914351 | Anti-viral aromatic hydrazones Compounds of the formula ##STR1## wherein Q is a hydrazone derivative; R1 is hydrogen, halogen, alkyl or alkoxy; R2 is hydrogen, halogen, alkyl, alkoxy, alkenoxy, alkynyloxy, halomethyl, trifluoromethoxy, alkylthio, nitro or cyano; a... | 06/22/1999 |
