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| Number | Title | Issue Date |
| 7270838 | Composition for treating chronic venous insufficiencies using an extract of red vine leaves The invention relates to a dietary supplement consisting of an aqueous extract of red vine leaves and an acceptable carrier which prevents and reduces the discomfort relating to mild-to-moderate chronic venous insufficiency of the legs. ... | 09/18/2007 |
| 7265087 | Exendin improves β-cell response in subjects with impaired glucose tolerance A composition for the treatment of impaired glucose tolerance (IGT) including a compound which binds to a receptor for glucagon-like peptide-1, and a pharmaceutical carrier. The amount of the compound present is an effective amount to improve pancreatic β-cell sens... | 09/04/2007 |
| 7235264 | Cerebral protection with a gas comprising xenon Xenon or xenon-containing gases and, where appropriate, an NO source are employed as medicament for cerebral protection. Cerebral protection is defined as reducing or preventing impairments of cerebral function of various causes, but especially secondary to perfusio... | 06/26/2007 |
| 7189761 | Nitric oxide donor composition and method for treatment of anal disorders A pharmaceutical composition contains a nitric oxide donor and advantageously an optional corticosteroid and/or topical anesthetic. The composition is useful in a method for treating anal disorders such as anal fissure, anal ulcer, hemorrhoidal disease, levator spas... | 03/13/2007 |
| 7122655 | Compositions involving M-RIP, and related methods for screening for anti-hypertensive agents, and uses thereof The present invention relates to screening methods that make use of Myosin Phosphatase-Rho interacting Protein (M-RIP) for the identification of novel therapeutics for hypertension and hypertensive conditions. Also disclosed are methods for treating or preventing hy... | 10/17/2006 |
| 7045152 | Treating pulmonary disorders with gaseous agent causing repletion of GSNO Pulmonary disorders in which the GSNO pool or glutathione pool in the lung is depleted and where reactive oxygen species in lung are increased, are treated by delivering into the lung as a gas, agent causing repletion or increase of the GSNO pool or protection again... | 05/16/2006 |
| 6991816 | Composition for treating chronic venous insufficiencies using an extract of red vine leaves The invention relates to a dietary supplement consisting of an aqueous extract of red vine leaves and an acceptable carrier which prevents and reduces the discomfort relating to mild-to-moderate chronic venous insufficiency of the legs. ... | 01/31/2006 |
| 6946484 | Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype Methods and formulations for inhibiting and preventing a malignant cell phenotype by administering to cells a low dose of a nitric oxide mimetic are provided. ... | 09/20/2005 |
| 6825234 | Compositions and methods for amelioration of human female sexual dysfunction The invention provides compositions and methods suitable for ameliorating female sexual dysfunction, and in particular, female sexual arousal disorder. In one embodiment, the invention provides a semisolid composition suitable for topical application comprising: an ... | 11/30/2004 |
| 6784179 | Tetracyclic derivatives, process of preparation and use A compound of formula (I) and salts and solvates thereof, in which: R0 represents hydrogen, halogen or C1-6 alkyl; R1 represents hydrogen, C1-6alkyl, C2-6 | 08/31/2004 |
| 6762202 | Infrared thermography and methods of use The present invention describes rapid noninvasive methods for measuring vasodilation or changes in blood flow in a patient following administration of at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-d... | 07/13/2004 |
| 6753338 | Methods for treating hypertension, angina, and congestive heart failure using of optically pure (-) amlodipine Methods and compositions are disclosed utilizing the optically pure (−) isomer of amlodipine. This compound is a potent drug for the treatment of hypertension while avoiding the concomitant liability of adverse effects associated with the racemic mixture of amlodi... | 06/22/2004 |
| 6562372 | Tocotrienol-containing powder, a process for preparing it and a tablet comprising compressed said powder into a tablet form A tocotrienol-containing powder prepared by a process wherein an oil containing a tocotrienol is treated with a lecithin, a cellulose and an emulsifying agent in water to form an emulsion, a powder substance is mixed with the formed emulsion to form a sus... | 05/13/2003 |
| 6544946 | Inhibitors for use in hemostasis and immune function The present invention relates to polynucleotide and polypeptide molecules for use as inhibitors in hemostasis and immune function. Such inhibitors are members of the family of proteins bearing a collagen-like domain and a globular domain. The inhibitors a... | 04/08/2003 |
| 6514536 | Drug preparations for treating sexual dysfunction Topical gelled compositions comprising a drug which causes vasodilation, and optionally prostaglandin E1, dispersed within a polymer matrix, and methods of treating sexual dysfunction, including both male and female sexual dysfunction, using sa... | 02/04/2003 |
| 6514934 | Imidazoline -adrenergic receptor antagonist compounds in combination with nitric oxide donors, compositions and methods of use The present invention is directed to nitrosated or nitrosylated -adrenergic receptor antagonists, compositions comprising -adrenergic receptor antagonists that are optionally substituted with at least one NO or NO2 moiety and comp... | 02/04/2003 |
| 6486207 | Compositions and methods for amelioration of human female sexual dysfunction The invention provides a composition suitable for topical application comprising: an effective amount of a prostaglandin, a polymer thickener, a lipophilic component, and a buffer system. In another embodiment, the invention provides a composition suitabl... | 11/26/2002 |
| 6462016 | Method for screening agonist or antagonist of the maxadilan receptor participating in vasodilating action, and compound found by the method There are provided a method to screen agonist or antagonist of the maxadilan receptor participating in vasodilating action, wherein a receptor of maxadilan is used, compounds which specifically bind to the receptor, and a tissue preparation having the rec... | 10/08/2002 |
| 6369059 | Tetracyclic derivatives, process of preparation and use A compound of formula (I) ##STR1## and salts and solvates thereof, in which: R0 represents hydrogen, halogen or C1-6 alkyl; R1 represents hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, haloC | 04/09/2002 |
| 6358536 | Nitric oxide donor compositions, methods, apparatus, and kits for preventing or alleviating vasoconstriction or vasospasm in a mammal The invention relates to compositions, methods, apparatus, and kits for alleviating or preventing vasoconstriction or vasospasm in a mammal. The compositions, methods, apparatus, and kits are also useful for alleviating or preventing ischemic tissue damag... | 03/19/2002 |
| 6340480 | Natural composition for the treatment of circulatory conditions A composition and method for treating circulatory conditions by promoting systemic vascular relaxation and dilation. Exemplary circulatory conditions are disclosed and include wound healing and/or reduction of hypertension. The composition is a natural co... | 01/22/2002 |
| 6335039 | Pharmaceutical formulations comprising vegetal material selected from trichilia The present invention refers to a method for producing vasodilation or analgesia in a mammal, comprising the use of vegetal material derived from the bark of a Trichilia species.... | 01/01/2002 |
| 6323211 | Compositions and methods for treating sexual dysfunctions The present invention describes methods for preventing and treating sexual dysfunctions in patients by orally administering at least one -adrenergic receptor antagonist and at least one compound that elevates endogenous nitric oxide or endothelium-... | 11/27/2001 |
| 6294517 | Compositions and kits comprising alpha-adrenergic receptor antagonists and nitric oxide donors and methods of use The present invention describes novel compositions and kits comprising alpha-adrenergic receptor antagonists and compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, or stimulate nitric... | 09/25/2001 |
| 6284140 | Dialysis solution for peritoneal dialysis The present invention relates to dialysis solutions for peritoneal dialysis, containing hydroxyethyl starch as the osmotically-active substance, electrolytes and, optionally, conventional additives, where the hydroxyethyl starch has a molecular weight Mw ... | 09/04/2001 |
| 6251436 | Drug preparations for treating sexual dysfunction Topical gelled compositions comprising a drug which causes vasodilation, and optionally prostaglandin E1, dispersed within a polymer matrix, and methods of treating sexual dysfunction, including both male and female sexual dysfunction, using sa... | 06/26/2001 |
| 6210343 | Use of misoprostol or/and misoprostol acid for diagnosis of vascular damage in a subject with erectile dysfunction A method is provided for diagnosing vascular damage in a subject with erectile dysfunction that includes applying an effective dose of a therapeutic formulation having an excipient and at least one of misoprostol and misoprostolic acid topically to the gl... | 04/03/2001 |
| 6103769 | Pharmaceutical composition containing nitric oxide Disclosed are pharmaceutical composition of a sterile, injectable physiologically acceptable solution containing nitric oxide (NO), processes for preparing the compositions and a process for detecting physiologically present NO. With these NO solutions, N... | 08/15/2000 |
| 6066649 | Drug for cardiovascular diseases The invention relates to a drug, which contains one or more inhibitors for the cGMP-stimulated phosphodiesterase (PDE II) together with conventional substrates and/or diluents. Preferably the drug contains erythro-9-(2-hydroxy-3-nonyl)-adenine or 2-o... | 05/23/2000 |
| 6054462 | Intranasal antimigraine compositions The present invention relates to a composition comprising an antimigraine compound of formula (I) and chitosan, which is particularly suited for intranasal administration. ##STR1## Process for preparing said composition, its use as a medicine and a n... | 04/25/2000 |
| 6042849 | Unit dosage forms for treatment of vasoconstriction and related conditions Magnesium is formulated in combination with vitamin E, vitamin C, folate, selenium, and optionally melatonin a unit dosage form for oral administration, for the treatment of vasoconstriction and the physiological and pathological conditions giving rise to... | 03/28/2000 |
| 6036977 | Drug preparations for treating sexual dysfunction Topical gelled compositions comprising a drug for treating sexual dysfunction dispersed within a polymer matrix and methods and treatments using said compositions.... | 03/14/2000 |
| 6027713 | Composition and method for the treatment of exercise induced pulmonary hemorrhage A composition for the treatment of exercise induced pulmonary hemorrhage, particularly in horses. The composition comprises arginine and is formulated for inhalation. The invention includes an inhaler apparatus specially adapted for the administration of ... | 02/22/2000 |
| 6020308 | Methods for improving therapeutic effectiveness of treatment of vascularization disorders The present invention is directed to the use of an inhibitor of NO activity, such as a nitric oxide scavenger or an NO synthase inhibitor, as as an adjunct to treatment of inappropriate tissue vascularization disorders.... | 02/01/2000 |
| 6007813 | Method and composition for treating ulcers and secretion of gastric acid Secretion of gastric acid and development of ulcers can be inhibited by administering to a patient in need thereof an effective amount of a hot water extract of the cultivated mycelia of Cordyceps sinensis.... | 12/28/1999 |
| 5994294 | Nitrosated and nitrosylated -adrenergic receptor antagonist compounds, compositions and their uses Disclosed are nitrosated and nitrosylated -adrenergic receptor antagonists, compositions of an -adrenergic receptor antagonist (-antagonist), which can optionally be substituted with at least one NO or NO2 moiety, and a com... | 11/30/1999 |
| 5989558 | Method of using rosmarinus officinalis for treating various diseases A method for treating various diseases with a dried total extract of Rosmarinus officinalis. The dried total extract is obtained by macerating Rosmarinus officinalis leaves in hydrated ethyl alcohol for a period of 10-20 days, filtering, and drying. The d... | 11/23/1999 |
| 5958427 | Nitric oxide donor compounds and pharmaceutical compositions for pulmonary hypertension and other indications The invention is directed to nitric oxide (NO) donor compounds and to pharmaceutical compositions containing such nitric oxide (NO) donor compounds, for delivering NO to the apical surface of a mucosa, where the nitric oxide is released for passage across... | 09/28/1999 |
| 5958877 | Method for counteracting vasospasms, ischemia, renal failure, and treating male impotence using calcitonin gene related peptide The present invention provides a method for counteracting vasospasms and treating male impotence using calcitonin gene-related peptide (CGRP). CGRP is a naturally occurring substance in the human body. As such, CGRP does not have the same toxicity and all... | 09/28/1999 |
| 5958413 | Use of antibodies to TNF or fragments derived thereof and xanthine derivatives for combination therapy and compositions therefor A combined preparation for simultaneous combined, simultaneous separate, or sequential use in the therapy of prophylaxis of disorders associated with undesirable high levels of TNF, e.g. septic or endotoxic shock and immunoregulatory and inflammatory diso... | 09/28/1999 |
