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| Number | Title | Issue Date |
| 8399435 | Compounds for the treatment of proliferative disorders The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These c... | 03/19/2013 |
| 8129340 | Inhibitors of protein phosphatase 1, GADD34 and protein phosphatase 1/GADD34 complex, preparation and uses thereof The present invention relates to the use of a protein phosphatase inhibitor selected from an inhibitor of the catalytic subunit of the protein phosphatase 1 (PP1), an inhibitor of GADD34 and an inhibitor of the PP1/GADD34 complex to prepare a pharmaceutical composit... | 03/06/2012 |
| 8067396 | Amino alcohol compounds or phosphonic acid derivatives thereof A compound having a formula II(a): wherein R1 and R2 are hydrogen lower alkyl, lower aliphatic acyl, or lower alkoxycarbonyl; R4 is C1-C4 alkyl; n is 2 or 3; X is a for... | 11/29/2011 |
| 7977322 | Modulators of ATP-binding cassette transporters The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also rel... | 07/12/2011 |
| 7947664 | Angiotensin II receptor antagonists A compound having the structure wherein R is an angiotensin receptor antagonist active group, Y is selected from the group consisting of and ... | 05/24/2011 |
| 7557095 | Therapeutic compounds Disclosed herein is a compound having a structure or a pharmaceutically acceptable salt thereof, or a prodrug thereof. Therapeutic methods, compositions, and medicaments related thereto are also disclosed. ... | 07/07/2009 |
| 7442814 | 1-methoxy-2-phenyl ethenes useful for the preparation of 5-carboxaldehyde-2-3-dihydrobenzoxepines The present invention relates to the compounds of general formula (I) wherein R, R1, R2 are as defined in claim 1. Compounds of f... | 10/28/2008 |
| 7410956 | Caspase inhibitor prodrugs The present invention relates to compounds of formula I which are prodrugs of caspase inhibitors and pharmaceutically acceptable salts thereof. This invention further relates to the release of caspase inhibitors from these compounds through selective bond cleavage. ... | 08/12/2008 |
| 7354895 | Phosphinyloxy, oxime and carboxylic acid derivatives which are useful as carboxypeptidase U inhibitors The present invention relates to compounds of Formula I, and pharmaceutically acceptable salts or solvates thereof, or solvates of such salts, which compounds inhibit carboxypeptidase U and thus can be used in the preventio... | 04/08/2008 |
| 7309802 | Preparation of isoxazolin-3-ylacylbenzene A process is described for preparing isoxazoles of the formula I where the substituents are as defined below: R1 is hydrogen, C1-C6-alkyl, ... | 12/18/2007 |
| 7282514 | Reactive probes for two-photon fluorescent imaging and sensing Fluorescent dyes and probes are key components in multiphoton based fluorescence microscopy imaging of biological samples. In order to address the demand for better performing dyes for two-photon based imaging, a new series of reactive fluorophores tailored for mult... | 10/16/2007 |
| 7265148 | Substituted pyrrole-indoles The present invention relates generally to substituted pyrrole-indoles such as substituted pyrrole-indoles, and methods of using them. ... | 09/04/2007 |
| 7253169 | Aza compounds, pharmaceutical compositions and methods of use The present invention relates to N-substituted cyclic aza compounds, pharmaceutical compositions comprising such compounds, and methods of their use for effecting neuronal activities. ... | 08/07/2007 |
| 7208481 | Aminodiphosphonate apolipoprotein E modulators The present invention relates to methods of use of aminodiphosphonate to modulate apolipoprotein E levels and the use of such compounds in therapy, including cardiovascular and neurological disease states. ... | 04/24/2007 |
| 7186749 | Pyrrolo-naphthyl acids and methods for using them The present invention relates to pyrrolo-naphthyl compounds of the formula and methods of using them to modulate PAI-1 expression and to treat PAI-1 related disorders. ... | 03/06/2007 |
| 7153833 | Therapeutic uses of SMR1 peptides A method for treating or reducing the severity of a disease or disorder mediated by a membrane metallopeptidase by administering to a mammal a SMR1-peptide or a pharmaceutically active amount of a SMR1-peptide. ... | 12/26/2006 |
| 7141592 | Substituted oxadiazolidinediones The present invention relates generally to substituted oxadiazolidinediones and methods of using them. ... | 11/28/2006 |
| 7105556 | Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method Compounds are provided which have the structure wherein Q is C or N, X1 is C or N, and R1, R2, R2a, R2b, R2c, R3, Y, A, m, n, X2 | 09/12/2006 |
| 7081436 | Paste formulation for seed treatment of plants Disclosed herein is a composition comprising a seed treatment formulation and an organosilicone additive of the formula: wherein: X is a number from 0 to 30; Y ... | 07/25/2006 |
| 7060393 | Optical recording medium and optical recording apparatus There is provided an optical recording medium comprising a recording layer containing a charge-generating material capable of generating a first electric charge and a second electric charge by beam irradiation, the second electric charge having a different polarity ... | 06/13/2006 |
| 7053071 | Induction of apoptosis in cancer cells The present invention provides compounds that are inducers or inhibitors of apoptosis or apoptosis preceded by cell-cycle arrest. In addition, the present invention provides pharmaceutical compositions and methods for treating mammals with leukemia or other forms of... | 05/30/2006 |
| 7030103 | Sulfonamidomethyl phosphonate inhibitors of β-lactamase The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural product and... | 04/18/2006 |
| 6965033 | Bisamidate phosphonate prodrugs Novel bisamidate phosphonate prodrugs of FBPase inhibitors of the Formula IA: and their use in the treatment of diabetes and other conditions associated with elevated blood glucose. ... | 11/15/2005 |
| 6921756 | Inhibitors of β-lactamase The invention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural product and... | 07/26/2005 |
| 6919322 | Phenyl Phosphonate Fructose-1,6-Bisphosphatase Inhibitors Novel FBPase inhibitors of the formula I are useful in the treatment of diabetes and other conditions associated with elevated blood glucose. ... | 07/19/2005 |
| 6884791 | Inhibitors of β-lactamase The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural product and... | 04/26/2005 |
| 6838474 | Sulphonamide derivatives as prodrugs of aspartyl protease inhibitors The present invention relates to prodrugs of a class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of prodrugs of HIV aspartyl protease inhibitors characterized by favorable aqueous solubility, hig... | 01/04/2005 |
| 6706698 | α-Substituted β-aminoethyl phosphonate derivatives The present invention relates to novel α-substituted-β-aminoethylphosphonate and α-substituted-β-aminovinylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and ver... | 03/16/2004 |
| 6699896 | Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia This invention provides compounds having the structure ##STR1## wherein A is OR5, or ##STR2## R1 is alkyl, cycloalkyl of 3-8 carbon atoms, thienyl, furyl, pyridyl, ##STR3## R2 is H, alkyl, or aryl; R3 | 03/02/2004 |
| 6500811 | Sulfonylaminophosphinic and sulfonylaminophosphonic acid derivatives, methods for their preparation and use Compounds of the formula I ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading enzymes is involved.... | 12/31/2002 |
| 6498151 | Aryldifluoromethylphosphonic acids with sulfur-containing substituents as PTP-1B inhibitors The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme. ##STR1## The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated d... | 12/24/2002 |
| 6486142 | Phosphonic acid derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B) The invention encompasses the novel class of compounds represented by formula I, which are inhibitors of the PTP-1B enzyme. ##STR1## The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases,... | 11/26/2002 |
| 6369042 | Antioxidative vitamin B6 analogs The present invention relates to novel antioxidative Vitamin B6 analogs and their use in the cosmetic, dermatological, pharmaceutical and/or nutritional fields. Analogs can be provided in suitable formulations intended in particular for caring ... | 04/09/2002 |
| 6300356 | Method for decreasing QT dispersion or inhibiting the progression of QT dispersion with an angiotensin II receptor antagonist Angiotensin II receptor antagonists are useful for decreasing QT dispersion or inhibiting the progression of QT prolongation in patients. Also disclosed is a method for monitoring the reduction in die risk of experiencing an adverse cardiac event, such as... | 10/09/2001 |
| 6218400 | Treatment method using a cGMP-Specific PDE inhibitor A compound of formula ##STR1## and salts and solvates thereof, wherein R0, R1, and R2 are defined in the specification. A compound of the present invention is a potent and selective inhibitor of cGMP-specific PDE and has u... | 04/17/2001 |
| 6200961 | Concentrates of organophosphorous insecticides A low volatile organic compound co-solvent system is disclosed for preparing emulsion concentrates of low melting organophosphorous insecticides wherein the bioefficacy of the insecticide active is significantly enhanced. The co-solvent system comprises a... | 03/13/2001 |
| 6197777 | Synthesis, anti-human immunodeficiency virus, and anti-hepatitis B virus activities of 1,3-oxaselenolane nucleosides A method and composition for the treatment of HIV infection, HBV infection, or abnormal cellular proliferation in humans and other host animals is disclosed that includes the administration of an effective amount of a 1,3-oxaselenolane nucleoside or a pha... | 03/06/2001 |
| 6187752 | Method for treating schizophrenia employing an ace inhibitor A method is provided for treating schizophrenia in a mammalian species by administering an ACE inhibitor, such as captopril, alone or with a neuroleptic such as cholecystokinin, fluphenazine or haloperidol.... | 02/13/2001 |
| 6174874 | Phosphonic acids derivatives as inhibitors of protein tyrosine phosphate 1B (PTP-1B) The invention encompasses the novel class of compounds represented by formula I which are inhibitors of the PTP-1B enzyme. ##STR1## The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases.... | 01/16/2001 |
| 6001847 | Chemical compounds A compound of formula ##STR1## and salts and solvates thereof, wherein R0, R1, and R2 are defined in the specification. A compound of the present invention is a potent and selective inhibitor of cGMP-specific PDE and ... | 12/14/1999 |
