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| Number | Title | Issue Date |
| 7291592 | Method for treating patients with massive blood loss Methods for treating a mammal suffering from massive blood loss comprising administering to the mammal a polymerized hemoglobin solution. ... | 11/06/2007 |
| 7265087 | Exendin improves β-cell response in subjects with impaired glucose tolerance A composition for the treatment of impaired glucose tolerance (IGT) including a compound which binds to a receptor for glucagon-like peptide-1, and a pharmaceutical carrier. The amount of the compound present is an effective amount to improve pancreatic β-cell sens... | 09/04/2007 |
| 7122655 | Compositions involving M-RIP, and related methods for screening for anti-hypertensive agents, and uses thereof The present invention relates to screening methods that make use of Myosin Phosphatase-Rho interacting Protein (M-RIP) for the identification of novel therapeutics for hypertension and hypertensive conditions. Also disclosed are methods for treating or preventing hy... | 10/17/2006 |
| 7115588 | Methods for treating a breach or puncture in a blood vessel The present invention relates to compositions comprising semi-crystalline β-1-4-N-acetylglucosamine polymers (p-GlcNac) and methods utilizing such polymers modulation of vascular structure and/or function. The compositions and methods disclosed are useful for stimu... | 10/03/2006 |
| RE39150 | Composition for creating vascular occlusions A composition including 2-hexyl cyanoacrylate and goal is useful in treating arteriovenous malformations (AVMs) and other body lumens to be blocked. ... | 06/27/2006 |
| 7041657 | Compositions and methods for modulation of vascular structure and/or function The present invention relates to compositions comprising semi-crystalline β-1-4-N-acetylglucosamine polymers (p-GlcNac) and methods utilizing such polymers modulation of vascular structure and/or function. The compositions and methods disclosed are useful for stimu... | 05/09/2006 |
| 6605447 | Methods and means of detecting nitric oxide synthase Methods for identifying and monitoring increased or decreased levels of inducible nitric oxide synthase in biological samples are provided. A collection device for detecting inducible nitric oxide synthase in biological samples is also provided. Detection... | 08/12/2003 |
| 6333057 | Composition and method for topical treatment of androgenic alopecia This invention relates to the topical and oral treatment of hair loss, especially androgenic alopecia, by providing formulations that include anti-androgens, especially extracts of the saw palmetto plant, co-enzyme Q, and acetyl carnitine, and optionally ... | 12/25/2001 |
| 6184254 | Methods of identifying modulators of perivascular sensory nerve Ca2+ receptors Methods of identifying compounds that relax or stimulate arterial tension through their action on perivascular sensory nerve calcium receptors are described. Compounds identified through such methods are useful for the treatment of hypertension, hypotensi... | 02/06/2001 |
| 6037366 | Composition for creating vascular occlusions A composition including 2-hexyl cyanoacrylate and gold is useful in treating arteriovenous malformations (AVMs) and other body lumens to be blocked.... | 03/14/2000 |
| 6020308 | Methods for improving therapeutic effectiveness of treatment of vascularization disorders The present invention is directed to the use of an inhibitor of NO activity, such as a nitric oxide scavenger or an NO synthase inhibitor, as as an adjunct to treatment of inappropriate tissue vascularization disorders.... | 02/01/2000 |
| 5965155 | Transdermal therapeutic system with pentylene tetrazol as active substance The invention relates to a pharmaceutic product as well as to a process for its production for a transdermal application in the prophylaxis and treatment of vasodilations, said pharmaceutic product comprising at least one skin-compatible auxiliary agent a... | 10/12/1999 |
| 5962008 | Topical medicament for use in treatment of anorectal inflammation A medicament for use in the treatment of anorectal inflammation in hemorrhoids and the like contains a petroleum base, water, phenylephrine hydrochloride, squalene, and 8-hydroxyquinoline.... | 10/05/1999 |
| 5942241 | Formulations and methods for providing prolonged local anesthesia A formulation and methods for inducing sustained regional local anesthesia in a patient comprising a substrate comprising a local anesthetic and an effective amount of a biocompatible, biodegradable, controlled release material prolonging the release of t... | 08/24/1999 |
| 5880101 | Clinical uses of polyene macrolides The present invention relates to the use of at least one polyene macrolide for the preparation of pharmaceutical compositions for the treatment of diseases that are associated with an impaired energy turnover. Particularly, the present inventions allows t... | 03/09/1999 |
| 5776979 | Method of use of cardiotonic drugs and inhibitors of nitric oxide synthesis to alleviate pathologic hypotension The present invention involves a method for prophylaxis or treatment of an animal for systemic hypotension induced by endotoxin and/or a biological response modifier such as the cytokines, IFN, TNF, IL-1 or IL-2 and the like. The method involves administe... | 07/07/1998 |
| 5770623 | Argine antagonists for inhibition of systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor A method for prophylaxis or treatment of an animal for systemic hypotension induced by internal nitrogen oxide production. The method involves administering a therapeutically effective amount of certain arginine derivatives to inhibit nitrogen oxide forma... | 06/23/1998 |
| 5593664 | Antiangiogenic oligomers The present invention relates to the use of certain anionic polyamide and polyurea oligomers for inhibiting angiogenesis, and for their use in treating diseases associated with angiogenesis. These oligomers have a number average molecular weight (Mn | 01/14/1997 |
| 5545625 | Preventing conversion of citrulline to argininosuccinate to limit pathological nitric oxide overproduction Administration of argininosuccinate synthetase activity reducing agents, e.g., argininosuccinate synthetase induction blocking agents (e.g., antibiotics that bind to DNA sequences present in the upstream regulatory region of the argininosuccinate syntheta... | 08/13/1996 |
| 5510331 | Antihypertensive peptides Peptides of the formula R1 --HX1 DX2 IX3 I wherein R1, X1, X2 and X3 are defined as in the specification having antihypertensive activity without vascocons... | 04/23/1996 |
| 5385935 | Method for the inhibition of restenosis associated with coronary intervention This invention provides a method for treating patients to inhibit restenosis associated with coronary intervention. A 600 mg dosage of Tranilast for a treatment period of three consecutive months after coronary intervention lowers the incidence of resteno... | 01/31/1995 |
| 5373010 | Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives A method of treating a mammal comprises administering to a mammal an effective amount to provide a desired therapeutic effect in the mammal of a compound selected from the group consisting of those having the formula: ##STR1## , pharmaceutically acce... | 12/13/1994 |
| 5340587 | Liposome/bronchodilator method & System A method and system for treating bronchial constriction. The system includes a liposome composition containing a 댢 -adrenoreceptor agonist in a liposome-entrapped form, and a device for aerosolizing a metered quantity of the composition.... | 08/23/1994 |
| 5312835 | Use of cardiotonic drugs and inhibitors of nitric oxide synthesis to alleviate pathologic hypotension The present invention involves a method for prophylaxis or treatment of an animal for systemic hypotension induced by endotoxin and/or a biological response modifier such as the cytokines, IFN, TNF, IL-1 or IL-2 and the like. Said method involves administ... | 05/17/1994 |
| 5216025 | Nitric oxide synthesis inhibitors for potentiating the action of pressor agents in certain hypotensive patients A method for treatment of an animal for systemic hypotension induced by internal nitric oxide production caused by endotoxin or cytokines. The method involves administering an 댑 adrenergic agonist and an amount of an inhibitor of nitric ... | 06/01/1993 |
| 5194448 | Use of nervonic acid and long chain fatty acids for the treatment of demyelinating disorders Composition containing nervonic acid (cis-tetracos-15-enoic acid) in a physiologically acceptable form are useful in the treatment of demyelinating disease, such as multiple sclerosis. Additional long chain fatty acids of chain length C16 to C26, especial... | 03/16/1993 |
| 5116878 | Medicinal composition for the treatment and prevention of the symptoms of heart failure, containing a vasoconstrictor alpha-stimulant agent as active principle This medicinal composition for the treatment and prevention of the symptoms of heart failure contains, by way of active principle, at least one compound chosen from 2-amino-1-(2,5-dimethoxyphenyl)-1-propanol (methoxamine) and its pharmaceutically acceptab... | 05/26/1992 |
| 5091194 | Cosmetic compositions comprising a native mineral substance for the treatment of phlebectasiae and process for preparing same The invention relates to cosmetic compositions for the treatment of phlebectasiae, particularly haemorrhoids and phlebectasiae mainly occurring on the lower limbs optionally accompanied with phlebitis, as well as for relieving the phlebalgia thereby induc... | 02/25/1992 |
| 5041284 | Method of preventing frostbite A method for preventing frostbite of body portions is disclosed. The method includes applying an antiperspirant composition to the body portion and covering the body portion with a thermally insulating material.... | 08/20/1991 |
| 5036107 | 1,7-substituted heptyn-2-ones and use 1-Phenyl-7-substituted-hept-5-yn-2-ones substituted with a C1 to C7 alkyl, C3 to C6 cycloalkyl, aryl, heteroaryl or heterocycloalkyl group at the 1-position and an amino, a dialkylamino, a piperidyl, a pyrrolidy... | 07/30/1991 |
| 5028627 | Method of using arginine derivatives to inhibit systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor A method for prophylaxis of treatment of an animal for systemic hypotension induced by internal nitrogen oxide production. The method involves administering a therapeutically effective amount of certain arginine derivatives to inhibit nitrogen oxide forma... | 07/02/1991 |
| 5010096 | Method of protecting mammals against neuronal damage resulting from cerebral ischemia The use of a compound of formula (I) or a physiologically acceptable salt or hydrate thereof in the treatment, relief or prevention of the effects of cerebral ischaemia ##STR1## Compounds of formula (I) are described in UK Published Patent Applicatio... | 04/23/1991 |
| 5002767 | Therapeutic composition containing alpha-linolenic acid and a compound capable of promoting the passage of the acid through the cell membrane, plant extract comprising the acid and the compound, and process for the preparation of the extract The invention relates to a therapeutic composition containing, as the active principle, -linolenic acid and an alcohol of vegetable origin, such as a tocopherol or sitosterol. Preferably, the composition contains other fatty acids and is an organic... | 03/26/1991 |
| 4994483 | 5-substituted-3-aminoalkyl indole derivatives for migraine Indole derivatives are disclosed of the general formula (I): ##STR1## wherein R1 is hydrogen, C1-6 alkyl or C3-6 alkenyl; R2 is a hydrogen, C1-3 alkyl, C3-6 alkenyl, phenyl, phen(C | 02/19/1991 |
| 4978332 | Treatments employing vasoconstrictive substances in combination with cytotoxic agents for introduction into cellular lesion areas A pharmaceutical composition and method of treating cellular disorders involving abnormal solid cellular growths which comprises administering a pharmaceutical composition containing cytotoxic agents in combination with a vasoconstrictive drug. Enhanced e... | 12/18/1990 |
| 4970301 | 2-(piperazinyl)-2-oxoethylene-substituted flavonoid compounds Compound of general formula I: ##STR1## in which: A is a single or double bond, R1 and R3, which may be identical or different, are each a hydrogen atom, an alkoxycarbonylmethylene radical of formula --CH2 CO2 | 11/13/1990 |
| 4853216 | Process and composition for the topical application of alpha1 adrenergic agonist for pilomotor effects Processes and Compositions for effecting a pilomotor effect on a hair-bearing skin area by the application of an alpha1 adrenergic agonist having essentially only alpha1 adrenergic agonist activity.... | 08/01/1989 |
| 4851450 | Compounds for inhibition of platelet activating factor activity The present invention is a group of biologically active agents, di-hydroxy alkyl glycerols with vicinal hydroxyl groups and their acetyl-derivatives having the general formula: ##STR1## where R is selected from the group of H and CH3 CO-- ... | 07/25/1989 |
| 4795756 | 3-(2-aminoethyl)indole derivatives Compounds are disclosed of formula (I) ##STR1## wherein R1 is H, C1-6 alkyl, C3-7 cycloalkyl, phenyl optionally substituted by C1-3 alkoxy or phen(C1-4) alkyl in which the phenyl ring is optional... | 01/03/1989 |
| 4785014 | Use of clonidine in memory enhancement Disclosed is a method of treating cognitive decline in a normal aged primate by administering thereto a therapeutically effective amount of 2-[(2,6-dichlorophenyl)-amino]-2-imidazoline or a nontoxic, pharmaceutically acceptable salt thereof. Administratio... | 11/15/1988 |
