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Class 514/922 - SIDE EFFECT REDUCTION BY INCORPORATION OF A SECOND DESIGNATED INGREDIENT


Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter involving the reducing or eliminating of
No. of patents: 235
Last issue date: 08/12/2008


1            
NumberTitleIssue Date
7410655Anticancer agent
An anticancer agent containing platinum preparation, humic substances, water and sodium chloride. Potassium tetrachloroplatinate is used as a platinum compound and lignohumic acid ammonium salts are used as humic substances taken in the following ratio of com...
08/12/2008
RE40418Treatment of neoplasms with CCI-779/EKB-569 combination
This invention provides the use of a combination of CCI-779 and EKB-569 in the treatment of neoplasms. ...
07/01/2008
7323461Use of methylene blue and related compounds to prevent or reverse an exaggerated hemodynamic reaction
The present invention relates to the use of the dye methylene blue (MB) or a related compound to prevent or reverse an exaggerated hemodynamic reaction in animals in need thereof, including humans. More specifically, the present invention concerns the use of MB or a...
01/29/2008
7307096Combined agents for treatment of glaucoma
A pharmaceutical composition for the prophylaxis or treatment of glaucoma which comprises an angiotensin II antagonist and at least one compound selected from an adrenaline receptor blocker, a prostaglandin and a carbonic anhydrase inhibitor; and a method for the pr...
12/11/2007
7189752Use of etodolac for the treatment of chronic lymphocytic leukemia
A method of treating cancer is provided comprising administering an amount of etodolac or analog theteof to a subject afflicted with leukemia that is effective to reduce the viability and/or to sensitize leukemia cells to an anti-cancer agent. ...
03/13/2007
7063865Composition and method for substantially reducing the deleterious effects of alcohol on the body
A composition that will substantially reduce the deleterious effects of alcohol on the body and substantially reduce the side effects associated with hangovers (i.e. headaches, dizziness, nausea, dry mouth, etc) when taken as recommended. The composition includes an...
06/20/2006
7030100Isoform specific inhibition for treatment of pain and reduction of anesthetic threshold
Several lines of evidence have shown a role for the nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) signaling pathway in the development of spinal hyperalgesia. However, the roles of effectors for cGMP are not fully understood in the processing of pain in th...
04/18/2006
7022315Administration of a thiol-based chemoprotectant compound
A method of administration of a thiol-based chemoprotectant agent including NAC (N-acetylcysteine) and STS (sodium thiosulfate) that markedly affects biodistribution and protects against injury from diagnostic or therapeutic intra-arterial procedures. A method for t...
04/04/2006
6986896Method of treating fungal conditions of the skin
Methods of treating fungal conditions and onychomycosis are described which include administration of a safe and effective amount of urea in a topical formulation to an affected area on the skin or around a nail of a patient in need of treatment. ...
01/17/2006
6942848Cyclodextrins in dental products
Oral rinse and dentifrice compositions, comprising a phenolic selected from the group consisting of menthol, eucalyptol, methyl salicylate, thymol, triclosan, and mixtures thereof; and a cyclodextrin selected from the group consisting of hydroxypropyl β-cyclodextri...
09/13/2005
6933320Combination comprising combretastatin and anticancer agents
An antitumor combination comprising a stilbene derivative and an anticancer compound selected from the group consisting of taxanes, alkylating agents, antimetabolites, vinca alkaloids, platinum compounds, epidophylloptoxins, and antibiotics as the active ingredients...
08/23/2005
6903130Pyrrolidineacetamide derivative alone or in combination for treatment of cns disorders
A use of (S)-(−)-α-ethyl-2-oxo-1-pyrrolidineacetamide for the manufacture of a medicament for treatment of particular disease and new pharmaceutical compositions comprising (S)-(−)-α-ethyl-2-oxo-1-pyrrolidineacetamide. ...
06/07/2005
6875745Method and composition for the treatment of cancer
We have discovered that the administration of a G1 and/or S phase drug such as β-lapachone in combination with a G2/M drug such as a taxane derivative such as paclitaxel resulted in a greater than additive (i.e., synergistic) reduction in the number of tumors (and ...
04/05/2005
6835728Drug combination for the treatment of depression and related disorders comprising mirtazapine
The invention relates to a combination comprising an amount of mirtazapine, or a pharmaceutically acceptable salt or solvate thereof, and an amount of gepirone, or a pharmaceutically acceptable salt or solvate thereof, optionally in association with one or more phar...
12/28/2004
6821968Stable taurolidine electrolyte solutions
A taurolidine composition includes an aqueous solution containing about 1.5-3% by weight taurolidine, the solution containing a stability-enhancing effective amount of at least one physiologically acceptable electrolyte, such that the solution is substantially isoto...
11/23/2004
6809120Composition containing propargylamine for enhancing cancer therapy
Antineoplastic drug modulators are described. The specific modulators referred to are propargylamines which can enhance the cytotoxic effects of antineoplastic drugs on cancer cells while protecting normal cells from damage. The propargylamine modulators can be used...
10/26/2004
6777415Methods of inducing cancer cell death and tumor regression
Methods are provided for treating cancer, comprising administering (1) a farnesyl protein transferase inhibitor in conjunction with (2) an additional Ras signaling pathway inhibitor to induce cancer cell death and tumor regression. ...
08/17/2004
6770653Method and dosage form for treating tumors by the administration of tegafur, uracil, folinic acid, paclitaxel and carboplatin
This invention provides a method of treating a tumor in a warm-blooded animal by administering an anti-tumor effective amount of tegafur, uracil, folinic acid, paclitaxel and carboplatin. ...
08/03/2004
6703400Methods for treating multidrug resistance
Methods are provided for treating multidrug resistance in refractory tumor cells comprising administering (1) a P-glycoprotein inhibitor in conjunction with (2) an antineoplastic agent....
03/09/2004
6686380Treatment of refractory tumors using epothilone derivatives
Methods of treating tumors in a mammal, especially a human that has demonstrated resistance to other chemotherapeutic agents, is disclosed. Specifically, methods of the present invention are effective in tumors that have initially been unresponsive to tax...
02/03/2004
6673842Method of treating onychomycosis
A method of treating onychomycosis is described which includes administration of an effective amount of urea in a topical formulation to an infected area around a nail of a patient....
01/06/2004
6664288Method and composition for the treatment of cancer
We have surprisingly discovered that the administration of a G1 and/or S phase drug such as ଲ-lapachone in combination with a G2/M drug such as a taxame derivative such as paclitaxel resulted in an unexpected greater than additive (i.e., synergistic...
12/16/2003
6656915Inhibiting T-cell proliferation
Enhancement of T-cell proliferation in a host inhibition is provided by administering 2'-deoxyguanosine and/or prodrug thereof and a PNP inhibitor. The PNP inhibitor has a Ki value of 50 nanomoles or less....
12/02/2003
6645972Methods of treating leukemia
The present invention provides a novel method for treating leukemia in a host that has been previously treated with a Bcr-Abl tyrosine kinase inhibitor comprising administering to the host a therapeutically effective amount of a compound having the formul...
11/11/2003
6617333Antineoplastic combinations comprising
This invention provides the use of a combination of CCI-779 and EKB-569 in the treatment of neoplasms....
09/09/2003
6602870Oral dosage form for administration of the combination of tegafur, uracil, folinic acid, and oxaliplatin and method of using the same
This invention provides a dosage form and a method of administering an anti-tumor composition comprising tegafur, uracil and folinic acid to potentiate the coadministration of oxaliplatin....
08/05/2003
6589990Methods and compositions for misoprostol compound treatment of erectile dysfunction
Therapeutic formulations and methods for treating erectile dysfunction with a misoprostol compound in a subject are provided, a method comprising: obtaining a therapeutic formulation having an effective dose of a misoprostol compound in an excipient carri...
07/08/2003
6566361Azapirone pain treatment
A method of treating pain with acetaminophen comprises the concurrent administration of an azapirone such as buspirone. This combination of agents surprisingly results in a strengthened analgesic response characterized by rapid onset, greater pain relief,...
05/20/2003
6558710Topical zinc compositions and methods of use
Compositions including zinc compounds and select amino acids in a carrier base, and methods of skin treatment with such compositions, are described. The compositions are useful for healing skin and minimizing the irritation incurred from contact with the ...
05/06/2003
6548540Method of treating cancer using dithiocarbamate derivatives
Dithiocarbamate, particularly tetraethylthiuram disulfide, and thiocarbamate anions strongly inhibit the growth of cancer cells of a variety of cell types. Such inhibitory effect is enhanced by heavy metal ions such as copper ions, cytokines and cerulopla...
04/15/2003
6541509Method for treating neoplasia using combination chemotherapy
The present invention concerns an unexpected synergistic combination of known antineoplastic agents which provides unexpectedly greater efficacy than the single agents alone. Accordingly, the present invention provides a method of treating neoplasia in a ...
04/01/2003
6537988Synergistic methods and compositions for treating cancer
The present invention provides a synergistic method for the treatment of cancer which comprises administering to a mammalian specie in need thereof a synergistically, therapeutically effective amount of: (1) at least agent selected from the group consisti...
03/25/2003
6531512Method of treating cancer in patients having a deficiency in p53 tumor suppressor gene
A method of treating cancer in a patient deficient in p53 tumor suppression gene is described herein by administering to a patient a therapeutically effective amount if a polyamine such as DENSPM in combination with an anticancer agent. Also described is ...
03/11/2003
6525089Pharmaceutical composition containing decursin
A pharmaceutical composition comprising decursin and its uses as a nephrotoxicity inhibitor, an antineoplastic agent, an antidiabetic agent, and as a cancer-cell differentiation induction agent are disclosed....
02/25/2003
6511982Treatment of pain
A method of treating pain with acetaminophen comprises the concurrent administration of buspirone. This combination of agents surprisingly results in a morphine-like analgesic response characterized by rapid onset, greater pain relief, and a longer durati...
01/28/2003
6511986Method of treating estrogen receptor positive carcinoma
This invention provides a method of treating or inhibiting an estrogen receptor positive carcinoma in a mammal in need thereof, which comprises providing said mammal with an effective amount of a combination of a rapamycin and an antiestrogen....
01/28/2003
6509380Method of treating iron overload with acetaminophen
The present invention relates to methods of controlling iron overload in a patient in need thereof. The present invention particularly relates to methods of treating hemochromatosis and other causes of iron overload....
01/21/2003
6503915Composition and method for treatment of cerebral ischemia
A composition and method for the treatment of cerebral ischemia is disclosed, the composition is a mixture of caffeine and alcohol and is used to treat cerebral ischemia by administering to a subject in need thereof a dose of an effective amount of caffei...
01/07/2003
6468504Composition comprising methylphenidate and another drug
A process of treating a subject that is undergoing methylphenidate therapy and concomitant therapy with another drug undergoes or interferes with P450 metabolism, wherein the methylphenidate is d-threo-methylphenidate....
10/22/2002
6458808Pharmaceutical composition for the treatment of cognitive cerebrovascular disease
A pharmaceutical composition comprising idebenone in synergistic combination with nimodipine for the treatment of cognitive disorders of cerebrovascular origin....
10/01/2002
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