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| Number | Title | Issue Date |
| 6350476 | Herbal chinese joint complex The present invention provides compositions comprising the ingredients of plants of species of the genera Stephania, Coix, Pinellia, Prunus, Phellodendron, Sophora, Tetrapanax, Stemona, Glycyrrhiza, Tripterygium, Forsythia and Siegesbeckia, wherein such c... | 02/26/2002 |
| 5908628 | Compositions with analgesic, antipyretic and antiinflammatory properties The present invention provides compositions comprising talc, silkworm excrement, and ingredients of plants of species of the genera Stephania, Coix, Pinellia, Prunus, Phellodendron, Sophora, Tetrapanax, Stemona, Glycyrrhiza, Tripterygium, Forsythia and Si... | 06/01/1999 |
| 5843999 | 2-phenylazulene derivatives and a manufacturing method of these compounds A series of new azulene derivatives are disclosed, which are represented by the following formula; ##STR1## wherein: R1 is hydrogen atom, lower alkoxycarbonyl group, carboxy group, halogen atom, lower alkyl group, phenyl group or lower alk... | 12/01/1998 |
| 5840758 | Oxime derivatives of fenamates as inhibitors of prostaglandin biosynthesis Compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein Y is selected from halogen, alkyl, and haloalkyl; n is 0, 1, 2, or 3; A is selected from (a) optionally substituted alkylene, (b) optionally substituted cyclo... | 11/24/1998 |
| 5663180 | Substituted cyclopentenes for the treatment of inflammation A class of 1,2-diarylcyclopentenyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula III: ##STR1## wherein each of R1 and R2 is in... | 09/02/1997 |
| 5648373 | CoA-IT and PAF inhibitors Coenzyme A-independent transacylase is required for the release of free arachidonic acid, and the production of arachidonic acid metabolites and platelet activation factor. Blocking of this enzyme inhibits the production of these inflammatory mediators an... | 07/15/1997 |
| 5286751 | Sustained/enhanced antipyretic response Sustained and enhanced antipyretic response is elicited in a mammalian organism in need of such treatment, i.e., a mammal suffering from elevated body temperature (fever), by administering thereto a unit dosage sustainedly enhancing, antipyretically effec... | 02/15/1994 |
| 4999379 | Novel pharmaceutical compositions for topical application with systemic action There are disclosed novel pharmaceutical compositions which comprise diclofenac or a salt thereof, a penetration agent such as 1-n-dodecylazacycloheptan-2-one or dimethyllauroylamide and, as vehicle, a mineral oil. These compositions have excellent skin p... | 03/12/1991 |
| 4472433 | Phenoxyphenyl acetic acids and their medicinal use A compound of the formula: ##STR1## wherein R1 is phenyl substituted with halogen or lower alkyl, and R4 is a group of the formula Cn H2n in which n is an integer of 1 to 7; or a pharmaceutically acceptable... | 09/18/1984 |
| 4440779 | Tricyclic derivatives of substituted pyrrole acids as analgesic and anti-inflammatory agents Tricyclic derivatives of substituted pyrrole acids, e.g., substituted 4,10-dihydro-10-oxo-1H-[1]benzoxepino[4,3-b]pyrrole-2-acetic acids or the 5-thia analogs thereof have been prepared via hydrolysis of a precursor or decarboxylation of a precursor-diaci... | 04/03/1984 |
| 4440784 | Anti-inflammatory, analgesic, and antipyretic pharmaceutical composition A new anti-inflammatory, analgesic, and antipyretic pharmaceutical composition is disclosed which contains a 3,5-di-tert-butyl-4-hydroxystyrene derivative of the formula: ##STR1## wherein R1 stands for a group represented by COR3 | 04/03/1984 |
| 4435425 | Fluorinated diaminobutane derivatives Fluorinated diaminobutane compounds in vivo are inhibitors of gamma-aminobutyric acid transaminase and have the following formula: ##STR1## wherein: R1 represents hydrogen, C1 -C6 alkyl, or phenyl-(C1 -C | 03/06/1984 |
| 4435392 | 2,5-Benzodiazocine derivatives and salts thereof, as well as pharmaceutical agent comprising as effective component at least one of the derivatives and salts A 2,5-benzodiazocine derivative represented by a formula ##STR1## wherein R1 is phenyl or p-methoxyphenyl, R2 is hydrogen or methyl, and R3 is p-methoxyphenethyl, 3-(p-fluorobenzoyl)-propyl, cyclopropylmethyl or ... | 03/06/1984 |
| 4431662 | 1-(1,3-Benzodioxol-5-yl)-2-pyrrolidinone and its medicinal use This invention relates to the compound of formula (I), 1-(1,3-benzodioxol-5-yl)-2-pyrrolidinone, its preparation; its use in medicine for treatment of pain, inflammation and fever; and pharmaceutical formulations containing it. ##STR1##... | 02/14/1984 |
| 4431656 | 3,5-di-Tert-butylstyrene derivatives, salts thereof, and pharmaceutical compositions containing the same as an active ingredient Novel compounds, 3,5-di-tert-butylstyrene derivatives and their salts, are disclosed, which derivatives are represented by the general formula: ##STR1## wherein R1 stands for an acyloxy group represented by R3 COO (R3... | 02/14/1984 |
| 4404215 | Piperidyl phenyl trifluoroethanols This invention relates to novel arylethanol and to process for producing the said compounds. The arylethanols of the invention have valuable pharmacological properties and find a use in human or animal therapy.... | 09/13/1983 |
| 4381313 | Phenylalkanoic compounds and therapeutic use thereof Novel phenylalkanoic compounds of the formula I ##STR1## wherein R1 and R2 independently from each other represent hydrogen or alkyl with 1 to 8 carbon atoms, salts of such compounds and salts thereof, therapeutic uses of the ph... | 04/26/1983 |
| 4379793 | Process for synthesis of esters of N-(4'-hydroxyphenyl)acetamide with derivatives of 5-benzoil-1-methyl pyrrole-2-acetic acids 4'-acetamidophenyl-2-(5'-p-toluyl-1'-methylpyrrole)acetate and related compounds exhibiting anti-inflammatory, analgesic and antipyretic activity are disclosed.... | 04/12/1983 |
| 4378358 | Benzothiazinopyrazoles having pharmacological activity 1,2 Benzothiazino[3,4-d]pyrazoles of the following general formula ##STR1## wherein R stands for a linear or branched (C2-4) alkyl chain bearing a substituent of formula ##STR2## in which the R" radicals may be the same or different a... | 03/29/1983 |
| 4366158 | 1-(8-Quinolyl)-2-pyrrolidone and its pharmaceutical compositions The compound of formula (I) ##STR1## and acid addition salts thereof are of value in medicine in the treatment or prophylaxis of pain, inflammation or fever. The compound and its salts may be administered alone or as a pharmaceutical formulation. The... | 12/28/1982 |
| 4363909 | Thiazolo[3,4-b]isoquinolines Isoquinoline derivatives of the formula ##STR1## wherein the symbol A1 represents an isoquinol-8-yl, 3-methylisoquinol-8-yl, 3-hydroxymethylisoquinol-5-yl, 3-carboxymethylisoquinol-5-yl, quinol-5-yl, thienopyridyl, benzimidazolyl, thi... | 12/14/1982 |
| 4362891 | Alkanoic acid derivatives An alkanoic acid compound is disclosed of formula: ##STR1## and certain of its physiologically acceptable salts and esters. The alkanoic acid compound and its salts and esters have an unexpectedly greater anti-inflammatory activity than representativ... | 12/07/1982 |
| 4359423 | 10H-1-Alkyl-10-oxabenzo,5,6 cyclohepta[1,2-G]pyrrole-2-acetic acids A compound of formula (II): ##STR1## wherein R is a C1-4 alkyl group; R1 is a hydrogen atom or a C1-4 alkyl group; R2 is a hydrogen or halogen atom, or a C1-4 alkyl, C1-4 alkoxy or C1-... | 11/16/1982 |
| 4356188 | 1-Naphthyl-acetic acid derivatives and their therapeutic applications This invention relates to 1-naphthyl-acetic acid derivatives having the general formula: ##STR1## in which: R1 is hydrogen atom or a straight- or branched-chain C1-6 alkyl group, R2 is a straight- or branched-chain al... | 10/26/1982 |
| 4356186 | Acetic acid derivatives and composition containing the same Novel acetic acid derivatives of the formula: ##STR1## wherein X is oxygen or sulfur; R1 is hydrogen or a lower alkyl; R2 is hydroxy, an alkoxy, an alkenyloxy, a cycloalkyloxy, an aryloxy, a substituted aryloxy, an aryl-lower al... | 10/26/1982 |
| 4353919 | Analgesic and antipyretic pharmaceutical compositions containing a benzothiazol-2(3H)-one Analgesic and antipyretic pharmaceutical dosage unit compositions containing as an active ingredient a compound of the formula ##STR1## wherein R5 is methyl or methoxy, and R4, R6 and R7 are hydrogen; or R | 10/12/1982 |
| 4351841 | Pharmaceutical preparation and method of treatment 5-Methylisoxazole-4-carboxylic acid-(4-trifluoromethyl)-anilide and a process for its preparation is described. The compound has an antirheumatic, antiphlogistic, antipyretic and analgesic action, and can be used for the treatment of multiple sclerosis.... | 09/28/1982 |
| 4350700 | Pharmaceutical composition containing 1,3,5-substituted biuret compound An analgesic, anti-inflammatory or anti-pyretic composition containing 1,3,5-substituted biuret compound of the formula, ##STR1## wherein R1 is a hydrogen atom, a lower alkyl group, a substituted lower alkyl group having chlorine atom(s), ... | 09/21/1982 |
| 4344943 | 6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof Novel 5-aroyl-6-chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-7-carboxylic acids represented by the formula ##STR1## and the pharmaceutically acceptable, non-toxic esters and salts thereof, wherein Y is chloro or bromo and Ar is an opt... | 08/17/1982 |
| 4342763 | P-Chloroacetophenone oxime compounds and pharmaceutical compositions Derivatives of p-chloroacetophenone oxime, the preparation thereof and the use thereof as medicaments. The compounds of the invention correspond to the general formula I ##STR1## wherein R1 and R2 each represent a lower alkyl radical... | 08/03/1982 |
| 4329340 | Pharmaceutical composition having antiphlogistic, antipyretic and analgesic activity Pharmaceutical compositions exhibiting antiphlogistic, antipyretic, analgesic activity and high gastroenteric tolerance are described. The active ingredient is imidazole salicylate of chemical formula (I). ##STR1##... | 05/11/1982 |
| 4327222 | 3,4-Diarylisoxazol-5-acetic acids and process for making same 3,4-Diarylisoxazol-5-acetic acids of the formula ##STR1## in which Ar1 and Ar2 are the same or different and are selected from phenyl and naphthyl, R1, R2, R3, and R4 are the same or d... | 04/27/1982 |
| 4310521 | Aspirin-isopropylantipyrine Aspirin-isopropylantipyrine (N-3'a-propylphenazonyl-2-acetoxybenzamide) of the following formula ##STR1## and its pharmaceutical use. This compound can be prepared by reacting 1-phenyl-2-methyl-3-aminomethyl-4-isopropylpyrazolone of the formula ... | 01/12/1982 |
| 4301313 | Halogenated ethynyl biphenyls This invention is directed to the use of certain arylacetylene compounds, principally as anti-inflammatory agents but also as anti-pyretic agents and as analgesic agents.... | 11/17/1981 |
| 4301177 | (3-Methyl-2-butenyl)propanedioic acid mono (1,2-diphenylhydrazide) and salts thereof The compound of the formula ##STR1## and non-toxic, pharmacologically acceptable salts thereof, which are useful as analgesics, antipyretics and anti-rheumatics.... | 11/17/1981 |
| 4293549 | Quinolinyl guanidines having antiinflammatory, analgesic or antipyretic activity This invention relates to new compounds, salts, complexes and acylated derivatives thereof, methods of producing said compounds, intermediates used in the method, pharmaceutical compositions containing the present compounds and methods of producing same, ... | 10/06/1981 |
| 4293713 | Novel 1,1,3,5-substituted biuret compound and a pharmaceutical composition containing the same A novel 1,1,3,5-substituted biuret compound of the formula: ##STR1## wherein R1 and R2 are respectively the same or different, and each are alkyl groups having 1 to 4 carbon atoms; R3 is a cyclohexyl group or a phenyl... | 10/06/1981 |
| 4288457 | Ethynylbenzene compounds and derivatives thereof Novel ethynylbenzene compounds and derivatives are described. Their use in the treatment of inflammation is also disclosed.... | 09/08/1981 |
| 4287197 | Antiviral isoquinoline derivatives Isoquinoline derivatives of the formula: ##STR1## wherein R1 represents alkyl of 1 through 8 carbon atoms, and n represents 1 or 2, are new compounds possessing useful pharmacological properties. They are particularly valuable as analgesic... | 09/01/1981 |
| 4285943 | Novel pharmaceutical compositions incorporating an aryltrifluoroethanol This invention relates to pharmaceutical compositions containing as active ingredient an aryltrifluoroethanol, and a process for producing the same. These pharmaceutical compositions are useful for treating or alleviating pain, hyperpyretic conditions and/or i... | 08/25/1981 |
