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| Number | Title | Issue Date |
| 7344725 | Use of inorganic nanoparticles to stabilize hydrogen peroxide solutions The use of inorganic nanoparticles to stabilize aqueous hydrogen peroxide solutions is described. The preferred nanoparticles are formed from clays. The use of nanoparticles formed from synthetic smectite clays is particularly preferred. The stabilized hydrogen pero... | 03/18/2008 |
| 7306802 | Ophthalmic compositions containing a synergistic combination of three polymers Ophthalmic compositions suitable for use as artificial tears or as vehicles for ophthalmic drugs are disclosed. The compositions contain a combination of three polymers that have a synergistic effect on viscosity. ... | 12/11/2007 |
| 7265098 | Polyacid/polyalkylene oxide gels and methods for their delivery The present invention relates to improved methods for delivering bioadhesive, bioresorbable, anti-adhesion compositions. Antiadhesion compositions can be made of intermacromolecular complexes of carboxyl-containing polysaccharides, polyethers, polyacids, polyalkylen... | 09/04/2007 |
| 7235535 | Method of enhancing drainage of lacrimal system with purinergic receptor agonists A method and preparation for enhancing drainage of lacrimal system in a subject in need of such treatment is disclosed. The method comprises administering to the ocular surfaces of the subject a purinergic receptor agonist such as uridine 5′-triphosphate (UTP), di... | 06/26/2007 |
| 7115667 | Ophthalmic fluid An ophthalmic fluid containing at least one triglyceride, diglyceride, or monoglyceride which is chemically similar or compatible with compounds found naturally in the lipid layer of the tear film of an ocular substrate. Preferably the glycerides are derived from a ... | 10/03/2006 |
| 6887858 | Method of treating dry eye disease with purinergic receptor agonists A method and preparation for the stimulation of tear secretion in a subject in need of such treatment is disclosed. The method comprises administering to the ocular surfaces of the subject a purinergic receptor agonist such as uridine 5′-triphosphate [UTP], dinucl... | 05/03/2005 |
| 6869938 | Compositions of polyacids and polyethers and methods for their use in reducing adhesions The present invention relates to improved methods for making and using bioadhesive, bioresorbable, anti-adhesion compositions made of intermacromolecular complexes of carboxyl-containing polysaccharides, polyethers, polyacids, polyalkylene oxides, multivalent cation... | 03/22/2005 |
| 6620797 | Artificial tear composition containing a combination of three demulcents Improved artificial tear compositions are described. The compositions are preferably formulated as sterile, isotonic solutions. The solutions contain a unique combination of three demulcents. The solutions preferably also contain one or more electrolytes ... | 09/16/2003 |
| 6565894 | Healthcare formulations comprising imidazole and hydrogen peroxide An ophthalmic solution comprising: 0.01 to 5 weight percent imidazole: 0.01 to 30 weight percent hydrogen peroxide and the balance water which can further comprisie 0.01 to 2 weight percent of a buffer adjusted so the pH of the formulation is between 5.5 ... | 05/20/2003 |
| 6506412 | Treatment of dry eye syndrome Dry-eye syndrome and other dryness effects of glandular malfunction are treated orally by a combination which includes a source of omega-3 fatty acid, a source of omega-6 fatty acid, vitamin A, vitamin B6, a source of magnesium and a water-soluble antioxi... | 01/14/2003 |
| 6369112 | Treatment of contact lenses with aqueous solution comprising a biguanide disinfectant stabilized by tyloxapol The present invention is directed to a biguanide-containing disinfecting solution containing tyloxapol in combination with a poloxamine for stabilizing the biguanide, which is especially useful for contact-lens solutions that provide enhanced disinfecting... | 04/09/2002 |
| 6365636 | Use of borate-polyol complexes in ophthalmic compositions Water-soluble borate-polyol complexes are useful as buffers and/or antimicrobials in aqueous ophthalmic compositions, including those containing polyvinyl alcohol. These compositions have greater antimicrobial activity than comparable compositions contain... | 04/02/2002 |
| 6254893 | Composition for treating dry eye A calcium-based ophthalmic composition for treating dry eye including a hydrophobic carrier, such as petrolatum, and a calcium salt. Also a method for treating dry eye comprising the step of administering the composition according to the present invention... | 07/03/2001 |
| 6180093 | Method and composition for rewetting contact lenses and relieving eye dryness The present invention is directed to a lubricant for contact lenses or dry eye or to provide relief from eye irritation. In particular, the composition contains a biguanide preservative in combination with polyvinylpyrollidone. An ophthalmic solution cont... | 01/30/2001 |
| 6143799 | Use of borate-polyol complexes in ophthalmic compositions Water-soluble borate-polyol complexes are useful as buffers and/or antimicrobials in aqueous ophthalmic compositions, including those containing polyvinyl alcohol. These compositions have greater antimicrobial activity than comparable compositions contain... | 11/07/2000 |
| 6124037 | Articles coated with in vivo polymerizable ophthalmic compositions Coatings for surgical instruments which comprise substituted fluoroalkyl or perfluoroalkyl monomers having anionic, cationic, and/or nonionic surface active functionality in the unsaturated fluorophobic ends.... | 09/26/2000 |
| 6113894 | Ophthalmic compositions and process of using An ophthalmic composition and process for treating blepharitis employing the composition of 0.5-10% of available nonionic surfactant in water to emulsify and remove lipids from the corneal surface.... | 09/05/2000 |
| 5981607 | Emulsion eye drop for alleviation of dry eye related symptoms in dry eye patients and/or contact lens wearers An eye drop composition for alleviation of dry eye related symptoms in dry eye patients and contact lens wearers includes an emulsion of a higher fatty acid glyceride, polysorbate 80 and an emulsion stabilizing amount of Pemulen.RTM. in water suitable for... | 11/09/1999 |
| 5922319 | Methods of treating eye conditions with human leukocyte elastase (HLE) inhibitory agents A method of reducing corneal scarring or fibroblast proliferation comprises applying to an area of a subject's eye afflicted with the condition a corneal scar-fibroblast proliferation-reducing amount of a free or polymer-bound HLE inhibitory agent under c... | 07/13/1999 |
| 5888493 | Ophthalmic aqueous gel formulation and related methods An ophthalmic formulation is described containing at least one pharmaceutically active substance, purified water, and an amount of gelling agent effective to form an aqueous gel. The gel has a viscosity of from 75,000 to 3,000,000 centipoise and does not ... | 03/30/1999 |
| 5889030 | Method for stabilizing pranoprofen and stable liquid preparation of pranaprofen A method for stabilizing pranoprofen, comprising placing an aqueous solution of pranoprofen in coexistence with an antioxidant, or placing an aqueous solution of pranoprofen under the conditions of limited supply of oxygen, and a stable aqueous preparatio... | 03/30/1999 |
| 5886054 | Therapeutic method for enhancing saliva The present invention relates to a therapeutic composition comprising an aqueous solution of at least one polymer and at least one electrolyte, wherein the aqueous solution is preferably buffered and optionally contains at least one mucin. The polymer can... | 03/23/1999 |
| 5869231 | Method for reproducibly determining the components of lacrimal fluid The invention relates to a sampling kit for obtaining, in a rapid and gentle manner, a defined volume of lacrimal fluid for the purpose of reproducibly determining components of the lacrimal fluid.... | 02/09/1999 |
| 5861148 | Ophthalmic compositions and process of using An ophthalmic composition and process for treating blepharitis employing the composition of 0.5-10% of available nonionic surfactant in water to emulsify and remove lipids from the corneal surface.... | 01/19/1999 |
| 5858996 | Compositions and methods for stabilizing polymers Compositions and methods for reducing the decomposition rate of polymeric bioadhesives and viscosity enhancers, such as poly(acrylic acids). The compositions include at least one strong, stable chelating agent, preferably an organophosphorous compound suc... | 01/12/1999 |
| 5856345 | Method for stabilizing pranoprofen and stable liquid preparation of pranoprofen A method for stabilizing pranoprofen, comprising placing an aqueous solution of pranoprofen in coexistence with an antioxidant, or placing an aqueous solution of pranoprofen under the conditions of limited supply of oxygen, and a stable aqueous preparatio... | 01/05/1999 |
| 5830508 | Composition for treating dry eye A calcium-based ophthalmic composition for treating dry eye is disclosed. The composition includes a hydrophobic carrier such as petrolatum and a calcium salt. The composition can further include a polyol such as glycerol, and an agent such as anhydrous l... | 11/03/1998 |
| 5800807 | Ophthalmic compositions including glycerin and propylene glycol There are disclosed ophthalmic compositions having high water-binding properties which are useful as: moisturizing and lubricating (i.e. artificial tear) solutions, dry eye therapies, contact lens wetting and lubricating solutions, and as delivery vehicle... | 09/01/1998 |
| 5770628 | Ophthalmic preparation for use as artificial tear Ophthalmic preparation for use as artificial tear containing hyaluronate as a viscosity thickener, preferably in the form of sodic salt and having a molecular weight of 500,000 to 4,000,000 daltons, at a concentration of 0.05 to 2% by weight, as well as t... | 06/23/1998 |
| 5707614 | Diagnostics apparatus for determining precorneal retention time of ophthalmic formulations Apparatus and method for measuring ophthalmic formulation retention on the surface of an eye include dissolving a fluorescent macromolecule in an ophthalmic formulation to form a fluorescently labelled formulation; topically administering the fluorescentl... | 01/13/1998 |
| 5683993 | Compositions and methods for stabilizing polymers Compositions and methods for reducing the decomposition rate of polymeric bioadhesives and viscosity enhancers, such as poly(acrylic acids). The compositions include at least one strong, stable chelating agent, preferably an organophosphorous compound suc... | 11/04/1997 |
| 5645827 | Muco-adhesive polymers Compositions comprising cationic polysaccharide polymers and anionic therapeutic agents which can have enhanced substantivity to mucosal surfaces are disclosed. These compositions are well suited, for example, for the delivery of anionic ophthalmic pharma... | 07/08/1997 |
| 5599534 | Reversible gel-forming composition for sustained delivery of bio-affecting substances, and method of use Reversibly gel-forming compositions for sustained delivery of bio-affecting substances are disclosed. The compositions exhibit significant changes in viscosity in response to changes in pH. The compositions contain relatively low concentrations of a stabl... | 02/04/1997 |
| 5599535 | Methods for the cyto-protection of the trabecular meshwork The invention concerns the recognition that certain non-steroidal anti-inflammatory agents produce cytoprotective effects on trabecular cells, and thus can be used to prevent injury to the cells and treat the loss of trabecular cells caused by oxidative o... | 02/04/1997 |
| 5597809 | Treatment of optic neuritis Methods of treating optic neuritis comprising administering a protective agent which inhibits glutamate-mediated retinal cell damage to a mammal at risk of developing optic neuritis.... | 01/28/1997 |
| 5595764 | Ophthalmic composition for treating dry eye An ophthalmologic composition therapeutic in the treatment of dry eye syndrome is disclosed. The composition is comprised of a minimally soluble salt of calcium that has been finely divided into particles having a mean diameter of 10 to 60 microns. The ca... | 01/21/1997 |
| 5561109 | Method for the healing of wounds caused by corneal injury A method for the healing of wounds caused by corneal injury, which includes administering to a mammalian patient in need thereof an effective wound healing amount of lactoferrin, lactoperoxidase or a combination of lactoferrin and lactoperoxidase as activ... | 10/01/1996 |
| 5527533 | Method of retarding and ameliorating central nervous system and eye damage A method of retarding and ameliorating eye diseases and injuries is disclosed. The method comprises administering astaxanthin in a therapeutically-effective amount to prevent, retard or treat eye and central nervous system diseases or injuries, such as ag... | 06/18/1996 |
| 5510101 | Ophthalmic pharmaceutical composition containing N-acetyl-cysteine and polyvinylalcohol An ophthalmic pharmaceutical composition containing an association of N-acetyl-cysteine and polyvinylalcohol useful for the treatment of keratoconjunctivitis sicca.... | 04/23/1996 |
| 5505953 | Use of borate-polyol complexes in ophthalmic compositions Water-soluble borate-polyol complexes are useful as buffers and/or antimicrobials in aqueous ophthalmic compositions, including those containing polyvinyl alcohol. These compositions have greater antimicrobial activity than comparable compositions contain... | 04/09/1996 |
